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    Integratable-fluid flow and property microsensor assembly
    1.
    发明授权
    Integratable-fluid flow and property microsensor assembly 失效
    可积分流体流量和性能微传感器组件

    公开(公告)号：US06794981B2

    公开(公告)日：2004-09-21

    申请号：US10150851

    申请日：2002-05-16

    申请人： Aravind Padmanabhan ,  Jay G. Schwichtenberg ,  Cleopatra Cabuz ,  Ernest Satren

    发明人： Aravind Padmanabhan ,  Jay G. Schwichtenberg ,  Cleopatra Cabuz ,  Ernest Satren

    IPC分类号： H01C304

    CPC分类号： G01F1/6842 ,  G01F1/6845 ,  G01F5/00 ,  G01N1/2247 ,  G01N25/18 ,  G01N25/488 ,  G01N33/0014 ,  G01N2001/2285

    摘要： An integratable fluid flow and property microsensor assembly is configured to be operably embedded in a microfluidic cartridge of the type used in lab-on-a-chip systems. The assembly is a robust package having a microstructure flow sensor contained within a housing in order to achieve a robust sensing device. The cartridge provides a flow path to the assembly, which directs the fluid across the flow sensor and returns the fluid to the cartridge flow path. The flow sensor monitors the controlled flow of fluid and transmits signals indicative of that flow. The assembly structure provides a robust sensor that is operable and accurate in many different applications.

    摘要翻译： 可整合的流体流动和性质微传感器组件被配置为可操作地嵌入在芯片实验室系统中使用的类型的微流体盒中。 该组件是具有包含在壳体内的微结构流量传感器的鲁棒封装，以便实现鲁棒的感测装置。 墨盒提供到组件的流动路径，其引导流体穿过流量传感器并将流体返回到墨盒流动路径。 流量传感器监测流体的受控流动并传输指示该流量的信号。 组装结构提供了一个鲁棒的传感器，在许多不同的应用中可操作和准确。

    Flow metered analyzer
    5.
    发明授权
    Flow metered analyzer 有权
    流量计分析仪

    公开(公告)号：US08361410B2

    公开(公告)日：2013-01-29

    申请号：US11428332

    申请日：2006-06-30

    申请人： Aravind Padmanabhan ,  Cleopatra Cabuz

    发明人： Aravind Padmanabhan ,  Cleopatra Cabuz

    IPC分类号： G01N21/00

    CPC分类号： B01L3/502746 ,  B01L3/50273 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/14 ,  B01L2300/1838 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N15/1484 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486

    摘要： A hematology analyzer or cytometer cartridge system having flow metering. It may have on- or off-cartridge flow metering and control. The system may have local and direct flow measurement to provide accurate counts per unit volume. There may be numerous arrangements for fluidic circuit checks of the cartridge. Examples may include checks pertaining to zero flow, interface, pressure, flow rate, fluid type and quality, backflow, dry qualification, temperature exposure limits, and so on, of the circuits and cartridge associated items.

    摘要翻译： 具有流量计量的血液分析仪或血细胞计数器系统。 它可以具有开/关流量计量和控制。 该系统可以具有本地和直接流量测量，以提供每单位体积的精确计数。 可能存在许多针对盒的流体回路检查的布置。 示例可以包括关于电路和盒相关物品的零流量，界面，压力，流速，流体类型和质量，回流，干质量鉴定，温度暴露限制等的检查。

    Microfluidic cartridge with reservoirs for increased shelf life of installed reagents
    6.
    发明授权
    Microfluidic cartridge with reservoirs for increased shelf life of installed reagents 有权
    具有储存器的微流控筒，以提高安装试剂的保质期

    公开(公告)号：US08097225B2

    公开(公告)日：2012-01-17

    申请号：US10900887

    申请日：2004-07-28

    申请人： Aravind Padmanabhan ,  Cleopatra Cabuz ,  Kenneth O. MacFadden

    发明人： Aravind Padmanabhan ,  Cleopatra Cabuz ,  Kenneth O. MacFadden

    IPC分类号： G01N21/00

    CPC分类号： B41J2/17513 ,  B01L3/502707 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/06

    摘要： A microfluidic cartridge that includes at least one reservoir for storing a reagent or the like for an extended period of time. In one illustrative embodiment, at least part of a wall of a reservoir includes a hydrophobic material, such as a polymonochlorotrifluoroethylene (PCTFE) homopolymer and/or copolymer. The hydrophobic material may help reduce leaching, evaporation, diffusion and/or other transfer of the reagent or one of its components from the reservoir. When the reagent or the like is lyophilized, the hydrophobic material may help keep water, water vapor and/or other gases or liquids from entering the reservoir prior to use of the microfluidic cartridge.

    摘要翻译： 一种微流体盒，其包括用于长时间存储试剂等的至少一个贮存器。 在一个示例性实施方案中，储存器的壁的至少一部分包括疏水性材料，例如聚单氯三氟乙烯（PCTFE）均聚物和/或共聚物。 疏水性材料可以帮助减少试剂或其一种组分从贮存器的浸出，蒸发，扩散和/或其它转移。 当试剂等被冻干时，在使用微流控盒之前，疏水材料可以帮助保持水，水蒸气和/或其它气体或液体不会进入储存器。

    Raman detection based flow cytometer
    9.
    发明申请
    Raman detection based flow cytometer 有权
    基于拉曼检测的流式细胞仪

    公开(公告)号：US20060103840A1

    公开(公告)日：2006-05-18

    申请号：US10991001

    申请日：2004-11-17

    申请人： Bernard Fritz ,  Aravind Padmanabhan ,  Cleopatra Cabuz

    发明人： Bernard Fritz ,  Aravind Padmanabhan ,  Cleopatra Cabuz

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/658 ,  G01N15/147

    摘要： A method and apparatus for enabling chemical identification of individual particles, cells of molecules by obtaining a Raman spectrum of a particle, cell or molecule as it flows past a sensing point in a flow cytometer. The particles, which may be cells or molecules, are associated with a suitable noble metal colloid or colloidal aggregate. Cellular particles may be associated with gold or silver colloidal particles by ultra-sonic sonification while in a sample preparation reservoir containing the gold or silver colloidal suspension. The colloid associated particles are then hydrodynamically focused into a single file by a fluid control module. The surface-enhance Raman Spectrum of individual particles are obtained by illuminating the particle with a laser as the particle flows past a sensing point and gathering the light that is non-elastically scattered (Raman scattered) by the particle. The surface-enhanced Raman spectrum is then analyzed to identify the particle.

    摘要翻译： 一种方法和装置，用于通过在流式细胞计数器中流过感测点时获得粒子，细胞或分子的拉曼光谱，从而能够化学鉴定单个颗粒，分子细胞。 可以是细胞或分子的颗粒与合适的贵金属胶体或胶体聚集体相关联。 在含有金或银胶体悬浮液的样品制备储存器中，细胞颗粒可以通过超声波超声处理与金或银胶体颗粒结合。 然后通过流体控制模块将胶体相关颗粒流体动力聚焦成单个文件。 当颗粒流过感测点并通过颗粒收集非弹性散射（拉曼散射）的光时，通过用激光照射颗粒来获得单个颗粒的表面增强拉曼光谱。 然后分析表面增强拉曼光谱以鉴定颗粒。