公开(公告)号：US09958364B2

公开(公告)日：2018-05-01

申请号：US15023729

申请日：2014-09-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  George W. Griesgraber ,  Semra Colak Atan ,  James I. Hembre ,  Robert T. Fitzsimons, Jr.

IPC: B01D71/44 ,  G01N1/40 ,  C07K1/34 ,  C08J7/18 ,  C07F9/38 ,  G01N33/544 ,  C07K1/18 ,  B01D67/00 ,  B01D71/52 ,  B01D71/56 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

CPC classification number: G01N1/405 ,  B01D67/0093 ,  B01D71/44 ,  B01D71/52 ,  B01D71/56 ,  B01D2323/345 ,  B01D2323/38 ,  B01D2325/14 ,  B01D2325/16 ,  B01J20/261 ,  B01J20/28038 ,  B01J20/321 ,  B01J20/3242 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/327 ,  C07F9/3808 ,  C07K1/18 ,  C07K1/34 ,  C08J7/18 ,  C08J2377/00 ,  G01N1/4077 ,  G01N33/544 ,  G01N2001/4088 ,  G01N2333/924

Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

公开(公告)号：US09669402B2

公开(公告)日：2017-06-06

申请号：US13785632

申请日：2013-03-05

Applicant: Jiali Liao ,  Russell Frost

Inventor： Jiali Liao ,  Russell Frost

IPC: B01D15/26 ,  C07K1/14 ,  B01J20/281 ,  B01J41/20 ,  C07K1/16 ,  B01D15/30 ,  B01D15/32 ,  B01D15/36 ,  B01D15/38 ,  B01J20/286 ,  B01J20/289 ,  B01J20/32

CPC classification number: B01J41/20 ,  B01D15/265 ,  B01D15/30 ,  B01D15/327 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/22 ,  B01J20/267 ,  B01J20/28016 ,  B01J20/281 ,  B01J20/286 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3208 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3265 ,  B01J20/3293 ,  B01J41/04 ,  B01J41/09 ,  B01J2220/52 ,  C07K1/14 ,  C07K1/16 ,  C07K1/165 ,  C07K16/00 ,  G01N30/482

Abstract: Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)—N(R1, R2)—R3-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; R1 and R2 are each selected from hydrogen and an alkyl comprising 1-6 carbons; R3 is an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR4, O, or S; wherein R4 is hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.

公开(公告)号：US09561252B2

公开(公告)日：2017-02-07

申请号：US14181097

申请日：2014-02-14

Applicant: GLYCOREX TRANSPLANTATION AB

Inventor： Kurt G. I. Nilsson

IPC: A61M1/36 ,  A61K35/16 ,  B01D15/38 ,  B01J20/32 ,  G01N37/00 ,  B01J20/28 ,  B01J20/26

CPC classification number: A61K35/16 ,  A61M1/3687 ,  B01D15/3804 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28009 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3274 ,  B01J2220/58 ,  G01N2400/38

Abstract: A Product is described and which contains at least one type of ligand bound to a separation material and which allows selective binding or cleavage of a biomolecule for example in human blood.

Abstract translation: 描述了一种产品，其含有与分离材料结合的至少一种类型的配体，并且其允许例如人血液中生物分子的选择性结合或切割。

公开(公告)号：US20160287617A1

公开(公告)日：2016-10-06

申请号：US15037661

申请日：2014-11-21

Applicant: NUTEK S.A. DE C.V.

Inventor： Javier Armando LARA ARELLANO ,  Miguel Àngel ROMERO MARTÍNEZ DEL SOBRAL ,  Irlanda Verónica GARCÍA ROSAS ,  Jose Antonio FIERRO HUESCA

IPC: A61K31/695 ,  A61K9/14 ,  A23K20/28 ,  B01J39/02 ,  B01J39/14 ,  A61K9/00 ,  B01J20/22

CPC classification number: A61K31/695 ,  A23K20/28 ,  A23K50/40 ,  A61K9/0056 ,  A61K9/145 ,  B01J20/12 ,  B01J20/223 ,  B01J20/3204 ,  B01J20/3253 ,  B01J39/02 ,  B01J39/14 ,  B01J39/17 ,  C01B39/40 ,  C01B39/44 ,  C07C217/08

Abstract: One embodiment relates to a mycotoxin adsorbent highly specific for A and B trichothecenes, and especially for vomitoxin (or deoxinivalenol) and T-2 toxin; as well as a process for the preparation of the mycotoxin adsorbent. The adsorbent may be obtained by modifying the surface of an aluminum silicate using an organic functionalized-chain compound which provides it with high polarity properties. The adsorbent may be used in the preparation of balanced animal feed that avoids the toxic effects of the trichothecenes present in the feed. The combination of the adsorbent with aluminum silicates or organic aluminum silicates may be used for the preparation of balanced animal feeds that avoid the toxic effects of mycotoxins.

Abstract translation: 一个实施方案涉及对A和B单端孢霉素特别是特异性的霉菌毒素吸附剂，特别是用于呕吐毒素（或脱氧新戊烯醇）和T-2毒素; 以及制备真菌毒素吸附剂的方法。 吸附剂可以通过使用赋予其极性特性的有机官能化化合物改性硅酸铝的表面来获得。 吸附剂可用于制备平衡动物饲料，避免饲料中存在的单端孢霉烯的毒性作用。 吸附剂与硅酸铝或有机硅酸铝的组合可用于制备平衡的动物饲料，以避免真菌毒素的毒性作用。

公开(公告)号：US20160231208A1

公开(公告)日：2016-08-11

申请号：US15023729

申请日：2014-09-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  George W. Griesgraber ,  Semra Colak Atan ,  James I. Hembre ,  Robert T. Fitzsimons, JR.

IPC: G01N1/40 ,  B01D67/00 ,  C08J7/18 ,  B01D71/44

CPC classification number: G01N1/405 ,  B01D67/0093 ,  B01D71/44 ,  B01D71/52 ,  B01D71/56 ,  B01D2323/345 ,  B01D2323/38 ,  B01D2325/14 ,  B01D2325/16 ,  B01J20/261 ,  B01J20/28038 ,  B01J20/321 ,  B01J20/3242 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/327 ,  C07F9/3808 ,  C07K1/18 ,  C07K1/34 ,  C08J7/18 ,  C08J2377/00 ,  G01N1/4077 ,  G01N33/544 ,  G01N2001/4088 ,  G01N2333/924

Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

Abstract translation: 可用于生物材料捕获的制品包括（a）多孔基材; 至少一种单价烯属不饱和基团，（2）至少一种选自酸性基团的单价配基官能团，碱性基团 除胍基以外的盐及其盐，和（3）与至少一个烯键式不饱和基团和至少一个配体官能团通过至少6个连接原子的链连接的单价基团的多价间隔基团 。

公开(公告)号：US09283543B2

公开(公告)日：2016-03-15

申请号：US13526410

申请日：2012-06-18

Applicant: Matthew R. Linford ,  David Scott Jensen ,  Landon Andrew Wiest

Inventor： Matthew R. Linford ,  David Scott Jensen ,  Landon Andrew Wiest

IPC: B01J20/287 ,  B01J20/286 ,  B01J20/32 ,  B01D15/34 ,  B01D15/36 ,  B01D15/38

CPC classification number: B01J20/3248 ,  B01D15/206 ,  B01D15/34 ,  B01D15/36 ,  B01D15/361 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3244 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3253 ,  G01N1/405 ,  Y10T428/2991

Abstract: Modified diamond particles for use in chromatography with a desired functional group at the diamond surface, formed from reaction of hydroxyl groups at diamond surfaces with a reactive molecule.

Abstract translation: 用于在金刚石表面具有所需官能团的色谱法的改性金刚石颗粒，由金刚石表面上的羟基与活性分子的反应形成。

公开(公告)号：US09266826B2

公开(公告)日：2016-02-23

申请号：US14374569

申请日：2013-01-31

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Kenji Hamase ,  Masashi Mita ,  Yousuke Toujo ,  Yukimitsu Suda

IPC: C07C275/30 ,  B01J20/288 ,  B01J20/32 ,  C07C273/18 ,  B01J20/29 ,  B01D15/38

CPC classification number: C07C275/30 ,  B01D15/3833 ,  B01J20/286 ,  B01J20/288 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3253 ,  B01J20/3261 ,  B01J20/3293 ,  B01J2220/4812 ,  B01J2220/58 ,  B01J2220/80 ,  C07B2200/07 ,  C07C273/1854

Abstract: An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.

Abstract translation: 本发明的一个实施方案是一种分离剂，其中由化学式表示的基团或由化学式表示的基团引入其表面。

公开(公告)号：US09168507B2

公开(公告)日：2015-10-27

申请号：US13625659

申请日：2012-09-24

Applicant: SIGMA-ALDRICH CO. LLC

Inventor： Daniel W. Armstrong

IPC: B01J20/286 ,  B01J20/32 ,  B01J20/288 ,  B01J20/29 ,  G01N30/88 ,  B01D53/02

CPC classification number: G01N30/62 ,  B01D53/02 ,  B01J20/288 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3253 ,  B01J20/3257 ,  B01J20/3282 ,  B01J20/3285 ,  B01J20/3287 ,  B01J2220/84 ,  B01J2220/86 ,  G01N1/22 ,  G01N2030/025 ,  G01N2030/8872

Abstract: This disclosure provides methods and devices for quantitating, separating and/or detecting water in a liquid, gas or solid sample comprising one or more chemicals, the method comprising: providing the liquid, gas or solid sample comprising water and the one or more chemicals; and exposing said liquid, gas or solid sample to at least one solid support including at least one dicationic and/or tricationic species of Formula I or II adsorbed, absorbed or immobilized on the solid support.

Abstract translation: 本公开提供了用于定量，分离和/或检测包含一种或多种化学品的液体，气体或固体样品中的水的方法和装置，所述方法包括：提供包含水和所述一种或多种化学品的液体，气体或固体样品; 以及将所述液体，气体或固体样品暴露于至少一种固体支持物，所述至少一种固体支持物包含吸收，吸收或固定在固体支持物上的式I或II的至少一种双阳离子和/或化合物种。

公开(公告)号：US20150158905A1

公开(公告)日：2015-06-11

申请号：US14110336

申请日：2012-04-05

Applicant: Warham Lance Martin

Inventor： Warham Lance Martin

IPC: C07K1/22 ,  C08G63/91 ,  C07C237/22

CPC classification number: C07K1/22 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  C07C237/22 ,  C07C259/06 ,  C07C271/16 ,  C08G63/914

Abstract: The disclosure provides a capture system and methods for isolating cysteine-containing peptides from biological fluid and proteolytic mixtures. The disclosure also provides compounds of formulae (II), (III), and (IV), useful in methods of the invention.

Abstract translation: 本公开提供了从生物流体和蛋白水解混合物中分离含半胱氨酸的肽的捕获系统和方法。 本公开还提供了可用于本发明方法的式（II），（III）和（IV）化合物。

公开(公告)号：US20150004065A1

公开(公告)日：2015-01-01

申请号：US14317719

申请日：2014-06-27

Applicant: SEB S.A. ,  ETHERA

Inventor： Jean-Pierre Soulie ,  Eric Marchal ,  Yves Bigay ,  Emmanuel Chevallier

IPC: A61L9/00

CPC classification number: A61L9/00 ,  B01D53/02 ,  B01D53/0415 ,  B01D53/72 ,  B01D53/82 ,  B01D2251/21 ,  B01D2251/80 ,  B01D2253/102 ,  B01D2253/108 ,  B01D2253/1124 ,  B01D2253/202 ,  B01D2257/7027 ,  B01D2257/708 ,  B01D2259/4143 ,  B01D2259/4145 ,  B01D2259/4508 ,  B01J20/18 ,  B01J20/20 ,  B01J20/28045 ,  B01J20/28052 ,  B01J20/28057 ,  B01J20/3204 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/62

Abstract: Provided is a filter cartridge for an air purifier, comprising a structure ensuring the retention of a filter medium, the filter medium comprising a standard absorbent material chosen from the group consisting of activated charcoal or zeolites, and the filter medium further comprises a nanoporous specific absorbent material functionalized with probe molecules in such a way that chemical pollutants of the aldehyde type can be trapped.

Abstract translation: 本发明提供了一种用于空气净化器的过滤筒，其包括确保过滤介质保持的结构，所述过滤介质包括选自活性炭或沸石的标准吸收材料，并且所述过滤介质还包含纳米多孔吸附剂 用探针分子功能化的材料，使得可以捕获醛类化学污染物。