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    Hybrid gradient delivery system and operation
    1.
    发明授权
    Hybrid gradient delivery system and operation 有权

    公开(公告)号：US11130074B2

    公开(公告)日：2021-09-28

    申请号：US16299805

    申请日：2019-03-12

    Applicant: Waters Technologies Corporation

    Inventor： Joseph A. Luongo ,  Craig Hamilton Dobbs

    IPC: B01D15/14 ,  B01D15/16 ,  G01N30/34 ,  G01N30/38 ,  G01N30/20

    Abstract: A solvent delivery system for a liquid chromatography system may include a first gradient proportioning valve in fluidic communication with a first plurality of sources of solvent and producing therefrom a first low-pressure gradient stream. The solvent delivery system may further include a second gradient proportioning valve in direct fluidic communication with an inlet of the first gradient proportioning valve and with a second plurality of sources of solvent, the second gradient proportioning valve producing a second low-pressure gradient stream from the second plurality of sources of solvent, wherein one solvent source of the first plurality of sources of solvent used by the first gradient proportioning valve to produce the first low-pressure gradient stream comprises the second low-pressure gradient stream. The solvent delivery system may also include a first pump in direct fluidic communication with the first gradient proportioning valve to receive and pressurize the first low-pressure gradient stream.

    HYBRID GRADIENT DELIVERY SYSTEM AND OPERATION
    2.
    发明申请
    HYBRID GRADIENT DELIVERY SYSTEM AND OPERATION 审中-公开

    公开(公告)号：US20190201811A1

    公开(公告)日：2019-07-04

    申请号：US16299805

    申请日：2019-03-12

    Applicant: Waters Technologies Corporation

    Inventor： Joseph A. Luongo ,  Craig Hamilton Dobbs

    IPC: B01D15/14 ,  B01D15/16 ,  G01N30/34

    CPC classification number: B01D15/14 ,  B01D15/166 ,  G01N30/20 ,  G01N30/34 ,  G01N30/38 ,  Y10T137/0363 ,  Y10T137/85986

    Abstract: A solvent delivery system for a liquid chromatography system may include a first gradient proportioning valve in fluidic communication with a first plurality of sources of solvent and producing therefrom a first low-pressure gradient stream. The solvent delivery system may further include a second gradient proportioning valve in direct fluidic communication with an inlet of the first gradient proportioning valve and with a second plurality of sources of solvent, the second gradient proportioning valve producing a second low-pressure gradient stream from the second plurality of sources of solvent, wherein one solvent source of the first plurality of sources of solvent used by the first gradient proportioning valve to produce the first low-pressure gradient stream comprises the second low-pressure gradient stream. The solvent delivery system may also include a first pump in direct fluidic communication with the first gradient proportioning valve to receive and pressurize the first low-pressure gradient stream.

    Gasket and Seal Apparatus
    3.
    发明申请
    Gasket and Seal Apparatus 审中-公开
    垫片和密封装置

    公开(公告)号：US20130076029A1

    公开(公告)日：2013-03-28

    申请号：US13626428

    申请日：2012-09-25

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Joseph A. Luongo ,  Charles T. Murphy ,  David R. Friswell ,  Mark W. Moeller ,  Peter Kirby

    IPC: F16L15/04

    CPC classification number: F16L15/04 ,  F16K27/02 ,  Y10T137/0491

    Abstract: Embodiments of the present invention feature devices and methods for holding fluids at high pressures. One embodiment of the present invention features a fluid containing conveying device for receiving and discharging fluids. The device comprises a housing having a chamber for containing a fluid. The housing has a first gasket receiving surface for receiving a gasket. A gasket formed of a deformable material and having a first abutment surface and second abutment surface. The first abutment surface received on the first gasket receiving surface and the second abutment surface for receiving a chamber closing piece. The chamber closing piece having a second gasket receiving surface, the chamber closing piece for closing the chamber. At least one of the first gasket receiving surface of the housing and the second gasket receiving surface of the chamber closing piece having a retaining grove, having at least one edge. Compression means for compressing the gasket, deforming the material such that the gasket is pressed into retaining groove and gripped by the edge of the cavity to prevent gasket movement.

    Abstract translation: 本发明的实施例的特征在于在高压下保持流体的装置和方法。 本发明的一个实施例的特征在于包含用于接收和排出流体的输送装置。 该装置包括具有用于容纳流体的室的壳体。 壳体具有用于接收垫圈的第一垫片接收表面。 由可变形材料形成并具有第一邻接表面和第二邻接表面的垫圈。 接收在第一垫片接收表面上的第一邻接表面和用于接收室闭合件的第二邻接表面。 所述腔室封闭件具有第二垫片接收表面，所述腔室封闭件用于封闭所述腔室。 壳体的第一垫片接收表面和腔室封闭件的第二垫片接收表面中的至少一个具有保留槽，其具有至少一个边缘。 用于压缩垫圈的压缩装置，使材料变形，使得垫圈被压入保持槽并被空腔的边缘夹持以防止垫圈移动。

    CORROSION PROTECTION IN TUBING USED IN CHROMATOGRAPHY
    4.
    发明申请
    CORROSION PROTECTION IN TUBING USED IN CHROMATOGRAPHY 审中-公开
    用于色谱中的管道中的腐蚀保护

    公开(公告)号：US20150048015A1

    公开(公告)日：2015-02-19

    申请号：US14382900

    申请日：2013-03-04

    Applicant: Waters Technologies Corporation

    Inventor： Kurt D. Joudrey ,  Trudeau D. Steven ,  Paul Keenan ,  Joseph A. Luongo ,  Daniel J. McCormick ,  Eugene Berthiaume

    IPC: B01D15/22 ,  G01N30/60

    CPC classification number: B01D15/22 ,  B01D15/08 ,  B01D15/40 ,  G01N30/02 ,  G01N30/56 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N2030/027 ,  G01N2030/6013

    Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.

    Abstract translation: 用于液相色谱系统的装置包括色谱端口和管组件，该管组件具有在一端与色谱端口相连的色谱管。 管的端部具有覆盖有耐腐蚀材料（例如金）的端面。 材料的耐腐蚀性能保护管的端部不受腐蚀或腐蚀，这提高了管的端面和端口的密封表面之间的密封的质量和可靠性。 或者，或者除了用耐腐蚀材料覆盖管的端面之外，可以在管的端面和端口之间设置由耐腐蚀材料覆盖或由其制成的垫圈。 该垫圈延伸管的到达，以便于在端口内从底部出来。

    Corrosion protection in tubing used chromatography
    5.
    发明授权
    Corrosion protection in tubing used chromatography 有权

    公开(公告)号：US10232287B2

    公开(公告)日：2019-03-19

    申请号：US14382900

    申请日：2013-03-04

    Applicant: Waters Technologies Corporation

    Inventor： Kurt D. Joudrey ,  Steven D. Trudeau ,  Paul Keenan ,  Joseph A. Luongo ,  Daniel J. McCormick ,  Eugene Berthiaume

    IPC: B01D15/08 ,  B01D15/22 ,  B01D15/40 ,  G01N30/02 ,  G01N30/56 ,  G01N30/60

    Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.

    FLUIDIC COUPLING SEAL
    7.
    发明申请
    FLUIDIC COUPLING SEAL 审中-公开
    流体接头密封

    公开(公告)号：US20150369403A1

    公开(公告)日：2015-12-24

    申请号：US14651835

    申请日：2013-12-16

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Sylvain Cormier ,  Joshua A. Shreve ,  Joseph A. Luongo ,  Paul Keenan ,  Kenneth Plant

    IPC: F16L19/02

    CPC classification number: F16L19/0212 ,  F16L19/0206 ,  G01N30/22 ,  G01N30/6026

    Abstract: Described is a coupling seal that includes a polymeric body having a bore extending from a first end to an internal sealing surface and a fluid channel extending from the internal sealing surface to a second end. The bore is configured to receive a tube having a fluid channel so that an endface of the tube engages the internal sealing surface. The second end of the polymeric body is configured to contact a sealing surface of a coupling body that has a fluid channel extending from the sealing surface. A fluidic seal occurs when the coupling seal is compressed between the endface and the sealing surface. A void between an outer surface of the polymeric body and an inner surface of the coupling body receives the deformation of the coupling seal while under compression to thereby prevent the fluid channel of the tube from being crushed or obstructed.

    Abstract translation: 描述了一种联接密封件，其包括具有从第一端延伸到内部密封表面的孔的聚合物主体和从内部密封表面延伸到第二端的流体通道。 孔构造成接收具有流体通道的管，使得管的端面与内部密封表面接合。 聚合物体的第二端构造成接触具有从密封表面延伸的流体通道的联接体的密封表面。 当连接密封件在端面和密封表面之间被压缩时，发生流体密封。 聚合物主体的外表面和联接体的内表面之间的空隙在压缩时接合联接密封件的变形，从而防止管的流体通道被压碎或阻塞。

    HYBRID GRADIENT DELIVERY SYSTEM AND OPERATION
    8.
    发明申请
    HYBRID GRADIENT DELIVERY SYSTEM AND OPERATION 审中-公开
    混合梯度交付系统和操作

    公开(公告)号：US20140367319A1

    公开(公告)日：2014-12-18

    申请号：US14364148

    申请日：2012-12-07

    Applicant: Waters Technologies Corporation

    Inventor： Joseph A. Luongo ,  Craig Hamilton Dobbs

    IPC: B01D15/14

    CPC classification number: B01D15/14 ,  B01D15/166 ,  G01N30/20 ,  G01N30/34 ,  G01N30/38 ,  Y10T137/0363 ,  Y10T137/85986

    Abstract: A liquid chromatography system includes a gradient proportioning valve in fluidic communication with sources of solvent. From the solvent sources, the gradient proportioning valve produces a low-pressure gradient stream. A first pump is in fluidic communication with the gradient proportioning valve to receive, pressurize, and move the pressurized low-pressure gradient stream to a flow-combining device. A second pump operates in parallel with the first pump and moves a pressurized solvent stream to the flow-combining device where the pressurized solvent stream combines with the low-pressure gradient stream to produce a high-pressure gradient stream. A second gradient proportioning valve can produce, from a second plurality of sources of solvent, a second low-pressure gradient stream, wherein the solvent stream moved by the second pump to the flow-combining device and combined with the other low-pressure gradient stream comprises the second low-pressure gradient stream.

    Abstract translation: 液相色谱系统包括与溶剂源流体连通的梯度比例阀。 从溶剂来源，梯度比例阀产生低压梯度流。 第一泵与梯度比例阀流体连通，以将加压的低压梯度流接收，加压并移动到流动组合装置。 第二泵与第一泵平行操作并将加压溶剂流移动到流动组合装置，其中加压溶剂流与低压梯度流结合以产生高压梯度流。 第二梯度比例阀可以从第二多个溶剂源产生第二低压梯度流，其中溶剂流由第二泵移动到流动组合装置并与其它低压梯度流 包括第二低压梯度流。

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