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25 条记录 (耗时 0.039 秒)

    Process for preparation of iodopropargyl carbamates
    7.
    发明授权
    Process for preparation of iodopropargyl carbamates 失效
    碘代炔丙基氨基甲酸酯的制备方法

    公开(公告)号：US5326899A

    公开(公告)日：1994-07-05

    申请号：US76561

    申请日：1993-06-14

    申请人： Barry C. Lange

    发明人： Barry C. Lange

    IPC分类号： B01J21/04 ,  B01J27/08 ,  B01J27/26 ,  B01J31/02 ,  B01J31/04 ,  B01J31/12 ,  C07B61/00 ,  C07C269/04 ,  C07C271/12 ,  C07C261/00

    CPC分类号： C07C269/04 ,  C07C271/12

    摘要： A Process for producing N-alkyl iodopropargyl carbamate comprising:A. reacting a dialkyl(C.sub.1 -C.sub.3) carbonate with propargyl alcohol in the presence of a first catalyst under conditions to produce dipropargyl carbonate;B. reacting said dipropargyl carbonate with an alkyl(C.sub.1 -C.sub.6)amine, optionally in the presence of a second catalyst, to produce N-alkyl(C.sub.1 -C.sub.6) propargyl carbamate;C. reacting said N-alkyl(C.sub.1 -C.sub.6) propargyl carbamate with an iodinating agent to produce N-alkyl(C.sub.1 -C.sub.6) iodopropargyl carbamate is disclosed.

    摘要翻译： 一种N-烷基碘炔丙基氨基甲酸酯的制备方法，其包括：A.在第一催化剂存在下，在产生碳酸二丙酯的条件下，使碳酸二烷基酯（C 1 -C 3）与炔丙醇反应; B.任选在第二催化剂存在下，使所述碳酸二丙酯与烷基（C 1 -C 6）反应，生成N-烷基（C 1 -C 6）炔丙基氨基甲酸酯; C.公开了使所述N-烷基（C 1 -C 6）炔丙基氨基甲酸酯与碘化剂反应以制备N-烷基（C1-C6）碘炔丙基氨基甲酸酯。

    Substituted 3-thioacryloyl compounds and their use as antimicrobial agents
    10.
    发明授权
    Substituted 3-thioacryloyl compounds and their use as antimicrobial agents 失效
    取代的3-硫代丙烯酰化合物及其作为抗微生物剂的用途

    公开(公告)号：US5464832A

    公开(公告)日：1995-11-07

    申请号：US166498

    申请日：1993-12-13

    申请人： Peter Osei-Gyimah ,  Samuel E. Sherba ,  Barry C. Lange ,  Rai J. Mehta ,  Rhoda W. Joseph

    发明人： Peter Osei-Gyimah ,  Samuel E. Sherba ,  Barry C. Lange ,  Rai J. Mehta ,  Rhoda W. Joseph

    IPC分类号： A01N37/36 ,  A01N41/12 ,  A01N43/10 ,  A01N43/40 ,  A01N43/50 ,  A01N43/713 ,  A01N43/78 ,  A01N47/42 ,  A01N47/48 ,  C07C323/54 ,  C07C323/60 ,  C07C331/14 ,  C07C335/32 ,  C07D213/70 ,  C07D213/89 ,  C07D233/42 ,  C07D257/04 ,  C07D277/36 ,  C07D277/74 ,  C07D333/28 ,  C07D211/06 ,  A61K31/535 ,  C07D263/04 ,  C07D265/30

    CPC分类号： C07D213/70 ,  A01N37/36 ,  A01N41/12 ,  A01N43/10 ,  A01N43/40 ,  A01N43/50 ,  A01N43/713 ,  A01N43/78 ,  A01N47/42 ,  A01N47/48 ,  C07C323/54 ,  C07C323/60 ,  C07C331/14 ,  C07C335/32 ,  C07D213/89 ,  C07D233/42 ,  C07D257/04 ,  C07D277/36 ,  C07D277/74 ,  C07D333/28

    摘要： A thioacryloyl compound of the formula ##STR1## wherein Z is selected from the group consisting of OR, R and NR.sup.1 R.sup.2 ;R is selected from the group consisting of hydrogen; (C.sub.1 -C.sub.18)alkyl; (C.sub.1 -C.sub.8)alkenyl; (C.sub.1 -C.sub.8)haloalkynyl; 2-(5-chlorothienyl)methyl; phenyl optionally substituted with one or more substituents selected from the group consisting of halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; phenacyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; arylalkyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl;R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.8)alkyl and phenyl, or R.sup.1 and R.sup.2 may be joined together with the nitrogen atom to which they are attached to form a ring containing 4 to 5 carbon atoms with or without an oxygen heteroatom;X is selected from the group consisting of hydrogen, halogen, phenyl, CO.sub.2 CH.sub.3, and (C.sub.1 -C.sub.3)alkyl; andY is selected from the group consisting of CN, CH(COCH.sub.3).sub.2, CH.sub.2 COCH.sub.3, CH.sub.2 CN, CH.sub.2 CO.sub.2 C.sub.2 H.sub.5 -propargyl, SCH.dbd.CHCO.sub.2 CH.sub.3, C(.dbd.NH)NH.sub.2 hydrochloride, and 2-(5-chlorothienyl)methyl;provided that when Z is NR.sup.1 R.sup.2, Y is CN; andprovided that when Z is R, X is hydrogen, and Y is CN, R is not phenyl.

    摘要翻译： 式Ⅰ的硫代丙烯酰化合物，其中Z选自OR，R和NR1R2; R选自氢; （C 1 -C 18）烷基; （C1-C8）烯基; （C1-C8）卤代炔基; 2-（5-氯噻吩基）甲基; 任选被一个或多个选自卤代，（C 1 -C 3）烷氧基 - ，硝基 - 和（C 1 -C 3）烷基的取代基取代的苯基; 任选被一个或多个选自环卤，（C1-C3）烷氧基 - ，硝基 - 和（C1-C3）烷基的取代基取代的苯乙烯酰基; 任选被一个或多个选自环卤，（C 1 -C 3）烷氧基 - ，硝基 - 和（C 1 -C 3）烷基的取代基取代的芳基烷基; R 1和R 2独立地选自（C 1 -C 8）烷基和苯基，或者R 1和R 2可以与它们所连接的氮原子一起形成含有或不含有氧杂原子的含有4至5个碳原子的环; X选自氢，卤素，苯基，CO 2 CH 3和（C 1 -C 3）烷基; 并且Y选自CN，CH（COCH 3）2，CH 2 COCH 3，CH 2 CN，CH 2 CO 2 C 2 H 5 - 炔丙基，SCH = CHCO 2 CH 3，C（= NH）NH 2盐酸盐和2-（5-氯噻吩基）甲基; 条件是当Z为NR1R2时，Y为CN; 并且条件是当Z是R时，X是氢，Y是CN，R不是苯基。