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1.发明申请Peptide and protein arrays and direct-write lithographic printing of peptides and proteins 有权肽和蛋白质阵列和肽和蛋白质的直写平版印刷公开(公告)号：US20050009206A1
公开(公告)日：2005-01-13
申请号：US10788414
申请日：2004-03-01
Applicant: Chad Mirkin , Jung-Hyurk Lim , David Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
Inventor： Chad Mirkin , Jung-Hyurk Lim , David Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
CPC classification number: G03B27/42 , Y10S977/857 , Y10S977/884 , Y10S977/885 , Y10S977/886
Abstract: The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.
Abstract translation: 本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。 特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。 可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。 图案可以是点直径和线宽小于1,000nm的点或线。 尖端和底物表面可适用于肽和蛋白质光刻。
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公开(公告)号：US20050277205A1
公开(公告)日：2005-12-15
申请号：US11062983
申请日：2005-02-22
Applicant: Ki-Bum Lee , Sungho Park , Chad Mirkin , Byung-Keun Oh
Inventor： Ki-Bum Lee , Sungho Park , Chad Mirkin , Byung-Keun Oh
IPC: C12Q1/68 , G01N33/531 , G01N33/553
CPC classification number: G01N33/531 , B82Y5/00
Abstract: The present invention relates to methods and compositions for separation of proteins. In particular, the present invention provides multicomponent nanorods for biomolecular separations of proteins.
Abstract translation: 本发明涉及分离蛋白质的方法和组合物。 特别地，本发明提供了用于蛋白质的生物分子分离的多组分纳米棒。
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3.发明申请GRAPHENE-ENCAPSULATED NANOPARTICLE-BASED BIOSENSOR FOR THE SELECTIVE DETECTION OF BIOMARKERS 有权用于生物标志物选择性检测的基于纳帕纳基的生物传感器公开(公告)号：US20120220053A1
公开(公告)日：2012-08-30
申请号：US13400021
申请日：2012-02-17
Applicant: Ki-Bum Lee , Sung Myung , Aniruddh Solanki
Inventor： Ki-Bum Lee , Sung Myung , Aniruddh Solanki
IPC: G01N27/00 , G01N27/414 , H01L21/335 , B82Y40/00 , B82Y99/00
CPC classification number: B82Y30/00 , G01N27/4145 , G01N27/4146 , H01L29/4908 , H01L29/7869 , H01L29/78696
Abstract: A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers.
Abstract translation: 具有在半导体衬底上彼此分开的源电极和漏电极的场效应晶体管（FET）和由均匀的还原型氧化烯石氧化物封装的半导体纳米颗粒层（rGO-NP）组成的栅电极，其中 栅电极设置在源极和漏极之间并且与源电极和漏电极接触。 还公开了使用FET的制备方法和测定方法，包括其中rGO-NPs用于生物标志物的结合伴侣功能化的方法。
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公开(公告)号：US20120115962A1
公开(公告)日：2012-05-10
申请号：US13270261
申请日：2011-10-11
Applicant: Ki-Bum Lee , Birju Shah , Prasad Subramaniam , Cheoljin Kim
Inventor： Ki-Bum Lee , Birju Shah , Prasad Subramaniam , Cheoljin Kim
CPC classification number: C08G83/004
Abstract: The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles.
Abstract translation: 本发明涉及药物递送载体，其包含一个或多个缀合至树枝状多胺的环糊精部分用于递送小分子和蛋白质治疗分子和核酸治疗分子，以及制备和使用递送载体的方法。
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公开(公告)号：US20120045512A1
公开(公告)日：2012-02-23
申请号：US13214824
申请日：2011-08-22
Applicant: Ki-Bum Lee , Aniruddh Solanki , Shreyas Shah
Inventor： Ki-Bum Lee , Aniruddh Solanki , Shreyas Shah
CPC classification number: A61L27/54 , A61L27/227 , A61L27/383 , A61L27/3878 , A61L27/50 , A61L2300/252 , A61L2300/608 , B82Y5/00 , C12N5/0619 , C12N5/0623 , C12N2506/08 , C12N2533/10 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.
Abstract translation: 本发明涉及促进神经干细胞向神经元分化的方法和底物。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170367606A1
公开(公告)日：2017-12-28
申请号：US15538458
申请日：2015-12-17
Applicant: Ki Bum LEE
Inventor： Ki Bum LEE
IPC: A61B5/0476 , G06Q50/22 , A61H1/00 , A63B69/04 , A61M21/00
CPC classification number: A61B5/0476 , A61B5/0006 , A61B5/165 , A61B5/4836 , A61H1/001 , A61H1/005 , A61H2201/1659 , A61H2201/501 , A61H2201/502 , A61H2201/5035 , A61H2201/5084 , A61H2230/105 , A61M2021/0005 , A63B69/04 , A63B71/0009 , A63B2071/0063 , A63B2071/0625 , A63B2071/063 , A63B2071/0636 , A63B2071/0638 , A63B2071/0691 , A63B2208/0233 , A63B2213/00 , A63B2220/16 , A63B2220/44 , A63B2220/80 , A63B2225/15 , A63B2225/20 , A63B2225/50 , G06Q50/22 , G16H20/30
Abstract: A rehabilitation system using an artificially intelligent horseback-riding apparatus for hippotherapy, the system comprising: an artificially intelligent horseback-riding apparatus which is ridable; a smartphone which can communicate with a cloud server and has installed an application for controlling the operation state of the artificially intelligent horseback-riding apparatus and operating the horseback-riding apparatus; a diagnostic device which is for diagnosing the state of a patient by means of a brain wave signal of the patient; an operating unit which is for operating the artificially intelligent horseback-riding apparatus; and a cloud server which is for storing, in the smartphone, treatment program and data, necessary for a patient treatment, and for transmitting same.
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7.发明授权Graphene-encapsulated nanoparticle-based biosensor for the selective detection of biomarkers 有权石墨烯包裹的基于纳米粒子的生物传感器用于生物标志物的选择性检测公开(公告)号：US09162885B2
公开(公告)日：2015-10-20
申请号：US13400021
申请日：2012-02-17
Applicant: Ki-Bum Lee , Sung Myung , Aniruddh Solanki
Inventor： Ki-Bum Lee , Sung Myung , Aniruddh Solanki
IPC: G01N33/551 , G01N33/553 , B82Y30/00 , H01L29/49 , H01L29/786 , G01N27/414
CPC classification number: B82Y30/00 , G01N27/4145 , G01N27/4146 , H01L29/4908 , H01L29/7869 , H01L29/78696
Abstract: A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers.
Abstract translation: 具有在半导体衬底上彼此分开的源电极和漏电极的场效应晶体管（FET）和由均匀的还原型氧化烯石氧化物封装的半导体纳米颗粒层（rGO-NP）组成的栅电极，其中 栅电极设置在源极和漏极之间并且与源电极和漏电极接触。 还公开了使用FET的制备方法和测定方法，包括其中rGO-NPs用于生物标志物的结合伴侣功能化的方法。
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8.发明授权Peptide and protein arrays and direct-write lithographic printing of peptides and proteins 有权肽和蛋白质阵列和肽和蛋白质的直写平版印刷公开(公告)号：US07842344B2
公开(公告)日：2010-11-30
申请号：US10788414
申请日：2004-03-01
Applicant: Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
Inventor： Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
IPC: B05D1/36
CPC classification number: G03B27/42 , Y10S977/857 , Y10S977/884 , Y10S977/885 , Y10S977/886
Abstract: The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.
Abstract translation: 本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。 特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。 可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。 图案可以是点直径和线宽小于1,000nm的点或线。 尖端和底物表面可适用于肽和蛋白质光刻。
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公开(公告)号：US09234171B2
公开(公告)日：2016-01-12
申请号：US13314891
申请日：2011-12-08
Applicant: Ki-Bum Lee , Shreyas Shah
Inventor： Ki-Bum Lee , Shreyas Shah
CPC classification number: C12N5/0618 , C12N2506/45 , C12N2529/10 , C12N2533/30 , C12N2533/50 , C12N2535/10 , C12N2537/10
Abstract: This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).
Abstract translation: 该申请公开了一种光反应性水凝胶基平台，其可以调节多种微环境信号以将人诱导的多能干细胞衍生的神经祖细胞（hiPSC-NPC）分化为神经元细胞。 本发明提供了用于将神经干细胞分化为用于治疗退行性疾病或病症（包括但不限于阿尔茨海默病，帕金森病或脊髓损伤（SCI））的神经元的新颖方法。
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10.发明授权公开(公告)号：US08697667B2
公开(公告)日：2014-04-15
申请号：US13270261
申请日：2011-10-11
Applicant: Ki-Bum Lee , Birju Shah , Prasad Subramaniam , Cheoljin Kim
Inventor： Ki-Bum Lee , Birju Shah , Prasad Subramaniam , Cheoljin Kim
IPC: C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04 , A61K31/535
CPC classification number: C08G83/004
Abstract: The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles.
Abstract translation: 本发明涉及药物递送载体，其包含一个或多个缀合至树枝状多胺的环糊精部分用于递送小分子和蛋白质治疗分子和核酸治疗分子，以及制备和使用递送载体的方法。
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