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1.发明公开公开(公告)号：US20240165978A1
公开(公告)日：2024-05-23
申请号：US18460013
申请日：2023-09-01
Applicant: Jun Hitosugi , Masayuki Tsuchiya , Yoshihito Tsuboi , Kenji Ishii
Inventor： Jun Hitosugi , Masayuki Tsuchiya , Yoshihito Tsuboi , Kenji Ishii
IPC: B41J29/19
CPC classification number: B41J29/19
Abstract: A printing apparatus includes a print execution device and an illumination device. The print execution device includes a plurality of heads to print an image on a print medium based on print data. The illumination device irradiates the printed image on the print medium with illumination light from behind a printed face of the print medium.
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公开(公告)号：US20230069955A1
公开(公告)日：2023-03-09
申请号：US17892167
申请日：2022-08-22
Applicant: Hiroki TAKAHASHI , Masayuki TSUCHIYA
Inventor： Hiroki TAKAHASHI , Masayuki TSUCHIYA
Abstract: A printed material includes a base material, an image layer, and an adhesive layer. The image layer includes an image of a first shape. The adhesive layer has a second shape. The image layer and the adhesive layer are on opposite sides of the base material.
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公开(公告)号：US08946386B2
公开(公告)日：2015-02-03
申请号：US10574045
申请日：2004-09-29
Applicant: Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
Inventor： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
IPC: A61K38/17 , C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566
CPC classification number: C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
Abstract: Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
Abstract translation: 分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。 用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。
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公开(公告)号：US08257703B2
公开(公告)日：2012-09-04
申请号：US12727162
申请日：2010-03-18
Applicant: Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
Inventor： Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
IPC: A61K39/395
CPC classification number: C07K16/3084 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/734 , G01N33/6854 , G01N33/686
Abstract: IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.
Abstract translation: 通过将编码H，L和J链的基因置于相同载体上以转化合适的宿主细胞，可以以五聚体的形式获得IgM。 编码J链的基因可以通过共转染来引入。 当没有J链表达时，IgM作为六聚体产生。 根据本发明获得的转化体获得高产量的IgM。 本发明还提供能够分离和定量聚合物IgM的方法。
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公开(公告)号：US20120156724A1
公开(公告)日：2012-06-21
申请号：US13329658
申请日：2011-12-19
Applicant: Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
Inventor： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
CPC classification number: C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
Abstract: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
Abstract translation: 本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。
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Patent Agency Ranking
公开(公告)号：US08008076B2
公开(公告)日：2011-08-30
申请号：US11587701
申请日：2005-04-27
Applicant: Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
Inventor： Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
CPC classification number: A01K67/027 , A01K2267/01 , A61K35/16 , C07K16/00 , C07K16/30
Abstract: An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.
Abstract translation: 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。
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公开(公告)号：US08008073B2
公开(公告)日：2011-08-30
申请号：US12874872
申请日：2010-09-02
Applicant: Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
Inventor： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
Abstract: Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
Abstract translation: 分离纯化抗人Mpl抗体。 使用遗传工程技术制备抗人Mpl双抗体和抗人Mpl sc（Fv）2，抗人Mpl sc（Fv）2也被人源化。 测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。
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公开(公告)号：US20080187537A1
公开(公告)日：2008-08-07
申请号：US11587701
申请日：2005-04-27
Applicant: Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
Inventor： Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
IPC: A61K39/395 , A61K35/12 , C12P21/04 , C07H21/00 , A61P43/00 , C07K16/18 , A61K31/70 , G01N33/574
CPC classification number: A01K67/027 , A01K2267/01 , A61K35/16 , C07K16/00 , C07K16/30
Abstract: An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.
Abstract translation: 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。
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公开(公告)号：US20060222643A1
公开(公告)日：2006-10-05
申请号：US10551504
申请日：2004-12-10
Applicant: Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
Inventor： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC: A61K39/395 , C07K16/44 , C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
Abstract: Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
Abstract translation: 分离和纯化抗人Mpl抗体，然后使用遗传工程技术纯化抗人Mpl双抗体和抗人Mpl sc（Fv）2。 此外，本发明人成功地将抗人Mpl sc（Fv）2人源化。 测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。
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公开(公告)号：US20050272092A1
公开(公告)日：2005-12-08
申请号：US11199124
申请日：2005-08-09
Applicant: Masayuki Tsuchiya , Kenji Yoshida
Inventor： Masayuki Tsuchiya , Kenji Yoshida
CPC classification number: C12N9/1276 , C12Y207/07049
Abstract: The present invention aims to provide a novel gene having a reverse transcriptase motif. The invention isolates a novel gene having a reverse transcriptase motif, and gives its complete base sequence determined. The invention also provides a protein encoded by the gene, and an antibody against the protein. The use of them is useful in developing a method for detecting telomerase activity, a method for detecting a cancer cell, a telomerase activity inhibitor, and a method for screening a telomerase activity inhibitor.
Abstract translation: 本发明旨在提供具有逆转录酶基序的新基因。 本发明分离具有逆转录酶基序的新基因，并确定其完整的碱基序列。 本发明还提供了由该基因编码的蛋白质和针对该蛋白质的抗体。 其使用可用于开发端粒酶活性检测方法，癌细胞检测方法，端粒酶活性抑制剂及筛选端粒酶活性抑制剂的方法。
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