公开(公告)号：US20160030413A1

公开(公告)日：2016-02-04

申请号：US14777111

申请日：2014-03-14

Applicant: ALUMEND, LLC

Inventor： Barbara R. HABERER ,  Therese J. DOWNEY ,  Ronald E. UTECHT

IPC: A61K31/473 ,  A61K41/00 ,  A61N5/06 ,  A61K9/00

CPC classification number: A61K31/473 ,  A61K9/0019 ,  A61K41/0042 ,  A61K45/06 ,  A61N5/062 ,  A61N2005/0602 ,  A61K2300/00 ,  A61K41/00

Abstract: Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

Abstract translation: 本文公开了用于组合物中应用于血管的化合物，其中所述化合物软化和/或破坏钙化斑块的结晶基质，以及急性恢复血管治疗部位的血管依从性，同时保持 血管成形术期间的腔内增益。 还公开了应用所公开的组合物的治疗方法。 还公开了斑块软化化合物。

公开(公告)号：US08951296B2

公开(公告)日：2015-02-10

申请号：US13826604

申请日：2013-03-14

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Robert J. Melder ,  Ayala Hezi-Yamit ,  Christopher W. Storment ,  Carol M. Sullivan

IPC: A61N5/00 ,  A61N5/06 ,  A61N5/067 ,  A61B18/00

CPC classification number: A61B18/18 ,  A61B2018/0022 ,  A61B2018/00434 ,  A61B2018/00791 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0661 ,  A61N2005/0666

Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.

Abstract translation: 用于人类神经功能的治疗光动力学调制的装置和方法。 根据该技术的方法的一个实施方案包括向人施用光敏剂，其中相比于血管的非神经组织，光敏剂优先在血管附近的神经处累积。 该方法还可以包括使用位于人体内的辐射发射体照射光敏剂，其中辐射具有使光敏剂反应并改变至少一部分神经的波长，从而提供交感神经活性的治疗性降低。 该技术的几个实施方案可用于破坏肾神经，例如肾去神经支配，用于治疗高血压，糖尿病，充血性心力衰竭和其它适应症。

公开(公告)号：US20150018753A1

公开(公告)日：2015-01-15

申请号：US14323244

申请日：2014-07-03

Applicant: UVL Blood Labs, Inc.

Inventor： Scot Johnson ,  Michael Harter

IPC: A61N5/06 ,  A61M25/00

CPC classification number: A61N5/0601 ,  A61B90/98 ,  A61B2017/00176 ,  A61N5/0624 ,  A61N2005/0602 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0661 ,  A61N2005/0662

Abstract: Systems and methods for illumination of a vascular space and its contents using an electromagnetic energy source that supplies a plurality of wavelengths ranging from ultraviolet to infrared are shown. Illumination can be performed using multiple wavelengths, simultaneously or sequentially, and can be performed in accordance with a protocol where an initial illumination produces an effect that is at least partially reversed by a subsequent illumination. Illumination protocols can be stored on a database and accessed via a user interface displayed on the electromagnetic energy source. The database can be used to store data related to performance of system components, and such data can be used to override or modify an illumination protocol.

Abstract translation: 示出了使用提供从紫外线到红外线的多个波长的电磁能源来照射血管空间及其内容物的系统和方法。 可以同时或顺序地使用多个波长来执行照明，并且可以根据其中初始照射产生至少部分地被后续照明反转的效果的协议来执行。 照明协议可以存储在数据库中，并通过电磁能源上显示的用户界面进行访问。 该数据库可用于存储与系统组件性能有关的数据，并且这些数据可用于覆盖或修改照明协议。

公开(公告)号：US20150005693A1

公开(公告)日：2015-01-01

申请号：US14487628

申请日：2014-09-16

Applicant: Lawrence J. Gerrans ,  Erhan H. Gunday

Inventor： Lawrence J. Gerrans ,  Erhan H. Gunday

IPC: A61N5/06 ,  A61M25/10 ,  A61B17/3205

CPC classification number: A61N5/062 ,  A61B17/3205 ,  A61K31/704 ,  A61K33/00 ,  A61K41/00 ,  A61K41/0038 ,  A61K41/008 ,  A61K45/06 ,  A61M25/1011 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61N5/0601 ,  A61N5/10 ,  A61N2005/0602 ,  A61N2005/1098 ,  A61K2300/00

Abstract: A system for treatment of tumors includes a vessel having a photosensitizing agent therein, a delivery device for communicating the photosensitizing agent from the vessel to tumor tissue, a light source for radiating the tumor tissue after the delivery device has delivered the photosensitizing agent to the tumor tissue, a catheter having at least one inflatable balloon positioned thereon, and a fluid source that repeatedly inflates and at least partially deflates the inflatable balloon such that a resecting outer surface of the balloon contacts the radiated tumor tissue and resects the tissue.

Abstract translation: 用于治疗肿瘤的系统包括其中具有光敏剂的血管，用于将光敏剂从血管传递到肿瘤组织的递送装置，用于在递送装置将光敏剂递送至肿瘤之后辐射肿瘤组织的光源 组织，具有定位在其上的至少一个可充气气囊的导管，以及反复膨胀并且至少部分地使可膨胀气囊缩小的流体源，使得球囊的切除外表面接触辐射的肿瘤组织并切除组织。

公开(公告)号：US20140378954A1

公开(公告)日：2014-12-25

申请号：US14369004

申请日：2012-12-15

Applicant: Technische Universität Ilmenau

Inventor： Andreas Schober ,  Michael Gebinoga ,  Uta Fernekorn

IPC: A61B17/00 ,  A61N5/06 ,  A61L24/00 ,  A61B18/22

CPC classification number: A61B17/00491 ,  A61B18/24 ,  A61B2017/00508 ,  A61B2017/00517 ,  A61B2017/00522 ,  A61B2017/0065 ,  A61B2018/206 ,  A61B2018/2065 ,  A61B2218/002 ,  A61B2218/007 ,  A61L24/0005 ,  A61L24/0036 ,  A61L24/0042 ,  A61L2300/00 ,  A61N5/0613 ,  A61N2005/0602 ,  A61N2005/0659 ,  A61N2005/067

Abstract: The present invention relates to a device for closing an open, bleeding wound of an animal or human body. The invention further relates to a device for processing tissue of a human or animal body, for example, a device for producing a support in a vessel of the body. The device for closing a bleeding wound firstly comprises a laser for irradiating the blood in the wound with infrared laser radiation. According to the invention, the laser radiation of the laser can be adjusted such that two- or multiphoton absorption occurs in irradiated regions of the blood, whereby the blood in the irradiated regions polymerises into a solidified biopolymer and closes the wound.

Abstract translation: 本发明涉及一种用于关闭动物或人体的开放，流血的伤口的装置。 本发明还涉及一种用于处理人或动物体的组织的装置，例如用于在身体的血管中产生支撑物的装置。 用于关闭出血的伤口的装置首先包括用红外激光辐射照射伤口中的血液的激光。 根据本发明，可以调节激光的激光辐射，使得在照射的血液区域中发生两次或多光吸收，由此照射区域中的血液聚合成固化的生物聚合物并闭合伤口。

公开(公告)号：US08741270B2

公开(公告)日：2014-06-03

申请号：US13772510

申请日：2013-02-21

Applicant: Ronald E. Utecht ,  Kaia L. Kloster ,  Millard M. Judy ,  Kevin J. Vaska

Inventor： Ronald E. Utecht ,  Kaia L. Kloster ,  Millard M. Judy ,  Kevin J. Vaska ,  James L. Matthews

IPC: A61K8/00 ,  A61K8/18 ,  A61Q17/04 ,  A01N43/04

CPC classification number: C08B37/003 ,  A61B17/00 ,  A61B17/08 ,  A61K8/736 ,  A61K31/722 ,  A61K41/00 ,  A61K41/0042 ,  A61K41/0057 ,  A61K47/61 ,  A61K2800/57 ,  A61K2800/81 ,  A61K2800/94 ,  A61L24/08 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0663 ,  A61Q17/04 ,  A61Q19/00

Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

Abstract translation: 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

公开(公告)号：US20130282084A1

公开(公告)日：2013-10-24

申请号：US13644367

申请日：2012-10-04

Applicant: Vessix Vascular, Inc.

Inventor： Prabodh Mathur ,  Meital Mazor ,  Dolores Perez

IPC: A61N5/00

CPC classification number: A61N5/00 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/124 ,  A61B2018/1467 ,  A61N5/0601 ,  A61N2005/0602

Abstract: A catheter and catheter system can use energy tailored for remodeling and/or removal of target material proximate to a body lumen, often of stenotic material or tissue in the luminal wall of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage the luminal wall when the structure expands. Feedback using one or parameters of voltage, current, power, temperature, impedance magnitude, impedance phase angle, and frequency may be used to selectively control the delivery of energy.

Abstract translation: 导管和导管系统可以使用定制用于重建和/或去除靠近体腔的目标材料的能量，通常是患者血管的腔壁中的狭窄材料或组织。 具有径向可扩张结构的细长柔性导管体可以具有多个电极或其它电外科能量输送表面，以在结构膨胀时径向地接合腔壁。 可以使用一个电压，电流，功率，温度，阻抗幅度，阻抗相位角和频率的反馈来选择性地控制能量传递。

公开(公告)号：US08535361B2

公开(公告)日：2013-09-17

申请号：US12802866

申请日：2010-06-16

Applicant: Teng Lew Lim ,  Kam Ming Yip ,  Teng Howe Lim

Inventor： Teng Lew Lim ,  Kam Ming Yip ,  Teng Howe Lim

IPC: A61N5/06 ,  A61B19/00

CPC classification number: A61N5/0622 ,  A61N5/0603 ,  A61N2005/0602 ,  A61N2005/0607 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0662

Abstract: The present invention is a non-invasive apparatus, system, and method for performing irradiation light therapy upon blood circulating within the nostrils of a living mammalian subject. The merit and medical value of the invention resides in its ability to achieve a reversal of red blood cell aggregation in-vivo without invading the tissues or organs of the living subject—a clinical result which leads to lower blood viscosity and improved blood circulation. In this manner, the invention provides the living mammalian subject with an enhanced immunity from diseases, a reduced vulnerability to hypertension, and a reduced risk of a cardiovascular incident. Furthermore, by altering the wavelengths transmitted by the light generating unit(s) and controlling the light energy dosage, the method and system can also fine-tuned further as intervention for various diseases.

Abstract translation: 本发明是一种用于对活体哺乳动物受试者的鼻孔内的血液循环进行照射光疗法的非侵入性装置，系统和方法。 本发明的优点和医学价值在于其能够在不侵犯活体受试者的组织或器官的情况下实现红细胞聚集反转的能力 - 导致血液粘度降低和血液循环改善的临床结果。 以这种方式，本发明提供了活的哺乳动物受试者具有增强的疾病免疫力，降低了对高血压的易感性，降低了心血管事件的风险。 此外，通过改变由光产生单元传输的波长并控制光能量，该方法和系统还可以作为各种疾病的干预进一步微调。

公开(公告)号：US20130165970A1

公开(公告)日：2013-06-27

申请号：US13772543

申请日：2013-02-21

Applicant: Ronald E. Utecht ,  Kaia L. Kloster ,  Millard M. Judy ,  Kevin J. Vaska ,  James L. Matthews

Inventor： Ronald E. Utecht ,  Kaia L. Kloster ,  Millard M. Judy ,  Kevin J. Vaska ,  James L. Matthews

IPC: A61L24/08 ,  A61B17/00

CPC classification number: C08B37/003 ,  A61B17/00 ,  A61B17/08 ,  A61K8/736 ,  A61K31/722 ,  A61K41/00 ,  A61K41/0042 ,  A61K41/0057 ,  A61K47/61 ,  A61K2800/57 ,  A61K2800/81 ,  A61K2800/94 ,  A61L24/08 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0663 ,  A61Q17/04 ,  A61Q19/00

Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

Abstract translation: 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

公开(公告)号：US20120226334A1

公开(公告)日：2012-09-06

申请号：US13469855

申请日：2012-05-11

Applicant: Allan Gardiner ,  Tai Huynh

Inventor： Allan Gardiner ,  Tai Huynh

IPC: A61N5/06

CPC classification number: A61N5/0619 ,  A61B5/015 ,  A61B5/02405 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/14551 ,  A61B5/4041 ,  A61B5/4266 ,  A61B5/4824 ,  A61B5/726 ,  A61N5/0622 ,  A61N5/0625 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0663 ,  G01J3/10 ,  G01J2003/1213

Abstract: This invention provides methods for treating cold extremities using localized electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and/or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. Responses can be monitored by measuring physiological variables including temperature and blood flow.

Abstract translation: 本发明提供了使用针对可兴奋组织（包括神经，肌肉和血管）的局部电磁辐射来治疗冷端的方法。 通过控制波长，波长带通，脉冲持续时间，强度，脉冲频率和/或这些特性随时间的变化，并且通过选择暴露于电磁辐射的部位，可以提供不同组织和器官的功能的改善。 可以通过测量包括温度和血流量在内的生理变量来监测反应。