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公开(公告)号：US11766402B2
公开(公告)日：2023-09-26
申请号：US16762439
申请日：2018-11-16
发明人： Elizabeth Shpall , Raghu Kalluri , Katy Rezvani , Mayela Mendt , Valerie Lebleu , Sushrut Kamerkar
IPC分类号： A61K35/28 , C12N15/113 , A61K9/127 , A61K9/00 , A61K31/7105 , A61K31/713 , A61K45/06 , C12N5/0775 , C12Q1/68
CPC分类号： A61K9/1271 , A61K9/0019 , A61K31/713 , A61K31/7105 , A61K35/28 , A61K45/06 , C12N5/0663 , C12N5/0667 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2320/31 , C12N2320/32 , C12N2500/02 , C12N2500/90
摘要： Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosomes.
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62.发明公开公开(公告)号：US20230295572A1
公开(公告)日：2023-09-21
申请号：US18187554
申请日：2023-03-21
发明人： Sarah Broeckx , Jan Spaas
IPC分类号： C12N5/077 , C12N5/0775
CPC分类号： C12N5/0655 , C12N5/0665 , C12N5/0663 , C12N5/0668 , C12N5/066 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2502/1352 , C12N2506/1369 , C12N2502/1358 , C12N2502/137 , C12N2502/1382
摘要： The current invention concerns a composition for treating trauma in a subject, where the composition includes isolated mesenchymal stem cells (MSCs), wherein the MSCs are tenogenic-induced and/or chondrogenic-induced, and where the trauma is tendon trauma, traumas of the ligaments, or trauma of cartilage.
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公开(公告)号：US20230293681A1
公开(公告)日：2023-09-21
申请号：US18045317
申请日：2022-10-10
申请人： Emory University
IPC分类号： A61K39/395 , A61K38/22 , A61P35/02 , C12N5/0789 , C12N5/0775 , C12N5/078 , A61K38/16 , A61K35/14 , A61K35/17 , A61K38/04 , A61K39/245
CPC分类号： A61K39/3955 , A61K38/2278 , A61P35/02 , C12N5/0647 , C12N5/0662 , C12N5/0634 , A61K38/16 , A61K35/14 , A61K35/17 , A61K38/04 , A61K39/245 , Y02A50/30
摘要： Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a VIP antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia or lymphoma, In certain embodiments, the cell is a blood cell, bone marrow cell, leukocyte, T-cell, natural killer cell, a hematopoietic stem cell, a G-CSF mobilized or non-mobilized blood mononuclear cell.
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公开(公告)号：US11759481B2
公开(公告)日：2023-09-19
申请号：US16814044
申请日：2020-03-10
摘要： The disclosure provides compositions comprising exosome subpopulations, and methods of their use in subjects having certain disorders including lung disorders, cardiovascular disorders, renal disorders and ischemic neural disorders.
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公开(公告)号：US20230287352A1
公开(公告)日：2023-09-14
申请号：US17739127
申请日：2022-05-08
发明人： Bin ZHENG , Yulin CAO , Wenchang PENG , Shixiang CHENG
IPC分类号： C12N5/0775 , C12N5/00 , A61K9/16
CPC分类号： C12N5/0663 , C12N5/0075 , A61K9/1647 , A61K9/1652 , A61K9/1694
摘要： A method for non-enzymatic 3D culture and amplification of mesenchymal stem cells (MSCs) includes the followings steps: preparing PLGA porous microspheres; preparing a PLGA-PEG-PLGA thermosensitive coating microcarrier; culturing and amplifying MSCs; and performing non-enzymatic separation of MSCs, including reducing a culture temperature to below a critical phase transition temperature, and centrifuging a culture medium to collect stem cells. The present invention adopts the method for non-enzymatic 3D culture and amplification of MSCs, wherein the PLGA porous microspheres are used as a cell culture microcarrier scaffold and the thermosensitive hydrogel PLGA-PEG-PLGA is coated on surfaces of such microspheres, without needing additional enzymolysis process, thus efficiently amplifying the stem cells.
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公开(公告)号：US20230270788A1
公开(公告)日：2023-08-31
申请号：US17767453
申请日：2020-10-08
申请人： GENECHEM INC. , UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS , INDUSTRY-ACADEMIC COOPERATION FOUNDATION,YONSEI UNIVERSITY
发明人： Sung Hoon KIM , Ah Reum BAEK , Sung Rae CHO , Jin Suk WOO , Li La KIM , Dae Hee KIM
IPC分类号： A61K35/28 , A61K35/545 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/545 , C12N5/0662 , C12N2500/34 , C12N2500/38 , C12N2501/11 , C12N2501/155 , C12N2501/12 , C12N2501/237
摘要： The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method of culturing stem cells in a medium containing a sialyloligosaccharide, a method of augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition including the stem cells as an active ingredient. The composition or the method according to one or more embodiments may suppress the aging of stem cells and may maintain and augment stemness.
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公开(公告)号：US20230265392A1
公开(公告)日：2023-08-24
申请号：US18295171
申请日：2023-04-03
IPC分类号： C12N5/0775 , A61P35/00 , A61K35/28 , C12N7/00 , C12N15/86
CPC分类号： C12N5/0667 , A61P35/00 , A61K35/28 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/24122 , C12N2710/24133
摘要： Provided herein are enhanced systems for potentiating cell-mediated oncolytic viral therapy. Also provided are modified viruses for such systems, and methods of treatment of cancers by administering such systems.
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公开(公告)号：US20230257714A1
公开(公告)日：2023-08-17
申请号：US18106327
申请日：2023-02-06
发明人： Ran YANG , Kenneth R. CHIEN
IPC分类号： C12N5/0775
CPC分类号： C12N5/0668 , C12N2501/415 , C12N2501/105 , C12N2501/115 , C12N2501/135 , C12N2500/32 , C12N2506/02
摘要： Methods for generating human induced mesenchymal stem cells (iMSC) from human pluripotent stem cells, such as embryonic stem cells, are provided. Progenitors of iMSCs are first generated in a two-step protocol, with further differentiation to iMSCs accomplished by a third step culture. The iMSCs express mesenchymal surface markers and exhibit trilineage differentiation to adipocytes, osteocytes and chondrocytes. Culture media, methods of isolating extracellular vesicles from the iMSCs and kits are also provided.
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公开(公告)号：US20230256022A1
公开(公告)日：2023-08-17
申请号：US18084206
申请日：2022-12-19
发明人： Piero ANVERSA , Annarosa LERI
IPC分类号： A61K35/28 , C12N5/077 , C12N5/0775
CPC分类号： A61K35/28 , C12N5/0657 , C12N5/0663 , C12N2501/727
摘要： Disclosed herein are compositions comprising myogenic bone marrow cells that are c-kit positive. Such compositions are useful for treating cardiac diseases or disorders. Also disclosed herein are methods of producing myogenic bone marrow cells are c-kit positive. Further disclosed are cardiopoietic genes having enhanced expression in c-kit positive myogenic bone marrow cells.
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公开(公告)号：US11718824B2
公开(公告)日：2023-08-08
申请号：US17332461
申请日：2021-05-27
申请人： Corning Incorporated
IPC分类号： C12N5/00 , C12N5/0735 , C12N5/0775 , C12M1/00 , B05D3/02
CPC分类号： C12N5/0068 , B05D3/0254 , C12M23/20 , C12N5/0037 , C12N5/0056 , C12N5/0606 , C12N5/0663 , C12N2500/90 , C12N2500/98 , C12N2533/30 , C12N2533/40 , C12N2533/50
摘要： An aqueous cell culture medium composition includes an aqueous cell culture solution configured to support the culture of mammalian cells. The composition further includes a synthetic polymer conjugated to a polypeptide dissolved in the aqueous cell culture solution. The synthetic polymer conjugated to a polypeptide is configured to attach to the surface of a cell culture article under cell culture conditions. Incubation of the aqueous cell culture medium composition on a cell culture surface under cell culture conditions results is attachment to the surface of the synthetic polymer conjugated to the polypeptide.
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