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公开(公告)号：US07662417B2
公开(公告)日：2010-02-16
申请号：US10513554
申请日：2002-05-08
CPC分类号： A23C19/16 , A23L3/3499 , A23L3/3517 , A23L3/3526 , A23L29/27 , A23V2002/00 , A23V2200/10 , A23V2200/22 , A23V2250/06 , A23V2250/5036 , A23V2250/0606 , A23V2250/5086 , A23V2250/5072 , A23V2250/5024 , A23V2250/5022 , A23V2250/5108 , A23V2250/5026
摘要： This invention relates to compositions comprising cationic preservatives and anionic hydrocolloids, to methods of preparing them and their application in food microbiological protection. Due to their composition, food products are susceptible to act as a culture medium for microorganisms, and this constitutes a possible risk to human health. Thus, food products require good protection against microbiological contamination. The present invention relates to the interaction between cationic preservatives derived from the condensation of fatty acids and esterified dibasic amino acids and anionic hydrocolloids, such as pectins, xanthan gums, carrageenans, acacia gums or agars. The most preferred cationic preservative is the ethyl ester of the lauramide of arginine monohydrochloride (LAE). As a result of this interaction, some anionic hydrocolloids are able to absorb LAE and precipitate together by the enhancement of their lipophilic properties. These new solid compounds can be isolated by filtration and, surprisingly, retain the microbiological inhibitory activity of LAE. The solid compounds contain approximately stoechiometric amounts of LAE and the anionic hydrocolloid. The preferred solid compound is LAE/xanthan gum. The solid compounds are stable and can be stored under normal conditions of temperature and humidity for long periods of time. The invention relates to the method of preserving food products using the new solid compounds and the food products obtained as a result of the application of the method.
摘要翻译： 本发明涉及包含阳离子防腐剂和阴离子水胶体的组合物，其制备方法及其在食品微生物保护中的应用。 由于它们的组成，食品易于作为微生物的培养基，这对人类健康构成可能的风险。 因此，食品需要良好的保护以防止微生物污染。 本发明涉及衍生自脂肪酸和酯化的二元氨基酸的缩合的阳离子防腐剂与阴离子水胶体如果胶，黄原胶，角叉菜胶，阿拉伯树胶或琼脂之间的相互作用。 最优选的阳离子防腐剂是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯。 作为这种相互作用的结果，一些阴离子水胶体能够吸收LAE并通过增强它们的亲油性而沉淀在一起。 这些新的固体化合物可以通过过滤分离，令人惊奇的是保留了LAE的微生物抑制活性。 固体化合物含有近似量的LAE和阴离子水胶体。 优选的固体化合物是LAE /黄原胶。 固体化合物稳定，可在正常温度和湿度条件下长时间贮存。 本发明涉及使用新的固体化合物和通过应用该方法获得的食品来保存食品的方法。
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公开(公告)号：US20100305055A1
公开(公告)日：2010-12-02
申请号：US12675823
申请日：2007-10-05
IPC分类号： A01N43/24 , A01P3/00 , A61P31/10 , A61K31/7048
CPC分类号： A23B4/22 , A01N43/90 , A23B4/20 , A23C19/11 , A23L3/3463 , A23L3/34635 , A01N2300/00
摘要： A solid composition comprising a cationic surfactant, such as the ethyl ester of the lauramide of the arginine mono-hydrochloride (LAE) and a polyene fungicide such as natamycin is provided. The solid composition is the basis for providing solutions of natamycin of increased concentration. The solid composition may be used for providing a dispersion of natamycin in a suitable liquid, such as tap water or an organic solvent. The dispersion may be further diluted with water. This leads to a solution of natamycin in water. The combination of the cationic surfactant and the polyene fungicide displays a biological effect which is stronger than the effect of each of the two components alone.
摘要翻译： 提供了包含阳离子表面活性剂，例如精氨酸单盐酸盐（LAE）的月桂酰胺的乙酯和多奈杀真菌剂如游霉素的固体组合物。 固体组合物是提供增加浓度的那他霉素溶液的基础。 固体组合物可用于提供游霉素在合适的液体如自来水或有机溶剂中的分散体。 分散体可以进一步用水稀释。 这导致游霉素在水中的溶液。 阳离子表面活性剂和多烯杀真菌剂的组合显示比单独的两种组分中的每一种的效果更强的生物效应。
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公开(公告)号：US20110230558A1
公开(公告)日：2011-09-22
申请号：US13129817
申请日：2009-11-20
IPC分类号： A61K31/221 , A01N47/44 , A01P1/00 , A61P31/04
CPC分类号： A61K31/23 , A23L3/3517 , A23L3/3526 , A23L3/3544 , A61K31/4164
摘要： This invention relates to a use of a composition for the inactivation of toxins containing cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCI (LAE). It has been found that cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCI (LAE) and its salts are effective against endotoxins, exotoxins and aflatoxins.
摘要翻译： 本发明涉及组合物用于灭活含有阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸HCl（LAE）的毒素的用途。 已经发现，阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸HCl（LAE）及其盐对内毒素，外毒素和黄曲霉毒素有效。
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公开(公告)号：US20110144203A1
公开(公告)日：2011-06-16
申请号：US13000383
申请日：2009-06-30
CPC分类号： A01N47/44 , A01N37/46 , A01N43/50 , A23L3/3463 , A23L3/3499 , A23L3/3517 , A23L3/3526 , A61L2/18 , C11D1/10 , C11D3/48
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the treatment of objects which are infected with spores. The spores may originate from bacteria or fungi.
摘要翻译： 衍生自脂肪酸和酯化二元氨基酸（例如月桂酸和精氨酸）的缩合的阳离子表面活性剂，特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯可用于治疗被感染的物体 与孢子。 孢子可能来源于细菌或真菌。
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5.发明申请公开(公告)号：US20100028325A1
公开(公告)日：2010-02-04
申请号：US12525718
申请日：2007-02-07
CPC分类号： A61K8/44 , A23L2/44 , A23L2/56 , A23L2/60 , A23L3/3526 , A23L3/3544 , A23L27/20 , A23L27/30 , A23L27/84 , A23L27/86 , A23V2002/00 , A61K2800/524 , A61Q11/00 , A23V2200/16 , A23V2250/264 , A23V2200/10 , A23V2250/06 , A23V2250/24
摘要： Use of cationic surfactants, derived from the condensation of fatty acids and esterified dibasic amino acids, of the formula (1): occasionally leads to a bitter taste, when the compound is present in a large concentration. The bitter taste can be masked by combination with a second component selected from the list consisting of sucralose, neohespiridin (NHDC), β-cyclodextrin, mono ammonium glycyrrhizinate (MAG), banana, mentholyptus, sodium dodecyl sulphate (SDS), anetol, menthol, thaumatin, adenosine monophosphate (AMP), aloten, arginine, sodium acetate, arilic acids (ferulic acid, caffeic acid), sclareolide, maltol, anane, phosphatidic acid, eucalyptol, lactisole, lysozyme, lactoglobulin, timol, borneol, acetol, phosphothreonine, phosphotyrosine, phosphoserine, Masking flavour 501521T, Masking flavour 501522, saccharine, aspartame, MK22 N&A FL for masking #25682, MM24 Prosweet N&A FL Enhancer, neodiosmin, xylitol, stevia and Natural and Functional Flavour (NAF®).
摘要翻译： 使用衍生自式（1）的脂肪酸和酯化的二元氨基酸缩合的阳离子表面活性剂：当化合物以大的浓度存在时，偶尔会导致苦味。 可以通过与选自三氯半乳蔗糖，新氯皮质素（NHDC），β-环糊精，甘草酸单铵（MAG），香蕉，薄荷醇，十二烷基硫酸钠（SDS），茴香醚，薄荷醇的列表组合的第二组分的组合掩蔽苦味 ，马齿苋，阿魏酸，磷脂酸，桉油醇，乳清蛋白，溶菌酶，乳球蛋白，酪醇，冰片，丙酮醇，磷酸苏氨酸，阿托品酸，阿魏酸，阿魏酸， ，磷酸丝氨酸，掩蔽调味剂501521T，掩蔽香料501522，糖精，阿斯巴甜，MK22 N＆A FL掩蔽＃25682，MM24 Prosweet N＆A FL Enhancer，neodiosmin，木糖醇，甜菊和天然和功能性香料（NAF）。
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公开(公告)号：US07399616B2
公开(公告)日：2008-07-15
申请号：US10501941
申请日：2002-02-01
摘要： The invention relates to a process for preparing a Na-acyl-L-arginine ester, derived from fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X— is Br—, Cl—, or HSO4— R1: is linear alkyl chain from an saturated fatty acid, or hydroxy-acid from 8 to 14 atoms of carbon bonded to the ∝-amino acid group through amidic bond. R2: is a linear or branched alkyl chain from 1 to 18 carbon atoms or aromatic. R3: is formula (II), where n can be from 0 to 4, from the appropriate organic acid and alcohol. The process is catalyzed by a hydrolase, more in particular a protease, the protease papain from Carica papaya being highly suitable . In order for the esterification reaction to run as wanted, the process is performed in a low-water-content organic medium. When the highly suitable papain from Carica papaya is used, a water activity of between 0.03 and 0.5 is selected.
摘要翻译： 本发明涉及根据下式（I）制备衍生自脂肪酸和酯化二元氨基酸的酰基-L-精氨酸酯的方法，其中：X-是Br-，Cl-或HSO 4 -R 1：来自饱和脂肪酸的直链烷基链，或通过酰胺键键合至α-氨基酸基团的8至14个碳原子的羟基酸。 R2：是1至18个碳原子或芳族的直链或支链烷基链。 R3：由适当的有机酸和醇组成的式（II），其中n可为0至4。 该方法由水解酶，更特别是蛋白酶催化，来自木瓜番木瓜的蛋白酶木瓜蛋白酶非常适合。 为了酯化反应按需要运行，该方法在低含水量的有机介质中进行。 当使用来自番木瓜的高度适宜的木瓜蛋白酶时，选择0.03至0.5之间的水分活度。
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公开(公告)号：US08933122B2
公开(公告)日：2015-01-13
申请号：US13000383
申请日：2009-06-30
IPC分类号： A61L101/36 , A61L2/16 , A01N37/44 , A01N37/46 , A01P1/00 , A01P3/00 , A01N47/44 , A01N43/50 , A23L3/3463 , A23L3/3499 , A23L3/3517 , A23L3/3526 , C11D1/10 , C11D3/48 , A61L2/18
CPC分类号： A01N47/44 , A01N37/46 , A01N43/50 , A23L3/3463 , A23L3/3499 , A23L3/3517 , A23L3/3526 , A61L2/18 , C11D1/10 , C11D3/48
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the treatment of objects which are infected with spores. The spores may originate from bacteria or fungi.
摘要翻译： 衍生自脂肪酸和酯化二元氨基酸（例如月桂酸和精氨酸）的缩合的阳离子表面活性剂，特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯可用于治疗被感染的物体 与孢子。 孢子可能来源于细菌或真菌。
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公开(公告)号：US20110275714A1
公开(公告)日：2011-11-10
申请号：US13144975
申请日：2010-01-12
CPC分类号： A01N43/50 , A01N37/30 , A01N47/44 , A23B4/20 , A23L3/3463 , A23L3/3526 , A61K31/216 , A61K31/4164
摘要： This invention relates to a use of a composition for protecting against mites and ticks containing cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCl (LAE). It has been found that cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCl (LAE) and its salts are effective acaricidal agents.
摘要翻译： 本发明涉及用于防止含有阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）的螨虫和蜱的组合物的用途。 已经发现，阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）及其盐是有效的杀螨剂。
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公开(公告)号：US20100330136A1
公开(公告)日：2010-12-30
申请号：US12812813
申请日：2009-02-11
IPC分类号： A61K8/72 , A61K8/44 , A61K8/02 , C07C279/14 , A61K8/81 , A61K8/85 , A61K8/11 , A61K8/92 , A61Q11/00
CPC分类号： A61Q11/00 , A23G3/364 , A23G3/40 , A23G4/066 , A23G4/12 , A23V2002/00 , A61K8/0216 , A61K8/44 , A61K8/494 , A23V2200/312 , A23V2200/222
摘要： This invention relates to a use of a composition for protecting oral cavity and teeth containing ethyl-Nα-lauroyl-L-arginate HCl (LAE), a corresponding composition and a corresponding method for protecting teeth. Because of nearly epidemic incidence of dental erosion, there is a continuing need for improved products that provide protection against dental erosion. Hence, it is an object of the present invention to protect teeth against dental erosion. Surprisingly, it has been found that ethyl-Nα-lauroyl-L-arginate HCl (LAE) and its salts attach to teeth and provide protection of teeth from erosion especially caused by the action of acid in food products and drinks such as chewing gum and lozenges compositions. Special advantages of this invention are: (a) sustained coating of the teeth by LAE and its homologues; (b) the coating agent provides a source of neutralizing plaque acids by providing sustained base formation. This is because arginines in LAE is degraded by bacteria on tooth in the mouth to produce ammonia. Thus, this chemistry not only provides the coating protection but also generates base to maintain pH balance on a sustained basis; and (c) avoid the use of brushing with abrasive cleansers.
摘要翻译： 本发明涉及一种用于保护口腔和含有乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）的牙齿的组合物的用途，相应的组合物和相应的保护牙齿的方法。 由于牙齿侵蚀发生几乎流行，因此需要改进的产品，以防止牙齿侵蚀。 因此，本发明的目的是保护牙齿免受牙齿侵蚀。 令人惊讶的是，已经发现乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）及其盐附着于牙齿，并且保护牙齿免受侵蚀，特别是由于酸在食品和饮料中的作用引起的，例如口香糖和 锭剂组合物 本发明的特殊优点是：（a）通过LAE及其同系物持续涂覆牙齿; （b）涂层剂通过提供持续的碱形成提供中和斑块酸源。 这是因为LAE中的精氨酸被口腔中的牙齿上的细菌降解以产生氨。 因此，这种化学不仅提供了涂层保护，而且还产生了基础，以持续地维持pH平衡; 和（c）避免使用磨料清洁剂进行刷牙。
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公开(公告)号：US20090326031A1
公开(公告)日：2009-12-31
申请号：US12375774
申请日：2006-08-03
IPC分类号： A61K31/221 , A61K31/4164 , A61P31/12
CPC分类号： A61K31/155 , A23L3/3463 , A23L3/3526 , A61K31/223 , A61L2/0082 , A61L2/0088 , A61L2/18 , A61L2/23 , C02F1/50 , C02F2305/04 , C11D1/50 , C11D1/58 , C11D3/48
摘要： Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the protection against the growth of the microorganisms. The cationic surfactants of this type are also effective against virus infections. Addition of LAE to cultures of Herpes virus type 1 Vaccinia virus and bovine parainfluenzae 3 virus leads to nearly complete reduction of the virus organisms in these cultures, such effects being observed after 5 and 60 minutes.
摘要翻译： 衍生自脂肪酸和酯化的二元氨基酸（例如月桂酸和精氨酸），特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯的缩合产生的阳离子表面活性剂可用于防止生长 微生物。 这种阳离子表面活性剂对于病毒感染也是有效的。 在1型疱疹病毒和牛副流感病毒3病毒的培养物中添加LAE导致这些培养物中病毒生物体的几乎完全减少，在5和60分钟后观察到这种效应。
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