公开(公告)号：US07811755B2

公开(公告)日：2010-10-12

申请号：US11329861

申请日：2006-01-10

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C12Q1/68 ,  C12M1/34 ,  C12M3/00

CPC classification number: C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

Abstract: The invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed in an array format on a substrate.

Abstract translation: 本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 这些方法可以在衬底上以阵列格式执行。

公开(公告)号：US07754742B2

公开(公告)日：2010-07-13

申请号：US12502252

申请日：2009-07-14

Applicant: Albert Khilevich ,  Bin Liu ,  Daniel Ray Mayhugh ,  Jeffrey Michael Schkeryantz ,  Deyi Zhang

Inventor： Albert Khilevich ,  Bin Liu ,  Daniel Ray Mayhugh ,  Jeffrey Michael Schkeryantz ,  Deyi Zhang

IPC: A61K31/4172 ,  A61K31/4439 ,  C07D233/64 ,  C07D401/12

CPC classification number: C07D233/92

Abstract: The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.

Abstract translation: 本发明提供某些咪唑羧酰胺衍生物，其药物组合物，其使用方法及其制备方法。

公开(公告)号：US07666594B2

公开(公告)日：2010-02-23

申请号：US11344942

申请日：2006-01-31

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20100041642A1

公开(公告)日：2010-02-18

申请号：US12541922

申请日：2009-08-15

Applicant: Duyan NGUYEN ,  Martha KELLY ,  Kristofer MOFFETT ,  Enrique Luis MICHELOTTI ,  Bin Liu

Inventor： Duyan NGUYEN ,  Martha KELLY ,  Kristofer MOFFETT ,  Enrique Luis MICHELOTTI ,  Bin Liu

IPC: A61K31/496 ,  C07D409/14 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/551 ,  A61P43/00

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D495/04

Abstract: Urea containing compounds that inhibit MAP kinases, pharmaceutical compositions including such compounds and methods for using these compounds to treat inflammatory diseases and cancer are described herein.

Abstract translation: 本文描述了抑制MAP激酶的含尿素化合物，包含这些化合物的药物组合物和使用这些化合物治疗炎性疾病和癌症的方法。

公开(公告)号：US20090010841A1

公开(公告)日：2009-01-08

申请号：US11972130

申请日：2008-01-10

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C07K16/30 ,  C07K16/46 ,  A61K39/395 ,  A61K51/10 ,  C12N15/13 ,  C12N5/10 ,  G01N33/574 ,  C12N5/06 ,  A61P35/00

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身有用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20080258030A1

公开(公告)日：2008-10-23

申请号：US12049624

申请日：2008-03-17

Applicant: Michael Hsuan ,  Bin Liu ,  Kaiml Lei

Inventor： Michael Hsuan ,  Bin Liu ,  Kaiml Lei

IPC: F16M13/00

CPC classification number: F16M13/00 ,  F16M11/041 ,  F16M11/2092 ,  F16M11/24 ,  F16M2200/028 ,  Y10S248/917 ,  Y10S248/919 ,  Y10S248/92 ,  Y10S248/922 ,  Y10S248/923

Abstract: A display support device includes a connecting member and a lower tube. The connecting member is adapted to be mounted on a rear surface of a flat display, and includes an upper tube. The lower tube is disposed below the upper tube. One of the upper and lower tubes has an internally threaded portion, and the other of the upper and lower tubes has an externally threaded portion engaging the internally threaded portion to allow for rotation and therefore movement of the lower tube relative to the upper tube, which results in a change to the total length of the upper and lower tubes.

Abstract translation: 显示器支撑装置包括连接构件和下管。 连接构件适于安装在平面显示器的后表面上，并且包括上管。 下管设置在上管下方。 上管和下管中的一个具有内螺纹部分，并且上管和下管中的另一个具有接合内螺纹部分的外螺纹部分，以允许下管相对于上管的旋转和因此移动， 导致上管和下管总长度的变化。

公开(公告)号：US07378447B2

公开(公告)日：2008-05-27

申请号：US10546906

申请日：2004-03-12

Applicant: Jennifer Rebecca Allen ,  Stephen Andrew Hitchcock ,  William Wilson Turner ,  Bin Liu

Inventor： Jennifer Rebecca Allen ,  Stephen Andrew Hitchcock ,  William Wilson Turner ,  Bin Liu

IPC: A01N37/18 ,  A01N31/165

CPC classification number: C07C323/41 ,  C07B2200/07 ,  C07C257/14 ,  C07C257/18 ,  C07C271/24 ,  C07C2601/02 ,  C07C2602/08 ,  C07D213/64 ,  C07D213/70 ,  C07D295/125 ,  C07D295/13

Abstract: The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor

Abstract translation: 本发明涉及式（I）化合物：它是M-1毒蕈碱受体的激动剂

公开(公告)号：US20080070869A1

公开(公告)日：2008-03-20

申请号：US11855984

申请日：2007-09-14

Applicant: Thomas Arrhenius ,  Mi Chen ,  Jie Fei Cheng ,  Yujin Huang ,  Alex Nadzan ,  Sovouthy Tith ,  David Wallace ,  Bin Liu ,  Masahiro Nishimoto ,  Gary Lopaschuk ,  Jason Dyck

Inventor： Thomas Arrhenius ,  Mi Chen ,  Jie Fei Cheng ,  Yujin Huang ,  Alex Nadzan ,  Sovouthy Tith ,  David Wallace ,  Bin Liu ,  Masahiro Nishimoto ,  Gary Lopaschuk ,  Jason Dyck

IPC: A61K31/66 ,  A61K31/155 ,  A61K31/185 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P3/04 ,  A61K31/277

CPC classification number: C07D231/06 ,  A61K31/16 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/44 ,  A61K31/5375 ,  C07C33/46 ,  C07C257/22 ,  C07C279/18 ,  C07C307/10 ,  C07C335/18 ,  C07D231/14 ,  C07D233/64 ,  C07D233/90 ,  C07D261/04 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D295/13 ,  C07D295/194 ,  C07D295/21 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D401/12 ,  C07F9/247 ,  C07F9/4021

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract translation: 本发明涉及新型化合物（I），其前药和药学上可接受的盐以及含有这样的化合物的药物组合物，其可用于治疗某些代谢疾病和通过抑制酶丙二酰辅酶A脱羧酶（丙二酰 - CoA脱羧酶，MCD）。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖的化合物和组合物和方法。

公开(公告)号：US07326731B2

公开(公告)日：2008-02-05

申请号：US10488519

申请日：2002-09-09

Applicant: Jennifer Rebecca Allen ,  Stephen Andrew Hitchcock ,  James Andrew Jamison ,  Bin Liu ,  William Wilson Turner, Jr.

Inventor： Jennifer Rebecca Allen ,  Stephen Andrew Hitchcock ,  James Andrew Jamison ,  Bin Liu ,  William Wilson Turner, Jr.

IPC: A61K31/16 ,  C07C233/00

CPC classification number: C07D207/325 ,  C07C257/14 ,  C07C2602/08 ,  C07D213/54 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D241/24 ,  C07D307/52 ,  C07D317/28 ,  C07D333/24 ,  C07D409/04 ,  Y02P20/582

Abstract: The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.

Abstract translation: 本发明涉及作为M-1毒蕈碱受体的激动剂的式I化合物：式I。

公开(公告)号：US20070206717A1

公开(公告)日：2007-09-06

申请号：US11366964

申请日：2006-03-02

Applicant: Michael Conner ,  Zeses Karoutas ,  Milorad Dzodzo ,  Bin Liu ,  Paul Joffre ,  Dmitry Paramonov ,  Levie Smith

Inventor： Michael Conner ,  Zeses Karoutas ,  Milorad Dzodzo ,  Bin Liu ,  Paul Joffre ,  Dmitry Paramonov ,  Levie Smith

IPC: G21C3/34

CPC classification number: G21C3/322 ,  Y02E30/32 ,  Y02E30/38

Abstract: A fuel assembly for a pressurized water reactor that includes a bottom nozzle, a plurality of elongated guide thimbles projecting upwardly from the bottom nozzle, an array of fuel rods, a plurality of support grids axially spaced along the guide thimbles, and at least two Intermediate Flow Mixing grids, which may have different configurations of mixing device formations, disposed between pairs of non-uniformly spaced, adjacent support grids at selected locations.

Abstract translation: 一种用于加压水反应器的燃料组件，其包括底部喷嘴，从底部喷嘴向上突出的多个细长导向套管，燃料棒阵列，沿导向套管轴向间隔开的多个支撑网格，以及至少两个中间体 流动混合网格，其可以具有不同配置的混合装置结构，设置在选定位置处的非均匀间隔的相邻支撑格栅对之间。