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公开(公告)号：US12083100B1
公开(公告)日：2024-09-10
申请号：US17938063
申请日：2022-10-05
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/422 , A01N43/80 , A61K9/00 , A61K31/415 , A61K31/42 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A61K9/08 , A61K9/10 , A61K9/107
CPC分类号： A61K31/415 , A01N43/80 , A61K9/0019 , A61K31/42 , A61K31/422 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/107
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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82.发明公开公开(公告)号：US20240252624A1
公开(公告)日：2024-08-01
申请号：US18000357
申请日：2021-06-16
发明人： Teshome Mebatsion , Aemro Kassa
IPC分类号： A61K39/295 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/17 , A61K39/255 , A61P31/14 , A61P31/16 , A61P31/22 , C07K14/005 , C12N15/86
CPC分类号： A61K39/295 , A61K39/12 , A61K39/145 , A61K39/17 , A61K39/255 , A61P31/14 , A61P31/16 , A61P31/22 , C07K14/005 , C12N15/86 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N2710/16334 , C12N2710/16343 , C12N2720/10022 , C12N2720/10034 , C12N2760/16122 , C12N2760/16134 , C12N2760/18122 , C12N2760/18134
摘要： Recombinant viral vectors and compositions that include them for use as vehicles to induce an immunological response. Multivalent viral vectors may be used in compositions or vaccines containing one or more recombinant viral vectors for protection against a variety of pathogens. Formation of these viral vectors may include insertion and expression of foreign genes to protect against a variety of pathogens. Further provided are methods of making and using the recombinant viral vectors, as well as immunogenic compositions that include the vectors and/or antigens. In particular, immunogenic compositions may include recombinant viral vectors such as vHVT509, vHVT522, and/or vHVT523.
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公开(公告)号：US20240181477A1
公开(公告)日：2024-06-06
申请号：US18418467
申请日：2024-01-22
IPC分类号： B05B3/10 , A01K45/00 , A61D1/02 , A61K9/00 , A61K9/06 , A61K35/00 , A61K35/741 , A61K39/00 , A61K39/17 , A61K39/215 , A61M11/00 , B01F23/213 , B01F35/32 , B01F101/00 , B05B1/28 , B05B7/24 , B05B9/08 , C12N7/00
CPC分类号： B05B3/1014 , A01K45/00 , A61D1/025 , A61K9/0073 , A61K9/06 , A61K35/741 , A61K39/17 , A61K39/215 , B01F23/21311 , B01F35/32025 , B05B1/28 , B05B3/105 , B05B3/1092 , B05B7/2416 , B05B7/2478 , B05B9/085 , B05B9/0894 , C12N7/00 , A61K2035/115 , A61K2039/543 , A61K2039/544 , A61K2039/552 , A61M11/00 , B01F2101/2202 , C12N2760/18134 , C12N2760/18171 , C12N2770/20034 , C12N2770/20071
摘要： The disclosure relates to an extended-range spray applicator, and methods of making and use thereof, for dosing vaccines and/or probiotics to avian animals at a distance.
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84.发明公开公开(公告)号：US20240132525A1
公开(公告)日：2024-04-25
申请号：US18210783
申请日：2023-06-16
IPC分类号： C07F5/02
CPC分类号： C07F5/027
摘要： The present disclosure describes boron containing pyrimidine compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the present disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.
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公开(公告)号：US11896659B2
公开(公告)日：2024-02-13
申请号：US18058657
申请日：2022-11-23
发明人： Arun Iyer , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn , Pablo E Pineyro Pineiro , Troy James Kaiser , Joseph Ralph Hermann
CPC分类号： A61K39/12 , A61K39/23 , A61P31/20 , A61P37/04 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C12N2750/10034 , C12N2750/10071 , C12N2750/14034
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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86.发明授权公开(公告)号：US11773066B2
公开(公告)日：2023-10-03
申请号：US17294761
申请日：2019-11-14
IPC分类号： C07D231/56 , A61K31/366 , A61K31/416 , A61K31/7048
CPC分类号： C07D231/56 , A61K31/366 , A61K31/416 , A61K31/7048 , C07B2200/07
摘要： The compound of formula I:
compositions thereof, processes for their preparation, and their uses as pesticides.-
公开(公告)号：US20230302111A1
公开(公告)日：2023-09-28
申请号：US18318933
申请日：2023-05-17
发明人： Jeremy KROLL , Mike ROOF
IPC分类号： A61K39/02 , A61K39/112 , A61K39/12 , C12N7/00 , A61K35/74 , A61K39/295 , A61K39/39 , A61K39/00
CPC分类号： A61K39/105 , A61K39/0241 , A61K39/0275 , A61K39/12 , C12N7/00 , A61K35/74 , A61K39/295 , A61K39/39 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N2750/10034 , Y02A50/30 , Y10S424/825
摘要： The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
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公开(公告)号：US11660300B2
公开(公告)日：2023-05-30
申请号：US16277893
申请日：2019-02-15
IPC分类号： A61K31/5377 , A61K31/04 , A61P1/02 , A61Q11/00 , A23K20/137 , A61K8/49 , C07D265/30
CPC分类号： A61K31/5377 , A23K20/137 , A61K8/49 , A61Q11/00 , C07D265/30 , A61K2800/74
摘要： Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. A cosmetic method of preventing or decreasing oral staining in an animal, comprising the step of exposing the oral cavity to a morpholino compound of general.
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89.发明授权公开(公告)号：US11583545B2
公开(公告)日：2023-02-21
申请号：US16966530
申请日：2019-02-07
发明人： James Pate
IPC分类号： A61K31/7048 , A61P33/00 , A61K9/00 , A61K31/4985 , A61K47/10 , A61K47/22
摘要： This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising eprinomectin and praziquantel in combination with a pharmaceutically acceptable carrier, and optionally an antioxidant. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
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90.发明授权公开(公告)号：US11554170B2
公开(公告)日：2023-01-17
申请号：US15624405
申请日：2017-06-15
发明人： Guillaume Rigaut , Alexis Guy André Lucien Parisot , Karelle De Luca , Christine Michele Pierrette Andreoni , Lydie Remolue , Marie Garinot , Jean-François Cotte , Patricia Probeck-Quellec , Jean Haensler , Véronique Chambon , Philippe Talaga
IPC分类号： A61K39/39 , C08F120/06 , A61K39/00 , A61K47/08 , A61K47/26
摘要： The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. The immunogens may include, but are not limited to: inactivated pathogens, attenuated pathogens, subunits, recombinant expression vectors, plasmids or combinations thereof. The animals may include, but are not limited to: humans, murine, canines, felines, equines, porcines, ovines, caprines and bovines.
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