公开(公告)号：US08906959B2

公开(公告)日：2014-12-09

申请号：US14022746

申请日：2013-09-10

申请人： Brandeis University

发明人： Daniel Perlman ,  Kenneth C. Hayes

IPC分类号： A23D7/00 ,  A23D9/00 ,  A01N43/16 ,  A61K31/35 ,  A23K1/16 ,  A23K1/18 ,  C11B7/00

CPC分类号： A23D9/00 ,  A23D7/001 ,  A23D7/003 ,  A23K20/158 ,  A23K50/50 ,  C11B7/0075

摘要： A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (PMF) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° C. and fluid at 35° C., and includes between 15% and 45% by weight linoleic acid. The weight ratio of disaturated triglyceride (DST) molecules to trisaturated triglyceride (TST) molecules is greater than 10:1, and the PMF hardstock fat contains approximately 50% to 95% by weight DST molecules, the majority of which contain either palmitic acid or a combination of palmitic and stearic acids at the sn-1 and sn-3 triglyceride positions and either oleic acid or linoleic acid at the sn-2 molecular position.

公开(公告)号：US08877267B2

公开(公告)日：2014-11-04

申请号：US11579794

申请日：2005-05-10

申请人： Arne Vernon Astrup ,  Inge Tetens ,  Agnete Dal Thomsen

发明人： Arne Vernon Astrup ,  Inge Tetens ,  Agnete Dal Thomsen

IPC分类号： A61K36/55 ,  A61K36/00 ,  A23L2/00 ,  A21D13/02 ,  A21D2/26 ,  A21D2/36 ,  A23L1/10 ,  A21D13/04

CPC分类号： A21D2/266 ,  A21D2/36 ,  A21D13/02 ,  A21D13/04 ,  A23L7/10 ,  A23L7/115 ,  A23V2002/00 ,  A61K36/55 ,  A61K2300/00 ,  A23V2200/332 ,  A23V2200/32 ,  A23V2250/21 ,  A23V2250/5106

摘要： The present invention relates to methods for reducing fat uptake in the gastrointestinal tract of a mammal in order to prevent a positive energy balance, weight gain, overweight and obesity, and to induce a negative energy balance and weight loss in subjects who wish to reduce their body weight. In particular, food and/or beverage ingredients and dietary supplements of the present invention comprises flaxseeds useful for increasing faeca fat excretion from the gastrointestinal tract.

摘要翻译： 本发明涉及用于减少哺乳动物胃肠道中的脂肪吸收的方法，以便防止正能量平衡，体重增加，超重和肥胖，并且在希望减少它们的受试者中诱导负能量平衡和体重减轻 体重。 特别地，本发明的食物和/或饮料成分和膳食补充剂包括可用于增加从胃肠道排出粪便脂肪的亚麻籽。

公开(公告)号：US08841239B2

公开(公告)日：2014-09-23

申请号：US12743441

申请日：2008-11-21

申请人： Ahmed A. Busnaina ,  Joey L. Mead ,  Carol M. F. Barry ,  Ming Wei

发明人： Ahmed A. Busnaina ,  Joey L. Mead ,  Carol M. F. Barry ,  Ming Wei

IPC分类号： G03F7/00 ,  G03F7/004 ,  C40B60/12 ,  B82Y40/00 ,  B05D1/18 ,  B82Y10/00 ,  C40B40/02 ,  C40B40/06 ,  C40B40/10 ,  G01N35/00 ,  B05D3/14 ,  G01N33/00

CPC分类号： C40B30/00 ,  B05D1/185 ,  B05D3/141 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N2033/0096 ,  G01N2035/00158 ,  G03F7/00 ,  G03F7/0002 ,  G03F7/004 ,  Y10S977/888 ,  Y10T428/2462

摘要： Nanoscale patterns prepared by lithography are used to direct the self-assembly of amphiphilic molecules to form patterned nanosubstrates having a desired distribution of chemical functional moieties. These patterns can be fabricated over a large area and require no special limitations on the chemistry the assembled amphiphiles. Hydrophilic/hydrophobic patterns can be created and used to direct the deposition of a single functional component to specific regions of the surface or to selectively assemble polymer blends to desired sites in a one step fashion with high specificity and selectivity. The selective deposition of functional moieties on a patterned surface can be based on electrostatic forces, hydrogen bonding, or hydrophobic interactions. The methods and patterned nanosubstrates of the invention can be used in the assembly of functional polymer systems, polyelectrolytes, biomolecules, conducting polymers, colloids and nanoparticles, and find wide technological applications in biosensors, biochips, photonics and electronics.

摘要翻译： 通过光刻制备的纳米尺度图案用于引导两亲分子的自组装以形成具有期望的化学功能部分分布的图案化的纳米底物。 这些图案可以在大面积上制造，并且对组装的两亲物的化学性质没有特别的限制。 可以产生亲水/疏水图案并用于将单个功能组分沉积到表面的特定区域，或以高特异性和选择性以一步的方式有选择地将聚合物共混物组装到所需位点。 功能部分在图案化表面上的选择性沉积可以基于静电力，氢键或疏水相互作用。 本发明的方法和图案化的纳米基质可用于功能性聚合物体系，聚电解质，生物分子，导电聚合物，胶体和纳米颗粒的组装，并且在生物传感器，生物芯片，光子学和电子学领域广泛应用。

公开(公告)号：US08784673B2

公开(公告)日：2014-07-22

申请号：US12619187

申请日：2009-11-16

申请人： Xugang Xiong ,  Laila Jaberansari ,  Ahmed Busnaina ,  Yung Joon Jung ,  Sivasubramanian Somu ,  Moneesh Upmanyu

发明人： Xugang Xiong ,  Laila Jaberansari ,  Ahmed Busnaina ,  Yung Joon Jung ,  Sivasubramanian Somu ,  Moneesh Upmanyu

IPC分类号： B44C1/22

CPC分类号： H01L51/0012 ,  B82Y10/00 ,  B82Y30/00 ,  H01B1/04 ,  H01B1/24 ,  H01L51/0048

摘要： Methods for fabricating templates for nanoelement assembly and methods for fluid-guided assembly of nanoelements are provided. Templates are fabricated by plasma modification of surface hydrophilicity and production of a network of hydrophobic trenches having a hydrophilic bottom surface. Single-walled carbon nanotubes (SWNT) can be assembled into stable films, ribbons, and wires of nanoscale thickness and nanoscale or microscale width and length. The nanofilm assemblies prepared according to the invention are highly conductive and can be used in the fabrication of a wide variety of microscale and nanoscale electronic devices.

摘要翻译： 提供了用于制造纳米元件组件模板的方法和用于纳米元件的流体引导组装的方法。 模板通过表面亲水性的等离子体改性和具有亲水底表面的疏水沟槽的网络的生产来制造。 单壁碳纳米管（SWNT）可以组装成纳米尺度和纳米尺寸或微米宽度和长度的稳定膜，带和线。 根据本发明制备的纳米薄膜组件是高导电性的，并且可以用于制造各种微尺寸和纳米尺寸的电子器件。

公开(公告)号：US08703188B1

公开(公告)日：2014-04-22

申请号：US13680216

申请日：2012-11-19

申请人： Azanta A/S

发明人： Nilesh Tanhaji Dumbre ,  Mahesh Mohanrao Bhadgale ,  Vardhaman Chandrakant Bafna

IPC分类号： A61K9/20

CPC分类号： A61K31/5377 ,  A61K9/0053 ,  A61K9/28 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a tablet comprising Nimorazole. In particular, the invention concerns a pharmaceutical composition or a tablet comprising Nimorazole or a pharmaceutically acceptable salt, for dispersion in water and administration via a tube to a patient with swallowing difficulties.

摘要翻译： 本发明涉及包含尼莫拉唑的片剂。 特别地，本发明涉及包含尼莫拉唑或其药学上可接受的盐的药物组合物或片剂，用于在水中分散并通过管向吞咽困难的患者施用。

公开(公告)号：US08691088B2

公开(公告)日：2014-04-08

申请号：US11409415

申请日：2006-04-21

申请人： Alexander R. Ivanov ,  Li Zang ,  Barry L. Karger

发明人： Alexander R. Ivanov ,  Li Zang ,  Barry L. Karger

IPC分类号： B01D15/08

CPC分类号： B01J20/28042 ,  B01J20/26 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28014 ,  B01J20/285 ,  B01J2220/58 ,  B01J2220/82 ,  B01J2220/84 ,  G01N30/52 ,  G01N30/6095 ,  G01N2030/528

摘要： A method of preparing an ultra-nanoscale-LC monolithic separation medium for use in capillary columns, or channels in microfabricated devices (microchips), and capillaries prepared by the method are disclosed. The application of moderate positive pressure to both ends of the capillary during the monolith polymerization process permits the preparation of monolithic capillary columns having very low i.d., e.g., 25 μm and smaller, with enhanced mass transfer properties and low back pressures, and excellent column-to-column reproducibility of retention times.

摘要翻译： 公开了一种制备用于毛细管柱或微细加工装置（微芯片）中的通道的超级纳米级LC整体式分离介质的方法和通过该方法制备的毛细管。 在整料聚合过程中，对毛细管两端施加适度的正压使得制备具有非常低的id，例如25μm或更小，具有增强的传质性能和低背压的单片毛细管柱， 保留时间至柱重现性。

公开(公告)号：US08460738B1

公开(公告)日：2013-06-11

申请号：US13464231

申请日：2012-05-04

申请人： Daniel Perlman

发明人： Daniel Perlman

IPC分类号： A23D9/007

CPC分类号： A61K31/575 ,  A23D7/0053 ,  A23D9/007 ,  A23L33/11

摘要： Edible phytosterol-containing compositions include molecular complexes of non-esterified phytosterols (P) and glycerine (G) in the form of liquid crystalline microparticles. Addition of an emulsifier (M) such as a monoglyceride or a modified lecithin, and optionally an ionic surfactant, to the complex facilitates its dispersal in an aqueous medium. A composition containing either the binary PG or ternary PGM molecular complexes can be formulated as a beverage, food product, or nutritional supplement. When administered to a human subject, the complexes sequester cholesterol in the gastrointestinal tract and reduce LDL cholesterol and total plasma cholesterol levels.

摘要翻译： 含食用植物甾醇的组合物包括液晶微粒形式的非酯化植物甾醇（P）和甘油（G）的分子复合物。 向复合物中加入乳化剂（M）如单酸甘油酯或改性卵磷脂和任选的离子表面活性剂有利于其在水性介质中的分散。 含有二元PG或三元PGM分子复合物的组合物可以配制成饮料，食品或营养补充剂。 当施用于人受试者时，复合物螯合胃肠道中的胆固醇并降低LDL胆固醇和总血浆胆固醇水平。

公开(公告)号：US09017505B2

公开(公告)日：2015-04-28

申请号：US13574714

申请日：2011-01-24

申请人： Joseph E. Gallagher

发明人： Joseph E. Gallagher

IPC分类号： B32B7/14 ,  A41D27/24 ,  B29C65/02 ,  B29C65/50 ,  B29C65/72 ,  B29C65/00 ,  A41H43/04 ,  A41D31/00 ,  B29C65/48 ,  B29C65/08 ,  B29C65/10 ,  B29C65/62

CPC分类号： A41D27/245 ,  A41D31/0005 ,  A41H43/04 ,  B29C65/02 ,  B29C65/08 ,  B29C65/10 ,  B29C65/4815 ,  B29C65/4825 ,  B29C65/483 ,  B29C65/5021 ,  B29C65/5035 ,  B29C65/5042 ,  B29C65/62 ,  B29C65/72 ,  B29C66/1142 ,  B29C66/1352 ,  B29C66/43 ,  B29C66/71 ,  B29C66/72343 ,  B29C66/727 ,  B29C66/7292 ,  B29C66/73175 ,  Y10T156/1049 ,  Y10T156/1052 ,  Y10T156/1062 ,  Y10T428/197 ,  Y10T428/2835 ,  B29K2023/10 ,  B29K2075/00 ,  B29K2067/00 ,  B29K2027/18 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2027/12 ,  B29K2033/08 ,  B29K2033/12 ,  B29K2061/00 ,  B29K2069/00 ,  B29K2077/00 ,  B29K2081/06

摘要： A waterproof invisible bather seam is formed between two fabric laminates, an outer shell fabric laminate and an inner lining fabric laminate. The seam includes an invisible seam tape that forms a hydrostatic bather within the seam. The design of the seam allows the formation of an effective hydrostatic barrier along the seams of a soft shell garment, while retaining flexibility, stretch, aesthetic appearance, and reversibility.

摘要翻译： 在两个织物层压板，外壳织物层压板和内衬织物层压板之间形成防水隐形泳衣。 接缝包括在接缝内形成静水浴的隐形缝带。 接缝的设计允许沿着软壳衣服的接缝形成有效的静水屏障，同时保持柔韧性，拉伸性，美观性和可逆性。

公开(公告)号：US08992615B2

公开(公告)日：2015-03-31

申请号：US14050523

申请日：2013-10-10

申请人： Mark Pitkin

发明人： Mark Pitkin

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61B17/15 ,  A61F2/78 ,  A61F2/46 ,  A61B17/72

CPC分类号： A61F2/30 ,  A61B17/15 ,  A61B17/7258 ,  A61F2/28 ,  A61F2/30721 ,  A61F2/30749 ,  A61F2/4644 ,  A61F2/78 ,  A61F2002/30434 ,  A61F2002/30848 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/30899 ,  A61F2002/7887 ,  A61F2220/0041 ,  A61L2430/02

摘要： An in-bone implantable shaft for prosthetic joints or for direct skeletal attachment of external limb prostheses, comprised of a central body fitted in the zone of the bone's medullary cavity conventionally prepared for implantation, and of side elements attached to the central body and fitted in the slots specially made in the bone's walls surrounding said medullary canal; said side elements have spaces between them, arranged to be filled by bone cells to provide a natural and safe osseolocking of the shaft. A method of preparing the bone for implantation of a prosthetic shaft, comprising the steps of: placing a cylindrical guide with slots made in the longitudinal direction of said guide inside said bone's canal which is conventionally prepared for implantation; cutting said bone's walls by progressing a saw along the edges of the slots of said guide; removing the guide; fitting the shaft in the bone's canal, provided that the side elements are fitted to the slots in the bone's walls.

公开(公告)号：US08637465B2

公开(公告)日：2014-01-28

申请号：US13322307

申请日：2009-05-27

申请人： Vladimir Berezin ,  Elisabeth Bock ,  Artur Kochoyan

发明人： Vladimir Berezin ,  Elisabeth Bock ,  Artur Kochoyan

IPC分类号： A61K38/17

CPC分类号： C07K16/42 ,  A61K38/179 ,  C07K2317/70

摘要： The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.

摘要翻译： 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途，其中NCAM和/或FGFRs起着重要作用。