利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

747 条记录 (耗时 0.043 秒)

    Systems and process for forming carbon nanotube sensors
    85.
    发明申请
    Systems and process for forming carbon nanotube sensors 有权
    用于形成碳纳米管传感器的系统和工艺

    公开(公告)号：US20120153262A1

    公开(公告)日：2012-06-21

    申请号：US12970997

    申请日：2010-12-17

    申请人： Makarand Paranjape ,  Jianyun Zhou

    发明人： Makarand Paranjape ,  Jianyun Zhou

    IPC分类号： H01L29/775 ,  H01L21/335 ,  B82Y15/00 ,  B82Y40/00 ,  B82Y99/00

    CPC分类号： H01L51/0048 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y40/00 ,  G01N27/4145 ,  H01L51/055 ,  H01L51/0558

    摘要： A process for forming a functionalized sensor for sensing a molecule of interest includes providing at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; providing a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for a bioreceptors that react with the molecule of interest; and applying a voltage to the third electrode, causing the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.

    摘要翻译： 用于形成用于感测感兴趣分子的功能化传感器的方法包括提供至少一个单壁或多壁碳纳米管，其具有与衬底接触的第一和第二电极; 在与所述至少一个具有与其接触的第一和第二电极的所述至少一个单壁或多壁碳纳米管的预定距离的基底上提供包括装饰材料的第三电极，其中所述装饰材料对生物感受器具有结合亲和力， 与感兴趣的分子; 以及向所述第三电极施加电压，使所述装饰材料在所述至少一个单壁或多壁碳纳米管上形成所述装饰材料的纳米颗粒。

    System and method for the separation of analytes
    86.
    发明授权
    System and method for the separation of analytes 有权
    用于分离分离物的系统和方法

    公开(公告)号：US08097472B2

    公开(公告)日：2012-01-17

    申请号：US12644341

    申请日：2009-12-22

    申请人： Thomas Wayne Schneider ,  James N. Baraniuk

    发明人： Thomas Wayne Schneider ,  James N. Baraniuk

    IPC分类号： G01N33/558

    CPC分类号： G01N27/44795 ,  G01N27/44721 ,  G01N27/44791 ,  G01N33/558

    摘要： A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).

    摘要翻译： 分离模块用于利用毛细管等电聚焦（“CIEF”）在第一微通道内，根据pI，即pI带分离或分离分析物。 级分被堆叠以形成塞子，其数量由多个与第一微通道整体连接的平行的第二微通道确定，根据在每个单个微通道中发现的缓冲特性，分段被引导到该第一微​​通道中。 在微通道内，使用毛细管电泳（“CE”），将栓塞根据不同的化学性质即“m / z”分离成蛋白质。

    Platinum Adlayered Ruthenium Nanoparticles, Method for Preparing, and Uses Thereof
    89.
    发明申请
    Platinum Adlayered Ruthenium Nanoparticles, Method for Preparing, and Uses Thereof 有权
    铂金钌纳米粒子，其制备方法及用途

    公开(公告)号：US20110256469A1

    公开(公告)日：2011-10-20

    申请号：US13081809

    申请日：2011-04-07

    申请人： YuYe Tong ,  Bingchen Du

    发明人： YuYe Tong ,  Bingchen Du

    IPC分类号： H01M4/92 ,  B01J23/46 ,  B01J37/16 ,  B01J37/02 ,  B01J37/08 ,  H01M8/22 ,  B01J37/34 ,  B82Y30/00

    CPC分类号： H01M8/1011 ,  B82Y30/00 ,  H01M4/8657 ,  H01M4/92 ,  H01M4/921 ,  H01M4/926 ,  Y02E60/523 ,  Y02P70/56

    摘要： A superior, industrially scalable one-pot ethylene glycol-based wet chemistry method to prepare platinum-adlayered ruthenium nanoparticles has been developed that offers an exquisite control of the platinum packing density of the adlayers and effectively prevents sintering of the nanoparticles during the deposition process. The wet chemistry based method for the controlled deposition of submonolayer platinum is advantageous in terms of processing and maximizing the use of platinum and can, in principle, be scaled up straightforwardly to an industrial level. The reactivity of the Pt(31)-Ru sample was about 150% higher than that of the industrial benchmark PtRu (1:1) alloy sample but with 3.5 times less platinum loading. Using the Pt(31)-Ru nanoparticles would lower the electrode material cost compared to using the industrial benchmark alloy nanoparticles for direct methanol fuel cell applications.

    摘要翻译： 已经开发了一种优异的工业可升级的一锅乙二醇基湿法化学方法来制备铂 - 钌钌纳米颗粒，其提供了对该层的铂填充密度的精细控制，并有效地防止了沉积过程中纳米颗粒的烧结。 用于亚单层铂的受控沉积的基于湿化学的方法在加工和使铂的使用方面是有利的，并且原则上可以直接扩大到工业级。 Pt（31）-Ru样品的反应性比工业基准PtRu（1：1）合金样品的反应性高约150％，但是铂负载的3.5倍。 与使用工业基准合金纳米颗粒直接甲醇燃料电池应用相比，使用Pt（31）-Ru纳米颗粒将降低电极材料成本。

    NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS
    90.
    发明申请
    NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS 有权
    NA通道，疾病和相关测定和组合物

    公开(公告)号：US20110230442A1

    公开(公告)日：2011-09-22

    申请号：US13059182

    申请日：2009-08-17

    申请人： Milton L. Brown ,  Scott Grindrod ,  Thomas H. Walls ,  Todd Hansen ,  Simeng Suy ,  Mikell A. Paige

    发明人： Milton L. Brown ,  Scott Grindrod ,  Thomas H. Walls ,  Todd Hansen ,  Simeng Suy ,  Mikell A. Paige

    IPC分类号： A61K31/69 ,  C07D233/76 ,  C07F5/02 ,  A61K31/4166 ,  C12Q1/02 ,  C07C231/10 ,  C07D209/14 ,  C07C231/02 ,  G01N33/574 ,  C12N5/07 ,  G01N21/00 ,  C12Q1/68 ,  A61P25/08 ,  A61P35/00

    CPC分类号： A61K31/4164 ,  C07D209/14 ,  C07D233/72 ,  C07D317/26

    摘要： Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

    摘要翻译： 公开了分子及其合成，用于阻断门控离子通道如电压门控钠通道（VGSC）和前列腺电压钠通道（PVSC）。 这些抑制剂具有优异的阻断效能，例如置换与VGSC的位点2结合的放射性配体[3 H] -Batrachotoxin-B（[3 H] -BTX-B）。 本发明的分子包含增加前列腺癌细胞（PC）中蛋白质结合位点的分子的结合亲和力的部分，其也是荧光的。 在一个实施方案中，本发明分子是可用于在疼痛，癫痫或前列腺癌中选择性地靶向过量或过度活跃的VGSC的抑制系统，从而抑制PC的​​增殖。 荧光部分还有助于药物在体外和体内生物系统中的筛选，跟踪和药效学研究。