公开(公告)号：US20240041699A1

公开(公告)日：2024-02-08

申请号：US18491072

申请日：2023-10-20

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Peter Lund Hammershøj

IPC分类号： A61J1/20 ,  A61M5/20 ,  A61B17/00 ,  A61M5/24 ,  A61M5/19 ,  A61M5/178 ,  A61M5/162 ,  A61M35/00 ,  A61J1/06

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2048 ,  A61J1/2082 ,  A61J1/2089 ,  A61M5/2046 ,  A61J1/2017 ,  A61B17/00491 ,  A61M5/2448 ,  A61M5/19 ,  A61M5/1782 ,  A61M5/2425 ,  A61M5/162 ,  A61M35/003 ,  A61M5/2053 ,  A61J1/06 ,  A61M2039/0027

摘要： A device for reconstituting a bioactive agent and forming a flowable paste is described. The device comprises a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.

公开(公告)号：US11801324B2

公开(公告)日：2023-10-31

申请号：US16407503

申请日：2019-05-09

申请人： Ferrosan Medical Devices A/S ,  Ethicon Inc.

发明人： Peter Lund Hammershøj ,  Kristian Larsen ,  Douglas B. Johns ,  Nicole Smith ,  Michael Cardinale ,  Gabriella Ferrara ,  Guanghui Zhang

IPC分类号： A61L24/04 ,  A61B17/12 ,  A61L24/00 ,  A61B17/00

CPC分类号： A61L24/043 ,  A61B17/12186 ,  A61L24/0042 ,  A61B2017/00495 ,  A61L2400/04 ,  A61L2400/06

摘要： The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.

公开(公告)号：US20170311939A1

公开(公告)日：2017-11-02

申请号：US15639237

申请日：2017-06-30

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Michael Wrang Mortensen

IPC分类号： A61B17/00 ,  A61L26/00 ,  A61M5/19 ,  A61M5/28 ,  A61M5/31 ,  A61M5/24 ,  A61M39/22

摘要： The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.

公开(公告)号：US20160120527A1

公开(公告)日：2016-05-05

申请号：US14895674

申请日：2014-06-20

申请人： FERROSAN MEDICAL DEVICES A/S

发明人： Kristian Larsen ,  Michael Wrang Mortensen

IPC分类号： A61B17/00 ,  A61L26/00 ,  A61M39/22 ,  A61M5/28 ,  A61M5/24

CPC分类号： A61B17/00491 ,  A61L26/0038 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  A61M5/19 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/3135 ,  A61M39/22 ,  A61M2005/3123 ,  A61M2005/3132 ,  C08L89/06

摘要： The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.

摘要翻译： 本公开内容涉及一种在冷冻干燥所述糊料之前对糊料进行真空膨胀的方法，以实现干糊剂组合物，其在添加水性介质时有效地重构以形成可流动的糊剂。 本公开还涉及一种用于在真空中保持干糊剂组合物的注射器。

公开(公告)号：US20240277326A1

公开(公告)日：2024-08-22

申请号：US18568044

申请日：2022-07-14

申请人： Ferrosan Medical Devices A/S

发明人： Peter Lund Hammershøj ,  Henning Uzoma Igwebuike ,  Lisbeth Nøhr Demant ,  Christian Brüel ,  Mikael Engmark ,  Vikram Kjøller Bhatia ,  Lars Tamstrup Axelsson ,  Simon Batchelor

IPC分类号： A61B17/00 ,  A61B34/30

CPC分类号： A61B17/00491 ,  A61B17/00234 ,  A61B34/30 ,  A61B2017/00876 ,  A61B2017/00946 ,  A61B2034/301 ,  A61B2034/305

摘要： The present disclosure relates to a laparoscopic applicator for dispensing a substance, e.g. a substance comprising a haemostatic agent, at a selected site by means of a surgical robotic arm, the laparoscopic applicator comprising a delivery tube; and an applicator tip connected to a distal end of the delivery tube, wherein the applicator tip is configured for being controllable operated by the robotic arm by a grip section in axial extension of the delivery tube, the grip section having a perimeter transverse to the axis comprising an apex shaped section, such that the grip section is configured for being clamped and spatially manipulated by the robotic arm.

公开(公告)号：US20210219969A1

公开(公告)日：2021-07-22

申请号：US17056595

申请日：2019-06-26

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Peter Lund Hammershøj

IPC分类号： A61B17/00 ,  A61J1/20

摘要： The invention regards a device for reconstituting a bioactive agent and forming a paste, the device comprising: —a container (2) containing the bioactive agent, —a first syringe (4) containing a liquid, —a second syringe (5) containing a paste forming material, —a connector element (6) configured for establishing sequential fluid connections between 1) the first syringe and the container, 2) the container and the second syringe, and 3) the first and second syringes, such that the liquid can be transferred from the first syringe to the container to reconstitute the bioactive agent, whereupon the reconstituted bioactive agent can be transferred from the container into the second syringe to form a paste, and the paste can be transferred to the first syringe.

公开(公告)号：US20180147355A1

公开(公告)日：2018-05-31

申请号：US15580181

申请日：2016-06-30

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Lise Sjørup Elle ,  Thomas Ingemann Jensen

IPC分类号： A61M5/20 ,  A61M5/315 ,  A61M5/24

CPC分类号： A61M5/2066 ,  A61M5/2448 ,  A61M5/2459 ,  A61M5/284 ,  A61M5/31596 ,  A61M2005/2086 ,  A61M2005/31598

摘要： The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition. In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.

公开(公告)号：US09724078B2

公开(公告)日：2017-08-08

申请号：US14895674

申请日：2014-06-20

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Michael Wrang Mortensen

IPC分类号： A61B17/00 ,  A61L26/00 ,  A61M39/22 ,  A61M5/28 ,  A61M5/24 ,  A61M5/31 ,  A61M5/19

CPC分类号： A61B17/00491 ,  A61L26/0038 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  A61M5/19 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/3135 ,  A61M39/22 ,  A61M2005/3123 ,  A61M2005/3132 ,  C08L89/06

摘要： The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.

公开(公告)号：US20150037314A1

公开(公告)日：2015-02-05

申请号：US14516728

申请日：2014-10-17

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen

IPC分类号： A61L24/10 ,  A61L2/04 ,  B65B1/04 ,  A61L2/20 ,  A61L2/10 ,  A61L24/00 ,  A61L2/08

CPC分类号： A61L26/0047 ,  A61K9/1658 ,  A61K31/047 ,  A61K31/70 ,  A61K38/014 ,  A61L2/04 ,  A61L2/07 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  A61L2/10 ,  A61L2/202 ,  A61L2/204 ,  A61L2/206 ,  A61L2/208 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/104 ,  A61L26/00 ,  A61L26/0038 ,  A61L26/0066 ,  A61L2300/254 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2400/06 ,  B65B1/04 ,  B65D81/32

摘要： Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.

摘要翻译： 公开了一种干组合物，其在添加水性介质时形成适用于止血程序的基本均匀的糊剂。 糊剂在加入液体后自发形成，因此不需要机械混合来形成所述糊料。 进一步公开的是制备所述干组合物的方法，由所述干组合物制成的糊剂和所述糊剂用于医疗和外科用途的方法。

公开(公告)号：US12059139B2

公开(公告)日：2024-08-13

申请号：US17056595

申请日：2019-06-26

申请人： Ferrosan Medical Devices A/S

发明人： Kristian Larsen ,  Peter Lund Hammershøj

IPC分类号： A61B17/00 ,  A61J1/20

CPC分类号： A61B17/00491 ,  A61J1/2037 ,  A61J1/2055 ,  A61J1/2062 ,  A61J1/2089 ,  A61J1/2096 ,  A61B2017/00495

摘要： The invention regards a device for reconstituting a bioactive agent and forming a paste, the device comprising:—a container (2) containing the bioactive agent,—a first syringe (4) containing a liquid,—a second syringe (5) containing a paste forming material,—a connector element (6) configured for establishing sequential fluid connections between 1) the first syringe and the container, 2) the container and the second syringe, and 3) the first and second syringes, such that the liquid can be transferred from the first syringe to the container to reconstitute the bioactive agent, whereupon the reconstituted bioactive agent can be transferred from the container into the second syringe to form a paste, and the paste can be transferred to the first syringe.