公开(公告)号：US10952983B2

公开(公告)日：2021-03-23

申请号：US16710302

申请日：2019-12-11

Applicant: KYOTO UNIVERSITY ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Jun Ogawa ,  Shigenobu Kishino ,  Teruo Kawada ,  Nobuyuki Takahashi ,  Tsuyoshi Goto ,  Yasunori Yonejima

IPC: A61K31/202 ,  A61K31/20 ,  A61K31/201 ,  A23L33/12

Abstract: The invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

公开(公告)号：US10285966B2

公开(公告)日：2019-05-14

申请号：US15578704

申请日：2016-06-02

Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD. ,  KYOTO UNIVERSITY

Inventor： Yasunori Yonejima ,  Jun Ogawa ,  Shigenobu Kishino

IPC: A61K31/231 ,  A23D9/007 ,  A61K8/37 ,  A61Q1/00 ,  A61Q19/00 ,  C07C69/732 ,  A23K20/158 ,  A23L33/12 ,  A61K8/36 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

公开(公告)号：US20180206540A1

公开(公告)日：2018-07-26

申请号：US15577119

申请日：2016-05-31

Applicant: LOTTE CO., LTD. ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Hiroaki ASHITANI ,  Toshiyuki KOYAMA ,  Yoko USAMIKRANK ,  Tomokazu ISHIZUKA ,  Keiji TADOKORO ,  Yusuke KABUKI ,  Yasunori YONEJIMA ,  Keiko HISA

IPC: A23L33/135 ,  A23G1/42

CPC classification number: A23L33/135 ,  A23G1/305 ,  A23G1/40 ,  A23G1/423 ,  A23G2200/02 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/3204 ,  A23Y2220/03 ,  A23Y2220/13 ,  A23Y2220/37 ,  A23Y2240/33 ,  A23Y2260/35 ,  A23Y2300/55

Abstract: By adding a viable lactic acid bacterium to a fat or oil composition, the present invention has succeeded in producing a lactic acid bacterium-containing fat or oil composition that has a high viability of the lactic acid bacterium and an excellent resistance to acids. By adding lactic acid bacteria powder or a chocolate with a high lactic acid bacterium concentration to a chocolate dough after tempering and before molding, moreover, the present invention has succeeded in producing a lactic acid bacterium-containing chocolate including a viable lactic acid bacterium by a simple producing method. Thus, provided is a lactic acid bacterium-containing chocolate with high palatability that contains a viable lactic acid bacterium.

公开(公告)号：US20180170854A1

公开(公告)日：2018-06-21

申请号：US15578694

申请日：2016-06-02

Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD. ,  KYOTO UNIVERSITY

Inventor： Yasunori YONEJIMA ,  Jun OGAWA ,  Shigenobu KISHINO

IPC: C07C69/732 ,  A23K20/158 ,  A23L33/12 ,  A61K8/37

CPC classification number: C07C69/732 ,  A23D9/007 ,  A23K20/158 ,  A23L33/12 ,  A61K8/37 ,  A61K31/231 ,  A61Q1/00 ,  A61Q19/00 ,  C07B53/00 ,  C11C3/00

Abstract: The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

公开(公告)号：US20170335355A1

公开(公告)日：2017-11-23

申请号：US15629716

申请日：2017-06-21

Applicant: KYOTO UNIVERSITY ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Jun OGAWA ,  Shigenobu KISHINO ,  Sakayu SHIMIZU ,  Yasunori YONEJIMA

IPC: C12P7/64 ,  C12R1/25

CPC classification number: C12P7/6409 ,  C12P7/64 ,  C12P7/6427 ,  C12R1/25

Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.

公开(公告)号：US09719115B2

公开(公告)日：2017-08-01

申请号：US14400116

申请日：2012-11-06

Applicant: KYOTO UNIVERSITY ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Jun Ogawa ,  Shigenobu Kishino ,  Sakayu Shimizu ,  Yasunori Yonejima

IPC: C12P7/64 ,  C12R1/25

CPC classification number: C12P7/6409 ,  C12P7/64 ,  C12P7/6427 ,  C12R1/25

Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.

公开(公告)号：US20170202890A1

公开(公告)日：2017-07-20

申请号：US15314829

申请日：2015-05-28

Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Yasunori YONEJIMA ,  Keiko HISA ,  Yoshie UCHIBORI

IPC: A61K35/747 ,  A23L33/135 ,  C12R1/24

CPC classification number: A61K35/747 ,  A23L33/10 ,  A23L33/135 ,  A23V2002/00 ,  A61K2035/11 ,  C12N1/20 ,  C12N15/09 ,  C12R1/24

Abstract: The present invention provides a lactobacillus that improves hyperuricemia, fatty liver and a lifestyle-related disease, and a composition containing the lactobacillus.

公开(公告)号：US09572844B2

公开(公告)日：2017-02-21

申请号：US14768665

申请日：2014-02-21

Applicant: NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Kenji Yamamoto ,  Chiaki Matsuzaki ,  Keiko Hisa

IPC: C12N1/20 ,  A61K39/02 ,  A61K35/744 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K36/06 ,  C12R1/01 ,  A61K45/06

CPC classification number: A61K35/744 ,  A23K10/18 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2260/35 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K36/06 ,  A61K45/06 ,  C12N1/20 ,  C12R1/01 ,  A23V2200/32 ,  A61K2300/00

Abstract: The present invention provides Leuconostoc mesenteroides NTM048 strain deposited under accession No. NITE BP-1519, or a mutant strain thereof or a processed bacterium thereof, and a lactobacillus preparation and an immunity (particularly intestinal immunity) stimulant, containing the lactobacillus or a processed bacterium thereof.

Abstract translation: 本发明提供了以登录号NITE BP-1519或其突变菌株或其加工细菌和乳杆菌制剂和免疫（特别是肠免疫）刺激剂沉积的肠系膜梭菌NTM048菌株，其含有乳杆菌或加工细菌 其中。

公开(公告)号：US20160000739A1

公开(公告)日：2016-01-07

申请号：US14768183

申请日：2014-02-13

Applicant: KYOTO UNIVERSITY ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Jun OGAWA ,  Shigenobu KISHINO ,  Yasunori YONEJIMA

IPC: A61K31/201

CPC classification number: A61K31/201 ,  A23K20/158 ,  A23L33/12 ,  A23V2002/00 ,  C07C59/42 ,  A23V2200/32 ,  A23V2250/186

Abstract: The present invention provides an intestinal tract-protecting agent, an agent for the prophylaxis or improvement of a disease caused by damage in intestinal tract barrier function, which contains hydroxylated fatty acid, particularly hydroxylated unsaturated fatty acid, having a hydroxyl group at the 10-position and/or the 12-position, which is an intermediate of the metabolism of unsaturated fatty acid by lactobacillus.

Abstract translation: 本发明提供一种肠道保护剂，用于预防或改善由肠道屏障功能损伤引起的疾病的药物，其包含羟基化脂肪酸，特别是羟基化不饱和脂肪酸，其在10- 位置和/或12位，其是乳酸杆菌不饱和脂肪酸代谢的中间体。

公开(公告)号：US20210079432A1

公开(公告)日：2021-03-18

申请号：US16642282

申请日：2018-08-30

Applicant: KYOTO UNIVERSITY ,  NITTO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Jun OGAWA ,  Shigenobu KISHINO ,  Kohey KITAO

IPC: C12P7/64 ,  C07C69/732

Abstract: The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.