Primer for fluorocarbon polymer substrates
    61.
    发明授权
    Primer for fluorocarbon polymer substrates 有权
    碳氟聚合物基材底漆

    公开(公告)号:US08383715B2

    公开(公告)日:2013-02-26

    申请号:US12121252

    申请日:2008-05-15

    IPC分类号: C08K3/34 C08L31/00

    摘要: An aqueous primer dispersion which contains surfactant-stabilized polymer particles, an organic solvent and a mineral thicker, when coated onto a fluorocarbon substrate, significantly increase the bond strength between the fluorocarbon substrate and a subsequently applied water-derived protective coating, provided that the amount of surfactant-stabilized polymer particles in the aqueous primer dispersion, if any, is about 8 wt. % or less.

    摘要翻译: 当涂布在氟碳基材上时,含有表面活性剂稳定的聚合物颗粒,有机溶剂和较厚的矿物的水性底漆分散体显着增加了碳氟化合物底物与随后施用的水源保护涂层之间的粘结强度,条件是量 表面活性剂稳定的聚合物颗粒在水性底漆分散体中(如果有的话)为约8wt。 % 或更少。

    Omni-Tomographic Imaging for Interior Reconstruction using Simultaneous Data Acquisition from Multiple Imaging Modalities
    62.
    发明申请
    Omni-Tomographic Imaging for Interior Reconstruction using Simultaneous Data Acquisition from Multiple Imaging Modalities 审中-公开
    使用多重成像模式的同时数据采集进行内部重建的全全面成像

    公开(公告)号:US20120265050A1

    公开(公告)日:2012-10-18

    申请号:US13439419

    申请日:2012-04-04

    申请人: Ge Wang

    发明人: Ge Wang

    摘要: Embodiments of the invention relate to omni-tomographic imaging or grand fusion imaging, i.e., large scale fusion of simultaneous data acquisition from multiple imaging modalities such as CT, MRI, PET, SPECT, US, and optical imaging. A preferred omni-tomography system of the invention comprises two or more imaging modalities operably configured for concurrent signal acquisition for performing ROI-targeted reconstruction and contained in a single gantry with a first inner ring as a permanent magnet; a second middle ring containing an x-ray tube, detector array, and a pair of SPECT detectors; and a third outer ring for containing PET crystals and electronics. Omni-tomography offers great synergy in vivo for diagnosis, intervention, and drug development, and can be made versatile and cost-effective, and as such is expected to become an unprecedented imaging platform for development of systems biology and modern medicine.

    摘要翻译: 本发明的实施例涉及全分层成像或大融合成像,即来自诸如CT,MRI,PET,SPECT,US和光学成像的多个成像模式的同时数据采集的大规模融合。 本发明的优选全向层析成像系统包括可操作地配置用于并行信号采集的两个或更多个成像模态,用于执行ROI目标重建并且包含在具有作为永磁体的第一内环的单个机架中; 包含X射线管,检测器阵列和一对SPECT检测器的第二中环; 以及用于容纳PET晶体和电子器件的第三外圈。 全方位层析成像在体内为诊断,干预和药物开发提供了巨大的协同作用,可以做到通用性和成本效益,因此有望成为系统生物学和现代医学发展的前所未有的成像平台。

    EXACT LOCAL COMPUTED TOMOGRAPHY BASED ON COMPRESSIVE SAMPLING
    63.
    发明申请
    EXACT LOCAL COMPUTED TOMOGRAPHY BASED ON COMPRESSIVE SAMPLING 有权
    基于压缩采样的局部计算机图像

    公开(公告)号:US20120063659A1

    公开(公告)日:2012-03-15

    申请号:US13264834

    申请日:2010-04-15

    申请人: Ge Wang Hengyong Yu

    发明人: Ge Wang Hengyong Yu

    IPC分类号: G06K9/00

    摘要: A system and method for tomographic image reconstruction using truncated projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the known sparsity models of the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.

    摘要翻译: 基于ROI的已知稀疏模型,使用截断的投影数据进行断层图像重建的系统和方法,其允许感兴趣区域(ROI)的精确内部重建(内部层析成像),从而在降低辐射剂量的同时提高图像质量。 另外,该方法包括使用通过ROI以多个角度射束的多个源的并行内部层析成像,并且能够实现更高的时间分辨率。

    FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS
    66.
    发明申请
    FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS 有权
    用于光学成像和治疗的光纤阵列

    公开(公告)号:US20110313298A1

    公开(公告)日:2011-12-22

    申请号:US13203800

    申请日:2010-03-01

    IPC分类号: A61B6/00 A61M37/00

    摘要: The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and can be adapted for use with any laser-based treatment or diagnostic in which light is used to detect or treat targets under or on the skin surface.

    摘要翻译: 本发明涉及光学成像和治疗领域。 更具体地说,本发明的实施例提供了用于基于光的治疗剂的微创光纤微针装置(FMD),其物理地穿透组织并将光直接传送到皮肤表面下方的目标区域(图1)。 本发明的优选实施例是一种光纤微针装置,包括:(a)一个或多个能够引导光并且包括约0.5-6mm的长度的基于二氧化硅的针,具有约100的外径的基部 -150微米,以及外径在约5-20微米范围内的尖端; (b)固定针的支撑构件; (c)套圈,其包括用于每个针的一个或多个孔,其中所述套圈可操作地构造成在所述针的所述长度的全部或某一部分处为每个针提供机械支撑。 本发明的实施方案可实现深度选择性和深度光热治疗剂,并且可适用于任何基于激光的治疗或诊断,其中光用于检测或治疗皮肤表面下或皮肤表面上的靶标。

    WORLD STAGE FOR PITCH-CORRECTED VOCAL PERFORMANCES
    67.
    发明申请
    WORLD STAGE FOR PITCH-CORRECTED VOCAL PERFORMANCES 有权
    世界舞台矫正视力表现

    公开(公告)号:US20110144983A1

    公开(公告)日:2011-06-16

    申请号:US12876133

    申请日:2010-09-04

    IPC分类号: G10L11/04

    摘要: Techniques have been developed to facilitate the capture performances on handheld or other portable computing devices and, in some cases, the pitch-correction and mixing of such vocal performances with backing tracks for audible rendering on such devices. Captivating visual animations and/or facilities for listener comment and ranking are provided in association with an audible rendering of a performance, e.g., a vocal performance captured and pitch-corrected at another similarly configured mobile device and mixed with backing instrumentals and/or vocals. Geocoding of captured vocal performances and/or listener feedback may facilitate animations or display artifacts in ways that are suggestive of a performance or endorsement emanating from a particular geographic locale on a user manipulable globe. In this way, implementations of the described functionality can transform otherwise mundane mobile devices into social instruments that foster a unique sense of global connectivity and community.

    摘要翻译: 已经开发出技术来促进手持式或其他便携式计算设备上的捕获性能,并且在某些情况下,将这种声音表演的音调校正和混合与用于在这些设备上的可听渲染的背景轨道进行混合。 提供与听众评论和排名相关的视觉动画和/或设施,以与在另一类似配置的移动设备上捕获和音调校正的演奏,例如声音表演的可听呈现相结合,并与后备乐器和/或声乐混合。 捕获的声乐表演和/或听众反馈的地理编码可以以暗示在用户可操纵的地球仪上从特定地理区域发出的表演或认可的方式促进动画或显示人造物。 以这种方式,所描述的功能的实现可以将平凡的移动设备转变成促进独特的全球连接感和社区感的社会工具。

    Interior Tomography and Instant Tomography by Reconstruction from Truncated Limited-Angle Projection Data
    68.
    发明申请
    Interior Tomography and Instant Tomography by Reconstruction from Truncated Limited-Angle Projection Data 失效
    通过截断的有限角度投影数据重建的内部层析成像和即时层析成像

    公开(公告)号:US20090196393A1

    公开(公告)日:2009-08-06

    申请号:US12362979

    申请日:2009-01-30

    IPC分类号: H05G1/60 G06K9/00

    摘要: A system and method for tomographic image reconstruction using truncated limited-angle projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the linear attenuation coefficient distribution of a subregion within the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.

    摘要翻译: 一种使用截断的有限角度投影数据进行断层图像重建的系统和方法,其基于ROI内的子区域的线性衰减系数分布,允许感兴趣区域(ROI)的精确内部重建(内部层析成像),从而提高图像质量 同时减少辐射剂量。 另外,该方法包括使用通过ROI以多个角度射束的多个源的并行内部层析成像,并且能够实现更高的时间分辨率。

    &agr;1,2-fucosyltransferase
    69.
    发明授权
    &agr;1,2-fucosyltransferase 有权
    α1,2-岩藻糖基转移酶

    公开(公告)号:US06670160B2

    公开(公告)日:2003-12-30

    申请号:US09848838

    申请日:2001-05-03

    IPC分类号: C12N910

    摘要: A bacterial &agr;1,2-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing &agr;1,2-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, Lewis B and H type 1, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors.

    摘要翻译: 提供细菌α1,2-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,2-岩藻糖基转移酶多肽及其活性片段,其可用于生产低聚糖例如Lewis X,Lewis Y,Lewis B和H型1,其在结构上类似于某些肿瘤 - 在哺乳动物中发现的相关碳水化合物抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。

    &agr;1,2 fucosyltransferase
    70.
    发明授权
    &agr;1,2 fucosyltransferase 有权
    α12岩藻糖基转移酶

    公开(公告)号:US06238894B1

    公开(公告)日:2001-05-29

    申请号:US09433598

    申请日:1999-11-02

    IPC分类号: C12N1904

    摘要: A bacterial &agr;1,2-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing &agr;1,2-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, Lewis B and H type 1, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors.

    摘要翻译: 提供细菌α1,2-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,2-岩藻糖基转移酶多肽及其活性片段,其可用于生产低聚糖例如Lewis X,Lewis Y,Lewis B和H型1,其在结构上类似于某些肿瘤 - 在哺乳动物中发现的相关碳水化合物抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。