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    HBV Polymerase Mutants
    1.
    发明申请
    HBV Polymerase Mutants 审中-公开

    公开(公告)号：US20190144840A1

    公开(公告)日：2019-05-16

    申请号：US16257784

    申请日：2019-01-25

    申请人： Transgene S.A.

    发明人： Perrine Martin ,  Nathalie Silvestre ,  Jean-Baptiste Marchand

    IPC分类号： C12N9/12 ,  C12P21/02 ,  C12N7/00 ,  C07K14/005 ,  A61K39/29 ,  C12N9/22

    摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.

    METHOD FOR ORTHOPOXVIRUS PRODUCTION AND PURIFICATION
    3.
    发明申请
    METHOD FOR ORTHOPOXVIRUS PRODUCTION AND PURIFICATION 审中-公开
    方法生产和纯化方法

    公开(公告)号：US20140073033A1

    公开(公告)日：2014-03-13

    申请号：US14077621

    申请日：2013-11-12

    申请人： TRANSGENE S.A.

    发明人： Claude SENE ,  Sylvie CAMPOURCY ,  Yves CORDIER

    IPC分类号： C12N7/00

    CPC分类号： C12N7/025 ,  A61K35/768 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2710/24152 ,  C12N2710/24251 ,  C12P21/00 ,  Y02A50/388 ,  Y02A50/39

    摘要： The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said purified Orthopoxvirus for the treatment and/or the prevention a cancer, an infectious disease and/or an autoimmune disorder, and uses thereof The present invention also relates to the use of an immortalized avian cell line obtained from an avian cell belonging to the Anatidae family, in particular Cairina moschata immortalized avian cell lines comprising a nucleic acid sequence coding a telomerase reverse transcriptase (TERT) and optionally an E1A nucleic acid sequence, for the production of a wild type, attenuated and/or recombinant Orthopoxvirus according to the process of the invention

    摘要翻译： 本发明涉及野生型，减毒型和/或重组型直痘病毒的生产和纯化方法。 本发明涉及通过本发明方法获得的纯化的野生型，减毒和/或重组的直痘病毒，以及包含用于治疗和/或预防癌症的感染性的包含所述纯化的直痘病毒的药物组合物，优选疫苗 疾病和/或自身免疫性疾病及其用途本发明还涉及从属于id科家族的鸟类细胞获得的永生化鸟类细胞系的用途，特别是Cairina moschata永生化鸟类细胞系，其包含编码 根据本发明的方法生产野生型，减毒和/或重组的直链痘病毒的端粒酶逆转录酶（TERT）和任选的E1A核酸序列

    IMMORTALIZED AVIAN CELL LINES COMPRISING E1A NUCLEIC ACID SEQUENCES
    4.
    发明申请
    IMMORTALIZED AVIAN CELL LINES COMPRISING E1A NUCLEIC ACID SEQUENCES 有权
    包含E1A核酸序列的完整的AVIAN细胞系

    公开(公告)号：US20130244246A1

    公开(公告)日：2013-09-19

    申请号：US13723946

    申请日：2012-12-21

    申请人： TRANSGENE S.A.`

    发明人： Philippe Erbs ,  Marina Kapfer ,  Nathalie Silvestre

    IPC分类号： C12N15/90

    CPC分类号： C12N15/907 ,  C12N7/00 ,  C12N15/902 ,  C12N2710/24152 ,  C12N2800/80

    摘要： This invention relates to immortalized avian cells, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.

    摘要翻译： 本发明涉及永生化鸟类细胞，以及这些细胞用于生产病毒的用途。 根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。

    Targeting peptides
    5.
    发明申请
    Targeting peptides 审中-公开
    靶向肽

    公开(公告)号：US20040102382A1

    公开(公告)日：2004-05-27

    申请号：US10346058

    申请日：2003-01-17

    申请人： TRANSGENE, S.A.

    发明人： Klaus Schughart ,  Ulla Rasmussen ,  Valerie Schreiber

    IPC分类号： A61K038/08 ,  A61K038/10 ,  C07K007/08

    CPC分类号： C07K7/06 ,  A61K47/6901 ,  A61K48/00 ,  C07K7/08 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345

    摘要： The present invention relates to targeting peptides and more specifically peptides that target heart and various tumors as well as to their use for targeting. The present invention also provides a composition comprising at least one therapeutic agent and at least one peptide of the invention or, alternatively, a nucleic acid molecule encoding such a peptide as well as its use for the preparation of a drug intended for gene transfer. The present invention also provides an adenoviral vector comprising at least one peptide of the invention exposed at the surface of the viral particle and its use for targeting tumor cells as well as a method for treating or preventing a cancer or a tumor comprising administering said adenoviral vector.

    摘要翻译： 本发明涉及靶向肽，更具体地涉及靶向心脏和各种肿瘤的肽以及其靶向用途。 本发明还提供包含至少一种治疗剂和本发明的至少一种肽的组合物，或者替代地，编码这种肽的核酸分子及其用于制备用于基因转移的药物的用途。 本发明还提供了包含在病毒颗粒表面暴露的至少一种本发明的肽及其靶向肿瘤细胞的用途的腺病毒载体以及用于治疗或预防癌症或肿瘤的方法，包括施用所述腺病毒载体 。

    Method for orthopoxvirus production and purification
    9.
    发明授权
    Method for orthopoxvirus production and purification 有权
    正痘病毒生产和纯化方法

    公开(公告)号：US09012198B2

    公开(公告)日：2015-04-21

    申请号：US14077621

    申请日：2013-11-12

    申请人： Transgene S.A.

    发明人： Claude Sene ,  Sylvie Campourcy ,  Yves Cordier

    IPC分类号： C12N7/02 ,  C12N7/00 ,  C12N15/86 ,  C12P21/00

    CPC分类号： C12N7/025 ,  A61K35/768 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N2710/24152 ,  C12N2710/24251 ,  C12P21/00 ,  Y02A50/388 ,  Y02A50/39

    摘要： The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said purified Orthopoxvirus for the treatment and/or the prevention a cancer, an infectious disease and/or an autoimmune disorder, and uses thereof. The present invention also relates to the use of an immortalized avian cell line obtained from an avian cell belonging to the Anatidae family, in particular Cairina moschata immortalized avian cell lines comprising a nucleic acid sequence coding a telomerase reverse transcriptase (TERT) and optionally an E1A nucleic acid sequence, for the production of a wild type, attenuated and/or recombinant Orthopoxvirus according to the process of the invention.

    摘要翻译： 本发明涉及一种生产和纯化野生型，减毒和/或重组直痘病毒的方法。 本发明涉及通过本发明方法获得的纯化的野生型，减毒和/或重组的直痘病毒，以及包含用于治疗和/或预防癌症的感染性的包含所述纯化的直痘病毒的药物组合物，优选疫苗 疾病和/或自身免疫性疾病及其用途。 本发明还涉及从属于id科家禽的禽类细胞，特别是Cairina moschata永生化鸟类细胞系获得的永生化鸟类细胞系的用途，其包含编码端粒酶逆转录酶（TERT）和任选的E1A的核酸序列 核酸序列，用于根据本发明的方法生产野生型，减毒和/或重组的直链痘病毒。

    Immortalized avian cell lines comprising E1A nucleic acid sequences
    10.
    发明授权
    Immortalized avian cell lines comprising E1A nucleic acid sequences 有权
    包含E1A核酸序列的永生化禽类细胞系

    公开(公告)号：US08809056B2

    公开(公告)日：2014-08-19

    申请号：US13723946

    申请日：2012-12-21

    申请人： Transgene S.A.

    发明人： Phillippe Erbs ,  Marina Kapfer ,  Nathalie Silvestre

    IPC分类号： C12N5/00 ,  C12N5/07 ,  C12N15/00

    CPC分类号： C12N15/907 ,  C12N7/00 ,  C12N15/902 ,  C12N2710/24152 ,  C12N2800/80

    摘要： This invention relates to immortalized avian cells, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.

    摘要翻译： 本发明涉及永生化鸟类细胞，以及这些细胞用于生产病毒的用途。 根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。