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    Disposable Direct Capture Device
    71.
    发明申请
    Disposable Direct Capture Device 有权
    一次性直接捕获设备

    公开(公告)号：US20150292991A1

    公开(公告)日：2015-10-15

    申请号：US14438961

    申请日：2013-12-13

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Benjamin Cacace

    IPC: G01N1/34

    CPC classification number: G01N1/34 ,  B01J39/26 ,  B01J41/20 ,  B01J47/014 ,  B01J47/022 ,  B01J47/127 ,  B01L3/505 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/123 ,  C07K1/14 ,  C07K1/36 ,  G01N1/405

    Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.

    Abstract translation: 本发明涉及一种液体样品制备装置，例如一次性可折叠的柔性聚合物袋，其包含用于从液体样品直接捕获生物分子的官能化成形聚合物纤维床的吸附帘。 功能化的聚合物纤维床包括原纤化的，脊状的或翼状的纤维结构，其显着增加纤维的表面积，导致当液体样品接触吸附窗帘时，含有生物分子的液体样品的分离，保留和/或纯化增强 的功能化成形纤维。 液体样品包括未澄清的液体进料或含有一种或多种感兴趣的生物分子的其它液体，包括但不限于疫苗，重组蛋白，细胞，干细胞，单克隆抗体（mAb），蛋白质，抗体，肽，寡肽，核酸， 寡核苷酸，RNA，DNA，寡糖和多糖。

    Methods And Devices Used For Redundant Sterile Filtration
    72.
    发明申请
    Methods And Devices Used For Redundant Sterile Filtration 有权
    用于冗余无菌过滤的方法和设备

    公开(公告)号：US20150283479A1

    公开(公告)日：2015-10-08

    申请号：US14440370

    申请日：2013-11-26

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

    IPC: B01D19/00

    CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

    Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more in-puts for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

    Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，该阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络具有一个或多个投入物，用于将液体原料引入流体工艺流中，以及一个或多个输出端口，用于将流体排出流体工艺流。 网络优选是基本上封闭的网络，并且优选地是无菌和/或无菌的。

    Device for the transfer of a medium
    75.
    发明授权
    Device for the transfer of a medium 有权
    传送介质的装置

    公开(公告)号：US09120585B2

    公开(公告)日：2015-09-01

    申请号：US14684510

    申请日：2015-04-13

    Applicant: EMD Millipore Corporation

    Inventor： Stephane Olivier

    IPC: B01L99/00 ,  B65B3/26

    CPC classification number: B65B3/26 ,  G01N1/18 ,  G01N35/1079 ,  G01N2001/1037 ,  G01N2001/2085

    Abstract: The device for the transfer of a medium comprises a magazine (2) and at least one transfer element (3) for transfer of said medium, said transfer element (3) comprising a duct (45) for transfer of said medium provided at one end with a needle (31), a septum (32), and a maneuvering unit (33) of said needle (31), said transfer element (3) also comprising means for locking (61, 65) adapted to cooperate with complementary locking means (15) of said magazine (2) to lock said needle (31) in a waiting position, said locking means (61, 62, 65) belonging to said maneuvering unit (33) and cooperating with said complementary locking means (15) at a location of said magazine (2) distinct from the location through which said duct (45) issues from the cavity (20), at the opposite end from the needle (31).

    Abstract translation: 用于传送介质的装置包括用于传送所述介质的盒（2）和至少一个传送元件（3），所述传送元件（3）包括用于传送在一端设置的所述介质的导管（45） 与所述针（31）的针（31），隔膜（32）和操纵单元（33）相连，所述传送元件（3）还包括用于锁定（61,65）的装置，所述装置适于与互补锁定装置 （3）的所述锁定装置（61,62,65）与所述互补锁定装置（15）配合，所述锁定装置（61,62,65）在所述弹匣（2）的所述锁定装置（15） 所述盒（2）的位置不同于所述管道（45）在与所述针（31）相对的端部从所述腔（20）发出的位置。

    Stirred Tank Bioreactor
    76.
    发明申请
    Stirred Tank Bioreactor 审中-公开
    搅拌罐生物反应器

    公开(公告)号：US20150210973A1

    公开(公告)日：2015-07-30

    申请号：US14677670

    申请日：2015-04-02

    Applicant: EMD Millipore Corporation

    Inventor： James E. Kelly ,  Joseph William Muldoon ,  Stephen Proulx ,  James Vigna

    IPC: C12M3/00 ,  C12M1/00

    CPC classification number: C12M23/46 ,  C12M23/20 ,  C12M23/28 ,  C12M23/38 ,  C12M23/48 ,  C12M27/00 ,  C12M29/00

    Abstract: The present invention is a disposable, presterilized bioreactor formed of molded plastic, having a top and body attached to each other. One or more ports are formed in the top, side and bottom of the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports, access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment locations are guaranteed through the use of the molded port features.

    Abstract translation: 本发明是由模制塑料形成的一次性预灭菌生物反应器，其具有彼此连接的顶部和主体。 一个或多个端口形成在壳体的顶部，侧面和底部。 低于液体/空气界面水平的一个或多个端口可用作采样端口，用于探针或排水口的接口或用于液体或气体的供应端口。 生物反应器为现有的玻璃或钢组件提供直接改造，利用现有的支撑结构和控制。 成型设计由于其通过模制工艺内置的固定尺寸克服了不连续性，死点等问题。 通过使用模制端口特性，可以保证可重现的探头和其他设备位置。

    Receiver Plate With Multiple Cross-Sections
    77.
    发明申请
    Receiver Plate With Multiple Cross-Sections 有权
    接收板与多个横截面

    公开(公告)号：US20150064081A1

    公开(公告)日：2015-03-05

    申请号：US14514853

    申请日：2014-10-15

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Brian Foley

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0858

    Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

    Abstract translation: 包括过滤板和接收板的多孔组件。 每个板包括多个孔，当过滤板与接收板放置成嵌套关系时，每个过滤板井具有相应的容纳板，井中延伸。 接收器板孔具有不均匀的横截面，以便当接收板和过滤板处于嵌套关系时，增加过滤板孔的外壁和对应的接收器板的内壁之间的间隙。 增加的间隙大小减少芯吸和交叉污染。 因此，提供了在上部区域中的最大横截面的多部分井和在下部区域中具有逐渐过渡的区域中的最小化横截面。 本发明的多孔组件还提高了将过滤板和接收板定位成适当的嵌套关系的重复性，并且在处理，混合和摇动操作期间提供了稳定性。

    Device For Filtration With A Set Of Least One Filter Cassette
    79.
    发明申请
    Device For Filtration With A Set Of Least One Filter Cassette 有权
    一套过滤器过滤装置

    公开(公告)号：US20150020366A1

    公开(公告)日：2015-01-22

    申请号：US14506946

    申请日：2014-10-06

    Applicant: EMD Millipore Corporation

    Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

    IPC: B23P19/04

    CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

    Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

    Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管和机械连接，其包括相对于歧管可移动地安装的夹板，并且适于将至少一个盒压靠在歧管上，用于驱动和引导夹板的装置， 所述歧管和所述板，致动器，其设置有主体和可相对于所述主体移动的构件，所述构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由所述歧管承载，并且所述主体 承载杆并且通过杆将板驱动到夹紧位置，在该夹紧位置处，构件处于中间缩回位置，在该夹紧位置中，其已经相对于其延伸位置移动比预定行程更短的行程。

    System And Method To Determine Sterilization Of A Device
    80.
    发明申请
    System And Method To Determine Sterilization Of A Device 有权
    确定装置灭菌的系统和方法

    公开(公告)号：US20140320268A1

    公开(公告)日：2014-10-30

    申请号：US14328410

    申请日：2014-07-10

    Applicant: EMD Millipore Corporation

    Inventor： Aaron Burke

    IPC: G06K7/10

    CPC classification number: G06K7/10366 ,  A61L2/26 ,  G06K19/0717 ,  G06K19/0723

    Abstract: A system and method for verifying the occurrence of an environmental condition is disclosed. Rather than store information concerning the occurrence and/or success of the sterilization process, the present invention modifies the wireless transmission characteristics of the device. In some embodiments, the bandwidth of the wireless transceiver is altered as a result of undergoing sterilization. In other embodiments, the resonance frequency of the circuit is affected. In other embodiments, one or more of these parameters are affected based on other environmental conditions, such as shock or vibration.

    Abstract translation: 公开了一种用于验证环境条件的发生的系统和方法。 本发明不是存储关于灭菌处理的发生和/或成功的信息，而是修改设备的无线传输特性。 在一些实施例中，作为进行灭菌的结果，无线收发器的带宽被改变。 在其他实施例中，电路的谐振频率受到影响。 在其他实施例中，这些参数中的一个或多个基于其他环境条件（例如冲击或振动）而受到影响。

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