利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.016 秒)

    Transgenic luciferase mouse
    4.
    发明授权
    Transgenic luciferase mouse 有权
    转基因荧光素酶小鼠

    公开(公告)号：US07041869B2

    公开(公告)日：2006-05-09

    申请号：US10679231

    申请日：2003-10-03

    申请人： Eric Charles Holland

    发明人： Eric Charles Holland

    IPC分类号： A01K67/00

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0393 ,  C12N15/8509 ,  C12N2830/007

    摘要： The present invention provides a transgenic animal expressing the reporter gene, luciferase, driven by a promoter (e.g. the E2F1 promoter) that acts as a sensor of cell cycle. The luciferase substrate, luciferin, emits light when metabolized, and the light is transmitted through mammalian tissues. Therefore, the transgenic animal model of the present invention allows for monitoring of areas of major cell cycle activity, a characteristic of cancer cells, under adequate visualization conditions. These transgenic animals are useful as in vivo models for testing preventative measures for cancer as well as for testing novel therapeutic modalities.

    摘要翻译： 本发明提供了表达报告基因的转基因动物，荧光素酶由作为细胞周期传感器的启动子（例如E2F1启动子）驱动。 荧光素酶底物荧光素在代谢时发光，光通过哺乳动物组织传播。 因此，本发明的转基因动物模型允许在适当的可视化条件下监测主要细胞周期活性的区域，癌细胞的特征。 这些转基因动物可用作测试癌症预防措施以及测试新型治疗方式的体内模型。

    Low voltage seismic sound source
    5.
    发明授权
    Low voltage seismic sound source 失效
    低压地震声源

    公开(公告)号：US06771565B2

    公开(公告)日：2004-08-03

    申请号：US10087374

    申请日：2002-03-01

    申请人： John Murray Jopling ,  Paul Dominic Forster ,  David Charles Holland ,  Richard Elliot Hale

    发明人： John Murray Jopling ,  Paul Dominic Forster ,  David Charles Holland ,  Richard Elliot Hale

    IPC分类号： H04R100

    CPC分类号： G01V1/157

    摘要： A boomer for generating acoustic signals in a marine seismic survey has a frame towed by a survey vessel. A coil is mounted to the frame and a conductive plate is adjacent to the coil. A capacitor is mounted to the frame, and control electronics system delivers an electric charge stored in the capacitor to the coil. The invention obviates the need for heavy conductive cables between the survey vessel and the boomer in conventional systems where the capacitors are carried by the vessel, while maintaining the desirable acoustic properties of the boomer.

    摘要翻译： 用于在海洋地震勘测中产生声学信号的生物体具有由测量船拖动的框架。 线圈安装在框架上，导电板与线圈相邻。 电容器被安装到框架上，并且控制电子系统将存储在电容器中的电荷传送到线圈。 本发明避免了在传统系统中的测量容器和起泡器之间需要重导电电缆，其中电容器由容器承载，同时保持了预期的声波特性。

    Reaction speed timing and training system for athletes
    6.
    发明授权
    Reaction speed timing and training system for athletes 失效
    运动员反应速度时间和训练系统

    公开(公告)号：US5901961A

    公开(公告)日：1999-05-11

    申请号：US740736

    申请日：1996-11-04

    申请人： Don Charles Holland, III

    发明人： Don Charles Holland, III

    IPC分类号： A63B69/00 ,  G07C1/22

    CPC分类号： A63B69/0053 ,  G07C1/22

    摘要： A system and particular components are disclosed to measure the reaction time of a user from a signal to start an athletic activity to the start of that activity and the completion time from the start to the finish of that activity. A remote control device responsive to manual input initiates a start signal and a signal to direct that activity toward one or more sensor pads to a user and to a data processor. One or more floor pads sense the presence of the user and signal the user's non-presence to the data processor. One or more sensor pads positioned spacedly distant from the floor pads sense manual contact by the user and signal that event to the data processor. The data processor determines the reaction time and the completion time of an activity from the times of the received signals, annunciates these times in visually cognizable form and stores the data. The sensor pads are compound in nature and provide structure that requires a particular type of contact or contact force above an adjustable predetermined threshold amount to signal completion time.

    摘要翻译： 公开了一种系统和特定组件来测量用户从开始运动活动的信号到该活动的开始的反应时间以及从该活动的开始到完成的完成时间。 响应于手动输入的遥控装置启动起始信号和信号，以将该活动引向用户和数据处理器的一个或多个传感器垫。 一个或多个底板感测用户的存在并且向用户指示数据处理器的不存在。 与地板垫间隔开距离地定位的一个或多个传感器垫感测到用户的手动接触并将该信号发送给数据处理器。 数据处理器从接收到的信号的时间确定活动的反应时间和完成时间，以视觉上可认可的形式告知这些时间并存储数据。 传感器焊盘本质上是复合的，并且提供了要求特定类型的接触或接触力高于可调节的预定阈值量以使信号完成时间的结构。