公开(公告)号：US08191756B2

公开(公告)日：2012-06-05

申请号：US11267541

申请日：2005-11-04

Applicant: Jonathan R. Coppeta ,  Kurt Shelton ,  Norman F. Sheppard, Jr. ,  Douglas Snell ,  Catherine M. B. Santini

Inventor： Jonathan R. Coppeta ,  Kurt Shelton ,  Norman F. Sheppard, Jr. ,  Douglas Snell ,  Catherine M. B. Santini

IPC: B23K20/12 ,  B23K31/00

CPC classification number: B81C1/00269 ,  A61K9/0097 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2207/00 ,  B23K20/02 ,  B33Y80/00 ,  B81B2201/06 ,  B81C1/00047 ,  B81C1/00095 ,  B81C2203/0109 ,  B81C2203/019 ,  B81C2203/038 ,  F16B4/004 ,  F16B5/08 ,  F16B11/004 ,  H01L23/10 ,  H01L23/3142 ,  H01L2224/05001 ,  H01L2224/05023 ,  H01L2224/051 ,  H01L2224/05568 ,  H01L2224/056 ,  H01L2224/16237 ,  H01L2224/81193 ,  H01L2924/01322 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/16315 ,  Y10T403/477 ,  H01L2924/00 ,  H01L2924/00014

Abstract: Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.

Abstract translation: 提供压缩冷焊方法，接头结构和密封的密封装置。 该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合 金属的接合面。 在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。 密封装置可以包含药物制剂，生物传感器或MEMS装置。

公开(公告)号：US20120003675A1

公开(公告)日：2012-01-05

申请号：US13050478

申请日：2011-03-17

Applicant: Scott T. Retterer ,  Mitchel J. Doktycz

Inventor： Scott T. Retterer ,  Mitchel J. Doktycz

IPC: C12P21/00 ,  C12M1/40 ,  C12M1/00 ,  C07H1/00 ,  B01J19/00 ,  C23F1/02 ,  C12Q1/54 ,  C07H21/04 ,  B82Y99/00

CPC classification number: B01L3/502746 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0867 ,  B01L2300/0896 ,  B01L2400/0472 ,  B81B2201/06 ,  B81C1/00126 ,  B82Y40/00 ,  C12P21/02

Abstract: Engineered reaction containers that can be physically and chemically defined to control the flux of molecules of different sizes and charge are disclosed. Methods for constructing small volume reaction containers through a combination of etching and deposition are also disclosed. The methods allow for the fabrication of multiple devices that possess features on multiple length scales, specifically small volume containers with controlled porosity on the nanoscale.

Abstract translation: 公开了可以物理和化学定义以控制不同尺寸和电荷的分子的通量的工程反应容器。 还公开了通过蚀刻和沉积的组合构造小体积反应容器的方法。 这些方法允许制造具有多个长度尺度上的特征的多个装置，特别是具有纳米尺度上具有受控孔隙率的小容积容器。

公开(公告)号：US20110200434A1

公开(公告)日：2011-08-18

申请号：US13060662

申请日：2010-09-17

Applicant: Bernard Dieny ,  Hélène Joisten ,  Philippe Sabon

Inventor： Bernard Dieny ,  Hélène Joisten ,  Philippe Sabon

IPC: F03G7/00 ,  B29C41/02

CPC classification number: B81C1/0019 ,  A61B1/00156 ,  B81B2201/038 ,  B81B2201/06 ,  B81C2201/038

Abstract: A microparticle includes an oblong flexible tail able to propel the microparticle in a solution along a trajectory using beats transverse to the trajectory, the tail including at least one magnetic element such that the magnetic element causes beats of the tail under the action of an external alternating magnetic field non-collinear with the trajectory and a head mechanically connected to a proximal end of the tail. The microparticle includes at least one layer of material formed from one piece and including the tail and the head, the dimensions and/or shape of the head being selected such that the beats of the proximal end of the tail are limited with respect to the beats of the distal end of the tail and such that the head does not perform a complete revolution around an axis parallel to the trajectory under the effect of the external alternating magnetic field.

Abstract translation: 微粒包括长方形柔性尾部，其能够使用横向于轨迹的搏动沿着轨迹将微粒推进到溶液中，尾部包括至少一个磁性元件，使得磁性元件在外部交替作用下引起尾巴的打击 与轨迹非共线的磁场和机械连接到尾端近端的磁头。 微粒包括至少一层材料，其由一个部件形成并包括尾部和头部，头部的尺寸和/或形状被选择为使得尾部的近端的节拍相对于节拍被限制 并且使得头部在外部交变磁场的作用下不围绕平行于轨迹的轴线执行完整的旋转。

公开(公告)号：US07854172B2

公开(公告)日：2010-12-21

申请号：US12372274

申请日：2009-02-17

Applicant: David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

Inventor： David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

IPC: G01L7/00

CPC classification number: G01L9/0075 ,  A61B5/03 ,  A61B2562/0247 ,  B81B7/007 ,  B81B2201/0264 ,  B81B2201/06 ,  B81B2207/096 ,  B81C1/00301 ,  G01L9/0073

Abstract: A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

公开(公告)号：US07741142B2

公开(公告)日：2010-06-22

申请号：US11286065

申请日：2005-11-22

Applicant: Manish Sharma

Inventor： Manish Sharma

IPC: H01L21/4763

CPC classification number: B81C1/00063 ,  B81B2201/06 ,  B81C2201/0133 ,  B81C2201/0153

Abstract: The present invention provides a method of fabricating a biosensor. The method includes providing a substrate which has a surface coating. The surface coating is deformable and the substrate includes a layered structure which has at least two electrically conductive layers separated by at least one electrically insulating layer. The method also includes imprinting a structure into the surface coating. Further, the method includes etching at least a region of the imprinted structure and the substrate to remove at least a portion of the structure and the substrate. The structure is shaped so that the etching forms at least a portion of the biosensor in the substrate and exposes at least a portion of each electrically conductive layer to form electrodes of the biosensor.

Abstract translation: 本发明提供一种制造生物传感器的方法。 该方法包括提供具有表面涂层的基底。 表面涂层是可变形的，并且衬底包括具有由至少一个电绝缘层分开的至少两个导电层的分层结构。 该方法还包括将结构压印到表面涂层中。 此外，所述方法包括蚀刻所述压印结构的至少一个区域和所述衬底以去除所述结构和所述衬底的至少一部分。 该结构被成形为使得蚀刻形成衬底中的生物传感器的至少一部分并且暴露出每个导电层的至少一部分以形成生物传感器的电极。

公开(公告)号：US20100068740A1

公开(公告)日：2010-03-18

申请号：US12513416

申请日：2007-11-05

Applicant: David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

Inventor： David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

IPC: C12M1/34 ,  B29C39/02 ,  C12Q1/02 ,  C12Q1/28 ,  C12Q1/54 ,  C12Q1/34

CPC classification number: B29D11/0074 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/163 ,  B29C39/02 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/06 ,  G01J3/10 ,  G01J3/1804 ,  G01J3/42 ,  G01N33/54386 ,  G01N2021/0346

Abstract: A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.

Abstract translation: 制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体， 并提取细长杆以在凝固体中形成圆柱形微通道。 在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。 还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。 提供额外的微流体装置，其用作光流体光谱仪。 光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。

公开(公告)号：US20090145623A1

公开(公告)日：2009-06-11

申请号：US12372274

申请日：2009-02-17

Applicant: David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

Inventor： David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

IPC: H05K5/06

CPC classification number: G01L9/0075 ,  A61B5/03 ,  A61B2562/0247 ,  B81B7/007 ,  B81B2201/0264 ,  B81B2201/06 ,  B81B2207/096 ,  B81C1/00301 ,  G01L9/0073

Abstract: A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Abstract translation: 压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封，同时保持与其他设备通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境，例如 体内植入和体内使用。 另外，采用新的制造方法构造传感器。

公开(公告)号：US20080102096A1

公开(公告)日：2008-05-01

申请号：US11860250

申请日：2007-09-24

Applicant: Renzo Molin ,  Alain Ripart

Inventor： Renzo Molin ,  Alain Ripart

IPC: A61F13/00

CPC classification number: B81B7/007 ,  B81B2201/06

Abstract: An implantable biocompatible component (10) integrating an active element of the type of a sensor for the measurement of a physiologic parameter, a micro-electromechanical system and an integrated electronic circuit. This component (10) has a substrate (12) and a lid (22) in silicon or quartz. The substrate (12) integrates the active element (14) and biocompatible metallic pads (16), electrically connected to the active element. The lid (22) encompasses and peripherally closes the substrate in a hermetic manner, level with the face integrating the active element. This component is void of metallic case for insulation between the active element and outside environment, and of insulative feedthrough for electrical connection to the active element. The substrate and lid can be directly welded to each other through their faces in vis-à-vis, or by interpositioning a sealing ring made of a biocompatible material.

Abstract translation: 整合了用于测量生理参数的传感器类型的有源元件，微机电系统和集成电子电路的可植入生物相容性部件（10）。 该组件（10）具有硅或石英的基板（12）和盖（22）。 基板（12）将有源元件（14）和与活性元件电连接的生物相容性金属焊盘（16）集成。 盖（22）以密封的方式包围并周边地封闭基板，与集成有源元件的面平齐。 该元件在有源元件和外部环境之间绝缘的金属外壳以及用于与有源元件电连接的绝缘馈通无效。 基板和盖子可以相对于彼此直接地彼此焊接，或者通过插入由生物相容性材料制成的密封环。

公开(公告)号：US20060286803A1

公开(公告)日：2006-12-21

申请号：US11424643

申请日：2006-06-16

Applicant: Christina Cole ,  Lloyd Whitman

Inventor： Christina Cole ,  Lloyd Whitman

IPC: H01L21/44

CPC classification number: B81C1/00206 ,  B81B2201/06

Abstract: Provided is a method for controllably activating a surface for stable amine-reactive chemistries. A surface containing nitride is exposed to a plasma having a reactive species containing hydrogen for a period of time sufficient to activate the substrate for amine-reactive chemistries. Amine-reactive chemical processes can then be applied to the activated surface to reliably and controllably bond molecules directly to said surface. The method is designed to create stable primary amines on the nitride substrate, so that any subsequent amine-reactive chemistry may proceed in a controlled manner that is directly proportional to the density of surface amines so created.

Abstract translation: 提供了一种用于可控地激活用于稳定的胺反应性化学物质的表面的方法。 将含有氮化物的表面暴露于具有含氢活性物质的等离子体的时间足以激活用于胺反应性化学物质的底物。 然后可以将胺反应性化学过程施加到活化表面，以可靠和可控地将分子直接结合到所述表面。 该方法被设计成在氮化物衬底上产生稳定的伯胺，使得任何随后的胺反应性化学物质可以以如此产生的表面胺的密度成正比的受控方式进行。

公开(公告)号：US20060174712A1

公开(公告)日：2006-08-10

申请号：US11314046

申请日：2005-12-20

Applicant: David O'Brien ,  Florent Cros ,  Jin Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

Inventor： David O'Brien ,  Florent Cros ,  Jin Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

IPC: G01L7/00

CPC classification number: G01L9/0075 ,  A61B5/03 ,  A61B2562/0247 ,  B81B7/007 ,  B81B2201/0264 ,  B81B2201/06 ,  B81B2207/096 ,  B81C1/00301 ,  G01L9/0073

Abstract: A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Abstract translation: 压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封，同时保持与其他设备通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境，例如 体内植入和体内使用。 另外，采用新的制造方法构造传感器。