公开(公告)号：US10401332B2

公开(公告)日：2019-09-03

申请号：US15062405

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: G01N30/30 ,  G01N30/02 ,  G01N30/54 ,  B01D15/40 ,  B01D15/16 ,  H01L33/64

Abstract: A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.

公开(公告)号：US10345277B2

公开(公告)日：2019-07-09

申请号：US15360558

申请日：2016-11-23

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  John Maillet

IPC: G01N30/30 ,  G01N30/54 ,  G01N30/60 ,  G01N30/46 ,  G01N30/02 ,  G01N30/88

Abstract: A thermal system for use in a column manager of a liquid chromatography system comprises a plurality of spatially separated individually controlled thermoelectric chips. A column module houses a plurality of thermally conductive troughs. Each trough resides in a separate thermal zone to be thermally conditioned individually by one of the individually controlled thermoelectric chips. Each trough is adapted to hold one or more liquid chromatography columns therein. A plurality of spatially separated thermal bridges includes a first thermal bridge thermally coupling one of the thermoelectric chips to a first one of the plurality of troughs and a second thermal bridge of the plurality of thermal bridges thermally coupling another of the thermoelectric chips to a second one of the plurality of troughs.

公开(公告)号：US20180252683A1

公开(公告)日：2018-09-06

申请号：US15909258

申请日：2018-03-01

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joshua A. Shreve

IPC: G01N30/32 ,  G01N30/72

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/724 ,  G01N2030/326

Abstract: The present disclosure relates to methodologies, systems and devices for controlling pressure of a mobile phase in a CO2-based chromatography system. A pump is used to pump a mobile phase containing CO2 and is located upstream of a chromatography column. A primary pressure control element is located downstream of the chromatography column and controls the pressure of the mobile phase within the column. A secondary pressure control element is located downstream of the primary pressure control element and maintains the pressure of the mobile phase above a threshold value between an outlet of the primary pressure control element and the point of detection within a detector. The detector is located downstream of both the primary pressure control element and the secondary pressure control element.

公开(公告)号：US10060886B2

公开(公告)日：2018-08-28

申请号：US14612532

申请日：2015-02-03

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Joshua A. Shreve

IPC: G01N30/34 ,  F04B23/04 ,  F04B49/06

CPC classification number: G01N30/34 ,  F04B23/04 ,  F04B49/065

Abstract: Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time. Initiations of the pump strokes of the second pump are offset in time relative to initiations of the pump strokes of the first pump such that variations in the flow rates of the first and second pumps due to initiation do not overlap in time. The volume of liquid contributed by a pump stroke is controlled according to the relative contribution of the respective pump to the composition gradient.

公开(公告)号：US20180111060A1

公开(公告)日：2018-04-26

申请号：US15791622

申请日：2017-10-24

Applicant: Waters Technologies Corporation

Inventor： Emily J. Berg ,  Joshua A. Shreve ,  Edwin H. Denecke

IPC: B01D15/40 ,  B01D15/16

CPC classification number: B01D15/40 ,  B01D15/10 ,  B01D15/161 ,  B01D15/163 ,  B01D19/0005 ,  B01D19/0021 ,  B01D19/0042 ,  B01D19/0057 ,  B01D19/0063 ,  B01D2257/504 ,  G01N30/84

Abstract: Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.

公开(公告)号：US20170016461A1

公开(公告)日：2017-01-19

申请号：US15280421

申请日：2016-09-29

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Neal B. Almeida

IPC: F15B15/14 ,  F16J15/3208

CPC classification number: F15B15/1461 ,  F04B1/0448 ,  F04B53/00 ,  F04B53/143 ,  F16J15/3208 ,  G01N30/32 ,  G01N2030/326

Abstract: Low-pressure and high-pressure reciprocating and rotary applications use seal assemblies to prevent leakage. One embodiment of a seal assembly includes a major annular body having opposing spaced-apart annular lips extending from a heel portion. The major annular body has a bore extending through the heel portion. A first spring is disposed between the lips, biasing the lips apart. A minor annular body extends from one of the lips of the major annular body. The minor annular body has opposing spaced-apart walls that extend from a base region and form a pocket. A second spring is disposed in the pocket between the spaced-apart walls, biasing the walls apart. During actuator operation, pressurized fluid urges one wall of the minor annular body against a pump head surface to produce a face seal and one of the lips of the major annular body against a rod surface to produce a radial seal.

Abstract translation: 低压和高压往复和旋转应用使用密封组件来防止泄漏。 密封组件的一个实施例包括主要环形体，其具有从跟部部分延伸的相对间隔开的环形唇部。 主环形体具有延伸穿过后跟部分的孔。 第一弹簧设置在嘴唇之间，使嘴唇分开。 小环形体从主环形体的一个唇部延伸。 小环形体具有从基部区域延伸并形成袋的相对的间隔开的壁。 第二弹簧设置在间隔开的壁之间的袋中，使壁分开。 在致动器操作期间，加压流体促使次环形体的一个壁抵靠泵头表面，以产生面密封件和主环形体的唇部中的一个抵靠杆表面以产生径向密封。

公开(公告)号：US20160266077A1

公开(公告)日：2016-09-15

申请号：US15062430

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Abhijit Tarafder ,  Joseph D. Michienzi ,  Joshua A. Shreve

IPC: G01N30/30

CPC classification number: G01N30/30 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053

Abstract: Analytical-scale separation column assemblies include a tube with a bore packed with a stationary phase through which a mobile phase flows. In one embodiment, thermal elements are disposed remotely from and unattached to the tube. The thermal elements are in thermal communication with an external surface of the tube for producing a spatial thermal gradient outside of and along a length of the tube. In another embodiment, discrete, spatially separated strips of thermally conductive material are disposed on and wrapped around an external surface of the tube. Thermal elements are disposed remotely from the tube. Each thermal element is in thermal communication with one strip of thermally conductive material by a heat-transfer device. The thermal elements produce a spatial thermal gradient outside of and along a tube length by controlling temperature of each strip of thermally conductive material disposed on and wrapped around the external surface of the tube.

Abstract translation: 分析级分离柱组件包括具有填充有流动相流过的固定相的孔的管。 在一个实施例中，热元件远离管并且不附接于管。 热元件与管的外表面热连通，用于在管的长度之外和沿着管的长度产生空间热梯度。 在另一个实施例中，离散的，空间上分离的导热材料条被布置在管的外表面上并且缠绕在管的外表面上。 热元件远离管放置。 每个热元件通过热传递装置与一条导热材料热连通。 热元件通过控制设置在管的外表面上并缠绕在管的外表面上的每个导热材料条的温度在管长度之外产生空间热梯度。

公开(公告)号：US20160266076A1

公开(公告)日：2016-09-15

申请号：US15062405

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: G01N30/30 ,  B01D15/16

CPC classification number: G01N30/30 ,  B01D15/16 ,  B01D15/161 ,  B01D15/40 ,  G01N30/02 ,  G01N30/54 ,  G01N2030/027 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  H01L33/645

Abstract: A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.

Abstract translation: 在分离塔内减少色谱带宽增长的系统和方法包括使流动相通过一段分离柱，并产生沿着分离柱外部和沿着分离柱长度的空间热梯度。 空间热梯度被特别配置为当流动相通过分离柱时抵消流动相的特性变化。 例如，抵消的特定变化可以是流动相的密度或温度的变化。 对于分析级列，例如，空间热梯度可以被配置为产生在分离柱的长度之外和沿着分离柱的长度，其基本上与流动相通过时沿柱长度预测形成的温度相匹配 分离柱，从而基本上防止在流动相中形成径向热梯度。

公开(公告)号：US09341277B2

公开(公告)日：2016-05-17

申请号：US14381974

申请日：2013-03-07

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Paul Keenan ,  John Maillet, Jr. ,  Ryan Hill

IPC: F16K27/02 ,  F16K1/38 ,  G01N30/20 ,  G01N30/32 ,  F16K31/06 ,  B01D15/40

CPC classification number: F16K27/02 ,  B01D15/40 ,  F16K1/38 ,  F16K31/0655 ,  G01N30/20 ,  G01N30/32 ,  Y10T137/0486 ,  Y10T137/6065

Abstract: Exemplary embodiments are directed to apparatus, systems and methods used in connection with a needle valve device operating in a pressurized flow system. The apparatus, systems and methods provide for automatic positioning of a needle relative to a seat in the needle valve device to provide consistent calibration with minimal user interaction after a maintenance event or upon a start-up of the pressurized flow system. The apparatus, systems and methods utilize a calibration collar secured to a shaft of an actuator within the needle valve device. The calibration collar includes one or more locking mechanism and a spring.

Abstract translation: 示例性实施例涉及与在加压流动系统中操作的针阀装置结合使用的装置，系统和方法。 该设备，系统和方法提供针相对于针阀装置中的座的自动定位，以在维护事件之后或在启动加压流动系统时提供一致的校准，同时最小的用户相互作用。 该装置，系统和方法利用固定在针阀装置内的致动器的轴上的校准轴环。 校准轴环包括一个或多个锁定机构和弹簧。

公开(公告)号：US20150369403A1

公开(公告)日：2015-12-24

申请号：US14651835

申请日：2013-12-16

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Sylvain Cormier ,  Joshua A. Shreve ,  Joseph A. Luongo ,  Paul Keenan ,  Kenneth Plant

IPC: F16L19/02

CPC classification number: F16L19/0212 ,  F16L19/0206 ,  G01N30/22 ,  G01N30/6026

Abstract: Described is a coupling seal that includes a polymeric body having a bore extending from a first end to an internal sealing surface and a fluid channel extending from the internal sealing surface to a second end. The bore is configured to receive a tube having a fluid channel so that an endface of the tube engages the internal sealing surface. The second end of the polymeric body is configured to contact a sealing surface of a coupling body that has a fluid channel extending from the sealing surface. A fluidic seal occurs when the coupling seal is compressed between the endface and the sealing surface. A void between an outer surface of the polymeric body and an inner surface of the coupling body receives the deformation of the coupling seal while under compression to thereby prevent the fluid channel of the tube from being crushed or obstructed.

Abstract translation: 描述了一种联接密封件，其包括具有从第一端延伸到内部密封表面的孔的聚合物主体和从内部密封表面延伸到第二端的流体通道。 孔构造成接收具有流体通道的管，使得管的端面与内部密封表面接合。 聚合物体的第二端构造成接触具有从密封表面延伸的流体通道的联接体的密封表面。 当连接密封件在端面和密封表面之间被压缩时，发生流体密封。 聚合物主体的外表面和联接体的内表面之间的空隙在压缩时接合联接密封件的变形，从而防止管的流体通道被压碎或阻塞。