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公开(公告)号：US20050217538A1
公开(公告)日：2005-10-06
申请号：US10711619
申请日：2004-09-29
CPC分类号： A61L24/02 , A61L2430/02 , C04B28/34 , C04B2111/00836 , C04B24/003
摘要： A calcium phosphate bone cement setting to a calcium-deficient hydroxyl apatite is modified by an organic phosphate ester of orthophosphoric acid or a salt of an organic phosphate ester. The base cement contains preferably tricalcium phosphate, dicalcium phosphate (anhydrous), calcium carbonate and precipitated hydroxyl apatite. The organic phosphate ester is added to the base cement in an amount of 0.5 to 5 percent by weight. The bone cement can be modified further by adding mineralized collagen I.
摘要翻译： 钙缺乏羟基磷灰石的磷酸钙骨水泥被正磷酸的有机磷酸酯或有机磷酸酯的盐改性。 基础水泥优选含有磷酸三钙，磷酸二钙（无水），碳酸钙和沉淀的羟基磷灰石。 将有机磷酸酯以0.5〜5重量％的量添加到基础水泥中。 通过加入矿化胶原I可进一步改变骨水泥。
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2.发明授权Support material for tissue engineering, for producing implants or implant materials, and an implant produced with the support material 有权用于组织工程，用于生产植入物或植入物材料的支撑材料以及由支撑材料生产的植入物公开(公告)号：US07763272B2
公开(公告)日：2010-07-27
申请号：US10799329
申请日：2004-03-12
申请人： Peter Offermann , Hartmut Worch , Wolfgang Pompe , Michael Gelinsky , Gerhilt Schmack , Gerald Hoffmann , Uwe Köckritz
发明人： Peter Offermann , Hartmut Worch , Wolfgang Pompe , Michael Gelinsky , Gerhilt Schmack , Gerald Hoffmann , Uwe Köckritz
IPC分类号： A61F2/02
CPC分类号： C12N5/0068 , A61F2/105 , A61F2/30756 , A61F2002/30062 , A61F2002/30225 , A61F2002/30448 , A61F2002/30602 , A61F2002/30762 , A61F2002/30766 , A61F2002/30892 , A61F2002/30971 , A61F2002/4648 , A61F2210/0004 , A61F2220/005 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61L27/18 , A61L27/3633 , A61L27/38 , A61L27/3847 , A61L27/3852 , B33Y80/00 , C12N2533/40 , C12N2533/50 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04
摘要： A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.
摘要翻译： 用于组织培养和细胞培养和用于生产植入材料，特别是骨，软骨或皮肤替代物或体外器官替代物或用于医学或生物技术中的其它应用的支架由生物相容性材料制成。 它至少有一种基材在至少一面被静电地植绒在纤维上。 通过静电植绒，纤维几乎垂直地布置在基材的表面上并表现出高的纤维拉出阻力。 支架提供弹性生长格子，其对于压缩是稳定的，用于体外细胞定植或体内细胞向内生长。 植入物或种植体材料可以用支架生产。
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3.发明授权Method of forming metal, ceramic or ceramic/metal layers on inner surfaces of hollow bodies using pulsed laser deposition 有权使用脉冲激光沉积在中空体的内表面上形成金属，陶瓷或陶瓷/金属层的方法
公开(公告)号：US6146714A
公开(公告)日：2000-11-14
申请号：US235978
申请日：1999-01-22
申请人： Steffen Beyer , Reiner Dietsch , Hermann Mai , Wolfgang Pompe
发明人： Steffen Beyer , Reiner Dietsch , Hermann Mai , Wolfgang Pompe
CPC分类号： H01J37/32321 , C23C14/046 , C23C14/28
摘要： A pulsed laser deposition (PLD) process is used for forming a functional metal, ceramic, or ceramic/metal layer on an inner wall of a hollow body. Simultaneously with the deposition process, a thin-film laser treatment is carried out, whereby a laser beam impinges on the coating layer as it is being formed to achieve a rapid heating followed by a rapid cooling and solidification of the deposited coating layer. In this context, the energy and material flux densities are prescribed and controlled as a function of the spacing of the condensation region from the substrate surface. Laser pulses having an energy of 1 to 2 Joules and a pulse repetition rate of 10 to 50 Hz are used. The pulse duration as well as the residual gas atmosphere in the vacuum deposition chamber are controlled so that the generated plasma flux forms the desired layered grain structure, namely a glassy amorphous structure, a columnar structure, or a polycrystalline structure. The coating or target material can be made of a conducting material and/or an insulating material. By continuously or discretely varying process parameters, it is possible to form graded layer coating systems having properties that vary through the thickness of the coating.
摘要翻译： 脉冲激光沉积（PLD）工艺用于在中空体的内壁上形成功能金属，陶瓷或陶瓷/金属层。 与沉积工艺同时进行薄膜激光处理，由此激光束在其形成时照射在涂层上以实现快速加热，随后沉积涂层的快速冷却和固化。 在本文中，能量和物质通量密度是根据冷凝区域与衬底表面间隔的函数来规定和控制的。 使用具有1至2焦耳的能量和10至50Hz的脉冲重复频率的激光脉冲。 控制真空沉积室中的脉冲持续时间和残余气体气氛，使得产生的等离子体通量形成所需的层状晶粒结构，即玻璃态无定形结构，柱状结构或多晶结构。 涂层或靶材料可以由导电材料和/或绝缘材料制成。 通过连续或离散地改变工艺参数，可以形成具有通过涂层厚度变化的特性的分层涂层体系。
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公开(公告)号：US08916690B2
公开(公告)日：2014-12-23
申请号：US13812497
申请日：2011-08-04
CPC分类号： A61L27/12 , A61F2/28 , A61L27/222 , A61L27/24 , A61L27/32 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/10 , A61L2300/412 , A61L2300/604 , A61L2300/63 , A61L2400/18 , A61L2420/00 , A61L2430/02 , C01B25/32
摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
摘要翻译： 本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。 它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。 从而促进骨再生和骨骼生长。 生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。 它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长， 与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。
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公开(公告)号：US20110189657A1
公开(公告)日：2011-08-04
申请号：US12666303
申请日：2008-06-27
申请人： Kai Ostermann , Wolfgang Pompe , Gerhard Rodel , Annett Gross
发明人： Kai Ostermann , Wolfgang Pompe , Gerhard Rodel , Annett Gross
CPC分类号： C12Q1/6897
摘要： The invention relates to a device and a method for the detection and amplification of a primary signal, utilizing an intracellular communication system, and the use thereof for the detection of substances such as phosphorus, sulfur, nitrogen, hormones, metabolic intermediates, fermentation products, and so forth. The device according to the invention for the detection and amplification of a primary signal contains cells of a first type for which a gene, which is responsible for the synthesis of a signal molecule, is under the control of a promoter which is regulated by the primary signal, and cells of a second type for which a specific gene is under the control of a promoter which is regulated by the separated signal molecule, in such a way that the secretion of the signal molecule is induced by a primary signal taken up by a cell of the first type, and the primary signal is amplified by the cells of the second type by the expression of the specific gene under the control of the signal molecule.
摘要翻译： 本发明涉及利用细胞内通信系统检测和扩增主要信号的装置和方法及其用于检测磷，硫，氮，激素，代谢中间体，发酵产物等物质的用途， 等等。 用于检测和扩增主要信号的根据本发明的装置包含第一类型的细胞，其中负责合成信号分子的基因处于由初级细胞调节的启动子的控制之下 信号和第二类型的细胞，其中特定基因处于由分离的信号分子调节的启动子的控制下，使得信号分子的分泌是由主要信号诱导的， 第一类型的细胞，并且通过在信号分子的控制下的特定基因的表达，第一类型的细胞被第二类型的细胞扩增。
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6.发明授权公开(公告)号：US06384197B1
公开(公告)日：2002-05-07
申请号：US09275398
申请日：1999-03-24
申请人： Karl Weis , Wolfgang Pompe , Jens Bradt
发明人： Karl Weis , Wolfgang Pompe , Jens Bradt
IPC分类号： A61K3817
摘要： The invention relates to a process for the preparation of mineralized collagen fibrils, where the fibril formation and mineralization take place in one process step, and to the use thereof as bone substitute material. The collagen is natural collagen.
摘要翻译： 本发明涉及一种用于制备矿化胶原纤维的方法，其中原纤维形成和矿化在一个工艺步骤中发生，并且其作为骨替代材料的用途。 胶原蛋白是天然胶原蛋白。
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公开(公告)号：US20130122067A1
公开(公告)日：2013-05-16
申请号：US13812497
申请日：2011-08-04
IPC分类号： A61F2/28
CPC分类号： A61L27/12 , A61F2/28 , A61L27/222 , A61L27/24 , A61L27/32 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/10 , A61L2300/412 , A61L2300/604 , A61L2300/63 , A61L2400/18 , A61L2420/00 , A61L2430/02 , C01B25/32
摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
摘要翻译： 本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。 它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。 从而促进骨再生和骨骼生长。 生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。 它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长， 与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。
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8.发明申请Method and Devices for the Detection of Microorganisms and/or the Activity Thereof 审中-公开用于检测微生物和/或其活性的方法和装置公开(公告)号：US20090215079A1
公开(公告)日：2009-08-27
申请号：US12096073
申请日：2006-12-01
申请人： Kai Ostermann , Wolfgang Pompe , Dagmar Wersing , Michael Mertig , Justin Gooding , Gerhard Rödel , Karolina Ihle
发明人： Kai Ostermann , Wolfgang Pompe , Dagmar Wersing , Michael Mertig , Justin Gooding , Gerhard Rödel , Karolina Ihle
CPC分类号： G01N33/56911 , G01N2333/245 , G01N2333/25 , G01N2333/255 , G01N2333/28
摘要： In a method for detection of microorganisms and/or their activity with biosensors, on a surface of a substrate over portions thereof at least one ligand for binding a receptor or at least one receptor for a ligand or at least one ligand for binding a receptor and at least one receptor for either the one or a further ligand are immobilized chemically, physically, or biologically, wherein physical or physicochemical changes, caused at receptors by binding of ligands that are emitted by microorganisms in the process of quorum sensing are measured.
摘要翻译： 在用于用生物传感器检测微生物和/或其活性的方法中，在基底表面上的至少一个用于结合受体的配体或用于配体的至少一个受体或至少一个用于结合受体的配体的配体 测量一个或另一个配体的至少一个受体化学，物理或生物学上的固定，其中测量在受感染过程中通过结合由微生物发出的配体在受体处引起的物理或物理化学变化。
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9.发明申请Substrate with Spatially Selective Metal Coating, Method for Production and Use Thereof 审中-公开基材与空间选择性金属涂层，其生产和使用方法公开(公告)号：US20090124488A1
公开(公告)日：2009-05-14
申请号：US11997163
申请日：2006-07-29
申请人： Jurgen Hofinger , Wolfgang Pompe , Michael Mertig , Alexander Kirchner , Nina Schreiber , Anja Bluher , Steffen Roos , Daniela Keck , Beate Katzschner
发明人： Jurgen Hofinger , Wolfgang Pompe , Michael Mertig , Alexander Kirchner , Nina Schreiber , Anja Bluher , Steffen Roos , Daniela Keck , Beate Katzschner
CPC分类号： C23C18/1889 , C23C18/31 , Y10T428/31678 , Y10T428/31681
摘要： A substrate with spatially selective metal coating is produced by first applying biological templates onto parts of the surface of the substrate and applying a metal coating only once the biological templates have been deposited on the substrate. The biological templates are for example surface layer proteins (S-layer) and the metal coating is a noble metal coating. The substrates with spatially selective metal coating are used in catalysts or solid-state electrolyte sensors.
摘要翻译： 具有空间选择性金属涂层的基底是通过首先将生物模板施加到基底表面的部分上并且仅在生物模板沉积在基底上之后施加金属涂层来制备的。 生物模板是例如表层蛋白（S层），金属涂层是贵金属涂层。 具有空间选择性金属涂层的基板用于催化剂或固态电解质传感器。
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10.发明授权Process for producing a gradient coating made of calcium phosphate phases and metal oxide phase on metallic implants 失效在金属植入物上生产由磷酸钙相和金属氧化物相制成的梯度涂层的方法
公开(公告)号：US5723038A
公开(公告)日：1998-03-03
申请号：US718445
申请日：1996-12-02
申请人： Dieter Scharnweber , Henrike Bersch , Hartmut Worch , Jurgen Hofinger , Curt Kranz , Wolfgang Pompe
发明人： Dieter Scharnweber , Henrike Bersch , Hartmut Worch , Jurgen Hofinger , Curt Kranz , Wolfgang Pompe
CPC分类号： C25D9/04 , A61L27/32 , A61F2310/00796 , Y10S623/901
摘要： The invention concerns a process for producing a gradient coating of calcium phosphat phases and metal oxide phases on metallic implants, in particular made of titanium or titanium alloys, for use as dental, jaw or joint implants. A solution containing calcium ions and phosphate ions is used as electrolyte of which the pH is slightly acidic to approximately neutral. The substrate electrodes are alternately polarized cathodically and anodically. The layer deposited in a gratuated manner is adherent, has a fine structure and is distinguished by a high degree of biocompatibility.
摘要翻译： PCT No.PCT / DE96 / 00197 Sec。 371日期1996年12月2日第 102（e）日期1996年12月2日PCT PCT 1996年2月6日PCT公布。 公开号WO96 / 24391 日期1996年8月15日本发明涉及在用作牙科，颌骨或关节植入物的金属植入物，特别是由钛或钛合金制成的钙磷脂相和金属氧化物相的梯度涂层的方法。 使用含有钙离子和磷酸根离子的溶液作为电解质，其pH值略微为中性至酸性。 基板电极在阴极和阳极交替极化。 以令人满意的方式沉积的层是粘附的，具有精细的结构并且被高度的生物相容性区分开来。
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