专利检索 ap:("The University of Chicago") AND inv:"Cory John Gerdts" 第 1 页

1.

发明授权
Microfluidic system 有权

公开(公告)号：US12097475B2

公开(公告)日：2024-09-24

申请号：US18412395

申请日：2024-01-12

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts

IPC分类号： B01L99/00 , B01F25/314 , B01F33/302 , B01J19/00 , B01L3/00 , B01L3/02 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/06 , B01L3/06 , G01N35/08 , G01N35/10

CPC分类号： B01F33/3021 , B01F25/314 , B01J19/0046 , B01L3/0293 , B01L3/502784 , B01L3/527 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/0694 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/06 , B01L3/502723 , B01L3/502746 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0433 , B01L2400/0487 , G01N35/08 , G01N2035/1034 , Y10T137/0318 , Y10T436/12

摘要： The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

2.

发明授权
Method for conducting an autocatalytic reaction in plugs in a microfluidic system 有权

公开(公告)号：US11278898B2

公开(公告)日：2022-03-22

申请号：US15926988

申请日：2018-03-20

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , B82Y30/00 , G01N35/08 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/6806

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

3.

发明申请
MICROFLUIDIC SYSTEM 审中-公开

公开(公告)号：US20170364101A1

公开(公告)日：2017-12-21

申请号：US15639151

申请日：2017-06-30

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts

IPC分类号： G05D7/06 , B01F5/04 , B01F13/00 , B01L3/02 , B01L3/00 , G01N1/38 , G01N35/08 , B01J19/00 , G01N35/10

摘要： The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

4.

发明授权
Method of crystallization in aqueous plugs flowing in immiscible carrier-fluid in microfluidic system 有权
标题翻译：在微流体系统中在不混溶的载体流体中流动的水性塞子中的结晶方法

公开(公告)号：US09592506B2

公开(公告)日：2017-03-14

申请号：US14517602

申请日：2014-10-17

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： G01N1/10 , B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , B82Y30/00 , G01N35/08 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/68

CPC分类号： B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25

摘要： A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.

摘要翻译： 公开了一种结晶方法，该方法包括提供包含至少三个通道的微流体系统的步骤，该通道具有至少一个结点; 在所述至少三个通道内提供连续流动的与水不混溶的载体流体，包含结晶靶的连续流动的第一含水流体和包含沉淀剂的连续流动的第二含水流体; 通过在所述至少三个通道的接合处分配含水流体与所述流动的载体流体形成至少一个塞子，所述至少一个塞子使所述至少一个塞子通过出口端口流入管道，并且停止管中的至少一个塞子的流动，其中结晶靶在管道中形成晶体。

5.

发明授权
Method for conducting reactions involving biological molecules in plugs in a microfluidic system 有权

公开(公告)号：US11478799B2

公开(公告)日：2022-10-25

申请号：US15926985

申请日：2018-03-20

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： B01L3/00 , B01J19/00 , B82Y30/00 , G01N35/08 , B01F25/433 , B01F33/302 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/6806

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

6.

发明申请
DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION 审中-公开

公开(公告)号：US20200070172A1

公开(公告)日：2020-03-05

申请号：US16555545

申请日：2019-08-29

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： B01L3/00 , C12Q1/6806 , B01J14/00 , C30B29/58 , C30B29/54 , C30B7/14 , C12N9/36 , C07K14/43 , B01D9/00 , G01N1/28 , G01N35/08 , B82Y30/00 , B01J19/00 , B01F13/00 , B01F5/06

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

7.

发明申请
Method for Conducting an Autocatalytic Reaction in Plugs in a Microfluidic System 审中-公开

公开(公告)号：US20180304268A1

公开(公告)日：2018-10-25

申请号：US15926988

申请日：2018-03-20

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： B01L3/00 , B01F5/06 , C12N9/36

CPC分类号： B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

8.

发明申请
Device and method for pressure-driven plug transport and reaction 审中-公开

公开(公告)号：US20180272352A1

公开(公告)日：2018-09-27

申请号：US15926992

申请日：2018-03-20

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng

IPC分类号： B01L3/00 , B01F5/06 , C12N9/36

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

9.

发明授权
Methods for manipulating spacing between microdroplets flowing in a microfluidic system 有权

公开(公告)号：US10054961B2

公开(公告)日：2018-08-21

申请号：US14184312

申请日：2014-02-19

申请人： The University of Chicago

发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts

IPC分类号： B01J19/00 , G01N1/38 , G01N35/10 , G05D7/06 , G01N35/08 , B01F13/00 , B01F5/04 , B01L3/02 , B01L3/00

CPC分类号： G05D7/0694 , B01F5/0471 , B01F13/0071 , B01J19/0046 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/0293 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N35/08 , G01N2035/1034 , Y10T137/0318

摘要： The present invention provides manipulation of spacing between microdroplets flowing in a microfluidic system. The manipulation includes increasing and/or decreasing spacing between a pair of adjacent droplets of a sample fluid flowing in an immiscible carrier fluid within a main microfluidic channel. The main microfluidic channel includes a region having one or more side branch channels. The spacing between the pair of droplets flowing through the region can be increased or reduced with either the addition of or removal of immiscible carrier fluid between the adjacent droplets via at least one of the side branch channels, wherein the pair of droplets remain intact while flowing through the region and continue to flow within the main microfluidic channel downstream of the region.