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公开(公告)号：US20060116756A1
公开(公告)日：2006-06-01
申请号：US11326546
申请日：2006-01-04
申请人： Jan Solem , Per-Ola Kimblad , Randolf Oepen , Bodo Quint , Gerd Seibold , Kenneth Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
发明人： Jan Solem , Per-Ola Kimblad , Randolf Oepen , Bodo Quint , Gerd Seibold , Kenneth Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/07 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2002/826 , A61F2002/828 , A61F2002/8483 , A61F2210/0004
摘要： A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
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公开(公告)号：US20050277983A1
公开(公告)日：2005-12-15
申请号：US10865736
申请日：2004-06-09
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译： 这里描述了用于优化锚固力的系统。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。
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公开(公告)号：US20050137691A1
公开(公告)日：2005-06-23
申请号：US10746942
申请日：2003-12-23
申请人： Amr Salahieh , Dwight Morejohn , Jeff Krolik , Kenneth Michlitsch
发明人： Amr Salahieh , Dwight Morejohn , Jeff Krolik , Kenneth Michlitsch
CPC分类号： A61F2/2418 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2250/006
摘要： Apparatus for endovascularly replacing a patient's heart valve, including: a custom-designed anchor; and a replacement valve, wherein the custom-designed anchor is adapted to engage native leaflets of the heart valve, and wherein the anchor and the valve are adapted for in vivo expansion and coupling to one another to form composite apparatus that endovascularly replaces the heart valve. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: providing apparatus comprising an anchor piece and a replacement valve piece; endovascularly delivering the anchor piece to a vicinity of the heart valve in a collapsed delivery configuration; expanding the anchor piece to a deployed configuration; engaging at least one valve leaflet of the heart valve with the anchor piece; endovascularly delivering the replacement valve piece to the vicinity of the heart valve in a collapsed delivery configuration; expanding the replacement valve piece to a deployed configuration; and coupling the valve piece to the anchor piece in vivo to form composite two-piece apparatus that endovascularly replaces the patient's heart valve.
摘要翻译： 用于血管内替代患者心脏瓣膜的装置，包括：定制设计的锚; 和替换阀，其中所述定制设计的锚适于接合所述心脏瓣膜的天然传单，并且其中所述锚固件和所述阀适于体内膨胀和彼此耦合以形成复合装置，所述复合装置血管内取代所述心脏瓣膜 。 本发明还包括一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：提供包括锚固件和替换阀件的设备; 在塌陷递送构造中将锚固件血管内输送到心脏瓣膜的附近; 将锚固件扩展到部署的配置; 将所述心脏瓣膜的至少一个瓣膜与所述锚固件接合; 在折叠的输送构造中将替换瓣膜血管内输送到心脏瓣膜的附近; 将更换的阀件扩展到部署的配置; 并且在体内将阀片联接到锚固件以形成血管内取代患者心脏瓣膜的复合两件式装置。
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公开(公告)号：US20070213735A1
公开(公告)日：2007-09-13
申请号：US11406486
申请日：2006-04-17
申请人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
发明人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
IPC分类号： A61B17/00
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.
摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。
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5.发明申请公开(公告)号：US20050203488A1
公开(公告)日：2005-09-15
申请号：US10797910
申请日：2004-03-09
CPC分类号： A61B5/1076 , A61B17/3478 , A61B18/1482 , A61B18/1492 , A61B90/39 , A61B2017/00004 , A61B2017/00544 , A61B2017/00818 , A61B2017/306 , A61B2018/00029 , A61B2018/00244 , A61B2018/00291 , A61B2018/00494 , A61B2018/00577 , A61B2018/00595 , A61B2018/00982 , A61B2018/1415 , A61B2018/144 , A61B2090/3908 , A61B2090/3912 , A61B2090/3937 , A61B2090/395 , A61B2090/3987 , A61B2090/3991 , A61B2218/002 , A61B2218/007
摘要： Apparatus and methods are provided for mapping out endoluminal gastrointestinal surgery, including endoluminal gastric reduction. Mapping is achieved by locally marking the interior of the gastrointestinal lumen at specified locations. In a first embodiment, the surgical map comprises localized RF scarring or mucosal ablation. In an alternative embodiment, the map comprises pegs. In another alternative embodiment, the map comprises dye and/or spheres injected into at least the submucosa. As a still further alternative, the map may comprise the shaft of an endoluminal surgical tool having specified dimensions and/or color-coding, etc. In another alternative embodiment, the map may be formed from surgical mesh. In one preferred embodiment, placement of the map is accurately achieved by approximating the interior of the stomach with an endoluminal support via suction ports and/or via an inflatable member disposed along the support. Methods of using apparatus of the present invention are provided.
摘要翻译： 提供装置和方法用于映射腔内胃肠手术，包括腔内胃减少。 通过在指定位置局部标记胃肠腔的内部来实现测绘。 在第一实施例中，手术图包括局部RF瘢痕形成或粘膜消融。 在替代实施例中，地图包括钉。 在另一替代实施方案中，该图包括至少注入至少粘膜下层的染料和/或球体。 作为另外的替代方案，地图可以包括具有特定尺寸和/或颜色编码等的腔内手术工具的轴。在另一替代实施例中，地图可以由外科手术网形成。 在一个优选实施例中，通过经由抽吸端口和/或经由沿着支撑件设置的可充气构件近似胃内支架来准确地实现贴图的放置。 提供了使用本发明装置的方法。
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公开(公告)号：US20110098708A9
公开(公告)日：2011-04-28
申请号：US11406486
申请日：2006-04-17
申请人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
发明人： Vahid Saadat , Jeffery Bleich , Kenneth Michlitsch , John Ashley
IPC分类号： A61B17/00
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.
摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。
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公开(公告)号：US20060155330A1
公开(公告)日：2006-07-13
申请号：US10523219
申请日：2003-07-25
申请人： Kenneth Michlitsch
发明人： Kenneth Michlitsch
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672
摘要： Apparatus (10) is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements (22) to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.
摘要翻译： 设置装置（10），用于通过在穿刺道内形成自体塞子来密封血管穿刺管道，并将该塞子挤压到穿刺管道中。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件（22），以在与血液凝固剂混合期间将抽出的血液与血管隔离，并且便于相对于血管的装置放置。
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公开(公告)号：US20060127595A1
公开(公告)日：2006-06-15
申请号：US11333090
申请日：2006-01-17
CPC分类号： B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/2014 , G03F7/2043 , Y10S430/143 , Y10T428/24802
摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.
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公开(公告)号：US20060106418A1
公开(公告)日：2006-05-18
申请号：US10523166
申请日：2003-07-25
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/0643 , A61B2017/00004 , A61B2017/00477 , A61B2017/00659
摘要： Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.
摘要翻译： 提供了用于密封容器或组织内的穿刺以提供止血的装置，包括联接到第二盘或弹簧的第一盘，并密封地接合到围绕穿刺的容器或组织。 至少第一盘优选地构造成在展开时基本上符合血管或组织的轮廓。 在一个实施例中，盘可以从与血管或组织的接合中释放，以在部署之后重新定位椎间盘。
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公开(公告)号：US20060100665A1
公开(公告)日：2006-05-11
申请号：US10523217
申请日：2003-07-25
申请人： Randolf Von Oepen , Gerd Seibold , Ib Joergensen , Kenneth Michlitsch , Stevan Nielsen , Tommy Conzelmann , Bodo Quint
发明人： Randolf Von Oepen , Gerd Seibold , Ib Joergensen , Kenneth Michlitsch , Stevan Nielsen , Tommy Conzelmann , Bodo Quint
IPC分类号： A61B17/04
CPC分类号： A61B17/12013 , A61B17/0057 , A61B2017/00349 , A61B2017/00637 , A61B2017/00659 , A61B2017/00672 , A61B2017/0406 , A61B2017/0496
摘要： Apparatus is provided for sealing a puncture in a blood vessel using at least one device that applies an internal compressive force upon a distal surface of the vessel. The devices preferably are deployable distal of the distal surface of the vessel, then retracted proximally to provide the internal compressive force, e.g., to promote coagulation and facilitate sealing of the puncture. Additionally, the devices of the present invention optionally may be used in combination with known techniques that provide an external compressive force upon an exterior surface of a patient's skin to expedite sealing of the puncture.
摘要翻译： 提供了使用至少一个在血管的远端表面上施加内部压缩力的装置来密封血管中的穿刺的装置。 装置优选地可展开在血管远侧表面的远端，然后向近侧缩回以提供内部压缩力，例如促进凝结并便于穿刺的密封。 另外，本发明的装置可以任意地与已知技术组合使用，这些技术在患者皮肤的外表面上提供外部压缩力，以加速穿刺的密封。
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