公开(公告)号：US12276660B2

公开(公告)日：2025-04-15

申请号：US17975537

申请日：2022-10-27

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding

IPC: G01N1/00 ,  B01L3/00 ,  G01N1/28 ,  G01N1/30 ,  G01N33/50 ,  G01N33/543 ,  G16B25/00 ,  G16B50/00 ,  G16H80/00

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g., 0.5 μL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

公开(公告)号：US12276584B2

公开(公告)日：2025-04-15

申请号：US18142008

申请日：2023-05-01

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi

IPC: G01N1/28 ,  G01N1/31 ,  G01N33/49 ,  G02B17/00 ,  G06V10/143 ,  G06V20/69 ,  G01N15/01

Abstract: Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.

公开(公告)号：US12265019B2

公开(公告)日：2025-04-01

申请号：US17268677

申请日：2019-08-16

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian

IPC: G01N21/31 ,  G01N21/01 ,  G02B21/00 ,  G02B21/06 ,  G02B21/18 ,  H04N23/56 ,  H04N23/57 ,  H04M1/02

Abstract: Disclosed is an optical system for interrogating a sample, an optical system for measuring the spectrum of a beam of light, an optical system for measuring the spectrum of two beams of light, a compact imaging-based sensor or sensors, and combinations thereof.

公开(公告)号：US20240377389A1

公开(公告)日：2024-11-14

申请号：US18416792

申请日：2024-01-18

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji LI ,  Yufan Zhang

IPC: G01N33/543 ,  B01L3/00 ,  G01N21/29 ,  G01N33/50

Abstract: Among other things, the present invention is related to bio/chemical sampling, sensing, assays and applications.

公开(公告)号：US20240309369A1

公开(公告)日：2024-09-19

申请号：US18388193

申请日：2023-11-09

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji QI ,  Jun Tian ,  Wu Chou

IPC: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/54 ,  A61P31/04

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/554 ,  A61P31/04 ,  C12N15/1137 ,  C12N2310/127 ,  C12N2310/3515 ,  C12Y305/02006

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US12064771B2

公开(公告)日：2024-08-20

申请号：US16616680

申请日：2018-05-23

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Hua Tan

IPC: B01L3/00 ,  B01L7/00

CPC classification number: B01L7/52 ,  B01L3/5088 ,  B01L2300/1811 ,  B01L2300/1822 ,  B01L2300/1827

Abstract: The disclosure provides a device and method for rapidly changing temperatures of a sample. An example of the device include: a first plate; a second plate; and a heating/cooling layer disposed on either the first or second plate. The first plate and the second plate face each other and are configured to receive a fluid sample sandwiched therebetween. The method includes depositing the fluid sample on one or both of the two plates, pressing the plates to form a thin layer of the sample, and changing and/or maintaining the temperature of the sample. The device or method can be used in, for example, PCR.

公开(公告)号：US20240192137A1

公开(公告)日：2024-06-13

申请号：US18584021

申请日：2024-02-22

Applicant: Essenlix Corporation

Inventor： Ji Qi ,  Stephen Y. Chou ,  Wei Ding

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6458 ,  G01N2021/6439 ,  G01N2201/021 ,  G01N2201/0634 ,  G01N2201/0636

Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.

公开(公告)号：US11933720B2

公开(公告)日：2024-03-19

申请号：US17621216

申请日：2020-06-22

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou ,  Hongbing Li

IPC: G01N21/31 ,  G01N21/03

CPC classification number: G01N21/31 ,  G01N21/03 ,  G01N2021/0346 ,  G01N2021/3129

Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.

公开(公告)号：US11927560B2

公开(公告)日：2024-03-12

申请号：US16484256

申请日：2018-02-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang

IPC: G01N27/403 ,  B01L3/00 ,  G01N1/28 ,  G01N1/38 ,  G01N21/84 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N27/403 ,  B01L3/502761 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/38 ,  G01N21/8483 ,  G01N33/4905 ,  G01N33/5438 ,  G01N35/00 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415

Abstract: Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.

公开(公告)号：US20230408534A1

公开(公告)日：2023-12-21

申请号：US18030980

申请日：2021-10-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Wu CHOU ,  Xing LI ,  Mingquan WU

IPC: G01N35/00 ,  G06T7/00

CPC classification number: G01N35/00613 ,  G01N35/00029 ,  G06T2207/20081 ,  G01N2035/00148 ,  G06T2207/30024 ,  G06T7/0012

Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments, the errors are random. One aspect of the present invention is to overcome the random errors or imperfections of an assay device or the operation of the assay device by measuring, in addition to measuring the analyte in a sample to generate an analyte test result, the trustworthiness of the analyte test result. The analyte test result will be reported, only when the trustworthiness meets a predetermined threshold, otherwise the analyte test result will be discarded. Various of parameter variation have been used for test trustworthy determination.