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    Method for purifying proteins
    81.
    发明授权
    Method for purifying proteins 有权
    蛋白质纯化方法

    公开(公告)号：US07754861B2

    公开(公告)日：2010-07-13

    申请号：US11388181

    申请日：2006-03-22

    Applicant: Egisto Boschetti ,  Lee O. Lomas

    Inventor： Egisto Boschetti ,  Lee O. Lomas

    IPC: A23J1/00 ,  C07K14/00 ,  C07K17/00 ,  C40B40/10

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.

    Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，结合污染蛋白质和少数靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

    PROCESS DESIGN USING MASS SPECTROMETRY
    82.
    发明申请
    PROCESS DESIGN USING MASS SPECTROMETRY 审中-公开
    使用大量光谱的工艺设计

    公开(公告)号：US20100173791A1

    公开(公告)日：2010-07-08

    申请号：US12651942

    申请日：2010-01-04

    Applicant: Egisto Boschetti

    Inventor： Egisto Boschetti

    IPC: C40B30/02 ,  C40B50/02 ,  C40B40/00

    CPC classification number: G01N33/6848 ,  C07K1/16 ,  G01N30/8675 ,  G01N2030/8831

    Abstract: The present invention provides a facile and efficient method for determining a chromatographic protocol for separating a target protein from one or more second protein impurity. Also provided is a database facilitating the determination of an appropriate separation protocol.

    Abstract translation: 本发明提供了一种用于确定用于从一种或多种第二种蛋白质杂质分离靶蛋白质的色谱方案的简便有效的方法。 还提供了便于确定适当分离方案的数据库。

    Photocrosslinked hydrogel surface coatings
    85.
    发明申请
    Photocrosslinked hydrogel surface coatings 审中-公开
    光交联水凝胶表面涂层

    公开(公告)号：US20070082019A1

    公开(公告)日：2007-04-12

    申请号：US10546173

    申请日：2004-02-20

    Applicant: Wenxi Huang ,  Yury Agroskin ,  Egisto Boschetti

    Inventor： Wenxi Huang ,  Yury Agroskin ,  Egisto Boschetti

    IPC: A61F2/02 ,  C12M1/34

    CPC classification number: H01J49/0418 ,  A61L27/52

    Abstract: A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. A hydrogel-coated substrate thus obtained is particularly useful as a probe for mass spectroscopic analysis, including SELDI analysis. Hydrogel particles also can be used for SELDI analysis.

    Abstract translation: 使用聚合物或共聚物前体分别形成具有光可交联官能团的单体亚单位和具有化学选择性功能性用于结合生物分子分析物的单体亚单位，当层原位形成时，水凝胶层有利地施加到基底上， 如蛋白质。 由此获得的水凝胶涂覆的基底特别可用作用于质谱分析的探针，包括SELDI分析。 水凝胶颗粒也可用于SELDI分析。

    Injectable and swellable microspheres for dermal augmentation
    89.
    发明申请
    Injectable and swellable microspheres for dermal augmentation 有权
    可注射和可溶胀的微球用于皮肤增强

    公开(公告)号：US20050025708A1

    公开(公告)日：2005-02-03

    申请号：US10919257

    申请日：2004-08-17

    Applicant: Jean-Marie Vogel ,  Egisto Boschetti

    Inventor： Jean-Marie Vogel ,  Egisto Boschetti

    IPC: A61L27/26 ,  A61L27/52 ,  A61K49/04 ,  A61K9/16 ,  A61K9/50

    CPC classification number: A61L27/52 ,  A61L27/26 ,  C08L33/26

    Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.

    Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。

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