公开(公告)号：US20060039905A1

公开(公告)日：2006-02-23

申请号：US11246980

申请日：2005-10-11

申请人： Jian Ni ,  Reiner Gentz ,  Craig Rosen ,  Fu-Tong Liu

发明人： Jian Ni ,  Reiner Gentz ,  Craig Rosen ,  Fu-Tong Liu

IPC分类号： C07K16/28 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395

CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/4726 ,  C07K14/705 ,  C07K14/70535 ,  C07K16/18 ,  C07K16/2851 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.

公开(公告)号：US06878812B2

公开(公告)日：2005-04-12

申请号：US09950688

申请日：2001-09-13

申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C12N1/21 ,  C12N9/00 ,  C12N9/64 ,  C12N15/57 ,  C07K16/00

CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

公开(公告)号：US06653445B1

公开(公告)日：2003-11-25

申请号：US09010147

申请日：1998-01-21

申请人： Jian Ni ,  Craig A. Rosen ,  Reiner Gentz ,  Jeffrey Y. Su ,  Geoffrey W. Krissansen ,  Ping Feng

发明人： Jian Ni ,  Craig A. Rosen ,  Reiner Gentz ,  Jeffrey Y. Su ,  Geoffrey W. Krissansen ,  Ping Feng

IPC分类号： C07K1400

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体，宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06312937B1

公开(公告)日：2001-11-06

申请号：US09372154

申请日：1999-08-11

申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

IPC分类号： C12N950

CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

公开(公告)号：US6046031A

公开(公告)日：2000-04-04

申请号：US9156

申请日：1998-01-20

申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C12N1/21 ,  C12N9/00 ,  C12N9/64 ,  C12N15/57 ,  C12P21/06

CPC分类号： C12N9/6489 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  A61K38/00 ,  C12N2799/026

摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

公开(公告)号：US5981220A

公开(公告)日：1999-11-09

申请号：US815718

申请日：1997-03-12

申请人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner Gentz

发明人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner Gentz

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/485 ,  C07K16/22 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  C12N15/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

摘要翻译： 公开了人表皮分化因子多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。 还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。

公开(公告)号：US20070203070A1

公开(公告)日：2007-08-30

申请号：US11744695

申请日：2007-05-04

申请人： Craig Rosen ,  Steven Ruben ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw ,  Carrie Fischer ,  Haodong Li ,  Daniel Soppet ,  Reiner Gentz ,  Ying-Fei Wei ,  Paul Moore ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Gregg Hastings

发明人： Craig Rosen ,  Steven Ruben ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw ,  Carrie Fischer ,  Haodong Li ,  Daniel Soppet ,  Reiner Gentz ,  Ying-Fei Wei ,  Paul Moore ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Gregg Hastings

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K16/00 ,  C07K4/00 ,  C12N15/00 ,  C12N15/09 ,  C12N5/00 ,  C12N5/08 ,  C12Q1/00 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/4702 ,  C07K14/4718 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2799/026

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050208621A1

公开(公告)日：2005-09-22

申请号：US10951993

申请日：2004-09-29

申请人： Craig Rosen ,  Steven Ruben ,  Yi Li ,  ZhiZhen Zeng ,  Hla Kyaw ,  Carrie Fishcher ,  Haodong Li ,  Daniel Soppet ,  Reiner Gentz ,  Ying-Fei Wei ,  Paul Moore ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Gregg Hastings

发明人： Craig Rosen ,  Steven Ruben ,  Yi Li ,  ZhiZhen Zeng ,  Hla Kyaw ,  Carrie Fishcher ,  Haodong Li ,  Daniel Soppet ,  Reiner Gentz ,  Ying-Fei Wei ,  Paul Moore ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Gregg Hastings

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/4702 ,  C07K14/4718 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2799/026

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US5808029A

公开(公告)日：1998-09-15

申请号：US444793

申请日：1995-05-19

申请人： Manfred Brockhaus ,  Zlatko Dembic ,  Reiner Gentz ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

发明人： Manfred Brockhaus ,  Zlatko Dembic ,  Reiner Gentz ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K1/16 ,  C07K1/22 ,  C07K1/26 ,  C07K4/12 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K14/705 ,  C07K14/715 ,  C07K16/06 ,  C07K16/24 ,  C07K16/28 ,  C12N1/21 ,  C12N5/10 ,  C12N15/02 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53

CPC分类号： C07K14/7151 ,  C07K16/2866 ,  A61K38/00 ,  C12N2799/026

摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

公开(公告)号：US5610279A

公开(公告)日：1997-03-11

申请号：US95640

申请日：1993-07-21

申请人： Manfred Brockhaus ,  Zlatko Dembic ,  Reiner Gentz ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

发明人： Manfred Brockhaus ,  Zlatko Dembic ,  Reiner Gentz ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K1/16 ,  C07K1/22 ,  C07K1/26 ,  C07K4/12 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K14/705 ,  C07K14/715 ,  C07K16/06 ,  C07K16/24 ,  C07K16/28 ,  C12N1/21 ,  C12N5/10 ,  C12N15/02 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  C07K16/46

CPC分类号： C07K14/7151 ,  C07K16/2866 ,  A61K38/00 ,  C12N2799/026

摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。