-
公开(公告)号:US08106166B2
公开(公告)日:2012-01-31
申请号:US12077290
申请日:2008-03-17
申请人: Xi He , Tong Yin , Qiang Tian , Weiguo Tao , Leroy Hood , Linheng Li
发明人: Xi He , Tong Yin , Qiang Tian , Weiguo Tao , Leroy Hood , Linheng Li
CPC分类号: C07K14/4702 , C07K16/18 , C07K2317/34 , G01N33/6842 , G01N33/6854 , G01N2800/06 , Y10S435/81
摘要: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.
摘要翻译: 本发明涉及一种纯化分子,包括抗体,其特异性结合于在氨基酸位置Serine552及其直向同源物磷酸化的哺乳动物直向同源物(包括人直向同源物)。 还提供了制备和使用这些纯化分子的方法。 进一步提供含有这种纯化分子的试剂盒。
-
公开(公告)号:US07447028B2
公开(公告)日:2008-11-04
申请号:US11309849
申请日:2006-10-12
申请人: Cheng-Tien Lai , Tao Li , Wei-Qiang Tian
发明人: Cheng-Tien Lai , Tao Li , Wei-Qiang Tian
IPC分类号: H05K7/20
CPC分类号: H01L23/467 , H01L2924/0002 , H01L2924/00
摘要: A heat dissipation device includes a heat sink, a fan producing an airflow flowing towards the heat sink, an air-guiding member positioned between the fan and the heat sink and a cover enclosing the fan and the heat sink. The air-guiding member includes an air deflector dividing the airflow produced by the fan into two airstreams. The air deflector guides the airstreams of the airflow flowing towards different portions of the heat sink. By the air deflector, the portion of the heat sink, which is hotter than the other portion of the heat sink, has more air flowing therethrough.
摘要翻译: 散热装置包括散热器,产生朝向散热器流动的气流的风扇,位于风扇和散热器之间的空气引导构件和封闭风扇和散热器的盖。 空气引导构件包括将由风扇产生的气流分成两个气流的空气导流器。 空气导流器引导朝向散热器的不同部分流动的气流的气流。 通过导风板,比散热器的其他部分更热的散热器部分具有更多的空气流过其中。
-
公开(公告)号:US20080062641A1
公开(公告)日:2008-03-13
申请号:US11309849
申请日:2006-10-12
申请人: Cheng-Tien Lai , Tao Li , Wei-Qiang Tian
发明人: Cheng-Tien Lai , Tao Li , Wei-Qiang Tian
IPC分类号: H05K7/20
CPC分类号: H01L23/467 , H01L2924/0002 , H01L2924/00
摘要: A heat dissipation device includes a heat sink, a fan producing an airflow flowing towards the heat sink, an air-guiding member positioned between the fan and the heat sink and a cover enclosing the fan and the heat sink. The air-guiding member includes an air deflector dividing the airflow produced by the fan into two airstreams. The air deflector guides the airstreams of the airflow flowing towards different portions of the heat sink. By the air deflector, the portion of the heat sink, which is hotter than the other portion of the heat sink, has more air flowing therethrough.
-
公开(公告)号:US20070015823A1
公开(公告)日:2007-01-18
申请号:US11305802
申请日:2005-12-16
申请人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
发明人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
IPC分类号: A61K31/35 , C07D405/14 , C07D405/02
CPC分类号: C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12
摘要: Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.
摘要翻译: 由式I表示的抗真菌化合物,其中R 1,R 2,R 3和R 4如本文所定义 。 分离或纯化的天然存在的20,21-二氢氨苄青霉素化合物。 本发明还提供了丝胶纤维素ambM,ambO,ambP和ambS突变株; 产生24-诺布曲菌素化合物的重组Sorangium cellulosum菌株; 以及使用本发明化合物治疗真菌感染的方法。
-
公开(公告)号:US06605710B2
公开(公告)日:2003-08-12
申请号:US09758623
申请日:2001-01-11
申请人: Richard C. Schwartz , Qiang Tian
发明人: Richard C. Schwartz , Qiang Tian
IPC分类号: C07H2104
CPC分类号: C07K14/4702 , A01K2217/05
摘要: The present invention provides a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophils, monocytes/macrophages, mast cells, and/or erythroid cells. Assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to induce or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles are described.
-
公开(公告)号:US06506733B1
公开(公告)日:2003-01-14
申请号:US09526300
申请日:2000-03-15
IPC分类号: A61K3805
CPC分类号: C07C271/22 , C07C235/78 , C07C275/24 , C07C317/28
摘要: Compounds of the formula: are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy of the disease.
摘要翻译: 具有下式的化合物,并且可用作半胱氨酸蛋白酶抑制剂,特别是用于治疗组织蛋白酶K或S对组织蛋白酶K或S有助于疾病的病理学或症状性疾病的疾病如骨质疏松症或自身免疫性疾病。
-
公开(公告)号:US06476026B1
公开(公告)日:2002-11-05
申请号:US09526485
申请日:2000-03-15
申请人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
发明人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
IPC分类号: A61K314439
CPC分类号: C07D213/70 , C07B2200/07 , C07C255/24 , C07C255/29 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/09 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/14 , C07D207/16 , C07D209/06 , C07D209/26 , C07D209/52 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/26 , C07D239/28 , C07D277/30 , C07D277/42 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/68 , C07D333/20 , C07D333/38 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
-
公开(公告)号:US20120167713A1
公开(公告)日:2012-07-05
申请号:US13340201
申请日:2011-12-29
申请人: Shibin XIE , Ou Ruan , Zhen Zhai , Qiang Tian
发明人: Shibin XIE , Ou Ruan , Zhen Zhai , Qiang Tian
IPC分类号: F02N15/02
CPC分类号: F02N15/023 , F02N15/043 , Y10T74/134
摘要: A startup device includes a starting motor, a drive gear mounted on an output shaft of the starting motor, a transmission mechanism, and a fly wheel. The transmission mechanism further includes a first gear engaging with the drive gear, and at least three second gears, each being disposed on an end face of the first gear through a unidirectional overrunning clutch. Each unidirectional overrunning clutch is mounted on a mounting shaft disposed on the end face of the first gear. The startup device further includes a third gear disposed on and end face of the fly wheel and engaged with the third gears.
摘要翻译: 启动装置包括起动电动机,安装在起动电动机的输出轴上的驱动齿轮,变速机构和飞轮。 传动机构还包括与驱动齿轮接合的第一齿轮和至少三个第二齿轮,每个齿轮通过单向超越离合器设置在第一齿轮的端面上。 每个单向超越离合器安装在设置在第一档的端面上的安装轴上。 启动装置还包括设置在飞轮的端面上并与第三齿轮接合的第三齿轮。
-
公开(公告)号:US20080043445A1
公开(公告)日:2008-02-21
申请号:US11616839
申请日:2006-12-27
申请人: WAN-LIN XIA , TAO LI , WEI-QIANG TIAN
发明人: WAN-LIN XIA , TAO LI , WEI-QIANG TIAN
IPC分类号: H05K7/20
CPC分类号: H01L23/4093 , H01L2924/0002 , H01L2924/00
摘要: A heat dissipation device includes a retention module surrounding a heat-generating component therein and a heat sink secured in the retention module. The retention module has a plurality of sidewalls. The heat sink includes a base positioned in the retention module for contacting with the heat-generating component. The base includes a plurality of first walls and a plurality of second walls. The sidewalls of the retention module enclose a periphery of the base, and the first walls and the second walls respectively abut against the sidewalls of the retention module when the base is located at a first position and a second position. A rotation of the base from the first position to the second position reduces an adhering force generated by a thermal grease located between the base and the heat-generating component.
摘要翻译: 散热装置包括围绕其中的发热部件的保持模块和固定在保持模块中的散热器。 保持模块具有多个侧壁。 散热器包括位于保持模块中的用于与发热部件接触的基座。 底座包括多个第一壁和多个第二壁。 保持模块的侧壁围绕基座的周边,并且当基座位于第一位置和第二位置时,第一壁和第二壁分别抵靠保持模块的侧壁。 基座从第一位置到第二位置的旋转减小了由位于基座和发热部件之间的导热油脂产生的粘合力。
-
公开(公告)号:US07259156B2
公开(公告)日:2007-08-21
申请号:US11133880
申请日:2005-05-17
申请人: Daniel V. Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
发明人: Daniel V. Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
IPC分类号: C07D225/06 , A61K31/395
CPC分类号: A61K31/33 , A61K31/675 , A61K31/7052 , C07D225/00
摘要: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
摘要翻译: 具有式I的结构的格尔德霉素化合物,其中Q 1,L 1,L 1,R 5,R 6, >和R 11如本文所定义,可用于治疗通过抑制细胞外热休克蛋白-90的功能而改善的疾病或病症。
-
-
-
-
-
-
-
-
-