公开(公告)号：US20180179172A1

公开(公告)日：2018-06-28

申请号：US15576307

申请日：2016-06-30

Applicant: Academia Sinica

Inventor： Rong-Jie CHIEN ,  Klim KING ,  Nai-Pin LIN ,  Yu-Hong CHENG

IPC: C07D307/22 ,  A61K31/365 ,  C07D307/83 ,  C07D333/36 ,  A61K45/06

CPC classification number: C07D307/22 ,  A61K31/155 ,  A61K31/365 ,  A61K31/366 ,  A61K31/4439 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/64 ,  A61K31/702 ,  A61K31/7042 ,  A61K45/06 ,  C07D307/33 ,  C07D307/83 ,  C07D333/32 ,  C07D333/36 ,  A61K2300/00

Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.

公开(公告)号：US09958396B2

公开(公告)日：2018-05-01

申请号：US14722510

申请日：2015-05-27

Applicant: Academia Sinica ,  Centre National de la Recherche Scientifique

Inventor： Chia-Fu Chou ,  Thierry Leichle ,  Yii-Lih Lin ,  Pattamon Teerapanich

IPC: G01N33/543 ,  G01N21/76 ,  B01L3/00 ,  G01N33/557 ,  G01N21/64

CPC classification number: G01N21/763 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0877 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/557 ,  G01N2021/6439

Abstract: A sensing device applied to an analyte molecule of a liquid sample and a buffer flow has at least one first inlet, at least one second inlet, a micro-flow channel, and at least one immobilization element. The first inlet is for inputting the liquid sample. The second inlet is for inputting the buffer flow. The micro-flow channel communicates with the first inlet and the second inlet. The immobilization element is for immobilizing sensing molecules for the analyte molecules. The analyte sample flow and the buffer flow, in the reverse direction, in the micro-flow channel enable the association and disassociation kinetics to be obtained. The present invention further provides a sensing system and a sensing method using the sensing device.

公开(公告)号：US20180099056A1

公开(公告)日：2018-04-12

申请号：US15567931

申请日：2016-04-19

Applicant: Academia Sinica

Inventor： Patrick C.H. Hsieh ,  Yuan-Yuan Cheng

IPC: A61K48/00 ,  A61K31/713 ,  A61K45/06 ,  A61K38/17 ,  A61P9/10

CPC classification number: A61K48/005 ,  A61K31/713 ,  A61K38/1709 ,  A61K45/06 ,  A61P9/10 ,  C12N2310/531 ,  C12N2710/10343 ,  A61K2300/00

Abstract: A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.

公开(公告)号：US20180072993A1

公开(公告)日：2018-03-15

申请号：US15699011

申请日：2017-09-08

Applicant: Academia Sinica

Inventor： Patrick C.H. Hsieh ,  Desy S. Lee

IPC: C12N5/077 ,  C12Q1/68 ,  A61K35/34 ,  G01N33/50

CPC classification number: C12N5/0657 ,  A61K35/34 ,  C12N2501/50 ,  C12N2501/65 ,  C12N2502/1323 ,  C12N2502/28 ,  C12N2506/02 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/5061

Abstract: Methods for promoting maturation of cardiomyocytes, involving introducing a microRNA combination containing miR-125b, miR-199a, miR-221, and/or miR222, or suppression of ErbB4 in immature cardiomyocytes, which may be co-cultured with endothelial cells.

公开(公告)号：US09891227B2

公开(公告)日：2018-02-13

申请号：US14701267

申请日：2015-04-30

Applicant: Academia Sinica

Inventor： Konan Peck ,  Pan-Chyr Yang ,  Yi-Chung Chang

IPC: G01N33/53 ,  G01N33/58 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N33/585 ,  G01N33/5308 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/56938

Abstract: Methods of assaying a biological target are disclosed. The method comprises: (a) providing a sample containing the biological target; (b) providing biotin-labeled first aptamers conjugated to a gold nanoparticle (GNP), and second aptamers conjugated to a magnetic bead, wherein the first and the second aptamers exhibit specific binding affinities to the target; (c) incubating the sample with the first and the second aptamers to obtain target-bound aptamers; (d) separating the target-bound aptamers from unbound aptamers; (e) eluting the first aptamers from the GNP; (f) incubating the eluted biotin-labeled first aptamers with streptavidin-magnetic beads and reporter gold nanoparticles (GNPs) to obtain a complex comprising: the bead, the first aptamers, attached to the bead; and the reporter GNPs captured by the bead through the first aptamers; (g) eluting the reporter GNPs captured; and (h) detecting the target by measuring and analyzing a light-scattering signal of the eluted reporter GNPs.

公开(公告)号：US09890111B2

公开(公告)日：2018-02-13

申请号：US14960025

申请日：2015-12-04

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Che Alex Ma ,  Ting-Jen Rachel Cheng ,  Wei-Chieh Cheng

IPC: C07C235/64 ,  C12Q1/18 ,  C12Q1/48 ,  C07C235/84

CPC classification number: C07C235/64 ,  C07C235/84 ,  C07K2299/00 ,  C12Q1/18 ,  C12Q1/48 ,  G01N2333/91102 ,  G01N2500/00

Abstract: The crystal structure at 2.16 Å resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from Escherichia coli, in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor-binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBP1b are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.

公开(公告)号：US20170327542A9

公开(公告)日：2017-11-16

申请号：US15115179

申请日：2015-01-26

Applicant: Academia Sinica

Inventor： Tsung-Lin LI ,  Syue-Yi LYU ,  Yu-Chen LIU ,  Chin-Yuan CHANG

IPC: C07K9/00 ,  C12P19/60 ,  A61K38/00

CPC classification number: C07K9/008 ,  A61K38/00 ,  C12P19/60 ,  Y02A50/473 ,  Y02A50/481

Abstract: Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described.

公开(公告)号：US20170290820A1

公开(公告)日：2017-10-12

申请号：US15496883

申请日：2017-04-25

Applicant: Academia Sinica

Inventor： Che-Kun James Shen ,  Yu-Chi Chou ,  Tsann-Long Su

IPC: A61K31/473 ,  G01N33/50 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/473 ,  A61K9/0053 ,  A61K45/06 ,  C07D221/14 ,  G01N33/5044 ,  G01N2333/805 ,  G01N2800/52 ,  A61K2300/00

Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.

公开(公告)号：US09777273B2

公开(公告)日：2017-10-03

申请号：US15322878

申请日：2015-08-05

Applicant: Industrial Technology Research Institute ,  Academia Sinica

Inventor： Yen-Ju Lin ,  Jui-Wen Huang ,  Fu-Tong Liu ,  Huan-Yuan Chen ,  Wei-Chen Hsieh

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

Abstract: A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.

公开(公告)号：US09763431B2

公开(公告)日：2017-09-19

申请号：US14920497

申请日：2015-10-22

Applicant: ACADEMIA SINICA ,  Yu-Ho Lin

Inventor： Yu-Ho Lin ,  Jyh-Yih Chen

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/46

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/0393 ,  C07K14/461 ,  C12N15/8509 ,  C12N2830/008

Abstract: The preset invention relates to a promoter to target a fluorescent protein to the muscles of fish, such as A. nigrofasciatus, for ornamental purposes, which is a Mlc3 (myosin, light polypeptide 3, skeletal muscle) promoter. The Mlc3 promoter has the nucleotides of tilapia (Oreochromis niloticus) myosin light chain 3 (Mlc3) promoter region, which is potential to be a tilapia Mlc3 promoter to enhance protein expression in muscle of fish, particularly for the generation of ornamental fish.