公开(公告)号：US5236592A

公开(公告)日：1993-08-17

申请号：US719245

申请日：1991-06-21

申请人： Philippe Dejardin ,  Feng Yan ,  Adrien Schmitt

发明人： Philippe Dejardin ,  Feng Yan ,  Adrien Schmitt

IPC分类号： A61L33/00 ,  A61L33/06 ,  A61M1/14 ,  B01D67/00 ,  B01D71/42

CPC分类号： B01D67/0088 ,  A61L33/0088 ,  A61L33/064 ,  B01D71/76 ,  B01D71/42 ,  B01D71/52

摘要： A composite material is disclosed that comprises a support membrane coated with an additive that reduces the thrombogenic character of the support. The support membrane is a copolymer of acrylonitrile and at least one ionic or ionizable monomer. The additive is a copolymer of acrylonitrile in which at least one of the comonomers is polyoxyethylene. The composite material of the invention is useful in the treatment of blood, and in particular, dialysis and plasmapheresis.

摘要翻译： 公开了一种复合材料，其包括涂覆有添加剂的支撑膜，其降低支架的血栓形成特性。 支撑膜是丙烯腈和至少一种离子或可离子化单体的共聚物。 添加剂是丙烯腈的共聚物，其中至少一种共聚单体是聚氧乙烯。 本发明的复合材料可用于治疗血液，特别是透析和血浆置换术。

公开(公告)号：US09375397B2

公开(公告)日：2016-06-28

申请号：US13096256

申请日：2011-04-28

申请人： Thierry Bettinger ,  Feng Yan ,  Sophie Mehier-Humbert ,  Peter Frinking

发明人： Thierry Bettinger ,  Feng Yan ,  Sophie Mehier-Humbert ,  Peter Frinking

IPC分类号： A61K48/00 ,  A61K9/00 ,  A61K41/00 ,  A61K47/48

CPC分类号： A61K9/0009 ,  A61K41/0028 ,  A61K47/6925 ,  A61K48/0008

摘要： Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.

公开(公告)号：US20150354006A1

公开(公告)日：2015-12-10

申请号：US14434063

申请日：2013-10-15

申请人： Ho Man CHAN ,  Nathan P. ENGLUND ,  Levi GARRAWAY ,  Min HU ,  Jacob JAFFE ,  Gregory KRYUKOV ,  Jun LIU ,  Xianghui LIU ,  Rob MCDONALD ,  Frank Peter STEGMEIER ,  Zhaofu WANG ,  Yan WANG ,  Haiping WU ,  Feng YAN

发明人： Ho Man Chan ,  Nathan P. Englund ,  Levi Garraway ,  Min Hu ,  Jacob Jaffe ,  Gregory Kryukov ,  Jun Liu ,  Xianghui Liu ,  Rob McDonald ,  Frank Peter Stegmeier ,  Zhaofu Wang ,  Yan Wang ,  Haiping Wu ,  Feng Yan

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/5011 ,  G01N33/57426 ,  G01N2333/91017 ,  G01N2440/12 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.

摘要翻译： 本发明提供检测癌细胞NSD2突变的方法，方法癌症诊断和筛选NSD2抑制剂的方法。

公开(公告)号：US20090263330A1

公开(公告)日：2009-10-22

申请号：US12440009

申请日：2007-09-04

申请人： Stephane Gorgerat ,  Christian Guillot ,  Feng Yan

发明人： Stephane Gorgerat ,  Christian Guillot ,  Feng Yan

IPC分类号： A61K49/22

CPC分类号： A61K49/223 ,  A61K49/1818 ,  A61K51/1251

摘要： Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.

摘要翻译： 用于诊断和/或治疗方法的图像增强造影剂，特别是以气体填充的微泡的形式，具有增强的稳定性。 气体填充的微泡由一层两亲性材料稳定，并含有0.15％至1.0％（摩尔）含有亲水性聚合物的脂质。 含有亲水性聚合物的脂质优选为与聚乙二醇连接的磷脂。

公开(公告)号：US09632058B2

公开(公告)日：2017-04-25

申请号：US13075027

申请日：2011-03-29

申请人： Feng Yan ,  Helen L. W. Chan ,  Hao Tang

发明人： Feng Yan ,  Helen L. W. Chan ,  Hao Tang

IPC分类号： G01N33/50 ,  G01N27/327 ,  G01N27/414

CPC分类号： G01N27/4145

摘要： A non-invasive glucose sensor (10) for detecting an amount of glucose in bodily fluid, comprising: an organic electrochemical transistor (OECT) having a gate electrode (20); wherein a surface of the gate electrode (20) is modified with an enzyme and a nanomaterial to increase sensitivity and selectivity of the gate electrode (20).

公开(公告)号：US08462556B1

公开(公告)日：2013-06-11

申请号：US13327586

申请日：2011-12-15

申请人： Yue Xu ,  Feng Yan ,  Ling Pu ,  Xiaoli Ji

发明人： Yue Xu ,  Feng Yan ,  Ling Pu ,  Xiaoli Ji

IPC分类号： G11C11/40 ,  G11C16/04

CPC分类号： G11C11/5671 ,  G11C11/5628 ,  G11C16/10 ,  G11C16/3445 ,  G11C16/3459 ,  G11C16/349

摘要： A localized trapping multi-level memory cell operating method includes the following steps. First, a localized trapping memory cell with the initial threshold voltage of approximately 2.5V is provided. Next, an erasing operation is performed to obtain a negative threshold level having uniform charge distribution along the channel region. Taking into account the over-erasure issue in the erasing operation, a programming operation is performed to precisely adjust the threshold voltage to a predetermined level of −2V to −1V. Then, with this negative voltage as a new initial state, a corresponding programming operation is performed and electrons are locally injected into the storage layer. By controlling the quantity of injected electrons, the MLC storage is achieved.

摘要翻译： 本地化陷阱多级存储单元操作方法包括以下步骤。 首先，提供具有大约2.5V的初始阈值电压的局部捕获存储单元。 接下来，执行擦除操作以获得沿通道区域具有均匀电荷分布的负阈值电平。 考虑到擦除操作中的过度擦除问题，执行编程操作以将阈值电压精确地调节到-2V至-1V的预定电平。 然后，利用该负电压作为新的初始状态，执行相应的编程操作，并将电子局部地注入存储层。 通过控制注入电子的数量，实现了MLC存储。

公开(公告)号：US20120117008A1

公开(公告)日：2012-05-10

申请号：US12942736

申请日：2010-11-09

申请人： Ning-Yi Xu ,  Feng-Hsiung Hsu ,  Feng Yan

发明人： Ning-Yi Xu ,  Feng-Hsiung Hsu ,  Feng Yan

IPC分类号： G06F9/46 ,  G06N5/02 ,  G06N5/04 ,  G06F15/18

CPC分类号： G06F9/5061

摘要： Systems, methods, and devices are described for implementing learning algorithms on data sets. A data set may be partitioned into a plurality of data partitions that may be distributed to two or more processors, such as a graphics processing unit. The data partitions may be processed in parallel by each of the processors to determine local counts associated with the data partitions. The local counts may then be aggregated to form a global count that reflects the local counts for the data set. The partitioning may be performed by a data partition algorithm and the processing and the aggregating may be performed by a parallel collapsed Gibbs sampling (CGS) algorithm and/or a parallel collapsed variational Bayesian (CVB) algorithm. In addition, the CGS and/or the CVB algorithms may be associated with the data partition algorithm and may be parallelized to train a latent Dirichlet allocation model.

摘要翻译： 描述了用于实现数据集学习算法的系统，方法和设备。 数据集可以被分割成可以被分配到诸如图形处理单元之类的两个或多个处理器的多个数据分区。 数据分区可以由每个处理器并行处理以确定与数据分区相关联的本地计数。 然后可以将本地计数聚合以形成反映数据集的本地计数的全局计数。 可以通过数据分割算法执行分割，并且处理和聚合可以通过并行折叠吉布斯采样（CGS）算法和/或并行折叠变分贝叶斯（CVB）算法来执行。 此外，CGS和/或CVB算法可以与数据分区算法相关联，并且可以并行化以训练潜在的Dirichlet分配模型。

公开(公告)号：US20110215227A1

公开(公告)日：2011-09-08

申请号：US13126079

申请日：2010-02-10

申请人： Feng Yan ,  Rong Zhang ,  Yi Shi ,  Lin Pu ,  Yue Xu ,  Fuwei Wu ,  Xiaofeng Bo ,  Haoguang Xia

发明人： Feng Yan ,  Rong Zhang ,  Yi Shi ,  Lin Pu ,  Yue Xu ,  Fuwei Wu ,  Xiaofeng Bo ,  Haoguang Xia

IPC分类号： H01L31/112 ,  H03F3/08

CPC分类号： H01L27/14643 ,  H01L27/14614 ,  H01L31/1136

摘要： The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface. This invented detector has excellent scalability, basic compatibility with the flash memory fabricating technology, low leakage current, higher imaging speed than CCD, non-sensitivity to processing defects, larger dynamic range than other structures and higher accuracy of signal readout.

摘要翻译： 本发明涉及一种具有复合介电栅极MOSFET结构的光敏检测器及其信号读出方法。 MOSFET结构检测器形成在p型半导体衬底上。 N型半导体区域位于p型半导体衬底的顶部的两侧，以形成源极和漏极。 依次将基底电介质层，光电子存储层，顶部电介质层和控制栅极堆叠在基板上。 顶部绝缘介电层可以防止存储在光电子存储层中的光电子泄漏到控制栅极中。 当光电子被收集并注入到要保持在其中的光电子储存层时，源极和漏极是浮置的。 存在用于检测基板或栅极表面上的入射光形成的透明或半透明窗口。 本发明的检测器具有优异的可扩展性，与闪存制造技术的基本兼容性，低漏电流，比CCD更高的成像速度，对处理缺陷的灵敏度，对其他结构的动态范围更大，信号读出精度更高。

公开(公告)号：US20090253986A1

公开(公告)日：2009-10-08

申请号：US12084933

申请日：2006-11-09

申请人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

发明人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

IPC分类号： A61B6/00 ,  A61B8/00 ,  G06K9/00

CPC分类号： A61B8/481 ,  A61B8/08 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52041 ,  G01S7/52071 ,  G01S7/52074

摘要： A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number.

摘要翻译： 提出了一种便于在医学成像应用中检测固定的造影剂的系统。 该系统包括用于提供在对应的获取时刻获得的输入图像的总数的序列的装置，其通过对经受施用能够在患者内循环的造影剂并且基本上固定在患者身上的患者的体部成像 每个输入图像包括多个输入值，每个输入值指示对可能包括所述造影剂的身体部分的对应部分的询问信号的响应;以及用于减少循环造影剂在所述生物靶内的贡献的装置 至少一个所选输入图像中的身体部分; 用于减少的装置包括用于通过用一组相应的滤波值替换所选择的输入图像的一组输入值来创建与每个所选择的输入图像相对应的滤波图像的装置，每个滤波值代表相应部分的最低响应 包括所选择的输入图像的一组多个输入图像中的身体部分的多个输入图像组合，所述多个输入图像由少于总数的多个输入图像组成。

公开(公告)号：US20090176915A1

公开(公告)日：2009-07-09

申请号：US11689866

申请日：2007-03-22

申请人： Feng Yan ,  John Texter

发明人： Feng Yan ,  John Texter

IPC分类号： C08K5/1535 ,  C09K3/00 ,  C08K5/05 ,  C08K5/41 ,  C08K5/20 ,  C08L23/00 ,  C08L33/12

CPC分类号： C08K5/34 ,  C08K5/19 ,  C08K5/42

摘要： The present invention relates to microemulsions of immiscible fluids stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C. The invention also relates to composite materials comprising a copolymer of ethylenically reactive species, wherein one of the species is a reactive ionic liquid surfactant having a melting point less than 80° C., and wherein the material also comprises non-reactive Class I fluid. The invention further relates to methods for synthesizing the composite materials comprising preparing a microemulsion of immiscible Class I fluid and Class II fluid stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C., and polymerizing the microemulsion to form a composite material.

摘要翻译： 本发明涉及由反应性离子液体表面活性剂稳定的不混溶流体的微乳液，其中离子液体表面活性剂的熔点低于80℃。本发明还涉及包含烯属反应性物质的共聚物的复合材料，其中物种之一 是具有低于80℃的熔点的反应性离子液体表面活性剂，并且其中所述材料还包含非反应性I类流体。 本发明还涉及用于合成复合材料的方法，包括制备不混溶的I类流体的微乳液和通过反应性离子液体表面活性剂稳定的II类流体，其中离子液体表面活性剂具有低于80℃的熔点，并使微乳液聚合 以形成复合材料。