公开(公告)号：US20170304308A1

公开(公告)日：2017-10-26

申请号：US15517581

申请日：2015-10-09

Applicant: The Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Xin-Ming Liu ,  Benson Edagwa

IPC: A61K31/52 ,  A61K9/51 ,  A61K9/00 ,  A61K47/69 ,  A61K31/513 ,  A61K47/64

CPC classification number: A61K31/52 ,  A61K9/0019 ,  A61K9/5146 ,  A61K31/513 ,  A61K47/542 ,  A61K47/551 ,  A61K47/64 ,  A61K47/6901 ,  A61K47/6907 ,  A61K47/6921 ,  A61K47/6929 ,  C07D411/04 ,  C07D473/16

Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.

公开(公告)号：US20170296703A1

公开(公告)日：2017-10-19

申请号：US15510338

申请日：2015-09-29

Applicant: The Board of Regents of the University of Nebraska

Inventor： Jingwei Xie ,  Jiang Jiang

IPC: A61L27/56 ,  D01D10/00 ,  A61L27/18 ,  D01D5/00 ,  A61L27/38

CPC classification number: A61L27/56 ,  A61K9/0092 ,  A61K9/70 ,  A61L27/18 ,  A61L27/38 ,  A61L2400/12 ,  D01D5/003 ,  D01D10/00 ,  D10B2331/041 ,  D10B2401/10

Abstract: Three dimensional nanofiber structures are provided and methods of production thereof.

公开(公告)号：US20170268021A1

公开(公告)日：2017-09-21

申请号：US15503649

申请日：2015-08-19

Applicant: TONGJI UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Jialin Zheng ,  Changhai Tian

IPC: C12N15/86 ,  A61K35/12

CPC classification number: C12N15/86 ,  A61K35/12 ,  C12N5/0619 ,  C12N2501/60 ,  C12N2510/00

Abstract: Provided are methods and compositions for transdifferentiation of a somatic cell, e.g., a fibroblast to a dopaminergic precursor, Specifically, provided are induced dopaminergic (iDP) cells, or master transcription factors (TFs) therefore, methods for making iDP cells, and methods and compositions for using them in, e.g., treating neurodegenerative diseases such as Parkinson's disease.

公开(公告)号：US09743987B2

公开(公告)日：2017-08-29

申请号：US14208515

申请日：2014-03-13

Applicant: Board of Regents of the University of Nebraska

Inventor： Shane Farritor ,  Thomas Frederick ,  Joe Bartels ,  Eric Markvicka ,  Jack Mondry

IPC: A61B19/00 ,  A61B34/30

CPC classification number: A61B34/30 ,  A61B2034/302 ,  Y10S901/28

Abstract: The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles.

公开(公告)号：US20170218463A1

公开(公告)日：2017-08-03

申请号：US15422409

申请日：2017-02-01

Applicant: The Board of Regents of the University of Nebraska

Inventor： Sally A. Mackenzie ,  Robersy Sanchez

IPC: C12Q1/68 ,  G06F19/00 ,  G06F19/24 ,  G06F19/22 ,  G06F19/18

CPC classification number: C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/154 ,  G16B20/00 ,  G16B20/20 ,  G16B30/00 ,  G16B40/00 ,  G16H50/20 ,  Y02A90/26

Abstract: A computer-implemented method of preparing a set of differentially informative methylated positions (DIMPs) or differentially informative methylated regions (DIMRs) from a sample methylome of an animal or plant having a phenotypic characteristic different from a wild-type of the same species of animal or plant, and the characteristic is associate with differences in methylation of the genome, comprises: providing a computer with the sample methylome, and a reference methylome of the wild-type of the same species of animal or plant; calculating with the computer a divergence between a plurality of cytosine positions of the sample methylome and the reference methylome; and selecting with the computer a set of DIMPs or DIMRs. Each DIMP or DIMR is selected based on an approximation of the energy required to produce the divergence between methylation levels of the plurality of cytosine positions of the sample methylome as compared to the wild-type methylome.

公开(公告)号：US20170156845A1

公开(公告)日：2017-06-08

申请号：US15438210

申请日：2017-02-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Marius C. Florescu

IPC: A61F2/06 ,  A61B17/11 ,  A61F2/915 ,  A61F2/958 ,  A61M1/36 ,  A61M25/10

CPC classification number: A61F2/06 ,  A61B17/11 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61F2/064 ,  A61F2/07 ,  A61F2/86 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/821 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/06 ,  A61L31/14 ,  A61M1/3655 ,  A61M25/104 ,  C08L67/04

Abstract: There is described an arteriovenous fistula stent, having a tubular body comprising a series of sinusoidal shaped struts along the length of the tubular body. A plurality of curvilinear connectors extend between and are attached to adjacent struts wherein a first end of a connector is attached to a distal face of a proximal strut apex and a second end of a connector is attached to a proximal face of a distal strut apex. A pair of unconnected strut apexes are between pairs of connected apexes. When the tubular body is in a stowed configuration a proximal aperture and a distal aperture are circular and when the tubular body is in a deployed configuration the distal aperture is oblong or ovoid. There is also described a method for inserting a stent for use in creation of an arteriovenous fistula by identifying a candidate artery and a candidate vein and dissecting the candidate vein. Next, inserting a stent into the vein and creating a breach in the candidate artery at a desired angle and location. Next, introducing the stent and vein into the candidate artery and forming the stent into a curvature angle selected to minimize turbulent blood flow in an anastomosis formed by the vein and the artery. Optionally, there is a step of fastening a distal portion of the stent to the artery.

公开(公告)号：US20170049761A1

公开(公告)日：2017-02-23

申请号：US15251855

申请日：2016-08-30

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian

IPC: A61K31/4425 ,  A61K38/17 ,  A61K31/4545 ,  A61K31/522 ,  A61K31/4015 ,  A61K31/44

CPC classification number: A61K31/4425 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/522 ,  A61K38/17 ,  A61K38/177 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both.

Abstract translation: 提供了用于预防和治疗少年神经元细胞脂褐色素沉积的材料和方法，包括施用有效量的半通道抑制剂或磷酸二酯酶-4抑制剂中的至少一种。 在一些实施方案中，所述方法包括施用有效量的每种半通道抑制剂和磷酸二酯酶-4抑制剂。 还提供了包含半通道抑制剂或磷酸二酯酶-4抑制剂的药物组合物，以及包含至少一种有效剂量的半通道抑制剂或磷酸二酯酶-4抑制剂或两者的组合的试剂盒。

公开(公告)号：US09577555B2

公开(公告)日：2017-02-21

申请号：US14243252

申请日：2014-04-02

Applicant: DEERE & COMPANY ,  The Board of Regents of the University of Nebraska

Inventor： Long Wu ,  Yue Zhao ,  Wei Qiao

IPC: H02P6/00 ,  H02P6/18 ,  H02P21/00 ,  H02P23/12

CPC classification number: H02P6/183 ,  H02P6/18 ,  H02P21/0007 ,  H02P21/18 ,  H02P23/12

Abstract: At least one example embodiment discloses a method of estimating a position of a rotor in a motor. The method includes obtaining a current regulation quality index based on a current command and a measured current, determining an estimated position of the rotor based on the current regulation quality index and position estimation data and controlling the motor based on the estimated position of the rotor.

Abstract translation: 至少一个示例性实施例公开了一种估计电动机中的转子的位置的方法。 该方法包括基于电流指令和测量电流获得电流调节质量指标，基于当前调节质量指标和位置估计数据确定转子的估计位置，并基于转子的估计位置来控制电动机。

公开(公告)号：US09517230B2

公开(公告)日：2016-12-13

申请号：US14744205

申请日：2015-06-19

Applicant: UNIVERSITY OF ROCHESTER ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Paul M. Dunman ,  Patrick D. Olson ,  Wayne Childers

IPC: A61K31/427 ,  C07D307/68 ,  C07D307/56 ,  C07D405/06 ,  C07D417/06 ,  A61K31/341 ,  A61K45/06 ,  A61K31/402 ,  C07D207/337 ,  C12Q1/44

CPC classification number: A61K31/427 ,  A61K31/341 ,  A61K31/402 ,  A61K45/06 ,  C07D207/337 ,  C07D307/56 ,  C07D307/68 ,  C07D405/06 ,  C07D417/06 ,  C12Q1/44 ,  G01N2333/922 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.

公开(公告)号：US20160346222A1

公开(公告)日：2016-12-01

申请号：US15111046

申请日：2015-01-14

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Howard E. Gendelman ,  Xin-Ming Liu

IPC: A61K9/51 ,  A61K45/06 ,  A61K31/46

CPC classification number: A61K9/5153 ,  A61K9/5123 ,  A61K31/46 ,  A61K45/06 ,  A61K47/24

Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.