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公开(公告)号:US20080004208A1
公开(公告)日:2008-01-03
申请号:US11791839
申请日:2005-12-05
申请人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
发明人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
CPC分类号: G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/16
摘要: In order to more accurately analyze a change in the complicated gene copy number in malignant lymphoma and identify a region affected by an important genomic aberration in greater detail so that the results can be used in diagnosing the type of disease and performing prognosis, genome-wide array CGH is carried out and thus human chromosome 136.23 to p36.32, human chromosome 1 q42.2 to q43, human chromosome 2 p11.2, human chromosome 2 q13, human chromosome 17 p11.2 to p13.3, and human chromosome 19 p13.2 to p13.3 are identified.
摘要翻译: 为了更准确地分析恶性淋巴瘤中复杂基因拷贝数的变化,并更详细地鉴定受重要基因组畸变影响的区域,使得结果可用于诊断疾病的类型并进行预后,全基因组 进行阵列CGH,因此人染色体136.23至p36.32,人染色体1 q42.2至q43,人染色体2 p11.2,人染色体2 q13,人染色体17 p11.2至p13.3和人染色体 19 p13.2至p13.3。
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公开(公告)号:US20070292853A1
公开(公告)日:2007-12-20
申请号:US10593349
申请日:2005-03-18
CPC分类号: C12Q1/6827 , C12Q2565/501 , C12Q2537/143 , C12Q2525/204
摘要: A DNA array for detecting a single nucleotide polymorphism of a gene, which comprises, on a solid support, a first probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with a polynucleotide of the gene, in which the probes are exactly complementary to the first polymorphism pattern of the gene, and a second probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with the polynucleotide of the gene, in which the probes are exactly complementary to the second polymorphism pattern of the gene, wherein probe lengths in the probe spots is different from each other. This DNA array enables more exact SNP detection.
摘要翻译: 一种用于检测基因的单核苷酸多态性的DNA阵列,其在固体支持物上包含由一个或多个探针点组成的第一探针斑点,每个探针点含有一个或多个与该基因的多核苷酸杂交的探针,其中 探针与基因的第一多态性模式完全互补,第二探针点组由一个或多个探针点组成,每个探针点含有一个或多个可与基因的多核苷酸杂交的探针,其中探针与第二个 基因的多态性模式,其中探针点中的探针长度彼此不同。 该DNA阵列能够进行更准确的SNP检测。
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公开(公告)号:US20070028332A1
公开(公告)日:2007-02-01
申请号:US10553124
申请日:2004-04-15
申请人: Noboru Endo , Kouki Yoshida , Miho Akiyoshi , Yasuko Yoshida , Chieko Ohsumi , Daisuke Igarashi
发明人: Noboru Endo , Kouki Yoshida , Miho Akiyoshi , Yasuko Yoshida , Chieko Ohsumi , Daisuke Igarashi
CPC分类号: C12N15/8273 , C12N9/90
摘要: This invention provides a novel gene that can impart salt stress tolerance to plants for a long period of time and salt stress tolerant transgenic plants to which such gene has been introduced. Such novel gene encodes the following protein (a), (b), or (c), and such salt stress tolerant transgenic plant has such gene introduced therein: (a) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing; (b) a protein consisting of an amino acid sequence derived from the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing by deletion, substitution, or addition of one or several amino acid residues and having activity of imparting salt stress tolerance to plants; or (c) a protein consisting of an amino acid sequence derived from the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing by deletion, substitution, or addition of one or several amino acid residues and having UDP-glucose 4-epimerase activity.
摘要翻译: 本发明提供了一种能够长时间赋予植物盐胁迫耐受性和引入这种基因的耐盐胁迫转基因植物的新型基因。 这样的新基因编码以下蛋白质(a),(b)或(c),并且这种耐盐胁迫转基因植物在其中引入了这样的基因:(a)由如SEQ ID NO所示的氨基酸序列组成的蛋白质 :序列表中的2个; (b)通过缺失,取代或添加一个或几个氨基酸残基并具有赋予盐胁迫活性的序列表中SEQ ID NO:2所示氨基酸序列的氨基酸序列组成的蛋白质 植物耐受性 或(c)由序列表中SEQ ID NO:2所示的氨基酸序列的氨基酸序列组成的蛋白质,通过缺失,取代或添加一个或几个氨基酸残基并具有UDP-葡萄糖4 - 同工酶活性。
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公开(公告)号:US20050145897A1
公开(公告)日:2005-07-07
申请号:US11008276
申请日:2004-12-10
IPC分类号: H01L21/28 , H01L21/285 , H01L21/304 , H01L21/318 , H01L21/336 , H01L21/768 , H01L21/8238 , H01L23/522 , H01L27/092 , H01L29/417 , H01L29/78 , H01L21/3205 , H01L29/76 , H01L31/062
CPC分类号: H01L29/665 , H01L21/28518 , H01L21/76832 , H01L21/76834 , H01L21/823814 , H01L21/823835 , H01L21/823842 , H01L29/6656 , H01L29/6659 , H01L29/7833 , H01L29/7842
摘要: A method of manufacture of a semiconductor device includes forming a gate insulating film and a gate electrode made of polycrystalline silicon over a semiconductor substrate; implanting ions into the semiconductor substrate to form a semiconductor region as a source or drain; forming a cobalt film and a titanium nitride film over the semiconductor substrate to cover the gate electrode; carrying out annealing to cause a reaction between Co and Si and the semiconductor region to form a CoSi layer; carrying out wet cleaning to remove the titanium nitride film and unreacted cobalt film to leave the CoSi layer over the gate electrode and semiconductor region; carrying out annealing to cause a reaction between the CoSi layer and the gate electrode and semiconductor region to form a CoSi2 layer; carrying out HPM cleaning; and forming over the semiconductor substrate a silicon nitride film by low-pressure CVD to cover the gate electrode.
摘要翻译: 一种制造半导体器件的方法包括在半导体衬底上形成栅极绝缘膜和由多晶硅制成的栅电极; 将离子注入到半导体衬底中以形成作为源极或漏极的半导体区域; 在所述半导体衬底上形成钴膜和氮化钛膜以覆盖所述栅电极; 进行退火以引起Co和Si之间的反应以及半导体区域以形成CoSi层; 进行湿式清洗以除去氮化钛膜和未反应的钴膜,使CoSi层离开栅电极和半导体区域; 进行退火以引起CoSi层和栅极电极和半导体区域之间的反应以形成CoSi 2 O 3层; 进行HPM清洗; 以及通过低压CVD在半导体衬底上形成氮化硅膜以覆盖栅电极。
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公开(公告)号:US20050053484A1
公开(公告)日:2005-03-10
申请号:US10504692
申请日:2003-02-18
申请人: Toshikazu Hirota , Yasuko Yoshida
发明人: Toshikazu Hirota , Yasuko Yoshida
IPC分类号: B01F11/02 , B01F13/00 , B01L3/00 , F04B43/04 , F04B53/10 , G01N27/447 , G01N37/00 , F04B17/00
CPC分类号: G01N27/44704 , B01F11/02 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0867 , B01L2300/1827 , B01L2400/0421 , B01L2400/0439 , B01L2400/0605 , B01L2400/0677 , B01L2400/082 , F04B43/043 , F04B53/1077 , G01N27/44791
摘要: A microchemical chip (10A) comprises a plate-shaped substrate (12), with a channel (14) formed on a surface of the substrate (12) through which a fluid flows. A fluid storage section (16) for storing the fluid communicates with the channel (14) at a starting end of the channel (14). A fluid discharge section (18) communicates with the channel (14) at a terminal end of the channel (14). An extruding pump section (22) is formed integrally on the substrate (12), at a portion of the channel (14) in the vicinity of the fluid storage section (16).
摘要翻译: 微化学芯片(10A)包括板状基板(12),其中在基板(12)的表面上形成有流体流过的通道(14)。 用于存储流体的流体存储部分(16)在通道(14)的起始端处与通道(14)通信。 流体排放部分(18)在通道(14)的终端处与通道(14)连通。 挤出泵部分(22)在流体存储部分(16)附近的通道(14)的一部分上一体地形成在基板(12)上。
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公开(公告)号:US6083931A
公开(公告)日:2000-07-04
申请号:US930680
申请日:1997-12-09
IPC分类号: A61K31/726 , A61P35/00 , C07H7/027 , A61K31/715
CPC分类号: A61K31/7012 , A61K31/726 , C07H7/027
摘要: The present invention is aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells when used alone. In addition, the present invention is also aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells while causing a small side effect and very small toxicity even for an extended time of administration. The cancer metastasis-inhibiting anticancer agent according to the present invention is characterized by containing sialic acid, its salt, a polymer of sialic acid or a salt of the polymer as an effective ingredient.
摘要翻译: PCT No.PCT / JP96 / 00268 Sec。 371日期1997年12月9日第 102(e)日期1997年12月9日PCT提交1996年2月8日PCT公布。 公开号WO97 / 28807 日期:1997年8月14日本发明旨在提供一种当单独使用时能抑制癌细胞转移的抗癌剂。 另外,本发明的目的还在于提供一种能够抑制癌细胞的转移,同时引起副作用小,毒性甚至延长施用时的毒性也非常小的抗癌剂。 根据本发明的癌转移抑制抗癌剂的特征在于含有唾液酸,其盐,唾液酸的聚合物或聚合物的盐作为有效成分。
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公开(公告)号:US5408601A
公开(公告)日:1995-04-18
申请号:US270325
申请日:1994-07-05
申请人: Takeo Nakamura , Syuichiro Yamada , Yasuko Yoshida
发明人: Takeo Nakamura , Syuichiro Yamada , Yasuko Yoshida
CPC分类号: G06F3/04845
摘要: A graphic editor for performing various editing processes such as inputting, moving, copying, and deleting a graphic pattern and a line on a display screen in a graphic editing system such as a CAD, etc. The graphic editor realizes a user interface for simultaneously selecting an object to be processed and a function, thus improving the efficiency of the editing operation. The editor comprises an area specifier for specifying an area as a rectangle having a diagonal whose start and end points are specified by the area specifier, and a graphic operating unit for determining the existence of a symbol or a line in a specified area to give a predetermined process on the symbol or the line. The predetermined processes can be identified by determining whether or not a symbol and/or a whole or a part of a line exists in or crosses a specified area.
摘要翻译: 一种图形编辑器,用于在诸如CAD等图形编辑系统中的显示屏幕上执行各种编辑处理,例如输入,移动,复制和删除图形图案和线。图形编辑器实现用于同时选择的用户界面 要处理的对象和功能,从而提高编辑操作的效率。 编辑器包括用于将区域指定为具有由区域说明符指定开始和结束点的对角线的矩形的区域说明符,以及图形操作单元,用于确定指定区域中的符号或行的存在以给出 符号或线上的预定过程。 可以通过确定符号和/或整个或一部分线是否存在于或跨越指定区域来识别预定过程。
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