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公开(公告)号：US20150122987A1
公开(公告)日：2015-05-07
申请号：US14561531
申请日：2014-12-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
Abstract translation: 本发明一般涉及用于质谱分析样品的系统和方法。 在某些实施方案中，本发明提供了一种质谱探针，其包括连接到高电压源的至少一种多孔材料，其中多孔材料与溶剂流离散。
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公开(公告)号：US08963079B2
公开(公告)日：2015-02-24
申请号：US14454811
申请日：2014-08-08
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
CPC classification number: H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
Abstract translation: 本发明一般涉及用于转移离子进行分析的系统和方法。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括用于将样品分子转化成大气压的区域中的气相离子的电离源，离子分析装置和可操作地耦合到气体的离子传递构件 气体发生装置，其中气体流动产生装置产生将气相离子通过离子传递构件转移到离子分析装置的入口的层流气流。
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公开(公告)号：US20150041638A1
公开(公告)日：2015-02-12
申请号：US14512579
申请日：2014-10-13
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang , Zhiping Zhang
CPC classification number: G01N30/95 , G01N30/91 , G01N33/49 , H01J49/0031 , H01J49/0404 , H01J49/0409 , H01J49/0431 , H01J49/167 , H01J49/168
Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
Abstract translation: 本发明一般涉及使用改进的润湿多孔材料的离子产生。 在某些方面，本发明一般涉及使用基本上防止样品扩散到基底中的润湿多孔基质进行离子生成的系统和方法。 在其它方面，本发明一般涉及使用润湿多孔材料和干燥剂的离子产生。 在其它方面，本发明一般涉及使用改性润湿多孔基材的离子产生，其中多孔基材的至少一部分包括改变样品和基底之间的相互作用的材料。
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公开(公告)号：US08890063B2
公开(公告)日：2014-11-18
申请号：US13727177
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US08859986B2
公开(公告)日：2014-10-14
申请号：US14151220
申请日：2014-01-09
Applicant: Purdue Research Foundation
Inventor： Robert G. Cooks , Ahmed M. Hamid , Alan K. Jarmusch , Zheng Ouyang
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
Abstract translation: 本发明一般涉及样品中微生物的质谱分析系统和方法。
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Patent Agency Ranking
公开(公告)号：US08859959B2
公开(公告)日：2014-10-14
申请号：US13727173
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US08803085B2
公开(公告)日：2014-08-12
申请号：US14180915
申请日：2014-02-14
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
CPC classification number: H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
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公开(公告)号：US20140141466A1
公开(公告)日：2014-05-22
申请号：US14151220
申请日：2014-01-09
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Robert Graham Cooks , Ahmed M. Hamid , Alan K. Jarmusch , Zheng Ouyang
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
Abstract translation: 本发明一般涉及样品中微生物的质谱分析系统和方法。
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公开(公告)号：US20140048697A1
公开(公告)日：2014-02-20
申请号：US14023851
申请日：2013-09-11
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
IPC: H01J49/04
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号：US20230230827A1
公开(公告)日：2023-07-20
申请号：US17979972
申请日：2022-11-03
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/16 , C12Q1/6806
CPC classification number: H01J49/167 , C12Q1/6806 , Y10T436/24 , Y10T436/255
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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