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    Cellular analysis
    74.
    发明授权
    Cellular analysis 有权

    公开(公告)号：US11468559B2

    公开(公告)日：2022-10-11

    申请号：US16607218

    申请日：2018-04-25

    Applicant: The University of Chicago

    Inventor： Marcus R. Clark ,  Maryellen L. Giger ,  Vladimir M. Liarski ,  Adam Sibley

    IPC: G06T7/00 ,  G06T7/136 ,  G06T7/143 ,  G06T7/73

    Abstract: A method of analyzing cell populations includes receiving, by a transceiver of a computing device, an image of a tissue sample. The method also includes analyzing, by a processor of the computing device, the image of the tissue sample using image analysis. The image analysis parameters are determined by machine learning. The method also includes determining, by the processor and based on the analyzing, one or more cell features, such as shape, of a cell in the tissue sample. The method further includes identifying, by the processor, an interaction of the cell with an additional cell based at least in part on the shape of the cell.

    Methods and composition for modifying enzymes
    76.
    发明授权
    Methods and composition for modifying enzymes 有权

    公开(公告)号：US11459400B2

    公开(公告)日：2022-10-04

    申请号：US15745496

    申请日：2016-07-15

    Applicant: The University of Chicago

    Inventor： Shohei Koide ,  Shun-Ichi Tanaka ,  Akiko Koide

    IPC: G01N33/53 ,  G01N33/569 ,  G01N33/573 ,  C07K16/40 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/527 ,  C12Q1/533 ,  C12Q1/00 ,  C12N9/38 ,  C07K14/78 ,  C12N9/20 ,  C12Q1/25 ,  G01N33/58 ,  G01N33/60

    Abstract: Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ≥50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.

    HETEROGENEOUS RARE-EARTH DOPED SYSTEMS
    78.
    发明申请
    HETEROGENEOUS RARE-EARTH DOPED SYSTEMS 有权

    公开(公告)号：US20220291450A1

    公开(公告)日：2022-09-15

    申请号：US17635088

    申请日：2020-08-14

    Applicant: THE UNIVERSITY OF CHICAGO

    Inventor： Tian ZHONG ,  Christina WICKER

    IPC: G02B6/122 ,  C03C3/095

    Abstract: Technologies for a strong rare-earth-ion interactions are disclosed. In the illustrative embodiment, a heterogeneous slot waveguide is formed with two layers of silicon surrounding a layer of Er:Y2O3, resulting in a waveguide that supports a TM mode with a strong confinement of electromagnetic field near the erbium dopants. The strong concentration of electromagnetic field and small mode volume allows for strong interactions between optical fields and the erbium dopants. In some embodiments, the slot waveguide structure may be configured as a microring resonator or a photonic crystal, resulting in small-mode-volume resonators with high Q-factors. In some embodiments, strong electro-optic and/or acousto-optic coupling may be achieved, resulting in quantum transducer able to coherently convert between signals in different systems.

    COMPOSITIONS AND METHODS COMPRISING PROTEASE-ACTIVATED THERAPEUTIC AGENTS
    79.
    发明申请
    COMPOSITIONS AND METHODS COMPRISING PROTEASE-ACTIVATED THERAPEUTIC AGENTS 有权

    公开(公告)号：US20220281936A1

    公开(公告)日：2022-09-08

    申请号：US17597793

    申请日：2020-07-24

    Applicant: The University of Chicago

    Inventor： Jeffrey HUBBELL ,  Jun ISHIHARA ,  Juan MENDOZA ,  Aslan MANSUROV

    IPC: C07K14/54 ,  C07K14/715 ,  A61K47/68 ,  A61K39/395 ,  A61P35/00

    Abstract: he disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.

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