公开(公告)号：US20060127595A1

公开(公告)日：2006-06-15

申请号：US11333090

申请日：2006-01-17

申请人： Jane Bearinger ,  Jeffrey Hubbell ,  Kenneth Michlitsch

发明人： Jane Bearinger ,  Jeffrey Hubbell ,  Kenneth Michlitsch

IPC分类号： B41M5/00 ,  C08F2/46

CPC分类号： B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/2014 ,  G03F7/2043 ,  Y10S430/143 ,  Y10T428/24802

摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.

公开(公告)号：US20070213735A1

公开(公告)日：2007-09-13

申请号：US11406486

申请日：2006-04-17

申请人： Vahid Saadat ,  Jeffery Bleich ,  Kenneth Michlitsch ,  John Ashley

发明人： Vahid Saadat ,  Jeffery Bleich ,  Kenneth Michlitsch ,  John Ashley

IPC分类号： A61B17/00

CPC分类号： A61B17/1659 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/00867 ,  A61B2017/32006 ,  A61B2017/3488 ,  A61B2090/08021

摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

公开(公告)号：US20050203488A1

公开(公告)日：2005-09-15

申请号：US10797910

申请日：2004-03-09

申请人： Kenneth Michlitsch ,  Vahid Saadat ,  Rodney Brenneman ,  Tracy Maahs

发明人： Kenneth Michlitsch ,  Vahid Saadat ,  Rodney Brenneman ,  Tracy Maahs

IPC分类号： A61B17/00 ,  A61B18/04 ,  A61B19/00

CPC分类号： A61B5/1076 ,  A61B17/3478 ,  A61B18/1482 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00544 ,  A61B2017/00818 ,  A61B2017/306 ,  A61B2018/00029 ,  A61B2018/00244 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61B2018/00982 ,  A61B2018/1415 ,  A61B2018/144 ,  A61B2090/3908 ,  A61B2090/3912 ,  A61B2090/3937 ,  A61B2090/395 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61B2218/002 ,  A61B2218/007

摘要： Apparatus and methods are provided for mapping out endoluminal gastrointestinal surgery, including endoluminal gastric reduction. Mapping is achieved by locally marking the interior of the gastrointestinal lumen at specified locations. In a first embodiment, the surgical map comprises localized RF scarring or mucosal ablation. In an alternative embodiment, the map comprises pegs. In another alternative embodiment, the map comprises dye and/or spheres injected into at least the submucosa. As a still further alternative, the map may comprise the shaft of an endoluminal surgical tool having specified dimensions and/or color-coding, etc. In another alternative embodiment, the map may be formed from surgical mesh. In one preferred embodiment, placement of the map is accurately achieved by approximating the interior of the stomach with an endoluminal support via suction ports and/or via an inflatable member disposed along the support. Methods of using apparatus of the present invention are provided.

摘要翻译： 提供装置和方法用于映射腔内胃肠手术，包括腔内胃减少。 通过在指定位置局部标记胃肠腔的内部来实现测绘。 在第一实施例中，手术图包括局部RF瘢痕形成或粘膜消融。 在替代实施例中，地图包括钉。 在另一替代实施方案中，该图包括至少注入至少粘膜下层的染料和/或球体。 作为另外的替代方案，地图可以包括具有特定尺寸和/或颜色编码等的腔内手术工具的轴。在另一替代实施例中，地图可以由外科手术网形成。 在一个优选实施例中，通过经由抽吸端口和/或经由沿着支撑件设置的可充气构件近似胃内支架来准确地实现贴图的放置。 提供了使用本发明装置的方法。

公开(公告)号：US20060116756A1

公开(公告)日：2006-06-01

申请号：US11326546

申请日：2006-01-04

申请人： Jan Solem ,  Per-Ola Kimblad ,  Randolf Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

发明人： Jan Solem ,  Per-Ola Kimblad ,  Randolf Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/07 ,  A61F2/88 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/8483 ,  A61F2210/0004

摘要： A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.

公开(公告)号：US20050277983A1

公开(公告)日：2005-12-15

申请号：US10865736

申请日：2004-06-09

申请人： Vahid Saadat ,  Richard Ewers ,  Tracy Maahs ,  Alex Khairkhahan ,  Kenneth Michlitsch

发明人： Vahid Saadat ,  Richard Ewers ,  Tracy Maahs ,  Alex Khairkhahan ,  Kenneth Michlitsch

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/064 ,  A61B17/08 ,  A61B19/00

CPC分类号： A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0644 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

摘要： Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

摘要翻译： 这里描述了用于优化锚固力的系统。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

公开(公告)号：US20050137691A1

公开(公告)日：2005-06-23

申请号：US10746942

申请日：2003-12-23

申请人： Amr Salahieh ,  Dwight Morejohn ,  Jeff Krolik ,  Kenneth Michlitsch

发明人： Amr Salahieh ,  Dwight Morejohn ,  Jeff Krolik ,  Kenneth Michlitsch

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/90

CPC分类号： A61F2/2418 ,  A61F2002/9528 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2250/006

摘要： Apparatus for endovascularly replacing a patient's heart valve, including: a custom-designed anchor; and a replacement valve, wherein the custom-designed anchor is adapted to engage native leaflets of the heart valve, and wherein the anchor and the valve are adapted for in vivo expansion and coupling to one another to form composite apparatus that endovascularly replaces the heart valve. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: providing apparatus comprising an anchor piece and a replacement valve piece; endovascularly delivering the anchor piece to a vicinity of the heart valve in a collapsed delivery configuration; expanding the anchor piece to a deployed configuration; engaging at least one valve leaflet of the heart valve with the anchor piece; endovascularly delivering the replacement valve piece to the vicinity of the heart valve in a collapsed delivery configuration; expanding the replacement valve piece to a deployed configuration; and coupling the valve piece to the anchor piece in vivo to form composite two-piece apparatus that endovascularly replaces the patient's heart valve.

摘要翻译： 用于血管内替代患者心脏瓣膜的装置，包括：定制设计的锚; 和替换阀，其中所述定制设计的锚适于接合所述心脏瓣膜的天然传单，并且其中所述锚固件和所述阀适于体内膨胀和彼此耦合以形成复合装置，所述复合装置血管内取代所述心脏瓣膜 。 本发明还包括一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：提供包括锚固件和替换阀件的设备; 在塌陷递送构造中将锚固件血管内输送到心脏瓣膜的附近; 将锚固件扩展到部署的配置; 将所述心脏瓣膜的至少一个瓣膜与所述锚固件接合; 在折叠的输送构造中将替换瓣膜血管内输送到心脏瓣膜的附近; 将更换的阀件扩展到部署的配置; 并且在体内将阀片联接到锚固件以形成血管内取代患者心脏瓣膜的复合两件式装置。

公开(公告)号：US07938830B2

公开(公告)日：2011-05-10

申请号：US11406486

申请日：2006-04-17

申请人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth Michlitsch ,  John E. Ashley

发明人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth Michlitsch ,  John E. Ashley

IPC分类号： A61B17/00

CPC分类号： A61B17/1659 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3421 ,  A61B2017/00261 ,  A61B2017/00867 ,  A61B2017/32006 ,  A61B2017/3488 ,  A61B2090/08021

摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

公开(公告)号：US20060184232A1

公开(公告)日：2006-08-17

申请号：US11404450

申请日：2006-04-14

申请人： Marc Gianotti ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Randolf Oepen ,  Gerd Seibold

发明人： Marc Gianotti ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Randolf Oepen ,  Gerd Seibold

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/0054

摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring, interconnected, web patterns, each web pattern composed of adjoining webs. Each adjoining web comprises a central section interposed between two lateral sections, forming concave or convex configurations. Embodiments of the present invention comprising curvature for tracking tortuous anatomy and reducing localized restoring forces are provided. Methods of using stents in accordance with the present invention are also provided.

摘要翻译： 本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。 幅材结构包括多个相邻的，互连的幅材图案，每个幅材图案由相邻的幅材组成。 每个邻接的腹板包括插入在两个横向部分之间的中心部分，形成凹形或凸形构造。 提供了包括用于跟踪曲折解剖结构并减少局部恢复力的曲率的本发明的实施例。 还提供了使用根据本发明的支架的方法。

公开(公告)号：US20050251160A1

公开(公告)日：2005-11-10

申请号：US10954666

申请日：2004-09-29

申请人： Vahid Saadat ,  Richard Ewers ,  Cang Lam ,  Robert Vaughan ,  Chris Rothe ,  Kenneth Michlitsch

发明人： Vahid Saadat ,  Richard Ewers ,  Cang Lam ,  Robert Vaughan ,  Chris Rothe ,  Kenneth Michlitsch

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/064 ,  A61B17/08 ,  A61B17/10 ,  A61B17/28 ,  A61B17/34

CPC分类号： A61F5/0086 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/06 ,  A61B17/06066 ,  A61B17/064 ,  A61B17/08 ,  A61B17/10 ,  A61B17/12013 ,  A61B17/1285 ,  A61B17/29 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0445 ,  A61B2017/0446 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0458 ,  A61B2017/0459 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/081 ,  A61B2017/3488

摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

摘要翻译： 本文描述了用于操纵和固定组织的装置。 在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US20050080483A1

公开(公告)日：2005-04-14

申请号：US10500188

申请日：2002-12-20

申请人： Jan Solem ,  Per Kimblad ,  Randolf Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

发明人： Jan Solem ,  Per Kimblad ,  Randolf Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

IPC分类号： A61F2/02 ,  A61F2/04 ,  A61F2/07 ,  A61F2/24 ,  A61F2/26 ,  A61F2/82 ,  A61F2/848

CPC分类号： A61F2/2451 ,  A61F2/07 ,  A61F2/2481 ,  A61F2/26 ,  A61F2002/043 ,  A61F2002/072 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/8483 ,  A61F2210/0004

摘要： A device for reshaping a cardiac valve (26), which is elongate and has such dimensions as to be insertable into a cardiac vessel (24). The device has two states, in a first state (K) of which the device has a shape that is adaptable to the shape of the vessel (24), and to the second state (k′) of which the device is transferable from said first state (K). Further, the device comprises a fixing means (22,23;22a,23a) for fixing the ends of the device within the vessel (24), when the device is first positioned therein, a shape-changing member (20;20a) for transferring the device to the second state (K′) by reshaping it, and a delay means (21;21a) for delaying said reshaping until the fixing of the ends of the device has been reinforced by keeping said device in said first state (K) until the delay means (21;21a) is resorbed.

摘要翻译： 一种用于整形心脏瓣膜（26）的装置，其是细长的并且具有可插入心脏容器（24）的尺寸。 该装置具有两种状态，其处于第一状态（K），其装置具有适应于容器（24）的形状的形状，以及第二状态（k'），其中装置可从所述第二状态 第一个状态（K）。 此外，该装置包括固定装置（22,23; 22a，23a），用于当装置首先定位在容器（24）内时将装置的端部固定，形状改变构件（20; 20a） 通过重新形成将装置转移到第二状态（K'），以及用于延迟所述重新成形的延迟装置（21; 21a），直到通过将所述装置保持在所述第一状态（K ），直到延迟装置（21; 21a）被再吸收。