利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

31 条记录 (耗时 0.021 秒)

    Irreversible colloidal chanis with recognition sites
    4.
    发明申请
    Irreversible colloidal chanis with recognition sites 审中-公开
    具有识别位点的不可逆胶体chanis

    公开(公告)号：US20050158723A1

    公开(公告)日：2005-07-21

    申请号：US10504776

    申请日：2003-02-19

    申请人： Jean-Louis Viovy ,  Jerome Bibette ,  Cecile Goubault ,  Marie Dutreix

    发明人： Jean-Louis Viovy ,  Jerome Bibette ,  Cecile Goubault ,  Marie Dutreix

    IPC分类号： B01J20/283 ,  G01N27/447 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/552 ,  G01N33/566 ,  C12Q1/68 ,  G01N33/551

    CPC分类号： G01N33/5434

    摘要： A collection of colloidal particles in the form of one or several chains, in which the chains are generated in an irreversible manner and have at least one recognition site for a species, the site being different from sites implicated in the linear organisation of the particles. The invention further relates to a method for production of the collection, particularly for detection and/or dosage of at least one species in a fluid and a surface element functionalised by a collection of colloidal chains and a hybridisation network including such a surface element.

    摘要翻译： 一种或多种链形式的胶体颗粒的集合，其中链以不可逆的方式产生并且具有至少一个物种的识别位点，该位点不同于涉及颗粒的线性组织的位点。 本发明进一步涉及一种用于生产该收集物的方法，特别是用于通过胶体链的收集功能化的流体和表面元件中的至少一种物质的检测和/或剂量以及包括这种表面元素的杂交网络。

    Integrated microfluidic element
    5.
    发明授权
    Integrated microfluidic element 失效
    集成微流体元件

    公开(公告)号：US06322753B1

    公开(公告)日：2001-11-27

    申请号：US09308563

    申请日：1999-06-23

    申请人： Peter Lindberg ,  Johan Roeraade ,  Mårten Stjernström ,  Jean Louis Viovy

    发明人： Peter Lindberg ,  Johan Roeraade ,  Mårten Stjernström ,  Jean Louis Viovy

    IPC分类号： B01L300

    CPC分类号： B01L3/502707 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  G01N30/6095 ,  Y10T156/10

    摘要： An integrated microfluidic element (1) composed of two juxtaposed plates (3, 5) bonded together, wherein at least one plate (3) has an etched structure or pattern of channels (7) on the surface facing the other plate (1) to form sealed micro channels (7), said element having micro spacers or posts (11) distributed over the etched surface of said one plate outside of said etched structure or pattern, and walls (9) surrounding said channels (7), said walls (9) having a height equal to that of said spacers or posts (11); and a method for the manufacture of such integrated microfluidic element.

    摘要翻译： 由两个并置的板（3,5）组成的集成的微流体元件（1），其结合在一起，其中至少一个板（3）在面向另一个板（1）的表面上具有蚀刻的通道（7）的结构或图案， 形成密封的微通道（7），所述元件具有分布在所述蚀刻结构或图案外部的所述一个板的蚀刻表面上的微间隔物或柱（11），以及围绕所述通道（7），所述壁 9）具有与所述间隔件或柱（11）的高度相等的高度; 以及用于制造这种集成微流体元件的方法。

    Methods and Compositions for Assaying Mutations in Nucleic Acids and Their Uses in Diagnosis of Genetic Diseases and Cancers
    7.
    发明申请
    Methods and Compositions for Assaying Mutations in Nucleic Acids and Their Uses in Diagnosis of Genetic Diseases and Cancers 审中-公开
    用于测定核酸中突变的方法和组合及其在遗传疾病和癌症诊断中的应用

    公开(公告)号：US20070281297A1

    公开(公告)日：2007-12-06

    申请号：US10582868

    申请日：2004-12-16

    申请人： Jean-Louis Viovy ,  Jeremie Weber ,  Dominique Stoppa-Lyonnet

    发明人： Jean-Louis Viovy ,  Jeremie Weber ,  Dominique Stoppa-Lyonnet

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/00

    CPC分类号： C12Q1/6827 ,  Y10T436/143333 ,  C12Q2527/137 ,  C12Q2537/113 ,  C12Q2565/125 ,  C12Q2527/125

    摘要： The present invention relates to a method for assaying the presence or the absence of at least one mutation on a strand of nucleic acid paired in a duplex form comprising at least the steps of contacting said duplex with at least one compound able to undergo a specific base pairing interaction with suspected mismatch and assaying for said mismatch by an analytical method. The invention further relates to the use in the diagnosis of predisposition to genetic diseases and cancers and in the diagnosis and prognosis of said diseases and cancers, like human breast cancer. The invention also relates to compositions including a compound able to undergo specific base pairing interaction, in association with a DNA fragment having a nucleic sequence relating to a gene on which point mutation(s) has been associated or putatively associated with a genetic disease or an increased predisposition to said disease.

    摘要翻译： 本发明涉及用于测定双链体配对的核酸链上存在或不存在至少一个突变的方法，该方法至少包括使所述双链体与至少一种能够经受特定碱基的化合物接触的步骤 配对相互作用与疑似错配，并通过分析方法测定所述错配。 本发明还涉及用于诊断遗传疾病和癌症易感性以及所述疾病和癌症如人乳腺癌的诊断和预后的用途。 本发明还涉及包含能够经历特异性碱基配对相互作用的化合物的组合，与具有与其上的点突变已经与遗传疾病相关联或推测相关的基因的核酸序列的DNA片段相关联，或 增加对所述疾病的倾向。

    Methods and compositions for assaying mutations and/or large scale alterations in nucleic acids and their uses in diagnosis of genetic diseases and cancers
    8.
    发明申请
    Methods and compositions for assaying mutations and/or large scale alterations in nucleic acids and their uses in diagnosis of genetic diseases and cancers 审中-公开
    用于测定核酸中的突变和/或大规模改变的方法和组合物及其在诊断遗传疾病和癌症中的用途

    公开(公告)号：US20070161032A1

    公开(公告)日：2007-07-12

    申请号：US11637123

    申请日：2006-12-12

    申请人： Jean-Louis Viovy ,  Claude Houdayer ,  Dominique Stoppa-Lyonnet ,  Jeremie Weber

    发明人： Jean-Louis Viovy ,  Claude Houdayer ,  Dominique Stoppa-Lyonnet ,  Jeremie Weber

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6816 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q2565/125 ,  C12Q2545/101 ,  C12Q2537/113 ,  C12Q2537/143

    摘要： The present invention relates to a method for detecting point mutation(s) and/or large scale alteration(s) relative to at least one nucleic acid fragment said method comprising at least the steps of providing a sample liable to contain said nucleic acid fragment and at least a second nucleic acid fragment acting as a quantitative reference, subjecting said fragments to suitable conditions for obtaining a product containing homoduplexes and possible heteroduplexes, conducting on said product an analytical method suitable for obtaining at least signal(s) discriminating the existing duplex form(s) of the first nucleic acid fragment and relative quantitative data concerning said first nucleic acid fragment The invention further relates to the use of this method in the diagnosis of predisposition to genetic diseases and cancers and in the diagnosis and prognosis of said diseases and cancers, like human breast cancer.

    摘要翻译： 本发明涉及相对于至少一个核酸片段检测点突变和/或大规模改变的方法，所述方法至少包括提供易于含有所述核酸片段的样品和 至少第二核酸片段作为定量参考，使所述片段经受合适的条件以获得含有同源双链体和可能的异源双链体的产物，在所述产物上进行适于获得至少鉴别现有双链体形式的信号的分析方法 第一核酸片段的相关定量数据和关于所述第一核酸片段的相对定量数据本发明还涉及该方法在诊断遗传疾病和癌症易感性以及所述疾病和癌症的诊断和预后中的用途 ，像人乳腺癌。

    Method and device for separating particles or molecules by migration through a ferrofluid
    9.
    发明授权
    Method and device for separating particles or molecules by migration through a ferrofluid 失效
    通过铁磁流体迁移分离颗粒或分子的方法和装置

    公开(公告)号：US06610186B1

    公开(公告)日：2003-08-26

    申请号：US09319078

    申请日：1999-08-30

    申请人： Pascal Mayer ,  Jérôme Bibette ,  Jean-Louis Viovy

    发明人： Pascal Mayer ,  Jérôme Bibette ,  Jean-Louis Viovy

    IPC分类号： G01N27447

    CPC分类号： B03C1/32 ,  B01D57/02 ,  G01N27/44786

    摘要： The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said medium. The method is characterised in that the separating medium is a ferrofluid, i.e. a colloidal suspension of magnetic particles and a magnetic field is applied to this ferrofluid generating therein at least an alternation of a zone rich in magnetic particles and a zone poor in magnetic particles, part at least of the region of the ferrofluid in which this alternation is generated is passed through by the particles or molecules to be separated during their migration.

    摘要翻译： 本发明涉及一种用于分离颗粒或分子的方法，由此将这些颗粒或分子引入分离介质中，并且在所述介质中向其施加移动力。 该方法的特征在于，分离介质是铁磁流体，即磁性颗粒的胶态悬浮液和磁场，其中产生至少一个富含磁性颗粒的区域和磁性颗粒较差区域的铁磁流体， 产生这种交替的铁磁流体区域中的至少一部分是在其迁移期间被待分离的颗粒或分子穿过。

    Devices for separating particles contained in a fluid
    10.
    发明授权
    Devices for separating particles contained in a fluid 失效
    用于分离包含在流体中的颗粒的装置

    公开(公告)号：US5593565A

    公开(公告)日：1997-01-14

    申请号：US310401

    申请日：1994-09-22

    申请人： Armand Ajdari ,  Jacques Lewiner ,  Jacques Prost ,  Jean-Louis Viovy

    发明人： Armand Ajdari ,  Jacques Lewiner ,  Jacques Prost ,  Jean-Louis Viovy

    IPC分类号： B01D17/06 ,  B01D21/00 ,  B03C5/02 ,  B01D57/02

    CPC分类号： B03C5/026 ,  B01D17/06 ,  B01D21/0009

    摘要： In order to separate, within a fluid (1), certain particles (2) contained therein, this fluid is arranged in a corridor (C) partly defined by two faces which are close together and substantially parallel to each other and to the direction of separation E and an exciting field is simultaneously applied to the entire volume of fluid contained in this corridor, according to a direction having at least one component perpendicular to the direction E, which exciting field varies along the said direction in a curve consisting of a regular sequence of mutually identical asymmetric patterns, the mean of this field, taken at each instant along the direction E, being zero, and means are provided for repetitively varying the effect of the exciting field on the particles. The substantially parallel faces may be electrodes between which a potential difference source is connected for producing an electric field thereby exciting particles in the corridor (C). At least one of the electrodes has a corrugated surface with a sequence of asymmetric grooves transverse to the separation direction.

    摘要翻译： 为了在流体（1）内分离其中包含的某些颗粒（2），该流体布置在通过两个面部分限定的走廊（C）中，该两个面彼此靠近并且基本上彼此平行，并且相对于 根据具有至少一个垂直于方向E的分量的方向，分离E和激励场同时施加到包含在该走廊中的整个体积的流体，该方向具有沿着所述方向的至少一个分量，所述曲线由常规 相互相同的不对称图案的顺序，沿着方向E在每个瞬间拍摄的该场的平均值为零，并且提供用于重复地改变激发场对颗粒的影响的装置。 大致平行的面可以是电极之间连接有电位差的电极，用于产生电场，从而激发走廊（C）中的颗粒。 至少一个电极具有波纹表面，其具有横向于分离方向的不对称凹槽的序列。