公开(公告)号：US6013284A

公开(公告)日：2000-01-11

申请号：US513853

申请日：1996-05-01

Applicant: Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

Inventor： Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

IPC: A23L27/00 ,  A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/36 ,  A61K8/42 ,  A61K8/64 ,  A61K8/66 ,  A61K8/68 ,  A61K8/73 ,  A61K8/92 ,  A61K8/97 ,  A61K8/99 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61Q19/00 ,  A61Q90/00

CPC classification number: A61K9/5123 ,  A23L27/70 ,  A23L27/72 ,  A61K8/11 ,  A61K8/14 ,  A61K8/66 ,  A61K8/97 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5161 ,  A61Q19/00 ,  B82Y5/00 ,  A61K2800/412 ,  A61K2800/413 ,  Y10S514/951 ,  Y10S514/952 ,  Y10T428/2991

Abstract: A synthetic particulate vector comprising a non-liquid hydrophilic nucleus and an outer layer at least partially consisting of amphiphilic compounds, which is combined with the nucleus by hydrophobic interactions and/or ionic bonds. A process for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtained according to such a process, and pharmaceutical, cosmeticological and food compositions comprising such vectors are also disclosed.

Abstract translation: PCT No.PCT / FR94 / 00228 Sec。 371日期：1996年5月1日 102（e）日期1996年5月1日PCT 1994年3月1日PCT公布。 WO94 / 20078 PCT公开号 日期1994年9月15日一种包含非液体亲水核和至少部分由两亲化合物组成的外层的合成颗粒载体，其通过疏水相互作用和/或离子键与核结合。 还公开了通过包封可离子化活性成分，根据这种方法获得的载体以及包含这种载体的药物，美容和食用组合物来制备颗粒载体的方法。

公开(公告)号：US09545340B1

公开(公告)日：2017-01-17

申请号：US12207137

申请日：2008-09-09

Applicant: Wayne H. Knox ,  Krystel R. Huxlin ,  Li Ding

Inventor： Wayne H. Knox ,  Krystel R. Huxlin ,  Li Ding

IPC: A61F9/008

CPC classification number: A61F9/00827 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00829 ,  A61F2009/00842 ,  A61F2009/00846 ,  A61F2009/00848 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/0088

Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

Abstract translation: 通过适应在水凝胶中开发的飞秒微加工方法，我们可以在生物组织中进行组织内折射指数整形（IRIS）。 我们将飞秒激光脉冲能量降低到光学击穿阈值以下，以产生与组织的折射率变化相关联的光栅图案。 为了增加双光子吸收，我们使用了两个（或更多）光子吸收发色团。

公开(公告)号：US09105456B2

公开(公告)日：2015-08-11

申请号：US13576294

申请日：2011-01-26

Applicant: Gongyu Jiang ,  Hui Mu ,  Li Ding

Inventor： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  G01N30/72

CPC classification number: H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

Abstract: A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

Abstract translation: 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US20140032184A1

公开(公告)日：2014-01-30

申请号：US14110703

申请日：2012-04-05

Applicant: Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

Inventor： Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

IPC: G06F17/50

CPC classification number: G06F17/5009 ,  G06F17/5095

Abstract: A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

Abstract translation: 公开了一种用于产生具有可操作以支撑车身沿着地形运动的轮式底盘的车辆的三维扫掠包络的计算机表示的方法，装置，介质和信号。 该方法包括接收表示3D地形的地形数据，接收定义车辆参数的数据，以及接收定义用于使车辆从地形上的初始位置移动到地形上的位移位置的路径的数据。 该方法还涉及使用参数在路径的连续位置处将车辆的计算机表示设置在地形的3D表示上。 处置涉及确定轮式底盘的车轮与地形的3D表示之间的接合点，以相对于地形布置底盘，以及相对于地形确定车体的对应3D位置。 该方法还包括在连续位置处产生车辆的多个空间范围，当在初始位置和位移位置之间移动时，空间范围限定车辆的3D扫描包络线。 在另一方面，公开了一种用于生成沿着相对于地形的3D表示布置的导轨移动的物体的三维扫描包络的计算机表示的方法。

公开(公告)号：US08507848B1

公开(公告)日：2013-08-13

申请号：US13357470

申请日：2012-01-24

Applicant: Li Ding ,  Gongyu Jiang ,  Wenjian Sun

Inventor： Li Ding ,  Gongyu Jiang ,  Wenjian Sun

IPC: H01J49/42 ,  H01J49/34 ,  H01J49/04

CPC classification number: H01J49/065 ,  H01J49/066

Abstract: This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.

Abstract translation: 本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。 这些线电极沿离子导向装置中限定的离子引导轴分布。 每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。 离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。 电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。

公开(公告)号：US08478573B2

公开(公告)日：2013-07-02

申请号：US11166659

申请日：2005-06-23

Applicant: Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

Inventor： Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

IPC: G06F17/50

CPC classification number: G06F17/5031

Abstract: A model for a circuit cell used in timing and signal integrity analysis in an integrated circuit design is automatically generated. A behavioral model, such as a gate current model is used in which the current in the circuit cell is determined as a function of the input voltage and the output voltage of the circuit cell as well as the history of at least one of the current, voltage, and charge values of the circuit cell. For example, the current in the circuit cell may be a function of the history of the current, which may be calculated incrementally using recursive convolution at each time step when using the model.

Abstract translation: 自动生成用于集成电路设计中的时序和信号完整性分析的电路单元的模型。 使用诸如栅极电流模型的行为模型，其中电路单元中的电流被确定为电路单元的输入电压和输出电压的函数以及电流单元中的至少一个的历史， 电压和电荷值。 例如，电路单元中的电流可以是电流的历史的函数，其可以在使用该模型时在每个时间步长处使用递归卷积来逐渐计算。

公开(公告)号：US08384025B2

公开(公告)日：2013-02-26

申请号：US13130254

申请日：2009-11-26

Applicant: Wenjian Sun ,  Li Ding

Inventor： Wenjian Sun ,  Li Ding

IPC: H01J49/26 ,  H01J49/42 ,  H01J49/10

CPC classification number: G01N27/622 ,  G01N15/0266

Abstract: A device for separating, enriching and detecting ions comprises: a gas tube, in which a carrier gas flows at a uniform rate; an ion source; multiple electrodes provided in the gas tube and applied with electric voltages respectively, so that at least an electric field is produced along the axis of the gas tube; an ion detector; and an ion extraction channel, by which specific enriched ions will be guided across the side wall of the gas tube toward the ion detector and be analyzed. The device enriches ions utilizing the following characteristic: compound ions with specific ion mobility maintain a dynamic balance for a period of time in a flow field under the combination of a carrier gas and a suitable electrical field against the direction of the carrier gas. Simultaneously, multiple compound particles with different ion motilities can be separated and enriched at positions with different electrical field intensities in a flow field in the same manner. The device also comprises synchronously export latitudinally enriched ions at different positions in a flow field, and performs later mass analysis using a mass spectrometer.

Abstract translation: 用于分离，富集和检测离子的装置包括：气体管，其中载气以均匀的速率流动; 离子源; 设置在气体管中并分别施加电压的多个电极，使得沿着气体管的轴线产生至少一个电场; 离子检测器 和离子提取通道，通过该离子提取通道将特定的富集离子引导穿过气体管的侧壁朝离子检测器进行分析。 该装置利用以下特征丰富离子：具有特定离子迁移率的复合离子在载气和合适的电场相对于载气方向的组合下在流场中保持动态平衡一段时间。 同时，具有不同离子运动的多种化合物颗粒可以以相同的方式在流场中分离富集在具有不同电场强度的位置。 该装置还包括在流场中同步输出纬向富集的离子，并使用质谱仪进行质量分析。

公开(公告)号：US08341574B2

公开(公告)日：2012-12-25

申请号：US12399704

申请日：2009-03-06

Applicant: Ravikishore Gandikota ,  Li Ding ,  Peivand Tehrani ,  Nahmsuk Oh ,  Alireza Kasnavi

Inventor： Ravikishore Gandikota ,  Li Ding ,  Peivand Tehrani ,  Nahmsuk Oh ,  Alireza Kasnavi

IPC: G06F17/50

CPC classification number: G06F17/5031 ,  G06F2217/84

Abstract: Embodiments of a computer system, a method, an integrated circuit and a computer-program product (i.e., software) for use with the computer system are described. These devices and techniques may be used to calculate the total time delay in a signal path due to crosstalk from a group of crosstalk aggressors that are associated with a group of signal paths. In order to properly account for statistical behaviors in the switching times and directions of the switching patterns in the group of signal paths, the time-delay contribution from each of these crosstalk aggressors may be modeled as a corresponding statistical random variable. Because the number of crosstalk aggressors are usually much larger than the number of stages in the signal path, the calculated total path delay may be less pessimistic. Furthermore, in order to detect potential timing violations, the time-delay contributions from additional dominant crosstalk aggressors can be modeled using non-statistical worst-case deterministic values.

Abstract translation: 描述了与计算机系统一起使用的计算机系统，方法，集成电路和计算机程序产品（即，软件）的实施例。 这些装置和技术可用于计算由于与一组信号路径相关联的一组串扰侵扰者的串扰引起的信号路径中的总时间延迟。 为了适当地考虑信号路径组中的切换模式的切换时间和方向的统计行为，来自每个这些串扰侵略者的时间延迟贡献可以被建模为相应的统计随机变量。 因为串扰攻击者的数量通常远大于信号路径中的级数，所以计算的总路径延迟可能不那么悲观。 此外，为了检测潜在的定时违规，可以使用非统计最坏情况确定性值来对附加的主要串扰侵扰者的时间延迟贡献进行建模。

公开(公告)号：US20120292498A1

公开(公告)日：2012-11-22

申请号：US13576294

申请日：2011-01-26

Applicant: Gongyu Jiang ,  Hui Mu ,  Li Ding

Inventor： Gongyu Jiang ,  Hui Mu ,  Li Ding

IPC: H01J49/02 ,  H01J49/26

CPC classification number: H01J49/063 ,  G01N30/7206 ,  H01J49/004 ,  H01J49/062 ,  H01J49/4215 ,  H01J49/4225

Abstract: A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

Abstract translation: 在本发明中提供串联质谱仪。 质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器 置于真空环境中。 仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型 在离子阱分析模式下由四极杆。 还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

公开(公告)号：US08294085B2

公开(公告)日：2012-10-23

申请号：US13140346

申请日：2009-12-22

Applicant: Li Ding

Inventor： Li Ding

IPC: H01J49/40 ,  H01J49/26 ,  B01D59/44

CPC classification number: H01J49/027 ,  H01J49/0036 ,  H01J49/4245

Abstract: A mass spectrometric analyzer and an analysis method based on the detection of ion image current are provided. The method in one embodiment includes using electrostatic reflectors or electrostatic deflectors to enable pulsed ions to move periodically for multiple times in the analyzer, forming time focusing in a portion of the ion flight region thereof, and forming an confined ion beam in space; enabling the ion beam to pass through multiple tubular image current detectors arranged in series along an axial direction of the ion beam periodically, using a low-noise electronic amplification device to detect image currents picked up by the multiple tubular detectors differentially, and using a data conversion method, such as a least square regression, to acquire a mass spectrum.

Abstract translation: 提供了基于离子图像电流检测的质谱分析仪和分析方法。 在一个实施例中的方法包括使用静电反射器或静电偏转器使得脉冲离子能够在分析器中周期性移动多次，形成时间聚焦在其离子飞行区域的一部分中，并在空间中形成约束离子束; 使得离子束能够通过使用低噪声电子放大装置周期性地沿着离子束的轴向方向串联布置的多个管状图像电流检测器，以差分地检测由多个管状检测器拾取的图像电流，并使用数据 转换方法，如最小二乘回归，以获得质谱。