公开(公告)号：US12055553B2

公开(公告)日：2024-08-06

申请号：US16491541

申请日：2018-03-09

申请人： The Regents of the University of California

发明人： Angela Zivkovic ,  Carlito B. Lebrilla ,  Emanual Maverakis

IPC分类号： G01N33/92 ,  A61K31/7004 ,  A61K31/7008

CPC分类号： G01N33/92 ,  A61K31/7004 ,  A61K31/7008 ,  G01N2333/775 ,  G01N2333/81 ,  G01N2400/00 ,  G01N2800/7095

摘要： Methods of detecting altered HDL functionality as well as adjusting HDL functionality are described.

公开(公告)号：US11981963B2

公开(公告)日：2024-05-14

申请号：US18124455

申请日：2023-03-21

申请人： Roche Sequencing Solutions, Inc.

发明人： Yann Astier

IPC分类号： C12Q1/6869 ,  G01N27/327 ,  G01N33/487

CPC分类号： C12Q1/6869 ,  G01N27/3278 ,  G01N33/48721 ,  C12Q1/6869 ,  C12Q2521/101 ,  C12Q2521/513 ,  C12Q2521/543 ,  C12Q2563/116 ,  C12Q2565/631

摘要： Methods for analyzing a nucleic acid molecule are described. Methods may include attaching the nucleic acid molecule to a particle having a first characteristic dimension. In addition, methods may include applying an electric field through an aperture to move the particle to the aperture. Also, methods may include applying a voltage across a first electrode and a second electrode. Further, methods may include contacting a portion of the nucleic acid molecule to both the first electrode and the second electrode within the aperture, where the portion may include a nucleotide. In addition, methods may include measuring a current through the first electrode, the portion of the nucleic acid molecule, and the second electrode, where the measured current runs in a direction parallel to a longitudinal axis of the aperture. Also, methods may include identifying the nucleotide of the portion of the nucleic acid molecule based on the current.

公开(公告)号：USD1024093S1

公开(公告)日：2024-04-23

申请号：US29811751

申请日：2021-10-15

申请人： Roche Molecular Systems, Inc.

设计人： Cindy K. Barnard ,  Sambasivarao Byrapuneni ,  Diwakar Chapagain ,  Archana P. Dorge ,  Catherine M. Jeu ,  Rengaraja Kesavan ,  Kaushal D. Parekh ,  Raman Ramanathan ,  David M. Schlossman ,  Vishakha Sharma

摘要： FIG. 1 is a front view of a first image in a sequence of a display screen or portion thereof with graphical user interface for patient timeline navigation showing our new design;
FIG. 2 is a front view of a second image thereof;
FIG. 3 is a front view of a third image thereof;
FIG. 4 is a front view of a fourth image thereof;
FIG. 5 is a front view of a fifth image thereof;
FIG. 6 is a front view of a sixth image thereof; and,
FIG. 7 is a front view of a seventh image thereof.
The outermost broken line rectangular indicates a boundary of a display screen or a portion thereof and forms no part of the claimed design. The broken lined text, patterns, and characters form no part of the claimed design. The appearance of the animated images sequentially transition from FIG. 1 to FIG. 7. The process or period in which one image transitions to another forms no part of the claimed design.

公开(公告)号：US11883223B2

公开(公告)日：2024-01-30

申请号：US16968088

申请日：2019-02-15

申请人： The Regents of the University of California

发明人： Guobao Wang ,  Souvik Sarkar ,  Ramsey D. Badawi

IPC分类号： A61B6/00 ,  G16H50/30 ,  A61B6/03 ,  G06T7/00

CPC分类号： A61B6/5217 ,  A61B6/037 ,  A61B6/481 ,  A61B6/50 ,  G06T7/0016 ,  G16H50/30 ,  A61B6/486 ,  A61B6/5205 ,  G06T2207/10076 ,  G06T2207/10104 ,  G06T2207/30056

摘要： A system and method for determining kinetic parameters associated with a kinetic model of an imaging agent in a liver is provided. An image reconstruction device can receive radiotracer activities corresponding to a predetermined time period. For example, these radiotracer activities can include PET scan data corresponding to a number of time frames. The radiotracer activities can be used to determine a liver time activity curve and a circulatory input function. The liver time activity curve and circulatory input function can be used along with a kinetic model of the liver to produce kinetic parameters. These kinetic parameters can be used to determine hepatic scores, such as a hepatic steatosis score, a hepatic inflammation score, and a cirrhosis score. These scores are indicative of diseases of the liver, including nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and hepatic fibrosis.

公开(公告)号：US11841350B2

公开(公告)日：2023-12-12

申请号：US17695672

申请日：2022-03-15

申请人： Bio-Rad Laboratories, Inc.

发明人： Christopher Belisle ,  Mark A. Snyder

IPC分类号： B01D15/22 ,  G01N30/52 ,  G01N30/60

CPC分类号： G01N30/52 ,  B01D15/22 ,  G01N30/6021 ,  G01N2030/522

摘要： A dynamic axial compression column is disclosed herein. This dynamic axial column utilized external compression to prevent the creation of end plate space in the column. The dynamic axial column can include a tube defining a first opening, a second opening, and a lumen extending there between. The dynamic axial column can include a first end plate assembly sealing the first opening and movably extending at least partially into the lumen via the first opening, a second end plate assembly sealing the second opening, a plurality of rods extending along the outside of the tube and connecting the first end plate assembly and the second end plate assembly, and a first plurality of compression devices external to the tube and engaging one of the plurality of rods to bias the first end plate assembly towards the second end plate assembly.

公开(公告)号：US11838714B1

公开(公告)日：2023-12-05

申请号：US17027699

申请日：2020-09-21

申请人： Apple Inc.

发明人： Jukka-pekka J. Sjoeroos ,  Zaki Moussaoui

IPC分类号： H04R1/10 ,  H02J50/00 ,  H02J50/70 ,  H02J50/10

CPC分类号： H04R1/1025 ,  H02J50/005 ,  H02J50/10 ,  H02J50/70 ,  H04R1/1016 ,  H02J2310/23

摘要： Electronic apparatuses according to embodiments of the present technology may include an enclosure having a lid. The enclosure may define a first cavity and a second cavity, and may include an enclosure battery. The apparatuses may include a first enclosure wireless charging coil extending about the first cavity. The apparatuses may include a second enclosure wireless charging coil extending about the second cavity. The apparatuses may include a first earbud having a first earbud battery and a first earbud wireless charging coil operably coupleable with the first enclosure wireless charging coil for wireless charging of the first earbud battery. The apparatuses may include a second earbud having a second earbud battery and a second earbud wireless charging coil operably coupleable with the second enclosure wireless charging coil for wireless charging of the second earbud battery.

公开(公告)号：US11755661B2

公开(公告)日：2023-09-12

申请号：US16836467

申请日：2020-03-31

申请人： Roche Molecular Systems, Inc.

发明人： Craig Atkinson

IPC分类号： G06F17/00 ,  G06F7/00 ,  G06F16/907 ,  G16H10/60 ,  G06F16/903 ,  G06F16/9038 ,  G06F16/901 ,  G06F40/284 ,  G06F3/0482

CPC分类号： G06F16/907 ,  G06F3/0482 ,  G06F16/9024 ,  G06F16/9038 ,  G06F16/90335 ,  G06F40/284 ,  G16H10/60

摘要： A computer-implemented method is provided. The method comprises: receiving, from a text field of a user interface, input text strings containing medical data; identifying, based on language semantics and grammatical structure, a keyword and one or more data values from the input text strings; providing the keyword as an input to a query of a medical data category database to obtain one or more categories associated with the keyword, the one or more categories including a first category; retrieving, from a template database, a first template associated with the first category, the first template including one or more fixed blocks and one or more variable blocks; inserting a data value corresponding to the keyword into a variable block of the first template to generate a replacement text string; and displaying the replacement text string in place of the input text strings in the text field.

公开(公告)号：US11739380B2

公开(公告)日：2023-08-29

申请号：US17200634

申请日：2021-03-12

申请人： Roche Sequencing Solutions, Inc.

发明人： Geoffrey Barrall ,  Jason Komadina ,  Marcin Rojek

IPC分类号： C12Q1/6874 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

CPC分类号： C12Q1/6874 ,  C12Q1/6869 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q1/6869 ,  C12Q2523/303 ,  C12Q2527/15 ,  C12Q2565/631

摘要： A method of analyzing a molecule is disclosed. A lipid bilayer is formed such that it divides a first reservoir characterized by a first reservoir osmolarity from a second reservoir characterized by a second reservoir osmolarity. An electrolyte solution is flowed to the first reservoir that tends to make a first change to a ratio of the first reservoir osmolarity to the second reservoir osmolarity. A voltage is applied across the lipid bilayer, wherein the lipid bilayer is inserted with a nanopore, and wherein a net transfer of ions between the first reservoir and the second reservoir tends to make a second change to the ratio of the first reservoir osmolarity to the second reservoir osmolarity, and wherein the first change to the ratio and the second change to the ratio tends to counter-balance each other.

公开(公告)号：USD996643S1

公开(公告)日：2023-08-22

申请号：US29884562

申请日：2023-02-13

申请人： Roche Sequencing Solutions, Inc.

设计人： Frantisek Foret ,  Ivona Voracova ,  Jan Prikryl ,  Jakub Novotny

摘要： FIG. 1 is a rear top perspective view of a first embodiment of an epitachophoresis device showing our new design;
FIG. 2 is a rear view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof;
FIG. 8 is a rear top perspective view of a second embodiment of the epitachophoresis device showing our new design;
FIG. 9 is a rear view thereof;
FIG. 10 is a front view thereof;
FIG. 11 is a left side view thereof;
FIG. 12 is a right side view thereof;
FIG. 13 is a top view thereof; and,
FIG. 14 is a bottom view thereof.

公开(公告)号：US11718870B2

公开(公告)日：2023-08-08

申请号：US16445635

申请日：2019-06-19

申请人： Roche Sequencing Solutions, Inc.

发明人： Yann Astier ,  Juraj Topolancik ,  Hannes Kuchelmeister ,  Frank Bergmann ,  Dieter Heindl ,  Nikolaus Klaus-Peter Stengele

IPC分类号： C12Q1/6869 ,  C12Q1/6876 ,  G01N15/10

CPC分类号： C12Q1/6869 ,  C12Q1/6876 ,  G01N15/1031 ,  G01N15/1056 ,  C12Q2525/117 ,  C12Q2535/122 ,  C12Q2563/113 ,  C12Q2563/116 ,  C12Q2563/155 ,  C12Q2565/607

摘要： Molecules may be analyzed (e.g., sequencing of nucleic acid molecules) by tunneling recognition at a tunneling junction. Embodiments of the present invention may allow detecting individual nucleotides and the sequencing of a nucleic acid molecule using a tunneling junction. By labeling a specific nucleotide with a moiety, tunneling junctions may generate a signal with a suitable signal-to-noise ratio. The tunneling recognition uses a tunneling current that is mostly through the moiety rather than mostly through the nucleotide or a portion of the molecule of interest. Because a single nucleotide can be detected with a signal with a suitable signal-to-noise ratio resulting from the tunneling current passing through the moiety, embodiments of the present invention may allow for fast detection of nucleotides using a tunneling current.