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    Affinity chromatography matrix
    82.
    发明授权
    Affinity chromatography matrix 有权

    公开(公告)号：US10189891B2

    公开(公告)日：2019-01-29

    申请号：US14385336

    申请日：2013-03-26

    Applicant: GE Healthcare BioProcess R&D AB

    Inventor： Mats Ander ,  Goran Bauren ,  Tomas Bjorkman ,  Per-Mikael Aberg ,  Gustav Rodrigo

    IPC: C07K1/22 ,  C07K14/31 ,  C07K16/00 ,  B01J20/286 ,  B01D15/38 ,  B01J20/291 ,  G01N33/68 ,  B01J20/32

    Abstract: The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to H18 of the B domain of Protein A or of Protein Z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to H18 of the B domain of protein A or of protein Z is not serine, threonine or lysine.

    Stackable Chromatography Column Modules
    83.
    发明申请
    Stackable Chromatography Column Modules 审中-公开

    公开(公告)号：US20180361272A1

    公开(公告)日：2018-12-20

    申请号：US15781305

    申请日：2016-12-07

    Applicant: GE HEALTHCARE BIOPROCESS R&D AB

    Inventor： Dan Hermansson ,  Klaus Gebauer ,  Mats Lundkvist

    IPC: B01D15/18 ,  G01N30/88 ,  G01N30/46 ,  G01N30/60 ,  B01D15/22

    Abstract: The invention discloses a chromatography column module stackable with like chromatography modules, comprising a column chamber (2) fluidically connected to a column inlet 3) and a column outlet (4), wherein the column inlet and outlet each comprise a valve (5), arranged to move from a closed position to an open position upon connection of the column inlet or outlet with a) a column outlet or inlet of a like chromatography module or b) with an outlet or inlet of a fluidics plate. The invention further discloses a stack of chromatography column modules and the use of the stack for separation of biomolecules.

    Parallel assembly of chromatography column modules
    84.
    发明授权
    Parallel assembly of chromatography column modules 有权

    公开(公告)号：US10092856B2

    公开(公告)日：2018-10-09

    申请号：US15793923

    申请日：2017-10-25

    Applicant: GE Healthcare BioProcess R&D AB

    Inventor： Klaus Gebauer

    IPC: B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  G01N30/60 ,  G01N30/46 ,  G01N30/88

    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

    METHOD AND SYSTEM FOR INTERACTION ANALYSIS
    85.
    发明申请
    METHOD AND SYSTEM FOR INTERACTION ANALYSIS 审中-公开

    公开(公告)号：US20180224439A1

    公开(公告)日：2018-08-09

    申请号：US15428342

    申请日：2017-02-09

    Applicant: GE Healthcare BioProcess R&D AB

    Inventor： Robert Karlsson

    IPC: G01N33/543 ,  G06F19/26

    CPC classification number: G16B45/00 ,  G01N33/54373 ,  G01N33/557 ,  G16B20/00 ,  G16B40/00

    Abstract: The present invention relates to a method of evaluation of molecular binding interactions at a sensing surface, and more particularly to a method for evaluation of screening data obtained from an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor that is independent of interaction models. Preferably the biosensor is a SPR biosensor.The invention also relates to a biosensor system arranged to perform the method and a computer program arranged to control the operation of the biosensor system.

    Method for Endotoxin Removal
    90.
    发明申请
    Method for Endotoxin Removal 审中-公开
    内毒素去除方法

    公开(公告)号：US20170067031A1

    公开(公告)日：2017-03-09

    申请号：US15355675

    申请日：2016-11-18

    Applicant: GE Healthcare BioProcess R&D AB

    Inventor： Patrik Adielsson ,  Tobias E. Soderman ,  Anna Akerblom

    IPC: C12N7/00 ,  B01D15/38

    CPC classification number: C12N7/00 ,  B01D15/3847 ,  C12N2760/16151

    Abstract: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.

    Abstract translation: 本发明涉及一种从样品中去除内毒素的方法，包括以下步骤：将包含一种或多种靶分子的样品与包含珠的色谱介质组合，所述珠粒具有由能够结合内毒素的配体功能化的内部多孔核心和 没有官能团的外部多孔层和足够小以从靶芯排出靶分子的孔径; 并从培养基中收集样品，其中样品包含与去除前相比至少75％以上，优选90％以下的内毒素水平，并且目标分子的产率为至少75％。

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