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    Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter
    61.
    发明授权
    Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter 有权
    通过可插入热交换导管控制患者体温的方法和系统

    公开(公告)号：US07175649B2

    公开(公告)日：2007-02-13

    申请号：US10645891

    申请日：2003-08-20

    申请人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环流动管线，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可重复使用的控制单元内的泵驱动机构接合的整体泵头。 可以设置多个控制单元以接收相同的热交换盒，使得最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

    Endovascular heat-and gas-exchange catheter device and related methods
    63.
    发明授权
    Endovascular heat-and gas-exchange catheter device and related methods 失效
    血管内置换气导管装置及相关方法

    公开(公告)号：US06702783B1

    公开(公告)日：2004-03-09

    申请号：US10068256

    申请日：2002-02-05

    申请人： Michael W. Dae ,  Timothy R. Machold

    发明人： Michael W. Dae ,  Timothy R. Machold

    IPC分类号： A61F712

    CPC分类号： A61F7/12 ,  A61F2007/0054 ,  A61F2007/126

    摘要： An endovascular catheter device capable of heat and gas exchange with a patient's bloodstream comprises a catheter shaft, a heat exchanger, and a gas exchange element. The heat exchanger and the gas exchange element are in fluid communication with one or more internal lumens of the catheter shaft. The catheter shaft may be connected to a control system that permits a heat exchange fluid to be delivered to the heat exchanger, and that permits a gas to be delivered to the gas exchange element. The catheter device may also comprise one or more flow disruption devices to disrupt the laminar flow of blood around the catheter device. The catheter device may be used to cool and oxygenate a patient's blood, and improve organ function.

    摘要翻译： 能够与患者的血流进行热交换和气体交换的血管内导管装置包括导管轴，热交换器和气体交换元件。 热交换器和气体交换元件与导管轴的一个或多个内部流体流体连通。 导管轴可以连接到控制系统，其允许将热交换流体输送到热交换器，并且允许气体被输送到气体交换元件。 导管装置还可以包括一个或多个流动破裂装置，以破坏导管装置周围的血液的层流。 导管装置可用于冷却患者血液并使其充氧，并改善器官功能。

    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
    64.
    发明授权
    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
    通过可插入热交换导管来控制患者体温的方法和系统

    公开(公告)号：US06620189B1

    公开(公告)日：2003-09-16

    申请号：US09707257

    申请日：2000-11-06

    申请人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F700

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。 可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元 。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    66.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US06544282B1

    公开(公告)日：2003-04-08

    申请号：US09790249

    申请日：2001-02-21

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    摘要翻译： 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以向体温低于该患者发抖阈值（通常约35.5℃）的患者施用抗发抖药物或麻醉。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。