公开(公告)号：US12016635B2

公开(公告)日：2024-06-25

申请号：US17330521

申请日：2021-05-26

申请人： HeartFlow, Inc.

发明人： Charles A. Taylor

IPC分类号： G06T7/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/029 ,  A61B5/055 ,  A61B5/107 ,  A61B5/11 ,  A61B5/22 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/08 ,  A61B34/00 ,  A61B34/10 ,  A61M5/00 ,  G01R33/56 ,  G01R33/563 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T11/00 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/69 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B90/00 ,  G06T7/10 ,  G06V10/46

CPC分类号： A61B34/10 ,  A61B5/0035 ,  A61B5/004 ,  A61B5/0044 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B5/1075 ,  A61B5/1118 ,  A61B5/22 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/745 ,  A61B6/03 ,  A61B6/032 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5205 ,  A61B6/5217 ,  A61B6/5229 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/065 ,  A61B8/481 ,  A61B8/5223 ,  A61B8/5261 ,  A61B34/25 ,  A61M5/007 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56366 ,  G06F17/10 ,  G06F18/10 ,  G06F18/22 ,  G06F18/24 ,  G06F30/20 ,  G06F30/23 ,  G06F30/28 ,  G06G7/60 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/12 ,  G06T7/13 ,  G06T7/149 ,  G06T7/20 ,  G06T7/60 ,  G06T7/62 ,  G06T7/70 ,  G06T7/73 ,  G06T7/74 ,  G06T11/00 ,  G06T11/001 ,  G06T11/008 ,  G06T11/20 ,  G06T11/60 ,  G06T15/10 ,  G06T17/00 ,  G06T17/005 ,  G06T17/20 ,  G06V10/40 ,  G06V10/42 ,  G06V10/44 ,  G06V20/698 ,  G16B5/00 ,  G16B45/00 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  G16H70/00 ,  A61B5/6868 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/108 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/3764 ,  A61B2576/00 ,  A61B2576/023 ,  G06T7/10 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10072 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20036 ,  G06T2207/20124 ,  G06T2207/30016 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06T2210/41 ,  G06T2211/404 ,  G06V10/467 ,  Y02A90/10 ,  G06T7/0012 ,  G06T2207/30048

摘要： Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

公开(公告)号：US11944387B2

公开(公告)日：2024-04-02

申请号：US18185445

申请日：2023-03-17

申请人： HeartFlow, Inc.

发明人： Sethuraman Sankaran ,  Christopher Zarins ,  Leo Grady

IPC分类号： A61B34/10 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  G06T7/00 ,  G06T7/20 ,  G06T11/00 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50

CPC分类号： A61B34/10 ,  A61B5/02007 ,  A61B5/4848 ,  A61B5/7275 ,  G06T7/0012 ,  G06T7/20 ,  G06T11/003 ,  G16H30/40 ,  G16H50/30 ,  G16H50/50 ,  A61B5/0035 ,  A61B5/0073 ,  A61B5/055 ,  A61B2034/105 ,  A61B2505/05 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/30104

摘要： A computer implemented method for assessing an arterio-venous malformation (AVM) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the AVM, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the AVM, by performing computer simulations of blood flow through the one or more blood vessels associated with the AVM in the patient-specific model.

公开(公告)号：US11918293B2

公开(公告)日：2024-03-05

申请号：US17106987

申请日：2020-11-30

申请人： HeartFlow, Inc.

发明人： Leo Grady ,  Charles A. Taylor ,  Christopher Zarins

IPC分类号： A61B34/10 ,  A61B5/026 ,  A61B6/00 ,  A61B6/03 ,  A61B8/06 ,  G06F30/20 ,  G06T7/00 ,  G06T7/11 ,  G09B9/00 ,  G09B23/30 ,  G16H50/50

CPC分类号： A61B34/10 ,  A61B5/0263 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B8/06 ,  G06F30/20 ,  G06T7/0012 ,  G06T7/11 ,  G09B9/00 ,  G09B23/303 ,  G16H50/50 ,  A61B2034/104 ,  A61B2034/105 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30056 ,  G06T2207/30084 ,  G06T2207/30104 ,  G06T2211/404

摘要： Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display.

公开(公告)号：US11883225B2

公开(公告)日：2024-01-30

申请号：US17456039

申请日：2021-11-22

申请人： HeartFlow, Inc.

发明人： Sethuraman Sankaran ,  Michiel Schaap ,  Leo Grady

IPC分类号： G06T7/62 ,  A61B6/00 ,  A61B5/02 ,  G06T7/00 ,  G16H30/40 ,  G16H50/30 ,  A61B6/03 ,  G16H40/67 ,  G16H50/20

CPC分类号： A61B6/5217 ,  A61B5/02007 ,  A61B6/032 ,  A61B6/468 ,  A61B6/504 ,  A61B6/507 ,  G06T7/0014 ,  G06T7/62 ,  G16H30/40 ,  G16H50/30 ,  G06T2207/30048 ,  G06T2207/30101 ,  G16H40/67 ,  G16H50/20

摘要： Systems and methods are disclosed for predicting healthy lumen radius and calculating a vessel lumen narrowing score. One method of identifying a lumen diameter of a patient's vasculature includes: receiving a data set including one or more lumen segmentations of known healthy vessel segments of a plurality of individuals; extracting one or more lumen features for each of the vessel segments; receiving a lumen segmentation of a patient's vasculature; determining a section of the patient's vasculature; and determining a healthy lumen diameter of the section of the patient's vasculature using the extracted one or more features for each of the known healthy vessel segments of the plurality of individuals.

公开(公告)号：US11854704B2

公开(公告)日：2023-12-26

申请号：US17812935

申请日：2022-07-15

申请人： HeartFlow, Inc.

发明人： Leo Grady ,  Charles A. Taylor ,  Campbell Rogers ,  Christopher K. Zarins ,  Gilwoo Choi

IPC分类号： G16H50/50

CPC分类号： G16H50/50

摘要： Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.

公开(公告)号：US11847781B2

公开(公告)日：2023-12-19

申请号：US17808000

申请日：2022-06-21

申请人： HeartFlow, Inc.

发明人： Leo Grady ,  Michiel Schaap ,  Edward Karl Hahn, III

IPC分类号： G06T7/00 ,  G16H50/20 ,  G16H30/40 ,  G16H50/50 ,  G06T11/00 ,  G16H10/60 ,  G06N20/00

CPC分类号： G06T7/0012 ,  G06T11/003 ,  G16H10/60 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  G06N20/00 ,  G06T2207/20081 ,  G06T2207/30004 ,  G06T2207/30104 ,  G06T2207/30172

摘要： Systems and methods are disclosed for determining anatomy directly from raw medical acquisitions using a machine learning system. One method includes obtaining raw medical acquisition data from transmission and collection of energy and particles traveling through and originating from bodies of one or more individuals; obtaining a parameterized model associated with anatomy of each of the one or more individuals; determining one or more parameters for the parameterized model, wherein the parameters are associated with the raw medical acquisition data; training a machine learning system to predict one or more values for each of the determined parameters of the parametrized model, based on the raw medical acquisition data; acquiring a medical acquisition for a selected patient; and using the trained machine learning system to determine a parameter value for a patient-specific parameterized model of the patient.

公开(公告)号：US11817219B2

公开(公告)日：2023-11-14

申请号：US17930090

申请日：2022-09-07

申请人： HeartFlow, Inc.

发明人： Mark Rabbat ,  Charles Taylor ,  Michiel Schaap ,  Timothy Fonte ,  Leo Grady

IPC分类号： G16H50/30 ,  G16H50/50 ,  G16H30/20 ,  A61B5/02 ,  A61B5/00

CPC分类号： G16H50/30 ,  A61B5/02007 ,  A61B5/4848 ,  A61B5/7278 ,  G16H30/20 ,  G16H50/50

摘要： Systems and methods are disclosed for assessing cardiovascular disease and treatment effectiveness based on adipose tissue. One method includes identifying a vascular bed of interest in a patient's vasculature; receiving a medical image of the patient's identified vascular bed of interest; identifying adipose tissue in the received medical image; receiving a geometric vascular model comprising a representation of the patient's identified vascular bed of interest; and computing an inflammation index associated with the geometric vascular model, using the identified adipose tissue.

公开(公告)号：US20230360804A1

公开(公告)日：2023-11-09

申请号：US18355500

申请日：2023-07-20

申请人： HeartFlow, Inc.

发明人： Bon-Kwon KOO ,  Gilwoo CHOI ,  Hyun Jin KIM ,  Charles A. TAYLOR

IPC分类号： G16H50/50 ,  A61B5/026 ,  G16H50/30 ,  G16H50/20 ,  A61B5/02 ,  A61B5/0215

CPC分类号： G16H50/50 ,  A61B5/026 ,  G16H50/30 ,  G16H50/20 ,  A61B5/02007 ,  A61B5/0215

摘要： Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed.

公开(公告)号：US20230360803A1

公开(公告)日：2023-11-09

申请号：US18342178

申请日：2023-06-27

申请人： HeartFlow, Inc.

发明人： Sethuraman SANKARAN ,  Leo GRADY ,  Charles A. TAYLOR

IPC分类号： G16H50/50 ,  G06T7/00 ,  G06N3/00 ,  A61B6/00 ,  A61B5/00 ,  G06F17/18

CPC分类号： G16H50/50 ,  G06T7/0012 ,  G06N3/00 ,  A61B6/00 ,  A61B5/7267 ,  A61B6/507 ,  A61B6/5217 ,  G06F17/18 ,  A61B5/026

摘要： Embodiments include methods and systems and for determining a sensitivity of a patient's blood flow characteristic to anatomical or geometrical uncertainty. For each of one or more of individuals, a sensitivity of a blood flow characteristic may be obtained for one or more uncertain parameters. An algorithm may be trained based on the sensitivities of the blood flow characteristic and one or more of the uncertain parameters for each of the plurality of individuals. A geometric model, a blood flow characteristic, and one or more of the uncertain parameters of at least part of the patient's vascular system may be obtained for a patient. The sensitivity of the patient's blood flow characteristic to one or more of the uncertain parameters may be calculated by executing the algorithm on the blood flow characteristic of at least part of the patient's vascular system, and one or more of the uncertain parameters.

公开(公告)号：US11803965B2

公开(公告)日：2023-10-31

申请号：US17739558

申请日：2022-05-09

申请人： HeartFlow, Inc.

发明人： Timothy A. Fonte ,  Leo J. Grady ,  Zhongle Wu ,  Michiel Schaap ,  Stanley C. Hunley ,  Souma Sengupta ,  Sophie Khem

IPC分类号： G06T7/00 ,  A61B6/00 ,  A61B5/026 ,  A61B6/03 ,  A61B8/08 ,  G01R33/563 ,  G16H50/50

CPC分类号： G06T7/0012 ,  A61B5/026 ,  A61B5/0261 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5217 ,  A61B8/0883 ,  A61B5/0263 ,  A61B6/037 ,  A61B6/507 ,  A61B6/5258 ,  A61B6/5294 ,  A61B8/5223 ,  A61B2576/02 ,  G01R33/5635 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10132 ,  G06T2207/30004 ,  G06T2207/30104 ,  G06T2207/30168 ,  G06T2207/30172 ,  G06T2207/30196 ,  G06T2210/41 ,  G16H50/50

摘要： Systems and methods are disclosed for assessing the quality of medical images of at least a portion of a patient's anatomy, using a computer system. One method includes receiving one or more images of at least a portion of the patient's anatomy; determining, using a processor of the computer system, one or more image properties of the received images; performing, using a processor of the computer system, anatomic localization or modeling of at least a portion of the patient's anatomy based on the received images; obtaining an identification of one or more image characteristics associated with an anatomic feature of the patient's anatomy based on the anatomic localization or modeling; and calculating, using a processor of the computer system, an image quality score based on the one or more image properties and the one or more image characteristics.