公开(公告)号：US12054533B2

公开(公告)日：2024-08-06

申请号：US17858629

申请日：2022-07-06

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Andrew Tustian ,  Ankit Vartak ,  Thomas Daly ,  Erica Pyles ,  Nisha Palackal ,  Shunhai Wang ,  Ning Li

IPC分类号： C07K1/36 ,  A61K38/18 ,  C07K1/113 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  C07K14/71 ,  C07K16/22 ,  C07K16/28 ,  C12N5/00 ,  C12N15/66 ,  C12P21/02 ,  C12P21/06 ,  G01N30/80 ,  G01N30/02

CPC分类号： C07K14/71 ,  A61K38/1866 ,  C07K1/113 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  C07K1/36 ,  C07K16/22 ,  C07K16/283 ,  C12N5/0018 ,  C12N5/0031 ,  C12N15/66 ,  C12P21/02 ,  C12P21/06 ,  G01N30/80 ,  C07K2317/622 ,  C07K2319/30 ,  C07K2319/33 ,  C12N2800/10 ,  G01N2030/027

摘要： The present disclosure pertains to methods for producing aflibercept from a host cell cultured in a chemically defined medium (CDM) including purification of aflibercept, wherein aflibercept following purification includes aflibercept variants that have at least one oxidized amino acid residue selected from the group consisting of tryptophan, histidine and a combination thereof.

公开(公告)号：US12036280B2

公开(公告)日：2024-07-16

申请号：US16690956

申请日：2019-11-21

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Hunter Chen ,  Erica Schlesinger

IPC分类号： A61K39/395 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

CPC分类号： A61K39/39591 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

摘要： The present invention pertains to compositions and methods of making high concentration protein formulations of a therapeutic protein.

公开(公告)号：US12021486B2

公开(公告)日：2024-06-25

申请号：US17480584

申请日：2021-09-21

申请人： Pvilion, Inc.

发明人： Robert Lerner ,  Todd Dalland ,  Colin Touhey

IPC分类号： H02S30/20 ,  H01L31/042 ,  H01L31/048 ,  H02S20/00

CPC分类号： H02S30/20 ,  H01L31/042 ,  H01L31/048 ,  H02S20/00 ,  Y02B10/10 ,  Y02E10/50 ,  Y10T29/49119

摘要： Systems and methods for applying flexible solar panels to flexible underlying membranes are disclosed. The embodiments disclosed herein involve systems and methods for applying flexible photovoltaic modules to flexible underlying membranes, including large and small span and permanent membrane structures.

公开(公告)号：US11899023B2

公开(公告)日：2024-02-13

申请号：US17982178

申请日：2022-11-07

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Yuetian Yan ,  Shunhai Wang

IPC分类号： G01N33/68 ,  G01N1/28 ,  G01N30/72 ,  G01N33/543

CPC分类号： G01N33/6848 ,  G01N1/28 ,  G01N30/7266 ,  G01N33/54366 ,  G01N2560/00

摘要： Methods and system for identification of dimer species using online chromatography and electrospray ionization mass spectrometry are provided. Also provided are methods and system for quantitation of heterodimer species using immunoprecipitation and liquid chromatography-mass spectrometry.

公开(公告)号：US11885811B2

公开(公告)日：2024-01-30

申请号：US17981839

申请日：2022-11-07

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Yuetian Yan ,  Shunhai Wang

IPC分类号： G01N33/00 ,  G01N33/68 ,  G01N30/72 ,  H01J49/00

CPC分类号： G01N33/6848 ,  G01N30/72 ,  H01J49/0036

摘要： The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.

公开(公告)号：US11872126B2

公开(公告)日：2024-01-16

申请号：US17886925

申请日：2022-08-12

申请人： enVVeno Medical Corporation

发明人： Susan I. Montoya ,  Marc Glickman ,  Yury Zhivilo

IPC分类号： A61F2/82 ,  A61F2/24 ,  A61F2/06 ,  A61F2/94 ,  A61F2/88 ,  A61F2/915 ,  A61L31/14 ,  A61L31/02

CPC分类号： A61F2/2418 ,  A61F2/06 ,  A61F2/2475 ,  A61F2/94 ,  A61F2/2427 ,  A61F2002/825 ,  A61F2210/00 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0086 ,  A61F2250/006 ,  A61F2250/0026 ,  A61F2250/0039

摘要： An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

公开(公告)号：US11848637B2

公开(公告)日：2023-12-19

申请号：US17481816

申请日：2021-09-22

申请人： Sunrun Inc.

发明人： Martin John Affentranger, Jr. ,  William Stanley Arbuckle ,  Brian David Peterson ,  Daniel Edward Ryan

IPC分类号： H02S20/23 ,  F24S25/30 ,  H02S30/10 ,  F24S25/00 ,  F16J15/10 ,  F24S25/61 ,  F24S25/60

CPC分类号： H02S20/23 ,  F16J15/104 ,  F24S25/00 ,  F24S25/30 ,  H02S30/10 ,  F24S25/61 ,  F24S2025/015 ,  F24S2025/021 ,  F24S2025/6003 ,  F24S2025/804 ,  Y02B10/10 ,  Y02B10/20 ,  Y02E10/47

摘要： Chemical flashings for track assemblies and mount assemblies employed in solar power installations are disclosed. In some embodiments, a track assembly having a base, a pair of rails, a sealant receiving cavity and a round groove extending into the base from the bottom of the base, and a compressible round seal disposed within the base extending past the bottom is disclosed. In some embodiments, a mount assembly having a vertical structure, a sealant receiving cavity and a round groove extending into the base from the bottom of the base, a compressible round seal disposed within the base extending past the bottom, and an excess sealant cavity is disclosed.

公开(公告)号：US11848548B1

公开(公告)日：2023-12-19

申请号：US18114621

申请日：2023-02-27

申请人： SunRun Inc.

发明人： Martin John Affentranger, Jr. ,  Daniel Edward Ryan

IPC分类号： H02G3/08

CPC分类号： H02G3/081 ,  H02G3/088

摘要： Enclosure assemblies employed in electrical installations, including those employed in solar power installations, which conform to NEMA 3R type rating defined by National Electrical Manufacturers Association (“NEMA”) are disclosed. In some embodiments, a base of a housing of an enclosure assembly having a seal-receiving groove, fastener retainers, fastener walls, a moisture diverter, attachment points; and conductor pass-through apertures is disclosed. In some embodiments, a base of a housing of an enclosure assembly having a forward portion with a forward fastener retainer and forward attachment points; an aft portion of the base having an aft fastener retainer and aft and attachment points, the groove located between the forward and aft portions, a moisture diverter located between the forward and aft portions; and drainage channels encompassing the forward and aft portions is disclosed. In some embodiments, a method for pre-positioning a fastener in a housing of an enclosure assembly is disclosed.

公开(公告)号：US11740092B2

公开(公告)日：2023-08-29

申请号：US17687957

申请日：2022-03-07

申请人： POR HOLDINGS LLC

发明人： Jeffrey Robert Moss ,  Francis W. Rush, III

IPC分类号： G01C21/20 ,  A62B18/08

CPC分类号： G01C21/206 ,  A62B18/08

摘要： An apparatus carried by an individual for aiding in directing the individual to a location of a starting point for a path of travel by the individual includes a sensor for determining the individual's initial orientation at the starting point and subsequent changes of orientations during the travel; a processor coupled to the sensor for assigning one of four orthogonal (Erections to each of the orientations as experienced by the individual; a memory coupled to the processor for saving at least the orthogonal orientation of the initial orientation and the last experienced orientation; and a display for presenting at least the last experienced orientation to permit the individual to subsequently reorient himself in the direct of the original orientation. The apparatus has particular utility for firefighters to assist in orienting themselves with respect to an initial point of reference (POR) when inside a active firefighting location.

公开(公告)号：US11723766B2

公开(公告)日：2023-08-15

申请号：US17183706

申请日：2021-02-24

申请人： enVVeno Medical Corporation

发明人： Susan I. Montoya ,  Marc Glickman ,  Yury Zhivilo

IPC分类号： A61F2/06 ,  A61F2/94 ,  A61F2/88 ,  A61F2/915 ,  A61L31/14 ,  A61L31/02 ,  A61F2/24 ,  A61F2/82

CPC分类号： A61F2/2418 ,  A61F2/06 ,  A61F2/2475 ,  A61F2/94 ,  A61F2/2427 ,  A61F2002/825 ,  A61F2210/00 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0086 ,  A61F2250/006 ,  A61F2250/0026 ,  A61F2250/0039

摘要： An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.