利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

90 条记录 (耗时 0.078 秒)

    ULTRA-SENSITIVE DETECTION OF MOLECULES BY CAPTURE-AND-RELEASE USING REDUCING AGENTS FOLLOWED BY QUANTIFICATION
    81.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES BY CAPTURE-AND-RELEASE USING REDUCING AGENTS FOLLOWED BY QUANTIFICATION 审中-公开
    通过使用量化后的还原剂捕获和释放分子的超敏感性检测

    公开(公告)号：US20100075439A1

    公开(公告)日：2010-03-25

    申请号：US12236488

    申请日：2008-09-23

    申请人： David C. Duffy ,  Evan Ferrell ,  Jeff Randall ,  David M. Rissin ,  David R. Walt

    发明人： David C. Duffy ,  Evan Ferrell ,  Jeff Randall ,  David M. Rissin ,  David R. Walt

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54306

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。

    ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS
    82.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS 有权
    对单分子阵列分子的超敏感检测

    公开(公告)号：US20100075407A1

    公开(公告)日：2010-03-25

    申请号：US12236486

    申请日：2008-09-23

    申请人： David C. Duffy ,  Evan Ferrell ,  Jeff Randall ,  David M. Rissin ,  David R. Walt

    发明人： David C. Duffy ,  Evan Ferrell ,  Jeff Randall ,  David M. Rissin ,  David R. Walt

    IPC分类号： C12M1/34 ,  G01N33/573

    CPC分类号： G01N33/54313 ,  C12Q1/6825 ,  G01N33/54326 ,  G01N33/54386

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。

    Electro-optical stimulation/measurement
    84.
    发明授权
    Electro-optical stimulation/measurement 有权
    电光刺激/测量

    公开(公告)号：US07480433B2

    公开(公告)日：2009-01-20

    申请号：US10503995

    申请日：2003-02-14

    申请人： David R. Walt ,  Sabine Szunerits

    发明人： David R. Walt ,  Sabine Szunerits

    IPC分类号： G02B6/06

    CPC分类号： G01D5/268 ,  A61B5/0071 ,  A61N1/08 ,  A61N1/205 ,  A61N5/0613 ,  A61N5/0622 ,  A61N2005/063 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/66

    摘要： An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

    摘要翻译： 电光系统包括包括多个光纤和多个电极的阵列和绝缘体。 光纤被配置为透射光，光纤在远端机构耦合在远端装置中并且在近端装置中在近端机械联接。 多个电极与对应的光纤的至少部分基本上同轴地布置，电极是导电的，电极和光纤成对设置，从而成对成对，每对中的一个部件之一被设置 围绕另一对组件的径向周边。 绝缘体设置在多个电极之间并且被配置为抑制多个电极之间的电能传递。

    High density optical data storage
    85.
    发明授权
    High density optical data storage 失效
    高密度光数据存储

    公开(公告)号：US06999657B2

    公开(公告)日：2006-02-14

    申请号：US10855958

    申请日：2004-05-28

    申请人： David R. Walt

    发明人： David R. Walt

    IPC分类号： G02B6/00 ,  G11B7/00 ,  G11B7/004 ,  G11C5/06

    CPC分类号： G11B7/1384 ,  G11B7/1387 ,  G11B7/24

    摘要： A data storage apparatus includes an array of optical fibers. The array has a first end and a second end. The first end of the array includes multiple optical fiber ends, each optical fiber end having an end face adapted for receiving light of a wavelength λ into the fiber for conveyance to the second end of the fiber array. The second end of the array includes multiple tapered optical fiber tips, each tapered optical fiber end having a minimum diameter less than λ. An opaque coating covers a portion of the tapered optical fiber tips. The data storage apparatus also includes a photochromic medium located within a distance λ of the second end of the array.

    摘要翻译： 数据存储装置包括光纤阵列。 阵列具有第一端和第二端。 阵列的第一端包括多个光纤端部，每个光纤端部具有适于将波长λ的光接收到光纤中的端面，用于传送到光纤阵列的第二端。 阵列的第二端包括多个锥形光纤末端，每个锥形光纤端具有小于λ的最小直径。 不透明涂层覆盖锥形光纤尖端的一部分。 数据存储装置还包括位于阵列的第二端的距离λ内的光致变色介质。

    Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
    87.
    发明授权
    Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations 失效
    用于远场观察的光学传感器设备，并在远程位置进行光学分析测量

    公开(公告)号：US5814524A

    公开(公告)日：1998-09-29

    申请号：US572005

    申请日：1995-12-14

    申请人： David R. Walt ,  Karri L Michael ,  Suneet Chadha

    发明人： David R. Walt ,  Karri L Michael ,  Suneet Chadha

    IPC分类号： G01N21/77 ,  G01N33/543 ,  G01N33/552

    CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N21/6456 ,  Y10S435/808 ,  Y10S436/80 ,  Y10S436/805

    摘要： The present invention is an optical sensor apparatus for far-field viewing and imaging as well as for the optical detection and analytical measurement of at least one species of analyte in a remotely-positioned fluid sample. The apparatus employs an imaging fiber comprising a fiber optic array and a Gradient Index lens; and utilizes a remotely-positioned solid substrate having light energy absorbing indicator ligands on an external surface for reactive contact with individual species of analytes when present in a fluid sample. The optical sensor apparatus is able to view an object and provide an image of the object located at a pre-set optical distance remote from the imaging fiber. The apparatus is also able to detect and identify, qualitatively and quantitatively, one or more analytes of interest in a flowing solid, gaseous, or liquid sample at remote locations distanced from the imaging fiber itself.

    摘要翻译： 本发明是用于远场观察和成像的光学传感器装置，以及用于远程定位的流体样品中的至少一种分析物的光学检测和分析测量。 该装置采用包括光纤阵列和渐变折射率透镜的成像光纤; 并且当存在于流体样品中时，利用在外表面上具有光能吸收指示剂配体的远程固定的固体基质用于与各种分析物的反应性接触。 光学传感器装置能够观察物体并提供位于远离成像光纤的预设光学距离处的物体的图像。 该设备还能够在远离成像纤维本身的远程位置处检测和鉴定在流动的固体，气体或液体样品中感兴趣的一种或多种感兴趣的分析物。

    Method for making fluorescent polymers
    88.
    发明授权
    Method for making fluorescent polymers 失效
    荧光聚合物的制备方法

    公开(公告)号：US5700897A

    公开(公告)日：1997-12-23

    申请号：US453442

    申请日：1995-05-30

    申请人： Stanley M. Klainer ,  David R. Walt ,  Amos J. Gottlieb

    发明人： Stanley M. Klainer ,  David R. Walt ,  Amos J. Gottlieb

    IPC分类号： C09K11/06 ,  G01N21/64 ,  G01N21/77 ,  G01N21/81 ,  G01N33/552 ,  C08G77/08

    CPC分类号： C09K11/06 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/552 ,  G01N2021/6432 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N21/81 ,  Y10T428/31645 ,  Y10T428/31855

    摘要： A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chromophores and lumophores, the photoactive moieties spaced apart so as to minimize chemical or physical interaction therebetween while optimizing the density of photoactive moieties. In one embodiment, a polymer chain is covalently bound to photoactive moieties through functional groups such as esters, amides, or the like. In a second embodiment, a polymer chain is inherently fluorescent and is formed from at least one monomeric unit. These devices are particularly useful as pH and oxygen sensors.

    摘要翻译： 提供了一种用于测量体液或组织的化学或生理参数的光纤感测装置。 纤维的一端连接聚合物，该聚合物包括选自发色团和间隙基团的多个光活性部分，间隔开的光活性部分，以使其间的化学或物理相互作用最小化，同时优化光活性部分的密度。 在一个实施方案中，聚合物链通过官能团如酯，酰胺等与光活性部分共价结合。 在第二个实施方案中，聚合物链固有地是荧光的并且由至少一个单体单元形成。 这些装置特别适用于pH和氧传感器。

    Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
    89.
    发明授权
    Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns 失效
    光学传感器，光学感测装置和使用光谱识别图案检测感兴趣分析物的方法

    公开(公告)号：US5512490A

    公开(公告)日：1996-04-30

    申请号：US289001

    申请日：1994-08-11

    申请人： David R. Walt ,  John S. Kauer

    发明人： David R. Walt ,  John S. Kauer

    IPC分类号： G01N21/64 ,  G01N21/77

    CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N21/77 ,  G01N2021/6484 ,  G01N2021/7793

    摘要： The present invention is an optical detection and identification system and provides an optic sensor, an optic sensing apparatus and methodology for detecting and evaluating one or more analytes or ligands of interest, either alone or in admixture. The optic sensor of the system is comprised of a supporting member and an array formed of heterogeneous, semi-selective thin films which function as sensing receptor units and are able to detect a variety of different analytes and ligands using spectral recognition patterns.

    摘要翻译： 本发明是光学检测和识别系统，并且提供用于单独或混合地检测和评估一种或多种感兴趣的分析物或配体的光学传感器，光学感测装置和方法。 系统的光学传感器由支撑构件和由异质半选择性薄膜形成的阵列组成，其作为感测受体单元，并且能够使用光谱识别模式检测各种不同的分析物和配体。