公开(公告)号：US08330231B2

公开(公告)日：2012-12-11

申请号：US13048976

申请日：2011-03-16

申请人： Da Zhang ,  Ning Liu ,  Mohamed S. Moosa

发明人： Da Zhang ,  Ning Liu ,  Mohamed S. Moosa

IPC分类号： H01L29/76 ,  H01L29/94 ,  H01L29/06

CPC分类号： H01L21/26586 ,  H01L21/26506 ,  H01L29/0847 ,  H01L29/165 ,  H01L29/66636 ,  H01L29/7834 ,  H01L29/7848

摘要： A transistor structure is formed by providing a semiconductor substrate and providing a gate above the semiconductor substrate. The gate is separated from the semiconductor substrate by a gate insulating layer. A source and a drain are provided adjacent the gate to define a transistor channel underlying the gate and separated from the gate by the gate insulating layer. A barrier layer is formed by applying nitrogen or carbon on opposing outer vertical sides of the transistor channel between the transistor channel and each of the source and the drain. In each of the nitrogen and the carbon embodiments, the vertical channel barrier retards diffusion of the source/drain dopant species into the transistor channel. There are methods for forming the transistor structure.

摘要翻译： 通过提供半导体衬底并在半导体衬底上方提供栅极形成晶体管结构。 栅极通过栅极绝缘层与半导体衬底分离。 在栅极附近提供源极和漏极，以限定栅极下方的晶体管沟道，并通过栅极绝缘层与栅极分离。 通过在晶体管沟道和源极和漏极中的每一个之间的晶体管沟道的相对的外部垂直侧上施加氮或碳来形成阻挡层。 在氮和碳实施方案中的每一个中，垂直沟道障碍阻止源极/漏极掺杂剂物质扩散到晶体管沟道中。 存在用于形成晶体管结构的方法。

公开(公告)号：US08114682B2

公开(公告)日：2012-02-14

申请号：US12442379

申请日：2007-09-17

申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

IPC分类号： G01N33/553

CPC分类号： G01N33/54373 ,  G01N2800/36 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/814 ,  Y10S436/817

摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative sex hormones in a serum sample.

摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同性激素的浓度，可用于评估不同临床情况。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性性激素的相关抗体。

公开(公告)号：US08110408B2

公开(公告)日：2012-02-07

申请号：US12441530

申请日：2007-09-17

申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

IPC分类号： G01N33/553

CPC分类号： G01N33/553 ,  G01N33/54373 ,  G01N2800/042 ,  Y10S435/808 ,  Y10S436/805

摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.

摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中糖尿病相关免疫学家的浓度，可用于诊断和/或早期诊断糖尿病，并预测一级亲属糖尿病的发病风险 。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定相关抗原和抗体，用于检测相应的糖尿病相关免疫学家 血清样品。

公开(公告)号：US08003407B2

公开(公告)日：2011-08-23

申请号：US11572568

申请日：2005-07-29

申请人： Siliang Zhou ,  William Rutter ,  Ning Liu

发明人： Siliang Zhou ,  William Rutter ,  Ning Liu

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/807 ,  Y10S436/81

摘要： The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least one analyte in a sample comprises: (1) a chromatographic strip, a sample filter, a fluid-impermeable barrier, and means for providing a mobilizable detectable agent that is capable of binding to the at least one analyte or to the capture agent after capturing the analyte to the chromatographic strip such that the mobilizable detectable agent migrates through the chromatographic strip and contacts sample that has passed through the sample filter and also has migrated through the chromatographic strip. The test strip allows detection with or without quantitation of an analyte in a sample containing whole cells.

摘要翻译： 本发明涉及一种侧流测定和系统，包括用于检测和定量样品中的分析物的测试条，例如含有细胞和流体的样品。 通常，根据本发明，用于检测样品中至少一种分析物的横向流动测定的测试条包括：（1）色谱条，样品过滤器，流体不可渗透屏障和用于提供 可移动的可检测试剂，其在将分析物捕获到色谱条之后能够结合至少一种分析物或捕获剂，使得可移动的可检测试剂迁移通过色谱条并接触通过样品过滤器的样品， 也已经通过色谱条带迁移。 测试条允许在含有全细胞的样品中检测有或没有定量分析物。

公开(公告)号：US07741183B2

公开(公告)日：2010-06-22

申请号：US12039361

申请日：2008-02-28

申请人： Tien Ying Luo ,  Ning Liu ,  Mohamed S. Moosa

发明人： Tien Ying Luo ,  Ning Liu ,  Mohamed S. Moosa

IPC分类号： H01L21/336 ,  H01L21/31 ,  H01L21/469

CPC分类号： H01L21/3144 ,  H01L21/28185 ,  H01L21/28202 ,  H01L21/3105 ,  H01L29/513 ,  H01L29/518 ,  H01L29/6659

摘要： A method of forming a semiconductor device includes providing a substrate for the semiconductor device. A base oxide layer is formed overlying the substrate by applying a rapid thermal oxidation (RTO) of the substrate in the presence of oxygen. A nitrogen-rich region is formed within and at a surface of the base oxide layer. The nitrogen-rich region overlies an oxide region in the base oxide layer. Afterwards, the semiconductor device is annealed in a dilute oxygen and hydrogen-free ambient of below 1 Torr partial pressure of the oxygen. The annealing heals bond damage in both the oxide region and the nitrogen-rich region in the base oxide layer. After annealing the semiconductor device in the dilute oxygen ambient, in-situ steam generation (ISSG) is used to grow and density the oxide region in the base oxide layer at an interface between the substrate and base oxide layer.

摘要翻译： 形成半导体器件的方法包括提供用于半导体器件的衬底。 通过在氧的存在下施加衬底的快速热氧化（RTO），在衬底上形成基底氧化物层。 在基底氧化物层的表面内和表面形成富氮区域。 富氮区域覆盖在基底氧化物层中的氧化物区域。 之后，半导体器件在氧低于1Torr分压的稀氧和无氢环境中进行退火。 该退火对基底氧化物层中的氧化物区域和富氮区域进行了愈合。 在稀氧环境中对半导体器件进行退火之后，使用原位蒸汽发生（ISSG）来生长和密集基底氧化物层中的氧化物区域，该基底氧化物层在衬底和基底氧化物层之间的界面处。

公开(公告)号：US20100052155A1

公开(公告)日：2010-03-04

申请号：US12614945

申请日：2009-11-09

申请人： Che-Jung Chang ,  Chin-Tien Chiu ,  Cheeman Yu ,  Hem Takiar ,  Jack Chang Chien ,  Ning Liu

发明人： Che-Jung Chang ,  Chin-Tien Chiu ,  Cheeman Yu ,  Hem Takiar ,  Jack Chang Chien ,  Ning Liu

IPC分类号： H01L23/04

CPC分类号： G06K19/077 ,  B29C45/14311 ,  B29C45/14647 ,  B29C2045/14327 ,  G06K19/07724 ,  G06K19/07732 ,  H01L23/10 ,  H01L23/544 ,  H01L24/48 ,  H01L24/97 ,  H01L2223/54433 ,  H01L2223/54486 ,  H01L2224/32145 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01029 ,  H01L2924/01079 ,  H01L2924/01322 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/181 ,  H01L2924/30107 ,  H01L2224/85 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

摘要： A flash memory card and methods of manufacturing same are disclosed. The card includes a semiconductor package fabricated to receive a single-sided or double-sided lid. A surface of the semiconductor package may be formed with holes, trenches and/or pockmarks. After the holes, trenches and/or pockmarks are formed, a lid may be attached to the package surface in an injection molding process. During the injection molding process, the molten plastic flows into the holes, trenches and/or pockmarks to interconnect with the surface of the semiconductor package. Thus, when the molten plastic hardens, the holes, trenches and/or pockmarks ensure that the lid remains firmly attached to semiconductor package.

摘要翻译： 公开了一种闪存卡及其制造方法。 卡包括制造成接收单面或双面盖的半导体封装。 半导体封装的表面可以形成有孔，沟槽和/或戳记。 在形成孔，沟和/或标记之后，可以在注射成型工艺中将盖子附接到包装表面。 在注射成型过程中，熔融的塑料流入与半导体封装的表面互连的孔，沟槽和/或戳痕。 因此，当熔融塑料硬化时，孔，沟槽和/或戳痕确保盖保持牢固地附接到半导体封装。

公开(公告)号：US20100047789A1

公开(公告)日：2010-02-25

申请号：US12441527

申请日：2007-08-20

申请人： Zhong Chen ,  Ning Liu

发明人： Zhong Chen ,  Ning Liu

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6883 ,  C12Q2565/628 ,  C12Q2600/156 ,  G01N21/553

摘要： The present invention discloses using SPR technology to postnatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of subtelomere imbalances and chromosome microdeletion syndromes is also disclosed.

摘要翻译： 本发明公开了使用SPR技术来检测与某些基因组紊乱有关的特异性DNA损失或增益。 还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于鉴定亚种不平衡和染色体微缺失综合征的DNA标记的固定是有利的。

公开(公告)号：US20100021971A1

公开(公告)日：2010-01-28

申请号：US12441525

申请日：2007-08-16

申请人： Zhong Chen ,  Ning Liu

发明人： Zhong Chen ,  Ning Liu

IPC分类号： C12P19/34

CPC分类号： C12Q1/6806 ,  C12Q2539/101 ,  C12Q2525/151

摘要： The invention discloses an innovative method to deplete repetitive sequences from human DNA. The method comprises (a) providing a source DNA containing both unique and repetitive sequences and sonicating the source DNA to smaller fragments; (b) providing a driver DNA containing sequences complementary to the repetitive sequences of the source DNA and labeled with a non-radioactive label, (c) hybridizing the source DNA and the driver DNA in the presence of a molecule that binds the label to form a complex; (d) removing the hybridized repetitive sequences from the complex by using RNAase and electrophoresis or by incubating with a mixture of phenol, chloroform, and ethanol; and (e) recovering the remaining source DNA wherein said repetitive sequences being significantly removed.

摘要翻译： 本发明公开了一种从人类DNA中消耗重复序列的创新方法。 该方法包括（a）提供含有唯一和重复序列的源DNA，并将源DNA超声处理成较小的片段; （b）提供含有与源DNA的重复序列互补并且用非放射性标记标记的序列的驱动DNA，（c）在结合标记的分子存在下使源DNA与驱动DNA杂交形成 一个复杂的 （d）通过使用RNA酶和电泳或通过与苯酚，氯仿和乙醇的混合物一起孵育从复合物中除去杂交的重复序列; 和（e）回收剩余的源DNA，其中显着除去所述重复序列。

公开(公告)号：US20100021882A1

公开(公告)日：2010-01-28

申请号：US12441792

申请日：2007-09-12

申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

IPC分类号： C12Q1/70

CPC分类号： B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/56983 ,  G01N2800/12 ,  Y10S435/808 ,  Y10S436/805

摘要： This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antigens used to detect the respective respiratory tract viruses-related immunological markers (antibodies) in blood for the diagnosis of respiratory tract infections.

摘要翻译： 本发明公开了使用SPR技术同时定性检测血清样品中呼吸道病毒相关免疫学标志物的存在，可用于诊断呼吸道感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于固定用于检测各个呼吸道病毒相关免疫标记（抗体 ）用于诊断呼吸道感染。

公开(公告)号：US20100015619A1

公开(公告)日：2010-01-21

申请号：US12445516

申请日：2007-09-21

申请人： Hongtao Zhang ,  Ning Liu ,  Zhong Chen

发明人： Hongtao Zhang ,  Ning Liu ,  Zhong Chen

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/16

摘要： This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step, individual chromosome specific STR markers (tetra-nucleotide repeats) are utilized. This invention particularly relates to multiplex analysis for the presence or absence of STR markers in genomic DNA isolated from peripheral blood, amniotic fluid, cultured amniocytes, chorionic villi, or fetal cells existing in maternal blood. This invention offers an efficient approach to identify chromosomal abnormalities by using STR markers.

摘要翻译： 本发明涉及用于检测和确认基因组畸变的测定法，例如染色体13,18,21，X和Y非整倍性以及22q11.2缺失，用于产前诊断。 为了检测，使用组合的STR标记（全部四核苷酸重复）来覆盖不同的染色体区域。 对于确认步骤，使用个体染色体特异性STR标记（四核苷酸重复）。 本发明特别涉及从外周血，羊水，培养的羊膜细胞，绒毛膜绒毛或存在于母体血液中的胎儿细胞分离的基因组DNA中存在或不存在STR标记的多重分析。 本发明提供了通过使用STR标记鉴定染色体异常的有效方法。