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公开(公告)号：US11278898B2
公开(公告)日：2022-03-22
申请号：US15926988
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , B82Y30/00 , G01N35/08 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/6806
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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2.发明授权Method of crystallization in aqueous plugs flowing in immiscible carrier-fluid in microfluidic system 有权在微流体系统中在不混溶的载体流体中流动的水性塞子中的结晶方法公开(公告)号：US09592506B2
公开(公告)日：2017-03-14
申请号：US14517602
申请日：2014-10-17
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: G01N1/10 , B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , B82Y30/00 , G01N35/08 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/68
CPC classification number: B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
Abstract: A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.
Abstract translation: 公开了一种结晶方法，该方法包括提供包含至少三个通道的微流体系统的步骤，该通道具有至少一个结点; 在所述至少三个通道内提供连续流动的与水不混溶的载体流体，包含结晶靶的连续流动的第一含水流体和包含沉淀剂的连续流动的第二含水流体; 通过在所述至少三个通道的接合处分配含水流体与所述流动的载体流体形成至少一个塞子，所述至少一个塞子使所述至少一个塞子通过出口端口流入管道，并且停止 管中的至少一个塞子的流动，其中结晶靶在管道中形成晶体。
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3.发明申请公开(公告)号：US20180272351A1
公开(公告)日：2018-09-27
申请号：US15926985
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
CPC classification number: B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20180154362A1
公开(公告)日：2018-06-07
申请号：US15825689
申请日：2017-11-29
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
IPC: B01L3/00 , C12Q1/44 , B01F3/08 , B01F5/06 , B01F13/00 , C12P19/34 , B01J19/00 , G01N15/14 , G01N35/08 , B01L7/00 , B82Y30/00
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20170232440A1
公开(公告)日：2017-08-17
申请号：US15586896
申请日：2017-05-04
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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Patent Agency Ranking
公开(公告)号：US09579622B2
公开(公告)日：2017-02-28
申请号：US14507938
申请日：2014-10-07
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song , Lewis Spencer Roach
IPC: B01L3/00 , B01J19/00 , B01F5/06 , B01F13/00 , G01N35/08 , C12P19/34 , C12Q1/44 , B82Y30/00 , G01N15/14
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
Abstract translation: 本发明提供微制造的底物和在这些底物内进行反应的方法。 反应发生在在载体流体流中输送的塞子中。
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7.发明授权公开(公告)号：US11478799B2
公开(公告)日：2022-10-25
申请号：US15926985
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: B01L3/00 , B01J19/00 , B82Y30/00 , G01N35/08 , B01F25/433 , B01F33/302 , G01N1/28 , B01D9/00 , C07K14/43 , C12N9/36 , C30B7/14 , C30B29/54 , C30B29/58 , B01J14/00 , C12Q1/6806
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20200070172A1
公开(公告)日：2020-03-05
申请号：US16555545
申请日：2019-08-29
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC: B01L3/00 , C12Q1/6806 , B01J14/00 , C30B29/58 , C30B29/54 , C30B7/14 , C12N9/36 , C07K14/43 , B01D9/00 , G01N1/28 , G01N35/08 , B82Y30/00 , B01J19/00 , B01F13/00 , B01F5/06
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US10118174B2
公开(公告)日：2018-11-06
申请号：US15825689
申请日：2017-11-29
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
IPC: B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , G01N35/08 , C12P19/34 , C12Q1/44 , B01F3/08 , B01L7/00 , B82Y30/00 , G01N15/14 , B01F5/04
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20180304268A1
公开(公告)日：2018-10-25
申请号：US15926988
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
CPC classification number: B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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