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    ANTIBIOTIC POLYMETHYLMETHACRYLATE BONE CEMENT
    83.
    发明申请
    ANTIBIOTIC POLYMETHYLMETHACRYLATE BONE CEMENT 审中-公开

    公开(公告)号：US20170173210A1

    公开(公告)日：2017-06-22

    申请号：US15386522

    申请日：2016-12-21

    申请人： HERAEUS MEDICAL GMBH

    发明人： Sebastian Vogt ,  Susann Klimas

    IPC分类号： A61L24/06 ,  A61L24/00

    CPC分类号： A61L24/06 ,  A61L24/001 ,  A61L24/0015 ,  A61L27/16 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/406 ,  A61L2430/02 ,  C08L33/12

    摘要： The invention proposes an antibiotic polymethylmethacrylate bone cement that is composed of methylmethacrylate, at least one polymethylmethacrylate or a polymethylmethacrylate-copolymer, at least one polymerisation initiator, such as in radical initiator, at least one polymerisation accelerator, and at least one radiopaquer, whereby the components are present in a powdered component and a liquid monomer component or in two components that are pasty at room temperature. The polymethylmethacrylate bone cement according to the invention comprises the cyclical lipopeptide, daptomycin, a pharmacologically tolerable salt of daptomycin, a solvate and/or a hydrate containing daptomycin and at least one calcium salt, which preferably comprises at least two different release profiles.

    CYANOACRYLATE ADHESIVE COMPOSITION AND METHOD FOR MAKING THE SAME
    87.
    发明申请
    CYANOACRYLATE ADHESIVE COMPOSITION AND METHOD FOR MAKING THE SAME 审中-公开
    氰基丙烯酸酯胶粘剂组合物及其制备方法

    公开(公告)号：US20170072092A1

    公开(公告)日：2017-03-16

    申请号：US14850198

    申请日：2015-09-10

    申请人： Fa-Ter CHU

    发明人： Fa-Ter CHU

    IPC分类号： A61L24/06 ,  A61L24/00 ,  A61L24/04

    CPC分类号： A61L24/06 ,  A61L24/0021 ,  A61L24/0042 ,  A61L24/043 ,  C08L35/04

    摘要： The present invention provides a method for making an adhesive composition. An adhesive substrate comprising at least a first cyanoacrylate monomer is provided and then mixed with a thickening agent containing polycyanoacrylate prepared by polymerization of a second cyanoacrylate monomer initiated with an aqueous solution of ammonium hydroxide or alcohol. In light of low boiling point of ammonium hydroxide and alcohol, they can be easily removed by heating at low temperature. As such, conventional premature polymerization of adhesive substrate owing to addition of a thickening agent containing residual accelerators can be overall improved.

    摘要翻译： 本发明提供一种制备粘合剂组合物的方法。 提供包含至少第一氰基丙烯酸酯单体的粘合剂基材，然后与含有通过聚合由氢氧化铵或醇的水溶液引发的第二种氰基丙烯酸酯单体制备的含有聚氰基丙烯酸酯的增稠剂混合。 根据氢氧化铵和醇的低沸点，它们可以通过在低温下加热而容易地除去。 因此，可以总体上改善由于添加含有残留加速剂的增稠剂而导致的粘合剂基材的常规过早聚合。

    METHOD AND COMPOSITION FOR STERILIZATION OF A POLYMERIZABLE MONOMER
    89.
    发明申请
    METHOD AND COMPOSITION FOR STERILIZATION OF A POLYMERIZABLE MONOMER 审中-公开
    可聚合单体灭菌的方法和组合物

    公开(公告)号：US20160346426A1

    公开(公告)日：2016-12-01

    申请号：US15231885

    申请日：2016-08-09

    申请人： Heraeus Medical GmbH

    发明人： Sebastian VOGT

    IPC分类号： A61L24/06 ,  C08L33/26 ,  C08F20/56 ,  A61L2/18 ,  A61L24/04

    CPC分类号： A61L24/06 ,  A61L2/16 ,  A61L2/18 ,  A61L24/043 ,  A61L24/046 ,  A61L2430/02 ,  C08F20/56 ,  C08L33/26 ,  C08L33/12

    摘要： A methods and mixtures are provided for sterilization of a polymerizable monomer, in which the mixture contains at least the polymerizable monomer, a compound (a), and a compound (b). Compound (a) is selected from the group of compounds (a1), compounds (a2), and compounds (a3), wherein compounds (a1) are represented by general formula (I): wherein R1, R2, R3, and R4, independent of each other, represent a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group; compounds (a2) are selected from the group of dimers of compounds (a1); and compounds (a3) are selected from the group of dialkyldicarbonates. Compound (b) is selected from the group of water and alcohols.

    摘要翻译： 其中R1，R2，R3和R4彼此独立地表示取代的烷基残基，未取代的烷基残基，卤素，硝基或氰基; 化合物（a2）选自化合物（a1）的二聚体; 和化合物（a3）选自二烷基二碳酸酯。 化合物（b）选自水和醇类。