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    Wound closure system and methods
    1.
    发明授权
    Wound closure system and methods 失效
    伤口闭合系统及方法

    公开(公告)号：US06955682B2

    公开(公告)日：2005-10-18

    申请号：US10143495

    申请日：2002-05-09

    申请人： Ajay K. Luthra ,  Shivpal S. Sandhu ,  Simon Jon Onis

    发明人： Ajay K. Luthra ,  Shivpal S. Sandhu ,  Simon Jon Onis

    IPC分类号： A61B17/12 ,  A61B17/00 ,  A61K35/14 ,  A61L24/00 ,  A61L26/00 ,  A61P7/04 ,  A61P41/00 ,  A61B17/08

    CPC分类号： A61B17/0057 ,  A61B2017/0065 ,  A61L24/0005

    摘要： A wound closure system and methods utilizes a patient's own blood. The system preferably includes a chamber with a needle and a plunger for transferring and storing blood prior to surgery and the use of reversible anticoagulants. The chamber is pre-loaded with a reversible anticoagulant to prevent the blood from clotting during storage. When the surgery is complete, a counteracting agent is mixed with the withdrawn blood to counteract the reversible anticoagulant and allow the blood to clot. The clottable blood is then reintroduced into the patient to close a wound.

    摘要翻译： 伤口闭合系统和方法利用患者自己的血液。 该系统优选地包括具有针的室和用于在手术之前转运和储存血液并使用可逆抗凝剂的柱塞。 该腔室预装有可逆抗凝血剂，以防止血液在储存过程中凝结。 当手术完成时，将抗反应剂与取出的血液混合以抵抗可逆抗凝剂并允许血液凝结。 然后将可凝结血液重新引入患者以闭合伤口。

    RAPAMYCIN CARBONATE ESTERS
    3.
    发明申请
    RAPAMYCIN CARBONATE ESTERS 审中-公开
    RAPAMYCIN碳酸钙

    公开(公告)号：US20090253733A1

    公开(公告)日：2009-10-08

    申请号：US12061416

    申请日：2008-04-02

    申请人： Alan Rhodes ,  Shivpal S. Sandhu ,  Simon J. Onis ,  John E. Mckendrick

    发明人： Alan Rhodes ,  Shivpal S. Sandhu ,  Simon J. Onis ,  John E. Mckendrick

    IPC分类号： A61K31/439 ,  C07D498/18 ,  C12P17/18

    CPC分类号： C07D498/18

    摘要： Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.

    摘要翻译： 某些实施方案包括通过脂肪酶催化的区域特异性方法合成的位置42的雷帕霉素的碳酸酯。 这些化合物或其药学上可接受的盐可用于治疗器官和组织移植排斥，自身免疫疾病，增殖性疾病，再狭窄，癌症或微生物感染。

    Coated surfaces for immobilizing negatively charged anticoagulating agents from blood fluid
    7.
    发明授权
    Coated surfaces for immobilizing negatively charged anticoagulating agents from blood fluid 有权
    用于从血液中固定带负电荷的抗凝剂的涂层表面

    公开(公告)号：US08263223B2

    公开(公告)日：2012-09-11

    申请号：US10389696

    申请日：2003-03-14

    申请人： Daniel G. Ericson ,  Shivpal S. Sandhu

    发明人： Daniel G. Ericson ,  Shivpal S. Sandhu

    IPC分类号： B32B9/00 ,  B32B27/08 ,  A61M37/00 ,  A61D1/00

    CPC分类号： A61B17/00491 ,  A61B17/0057 ,  Y10T428/2996 ,  Y10T428/31928

    摘要： A wound closure apparatus is provided which utilizes blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing, the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents, and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with, and/or associated with preferred procedures are also disclosed. The invention provides a clotting cascade initiation apparatus (1) including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources can be received, and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.

    摘要翻译： 提供了一种创伤闭合装置，其利用血液流体，通过在基本上封闭的无菌容器内激活身体外部的血液流体的凝血级联，然后将血液流体引入伤口部位以完成凝血。 还公开了一种用于提供抑制抗凝剂的方法以及减缓纤维蛋白凝块降解的装置。 还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。 本发明提供了一种凝血级联引发装置（1），其包括基本上封闭的无菌容纳室，其中可以接收自体或来自供体来源的血液的等分试样并保留。 在优选的实施方案中，无菌容纳室还包括肝素结合剂，其将结合肝素并将其从血液中除去。 在另外的实施方案中，容纳室还将包括促凝剂，其中当血液流体被接受到无菌容纳室中时可以开始凝血级联。

    HEPARIN COATINGS
    8.
    发明申请
    HEPARIN COATINGS 审中-公开
    HEPARIN涂料

    公开(公告)号：US20110274821A1

    公开(公告)日：2011-11-10

    申请号：US13183922

    申请日：2011-07-15

    申请人： Ajay K. Luthra ,  Shivpal S. Sandhu ,  John O. Hudson

    发明人： Ajay K. Luthra ,  Shivpal S. Sandhu ,  John O. Hudson

    IPC分类号： B05D3/10

    CPC分类号： C08B37/0075 ,  A61L27/20 ,  A61L27/34 ,  A61L27/507 ,  A61L27/52 ,  A61L33/0011 ,  A61L33/0064 ,  C08B37/0063 ,  C08B37/0069 ,  Y10S514/822 ,  Y10S514/944 ,  Y10S514/953 ,  C08L39/06

    摘要： The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.

    摘要翻译： 本发明包括由聚合多糖大分子单体制成的医用水凝胶。 大分子单体优选用可聚合基团（例如甲基丙烯酸酯）装饰的多糖。 大分子单体也可以制成聚合在一起的至少两种大分子单体的聚合物。 这些聚合物优选为多臂或高分子量并用于医疗用途，例如在医疗装置上制备涂层。 本文还公开了N-乙烯基吡咯烷酮的大分子单体。