Abstract:
The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (nullRNAnull). Direct, non-competitive binding assays are advantageously used to screen libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
Abstract:
The present invention provides an extrudable, crosslinked, greasy heat-radiating material which can find completely new ways of use (in terms of methods of operation and putting it in a service area), because it can be formed into any shape after it is extruded from the container in which it is held (e.g., syringe or tube) to be put or placed in a gap of any shape between a heat-generating body and heat-radiating body, where it keeps shape self-retainability even when kept under a very light load, e.g., kept on a slanted plate, unlike the conventional thermoconductive silicone rubber composition or thermoconductive silicone oil compound, whose applicable areas are limited to formed articles, represented by sheet, and coating. The present invention also provides a container filled with and sealing the extrudable, crosslinked, greasy heat-radiating material, process for producing the container, and method of heat radiation using the container. More specifically, the present invention provides the extrudable, crosslinked, greasy heat-radiating material comprising a crosslinked silicone gel (A) dispersed with a thermoconductive filler (B) and shape self-retainable in spite of being fluid, wherein the thermoconductive filler (B) is incorporated at 5 to 500 parts by weight per 100 parts by weight of the crosslinked silicone gel (A); container filled with and sealing the extrudable, crosslinked, greasy heat-radiating material; process for producing the container; and method of heat radiation using the container put or placed in a gap between a heat-generating body and heat-releasing body.
Abstract:
The present invention provides a new composite material comprising a porous matrix made of metal, metal alloy or semiconducting material and hollow fullerene-like nanoparticles of a metal chalcogenide compound or mixture of such compounds. The composite material is characterized by having a porosity between about 10% and about 40%. The amount of the hallow nanoparticles in the composite material is 1-20 wt. %.
Abstract:
A composition having lubricity such as a low degree of friction and wear and capable of supplying a lubricant continuously to a surface of a slide surface is disclosed. Also, a slide bearing, a retainer for a rolling bearing, and a seismically isolated apparatus formed by molding the composition are disclosed. The composition is composed by adding a porous silica and a lubricant to a base material; adding the lubricant-impregnated porous silica to the base material; or adding the lubricant-impregnated porous silica and the lubricant to the base material.
Abstract:
A solid lubricant and composition useful for lubricating the flanges of locomotive wheels, railcar wheels, rail track and in applications where it is desirable to reduce friction when metal contacts metal. The solid lubricant having from about twenty-five percent to about seventy percent by volume of a polymeric carrier, about five to seventy-five percent by volume of organic and inorganic extreme pressure additives, about zero to twenty percent by volume synthetic extreme pressure anti-wear liquid oil, and about zero to one percent by volume optical brightener.
Abstract:
A powdery mold-releasing lubricant according to the present invention uses a powdery mixture of a powdery organic material, which is evaporated or decomposed by heating to generate a gas, and a powdery inorganic material. A gas-solid mixed layer formed with the gas generated from the powdery mixture and the powdery inorganic material is used as a heat-insulating boundary layer. The powdery mold-releasing lubricant is inexpensive and has a superior mold lubricity.
Abstract:
A self-lubricating coating is provided which includes a mixture of a curable acrylate composition including a dipentaerythritol pentaacylate and a solid lubricant, such as polytetraflourethylenr. The curable acrylate composition may also include triethylene glycol dimethacrylate. An aramid pulp may also be added to the coating mixture. Also disclosed is a method of manufacturing the coating, and a self-lubricating bearing having the coating disposed on its surface.
Abstract:
The invention relates to a lubricant which can be used as a mandrel lubricant with a content of 75 to 90 wt. % of graphite and contains 1 to 10 wt. % of a phosphate. Said lubricant can also contain 1 to 4 wt % alkali silicate, 1 to 10 wt. % bentonite, 0.5 to 1 wt. % silico-phosphate and common solid lubricants. Said lubricant is preferably used as an aqueous suspension with a solid content of 20 to 40 wt. %.
Abstract:
The present invention provides compositions and methods for the coating and/or ballistics conditioning of firearm projectiles and firearm components including gun barrels, firearm chambers, fully assembled cartridges, shot gun shells, shotgun wads, shot capsules and sabots with molybdenum disulfide. The composition comprises powdered molybdenum disulfide suspended in a carrier comprising a volatile solvent and a binder selected from cellulosic-, alkyd- and acrylic-resins. Methods for the conditioning of firearm bores by the formation of a hardened layer comprising a product of the reaction or interaction of molybdenum disulfide with materials in the barrel bore are also disclosed.
Abstract:
A stainless steel wire is plated with nickel (Ni) to a thickness of from not less than 1 .mu.m to not more than 5 .mu.m. An inorganic salt coat film mainly composed of at least one of potassium sulfate and borax (borate) and free from fluorine (F) or chlorine (Cl) is then deposited on the nickel (Ni) plate 2 as the substrate. The steel wire is then drawn to a reduction of area of not less than 60% to adjust the surface roughness thereof to a range of from 0.80 to 12.5 .mu.mRz, preferably from 1.0 to 10.0 .mu.mRz.