公开(公告)号：US06473646B2

公开(公告)日：2002-10-29

申请号：US09551310

申请日：2000-04-18

申请人： Weimin Sun ,  Veerichetty Kadhiresan ,  Bruce H. KenKnight ,  Richard S. Sanders

发明人： Weimin Sun ,  Veerichetty Kadhiresan ,  Bruce H. KenKnight ,  Richard S. Sanders

IPC分类号： A61N1362

CPC分类号： A61N1/36542

摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.

摘要翻译： 一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。 通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。 本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。

公开(公告)号：US06400986B1

公开(公告)日：2002-06-04

申请号：US09545945

申请日：2000-04-10

申请人： Weimin Sun ,  Bruce H. KenKnight ,  Martin Tze ,  Yatheendhar Manicka

发明人： Weimin Sun ,  Bruce H. KenKnight ,  Martin Tze ,  Yatheendhar Manicka

IPC分类号： A61N1362

CPC分类号： A61N1/3962

摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.

摘要翻译： 公开了以自适应方式递送抗心动过速起搏的方法和装置。 具有抗心动过速起搏能力的心脏节律管理装置，例如可植入心脏起搏器，在检测到可终止的心律失常时，根据选定的起搏方案提供抗心动过速起搏治疗。 协议从可用协议库中选择。 在用于选择协议的结果表中保留了每种可用协议在转换快速性心律失常方面的成功和失败的记录。

公开(公告)号：US5861019A

公开(公告)日：1999-01-19

申请号：US900624

申请日：1997-07-25

申请人： Weimin Sun ,  Gregory J. Haubrich ,  Garry L. Dublin

发明人： Weimin Sun ,  Gregory J. Haubrich ,  Garry L. Dublin

IPC分类号： H01Q1/27 ,  H01Q1/40 ,  H01Q9/04 ,  H04B1/38

CPC分类号： H01Q9/0407 ,  H01Q1/273 ,  H01Q1/40 ,  H01Q1/405 ,  A61N1/37229

摘要： A microstrip RF telemetry antenna is formed on or within the exterior surface of an implantable medical device housing that is formed either of a conductive metal or of a non-conductive dielectric material. The microstrip antenna is formed of an electrically conductive radiator patch layer that is laminated upon an exterior facing side of a dielectric substrate layer of relatively constant thickness. A conductive ground plane layer is formed on the opposite side of the dielectric substrate layer to extend parallel to and at least coextensively with the radiator patch layer. The radiator patch layer is coupled to the transceiver circuitry within the implantable medical device housing by a feedthrough extending through the dielectric substrate layer, the ground plane layer and the implantable medical device housing side wall. If the implantable medical device housing is conductive it may form the ground plane layer over which the dielectric substrate layer and the radiator patch layer are formed through deposition or other techniques. If the implantable medical device housing is formed of a suitable non-conductive dielectric material, the ground plane layer is formed on an interior surface thereof and the radiator patch layer is formed on an exterior housing surface thereof, preferably by deposition techniques. The ground plane layer may be recessed to form a cavity backed ground plane that receives the dielectric layer and radiator patch layer within the cavity. The exterior surfaces of the radiator patch layer, the dielectric layer and any exposed surface of the ground plane layer may be electrically insulated by a radome layer.

摘要翻译： 在由可导电金属或非导电介电材料形成的可植入医疗装置外壳的外表面上或内部形成微带RF遥测天线。 微带天线由层叠在相对恒定厚度的电介质基板层的面向外侧的导电散热器贴片层形成。 导电接地层形成在电介质基底层的相对侧上，以平行于并且至少与散热器贴片层共延伸。 辐射器贴片层通过延伸穿过电介质基底层，接地平面层和可植入医疗器件外壳侧壁的馈通件耦合到可植入医疗器械外壳内的收发器电路。 如果可植入医疗装置壳体是导电的，则可以形成通过沉积或其它技术在其上形成电介质基底层和辐射器贴片层的接地平面层。 如果可植入医疗器件壳体由合适的非导电介电材料形成，则接地平面层形成在其内表面上，散热器贴片层优选地通过沉积技术形成在其外壳表面上。 接地平面层可以凹入以形成空腔背面的接地平面，其接收空腔内的电介质层和散热器贴片层。 散热器贴片层，电介质层和接地平面层的任何暴露表面的外表面可以由天线罩层电绝缘。

公开(公告)号：US5778881A

公开(公告)日：1998-07-14

申请号：US759494

申请日：1996-12-04

申请人： Weimin Sun ,  Eric J. Panken ,  William J. Combs

发明人： Weimin Sun ,  Eric J. Panken ,  William J. Combs

IPC分类号： A61B5/042 ,  A61B5/0464 ,  A61N5/0402

CPC分类号： A61B5/726 ,  A61B5/0422 ,  A61B5/0464 ,  A61B5/7203 ,  A61B5/7267 ,  A61B5/7225

摘要： This is a method and apparatus for the automated discrimination of cardiac events of interest, including P-waves, R-waves, T-waves, and specific arrhythmic sequences, in EGM signals for data storage in an implantable monitor or to control operations of an implantable cardiac stimulator through the use of Hidden Markov Modeling techniques and a reduced set of observations. The number of computations and computation time during a heart cycle is reduced by timing the frames of A-EGM samples to the detection of A-SENSE events by the atrial sense amplifier. The A-EGM sample frame is defined in a window preceding and following each A-SENSE event. The A-EGM sample frames are wavelet transformed, and a number of selected W.T. coefficients for each sample frame are saved in a buffer. Each set of saved W.T. coefficients therefore represents either a P-wave or an intrinsic or paced far field R-wave (including fusion beats) unless noise continuously causes A-SENSE events to occur. When the V-SENSE event occurs, an R-trigger is generated, and each set of saved W.T. coefficients is subjected to the HMM algorithm for a determination as to whether the preceding (and any concurrent) A-SENSE events from which the saved W.T. coefficients were derived are P-waves or R-waves. In addition, when the V-SENSE occurs, the HMM algorithm determines stochastically whether or not the successive sets of saved W.T. coefficients represent P-P sequences, far field R-R sequences or P-R sequences or the like.

摘要翻译： 这是用于在可植入监视器中用于数据存储的EGM信号中自动辨别感兴趣的心脏事件（包括P波，R波，T波和特定心律失常序列）的方法和装置，或用于控制 植入式心脏刺激器通过使用隐马尔可夫建模技术和一组减少的观察结果。 通过将A-EGM样本的帧定位为由心房感觉放大器检测A-SENSE事件来减少心脏周期中的计算和计算时间的数量。 A-EGM采样帧在每个A-SENSE事件之前和之后的窗口中定义。 A-EGM采样帧被小波变换，并且每个采样帧的多个选定的W.T系数被保存在缓冲器中。 因此，除非噪声连续地导致A-SENSE事件发生，所以每组保存的W.T.系数因此表示P波或固有或起搏的远场R波（包括融合节拍）。 当V-SENSE事件发生时，产生R-触发，并且每一组保存的WT系数经受HMM算法以确定是否存在保存的WT的先前（和任何并发）A-SENSE事件 导数系数是P波或R波。 此外，当V-SENSE发生时，HMM算法随机确定保存的W.T.系数的连续组是否表示P-P序列，远场R-R序列或P-R序列等。

公开(公告)号：US5614862A

公开(公告)日：1997-03-25

申请号：US622655

申请日：1996-03-26

申请人： Weimin Sun

发明人： Weimin Sun

IPC分类号： H03D3/00 ,  H04L27/14 ,  H03D1/00 ,  H03D5/00

CPC分类号： H03D3/006 ,  H03D3/007

摘要： A DMUX 11 outputs data in a digital FM signal in a circulation to produce signals S1 to S4. An MUX 14 alternately outputs inverted signals of the signals S1 and S3, obtaining a signal Si.sub.(k). An MUX 15 alternately outputs inverted signals of the signals S2 and S4, obtaining a signal Sq.sub.(k). An interpolation circuit 17 inserts data having a value of zero between individual data in the output signal of the MUX 14, and cuts off the high-frequency component of the resultant signal, obtaining a signal Si.sub.(i). A second interpolation circuit 19 inserts data having a value of zero between individual data in the output signal of the MUX 15, and cuts off the high-frequency component of the resultant signal, obtaining a signal Sq.sub.(i). An arithmetic operation circuit 2 computes SI.sub.(i-1) .multidot.SQ.sub.(i) -SI.sub.(i) .multidot.Sq.sub.(i-1), and integrates it to obtain a digital demodulated signal.

摘要翻译： DMUX11在循环中输出数字FM信号中的数据，产生信号S1〜S4。 MUX 14交替地输出信号S1和S3的反相信号，获得信号Si（k）。 MUX 15交替地输出信号S2和S4的反相信号，获得信号Sq（k）。 内插电路17将MUX14的输出信号中各个数据之间的值为零的数据插入，并切断所得到的信号的高频分量，得到信号Si（i）。 第二插值电路19在MUX15的输出信号中插入个数为零的数据，并切断所得信号的高频分量，得到信号Sq（i）。 算术运算电路2计算SI（i-1）×SQ（i）-SI（i）×Sq（i-1），并对其进行积分以获得数字解调信号。

公开(公告)号：US5530660A

公开(公告)日：1996-06-25

申请号：US535357

申请日：1995-09-28

申请人： Weimin Sun ,  Shigeki Kajimoto

发明人： Weimin Sun ,  Shigeki Kajimoto

IPC分类号： H03H17/04 ,  H03H17/02 ,  G06F17/10

CPC分类号： H03H17/0294

摘要： The filter coefficients of a digital band pass elliptic filter can be approximated to a linear function of the center frequency of the pass band width. The filter coefficients of a band pass digital filter having a predetermined center frequency and the slope of this linear function are stored in first and second memories. A central processing unit (CPU) obtains the difference between a desired center frequency and a predetermined center frequency. A multiplier multiplies the slope stored in the second memory by the difference obtained by the CPU. An adder adds each of the filter coefficients stored in the first memory to an associated one of the products output from the multiplier. The adding results become the filter coefficients for obtaining the desired center frequency. Those filter coefficients are set in a digital filter.

公开(公告)号：US09382586B2

公开(公告)日：2016-07-05

申请号：US13576740

申请日：2011-02-04

申请人： Feras Hantash ,  Weimin Sun ,  David C. Tsao ,  Dana Marie Root ,  Charles M Strom

发明人： Feras Hantash ,  Weimin Sun ,  David C. Tsao ,  Dana Marie Root ,  Charles M Strom

IPC分类号： C07H21/04 ,  C12Q1/68 ,  G06F19/10

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/683 ,  C12Q1/6858 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/10 ,  C12Q2525/151 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2537/16

摘要： Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5′-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.

摘要翻译： 提供了FMR1基因中存在或不存在CGG重复序列的扩增存在或不存在的方法，其中FMR2基因中CCG重复序列的扩增存在或不存在。 该方法可用于鉴定由于在5'-非翻译区域中CGG重复和CCG重复的扩增，FMR1基因和FMR2基因的正常/中间，相对于前体或全突变等位基因的个体。 该方法还可用于筛选脆性X综合征的新生儿或筛选妇女以确定CCG重复道全部前体的杂合状态。 这些方法在估算前遗症和全突变载体频率以及估计人群中FXTAS和FXPOI的患病率方面也很有用。 方法简单，快速，需要少量样品。

公开(公告)号：US20120222892A1

公开(公告)日：2012-09-06

申请号：US13040127

申请日：2011-03-03

申请人： Weimin Sun ,  Peter J. Zampardi ,  Hongxiao Shao

发明人： Weimin Sun ,  Peter J. Zampardi ,  Hongxiao Shao

IPC分类号： H05K1/09 ,  H05K3/00 ,  C25D7/00 ,  C25D5/02 ,  C25D19/00

CPC分类号： H01L23/66 ,  C25D5/022 ,  C25D5/12 ,  C25D7/0607 ,  C25D17/00 ,  H01L23/49838 ,  H01L23/49866 ,  H01L24/03 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L24/85 ,  H01L2223/6605 ,  H01L2223/6611 ,  H01L2224/03424 ,  H01L2224/03462 ,  H01L2224/03464 ,  H01L2224/04042 ,  H01L2224/05144 ,  H01L2224/05147 ,  H01L2224/05155 ,  H01L2224/05164 ,  H01L2224/05644 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48095 ,  H01L2224/48229 ,  H01L2224/48644 ,  H01L2224/48655 ,  H01L2224/48664 ,  H01L2224/49111 ,  H01L2224/85205 ,  H01L2224/85411 ,  H01L2224/85416 ,  H01L2224/85444 ,  H01L2224/85447 ,  H01L2224/85455 ,  H01L2224/85464 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01046 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/1421 ,  H01L2924/15747 ,  H01L2924/2064 ,  H05K1/0243 ,  H05K1/09 ,  H05K1/111 ,  H05K3/10 ,  H05K3/244 ,  H05K3/3452 ,  H05K2203/049 ,  H05K2203/0597 ,  H01L2924/00 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2224/45099

摘要： To reduce the RF losses associated with high RF loss plating, such as, for example, Ni/Pd/Au plating, the solder mask is reconfigured to prevent the edges and sidewalls of the wire-bond areas from being plated in some embodiments. Leaving the edges and sidewalls of the wire-bond areas free from high RF loss plating, such as Ni/Pd/Au plating, provides a path for the RF current to flow around the high resistivity material, which reduces the RF signal loss associated with the high resistivity plating material.

摘要翻译： 为了减少与诸如例如Ni / Pd / Au电镀的高RF损耗电镀相关联的RF损耗，在一些实施例中，重新配置焊接掩模以防止引线接合区域的边缘和侧壁被电镀。 离开没有高RF损耗电镀（例如Ni / Pd / Au电镀）的引线键合区域的边缘和侧壁提供了用于RF电流围绕高电阻率材料流动的路径，这降低了与 高电阻率电镀材料。

公开(公告)号：US07643877B2

公开(公告)日：2010-01-05

申请号：US11061315

申请日：2005-02-18

申请人： Richard Milon Dujmovic, Jr. ,  Phil Foshee ,  Richard Fogoros ,  Joseph M. Smith ,  Douglas R. Daum ,  Weimin Sun

发明人： Richard Milon Dujmovic, Jr. ,  Phil Foshee ,  Richard Fogoros ,  Joseph M. Smith ,  Douglas R. Daum ,  Weimin Sun

IPC分类号： A61N1/08 ,  A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3937 ,  A61N1/3943

摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.

摘要翻译： 心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。 血管内除颤电极植入心脏。 通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。 建立心脏周围电场的期望最小值。 测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。 使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。 在一个示例中，该装置还包括除颤电击电路和刺激电路。

公开(公告)号：US20080124712A1

公开(公告)日：2008-05-29

申请号：US11588184

申请日：2006-10-26

申请人： Feras M. Hantash ,  Weimin Sun ,  Shengbiao Wang

发明人： Feras M. Hantash ,  Weimin Sun ,  Shengbiao Wang

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The methods, compositions and kits disclosed herein relate generally to the detection of nucleic acids and nucleic acid mutations, such as mutations that may be correlated with disease. More specifically, the methods, compositions and kits relate to the detection of mutations in the α-globin gene cluster, to determining the gene dosage of α-globin in a subject, and to diagnosing the subject based on the presence or absence of mutations and/or gene dosage determination.

摘要翻译： 本文公开的方法，组合物和试剂盒通常涉及核酸和核酸突变的检测，例如可能与疾病相关的突变。 更具体地说，方法，组合物和试剂盒涉及检测α-珠蛋白基因簇中的突变，确定受试者中α-珠蛋白的基因剂量，以及基于突变的存在或不存在来诊断受试者，以及 /或基因剂量测定。