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1.发明申请OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE BINDING, DETECTION, DIFFERENTIATION, ISOLATION AND SEQUENCING OF INFLUENZA A; INFLUENZA B; NOVEL INFLUENZA A/H1N1; AND A NOVEL INFLUENZA A/H1N1 RNA SEQUENCE MUTATION ASSOCIATED WITH OSELTAMIVIR RESISTANCE 失效优化的探针和引物和使用它们的方法用于结合，检测，分化，分离和测序的流感A; 流感B 新流感A / H1N1; 和与OSELTAMIVIR抗性相关的新型流感A / H1N1 RNA序列突变公开(公告)号：US20110250583A1
公开(公告)日：2011-10-13
申请号：US12887193
申请日：2010-09-21
申请人： James R. Hully , David L. Dolinger , Alice A. Jacobs , Damien Slater , Heather L.B. Kiefer , Chesley Leslin , Juan Manuel Anzola
发明人： James R. Hully , David L. Dolinger , Alice A. Jacobs , Damien Slater , Heather L.B. Kiefer , Chesley Leslin , Juan Manuel Anzola
CPC分类号： C12Q1/701
摘要： Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B, 2009 influenza A/H1N1, and a 2009 influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance.
摘要翻译： 本文描述了可用于结合，检测，分化，分离和测序甲型流感，乙型流感，2009年流感A / H1N1和与奥司他韦耐药相关的2009流感A / H1N1 RNA序列突变的引物和探针。
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2.发明申请OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION, SCREENING, ISOLATION AND SEQUENCING OF VANCOMYCIN RESISTANCE GENES AND VANCOMYCIN RESISTANT ENTEROCOCCI 审中-公开优化的探针和引物以及使用它们进行检测，筛选，分离和测序的抗血清型基因和抗生素耐药基因的方法公开(公告)号：US20110200995A1
公开(公告)日：2011-08-18
申请号：US12875849
申请日：2010-09-03
CPC分类号： C12Q1/689 , C12Q1/6806 , C12Q2600/16
摘要： Described herein are primers and probes useful for detecting, screening, isolating, and sequencing of the vancomycin resistance genes and vancomycin resistant Enterococci and methods of using the described primers and probes.
摘要翻译： 本文描述了可用于万古霉素抗性基因和耐万古霉素肠球菌的检测，筛选，分离和测序的引物和探针以及使用所述引物和探针的方法。
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3.发明授权Clinically intelligent diagnostic methods utilizing micromixers disposed in wells 有权临床智能诊断方法利用微孔混合器置于井中公开(公告)号：US08883417B2
公开(公告)日：2014-11-11
申请号：US13181903
申请日：2011-07-13
申请人： Alice A. Jacobs , Boris Nikolic , Vineet Gupta
发明人： Alice A. Jacobs , Boris Nikolic , Vineet Gupta
IPC分类号： C12Q1/68 , G01N33/53 , B01F13/00 , B01F13/08 , B01J19/00 , B01L3/00 , B82Y30/00 , G01N33/543 , G01N33/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
摘要翻译： 本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。 在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。 基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。
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4.发明授权Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza A; influenza B; novel influenza A/H1N1; and a novel influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance 失效优化的探针和引物及其使用方法用于甲型流感的结合，检测，分化，分离和测序; 乙型流感; 新型流感A / H1N1; 和与奥司他韦抗性相关的新型流感A / H1N1 RNA序列突变公开(公告)号：US08758996B2
公开(公告)日：2014-06-24
申请号：US12887193
申请日：2010-09-21
申请人： James R. Hully , David L. Dolinger , Alice A. Jacobs , Damien Slater , Heather L. B. Kiefer , Chesley Leslin , Juan Manuel Anzola
发明人： James R. Hully , David L. Dolinger , Alice A. Jacobs , Damien Slater , Heather L. B. Kiefer , Chesley Leslin , Juan Manuel Anzola
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B, 2009 influenza A/H1N1, and a 2009 influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance.
摘要翻译： 本文描述了可用于结合，检测，分化，分离和测序甲型流感，乙型流感，2009年流感A / H1N1和与奥司他韦耐药相关的2009流感A / H1N1 RNA序列突变的引物和探针。
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5.发明申请OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE BINDING, DETECTION, DIFFERENTIATION, ISOLATION AND SEQUENCING OF INFLUENZA A; INFLUENZA B AND RESPIRATORY SYNCYTIAL VIRUS 审中-公开优化的探针和引物和使用它们的方法用于结合，检测，分化，分离和测序的流感A; 流感病毒B和呼吸道感染病毒公开(公告)号：US20130059748A1
公开(公告)日：2013-03-07
申请号：US13542091
申请日：2012-07-05
申请人： James R. Hully , Alice A. Jacobs , Damien Slater , Heather Kiefer , Chesley Leslin , Juan Anzola
发明人： James R. Hully , Alice A. Jacobs , Damien Slater , Heather Kiefer , Chesley Leslin , Juan Anzola
CPC分类号： C12Q1/701 , C12Q1/6813 , C12Q1/686
摘要： Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B and RSV viruses.
摘要翻译： 本文描述的是用于结合，检测，分化，分离和测序甲型流感，乙型和丙型流感病毒的引物和探针。
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6.发明申请OPTIMIZED PPROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION, SCREENING, ISOLATING AND SEQUENCING OF MRSA, MSSA STAPHYLOCOCCUS MARKERS, AND THE ANTIBIOTIC RESISTANCE GENE MEC A 审中-公开优化的PPROBES和PRIMERS及其使用方法用于检测，筛选，分离和测序MRSA，MSSA STAPHYLOCOCCUS标记和抗生素耐药基因MEC A公开(公告)号：US20110306510A1
公开(公告)日：2011-12-15
申请号：US12875663
申请日：2010-09-03
申请人： Heinz R. Reiske , Chunyang Zheng , David L. Dolinger , Alice A. Jacobs , Philip T. Moen , Chesley Leslin , Juan Manuel Anzola , James R. Hully
发明人： Heinz R. Reiske , Chunyang Zheng , David L. Dolinger , Alice A. Jacobs , Philip T. Moen , Chesley Leslin , Juan Manuel Anzola , James R. Hully
CPC分类号： C07H21/00 , C07H21/04 , C12Q1/689 , C12Q2600/16 , C12Q2600/166 , Y10T436/143333
摘要： Described herein are primers and probes useful for the detection, screening, isolation and sequencing of MRSA, MSSA, Staphylococci markers, and the antibiotic resistance gene mecA.
摘要翻译： 本文描述了可用于MRSA，MSSA，葡萄球菌标记和抗生素抗性基因mecA的检测，筛选，分离和测序的引物和探针。
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7.发明申请OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE SCREENING, DETECTION, ISOLATION, QUANTITATION, MONITORING AND SEQUENCING OF PROSTATE CANCER ASSOCIATED VIRUSES AND HOST BIOMARKERS 审中-公开优化的寡核苷酸和使用相同方法筛选，检测，分离，定量，监测和测序相关癌症病毒和宿主生物标志物公开(公告)号：US20110256537A1
公开(公告)日：2011-10-20
申请号：US13085303
申请日：2011-04-12
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/158 , C12Q2600/16
摘要： Described herein are oligonucleotides useful for screening, detecting, isolating, quantitating, monitoring and sequencing of viruses and host biomarkers associated with prostate cancer and methods and kits of using the described oligonucleotides.
摘要翻译： 本文描述了可用于筛选，检测，分离，定量，监测和测序与前列腺癌相关的病毒和宿主生物标志物的寡核苷酸，以及使用所述寡核苷酸的方法和试剂盒。
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8.发明申请OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE DETECTION, ISOLATION, AMPLIFICATION, QUANTIFICATION, MONITORING, SCREENING AND SEQUENCING OF CLOSTRIDIUM DIFFICILE GENES ENCODING TOXIN B, AND/OR TOXIN A AND/OR BINARY TOXIN 审中-公开优化的寡核苷酸和使用它们的方法用于检测，分离，扩增，定量，监测，筛选和测序编码毒素B和/或毒素A和/或二次毒素的杀虫剂基因公开(公告)号：US20110256535A1
公开(公告)日：2011-10-20
申请号：US13024896
申请日：2011-02-10
申请人： David L. DOLINGER , James R. HULLY , Alice A. JACOBS , Chesley LESLIN , Heinz R. REISKE , Chunyang ZHENG
发明人： David L. DOLINGER , James R. HULLY , Alice A. JACOBS , Chesley LESLIN , Heinz R. REISKE , Chunyang ZHENG
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Described herein are oligonucleotides useful for detecting, isolating, amplifying, quantitating, monitoring, screening and sequencing the C. Difficile genes encoding toxin B, and/or toxin A, and/or binary toxin, and methods of using the described oligonucleotides.
摘要翻译： 本文描述的是可用于检测，分离，扩增，定量，监测，筛选和测序C.编码毒素B和/或毒素A和/或二元毒素的复合基因的寡核苷酸，以及使用所述寡核苷酸的方法。
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9.发明申请OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE DETECTION, ISOLATION, QUANTIFICATION, MONITORING AND SEQUENCING OF BORDETELLA 审中-公开优化的寡核苷酸及其使用方法进行BORDETELLA的检测，分离，定量，监测和测序公开(公告)号：US20100330573A1
公开(公告)日：2010-12-30
申请号：US12823692
申请日：2010-06-25
申请人： Earl T. Larson , Alice A. Jacobs , James R. Hully , David L. Dolinger , Juan Manuel Anzola , Chesley M. Leslin , Pamela Shaw
发明人： Earl T. Larson , Alice A. Jacobs , James R. Hully , David L. Dolinger , Juan Manuel Anzola , Chesley M. Leslin , Pamela Shaw
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Described herein are oligonucleotides useful for detecting, isolating, quantitating, monitoring and sequencing B. pertussis, B. parapertussis and/or the genus Bordetella, and methods of using the described oligonucleotides.
摘要翻译： 本文描述了可用于检测，分离，定量，监测和测序百日咳杆菌，副百日咳杆菌和/或博德特氏菌属的寡核苷酸，以及使用所述寡核苷酸的方法。
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公开(公告)号：US20100173797A1
公开(公告)日：2010-07-08
申请号：US12614895
申请日：2009-11-09
申请人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
发明人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
IPC分类号： C40B30/04
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
摘要翻译： 本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。 在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。 基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。
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